Robert J Wechsler-Reya

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells
    Zeng Jie Yang
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 14:135-45. 2008
  2. ncbi request reprint Hit 'em where they live: targeting the cancer stem cell niche
    Zeng Jie Yang
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 11:3-5. 2007
  3. ncbi request reprint Caught in the matrix: how vitronectin controls neuronal differentiation
    R J Wechsler-Reya
    Dept of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Trends Neurosci 24:680-2. 2001
  4. ncbi request reprint Analysis of gene expression in the normal and malignant cerebellum
    Robert J Wechsler-Reya
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Recent Prog Horm Res 58:227-48. 2003
  5. ncbi request reprint Morphing into cancer: the role of developmental signaling pathways in brain tumor formation
    Marie P Fogarty
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurobiol 64:458-75. 2005
  6. pmc Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors
    Trudy G Oliver
    Department of Pharmacology and Cancer Biology and Bioinformatics Shared Resource, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 100:7331-6. 2003
  7. pmc Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma
    Tracy Ann Read
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 15:135-47. 2009
  8. ncbi request reprint Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma
    Trudy G Oliver
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 132:2425-39. 2005
  9. pmc N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma
    Jessica D Kessler
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genes Dev 23:157-70. 2009
  10. pmc Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells
    Marie P Fogarty
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 104:2973-8. 2007

Research Grants

  1. Control of Cerebellar Development by FGF signaling
    Robert Wechsler Reya; Fiscal Year: 2004
  2. Control of Medulloblastoma Migration & Survival by Unc5c
    Robert J Wechsler Reya; Fiscal Year: 2010
  3. Stem Cells, Progenitors, and the Origin of Medulloblastoma
    Robert J Wechsler Reya; Fiscal Year: 2010
  4. Stem Cells, Progenitors, and the Origin of Medulloblastoma
    Robert Wechsler Reya; Fiscal Year: 2009
  5. Control of Medulloblastoma Migration & Survival by Unc5c
    Robert Wechsler Reya; Fiscal Year: 2009
  6. Control of Medulloblastoma Migration & Survival by Unc5c
    Robert Wechsler Reya; Fiscal Year: 2007
  7. Control of Cerebellar Development by FGF signaling
    Robert Wechsler Reya; Fiscal Year: 2007
  8. Control of Medulloblastoma Migration & Survival by Unc5c
    Robert Wechsler Reya; Fiscal Year: 2006
  9. Control of Cerebellar Development by FGF signaling
    Robert Wechsler Reya; Fiscal Year: 2005
  10. Control of Cerebellar Development by FGF signaling
    Robert Wechsler Reya; Fiscal Year: 2006

Collaborators

Detail Information

Publications16

  1. pmc Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells
    Zeng Jie Yang
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 14:135-45. 2008
    ..These studies suggest that medulloblastoma can be initiated in progenitors or stem cells but that Shh-induced tumorigenesis is associated with neuronal lineage commitment...
  2. ncbi request reprint Hit 'em where they live: targeting the cancer stem cell niche
    Zeng Jie Yang
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 11:3-5. 2007
    ..Disrupting this niche impairs CSC self-renewal and thereby significantly inhibits the growth of tumors. Targeting the unique microenvironment of CSCs may be the key to effective cancer therapy...
  3. ncbi request reprint Caught in the matrix: how vitronectin controls neuronal differentiation
    R J Wechsler-Reya
    Dept of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Trends Neurosci 24:680-2. 2001
    ..A recent study suggests that the extracellular matrix protein vitronectin might tell GCPs when to stop dividing and begin differentiation...
  4. ncbi request reprint Analysis of gene expression in the normal and malignant cerebellum
    Robert J Wechsler-Reya
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Recent Prog Horm Res 58:227-48. 2003
    ..This review summarizes recent studies of gene expression in the cerebellum and discusses the value of such approaches for understanding development and tumorigenesis in this tissue...
  5. ncbi request reprint Morphing into cancer: the role of developmental signaling pathways in brain tumor formation
    Marie P Fogarty
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurobiol 64:458-75. 2005
    ..This review summarizes our current knowledge about the roles of morphogens in central nervous system tumorigenesis...
  6. pmc Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors
    Trudy G Oliver
    Department of Pharmacology and Cancer Biology and Bioinformatics Shared Resource, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 100:7331-6. 2003
    ..Finally, cyclin D1 and N-myc are overexpressed in murine medulloblastoma. These findings suggest that cyclin D1 and N-myc are important mediators of Shh-induced proliferation and tumorigenesis...
  7. pmc Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma
    Tracy Ann Read
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 15:135-47. 2009
    ..CD15 is also found in a subset of human medulloblastomas, and tumors expressing genes similar to those found in murine CD15(+) cells have a poorer prognosis. Thus, CD15 may represent an important marker for TPCs in medulloblastoma...
  8. ncbi request reprint Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma
    Trudy G Oliver
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 132:2425-39. 2005
    ..The identification and molecular characterization of pre-neoplastic cells provides insight into the early steps in medulloblastoma formation, and may yield important markers for early detection and therapy of this disease...
  9. pmc N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma
    Jessica D Kessler
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genes Dev 23:157-70. 2009
    ..These studies provide the first direct evidence that PNCs can give rise to tumors, and demonstrate that identification of genetic changes that promote tumor progression is critical for designing effective therapies for cancer...
  10. pmc Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells
    Marie P Fogarty
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 104:2973-8. 2007
    ..These findings suggest that FGF is a potent inhibitor of Shh signaling and may be a useful therapy for tumors involving activation of the hedgehog pathway...
  11. pmc Stem cells and the origin and propagation of brain tumors
    Brian A Emmenegger
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Child Neurol 23:1172-8. 2008
    ..The goal of this review is to sort out some of that confusion and highlight what we know and what we have yet to learn...
  12. pmc Isolation of neural stem cells from the postnatal cerebellum
    Audra Lee
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Neurosci 8:723-9. 2005
    ..Identification of cerebellar stem cells has important implications for the understanding of cerebellar development and the origins of medulloblastoma...
  13. pmc Targeting sonic hedgehog-associated medulloblastoma through inhibition of Aurora and Polo-like kinases
    Shirley L Markant
    Authors Affiliations Tumor Initiation and Maintenance Program, National Cancer Institute NCI Designated Cancer Center, Sanford Burnham Medical Research Institute Sanford Consortium for Regenerative Medicine Departments of Pediatrics, Neurosciences, and Neurosurgery, University of California San Diego, La Jolla Rady Children s Hospital, San Diego, California Departments of Pharmacology and Cancer Biology, Medicine, Division of Pulmonary, Allergy, and Critical Care, Pediatrics, Division of Pediatric Hematology Oncology, and Surgery, Duke University Medical Center, Durham, North Carolina German Cancer Research Center DKFZ, Heidelberg, Germany and Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Cancer Res 73:6310-22. 2013
    ..Our findings suggest that targeting G2-M regulators may represent a novel approach for treatment of human medulloblastoma...
  14. pmc Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues
    Carrie E Johnson
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27708, USA
    Proc Natl Acad Sci U S A 104:20820-5. 2007
    ..Moreover, they raise the possibility that this phenomenon could be exploited therapeutically to selectively kill brain cancer cells while sparing the surrounding brain parenchyma...
  15. ncbi request reprint Getting at the root and stem of brain tumors
    Trudy G Oliver
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 42:885-8. 2004
    ..We will examine these possibilities and discuss their implications for the understanding and treatment of brain tumors...
  16. pmc Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2
    Alison R Meloni
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Mol Cell Biol 26:7550-60. 2006
    ..Together, these data suggest that GRK2 plays a positive role in Smoothened signaling, at least in part, through the promotion of an association between beta-arrestin 2 and Smoothened...

Research Grants14

  1. Control of Cerebellar Development by FGF signaling
    Robert Wechsler Reya; Fiscal Year: 2004
    ..Moreover, by deepening our understanding of cell cycle regulation in normal granule cell precursors, these studies may shed light on the loss of cell cycle control in medulloblastoma, the most common malignant brain tumor in children ..
  2. Control of Medulloblastoma Migration & Survival by Unc5c
    Robert J Wechsler Reya; Fiscal Year: 2010
    ..This, in turn, will pave the way for developing new treatments that can be used to fight this devastating disease. ..
  3. Stem Cells, Progenitors, and the Origin of Medulloblastoma
    Robert J Wechsler Reya; Fiscal Year: 2010
    ..Identifying these cells may allow us to develop more effective methods for eradicating the tumor. ..
  4. Stem Cells, Progenitors, and the Origin of Medulloblastoma
    Robert Wechsler Reya; Fiscal Year: 2009
    ..Identifying these cells may allow us to develop more effective methods for eradicating the tumor. ..
  5. Control of Medulloblastoma Migration & Survival by Unc5c
    Robert Wechsler Reya; Fiscal Year: 2009
    ..This, in turn, will pave the way for developing new treatments that can be used to fight this devastating disease. ..
  6. Control of Medulloblastoma Migration & Survival by Unc5c
    Robert Wechsler Reya; Fiscal Year: 2007
    ..This, in turn, will pave the way for developing new treatments that can be used to fight this devastating disease. ..
  7. Control of Cerebellar Development by FGF signaling
    Robert Wechsler Reya; Fiscal Year: 2007
    ..Moreover, by deepening our understanding of cell cycle regulation in normal granule cell precursors, these studies may shed light on the loss of cell cycle control in medulloblastoma, the most common malignant brain tumor in children ..
  8. Control of Medulloblastoma Migration & Survival by Unc5c
    Robert Wechsler Reya; Fiscal Year: 2006
    ..This, in turn, will pave the way for developing new treatments that can be used to fight this devastating disease. ..
  9. Control of Cerebellar Development by FGF signaling
    Robert Wechsler Reya; Fiscal Year: 2005
    ..Moreover, by deepening our understanding of cell cycle regulation in normal granule cell precursors, these studies may shed light on the loss of cell cycle control in medulloblastoma, the most common malignant brain tumor in children ..
  10. Control of Cerebellar Development by FGF signaling
    Robert Wechsler Reya; Fiscal Year: 2006
    ..Moreover, by deepening our understanding of cell cycle regulation in normal granule cell precursors, these studies may shed light on the loss of cell cycle control in medulloblastoma, the most common malignant brain tumor in children ..
  11. Control of Cerebellar Development by FGF signaling
    Robert Wechsler Reya; Fiscal Year: 2005
    ..Moreover, by deepening our understanding of cell cycle regulation in normal granule cell precursors, these studies may shed light on the loss of cell cycle control in medulloblastoma, the most common malignant brain tumor in children ..
  12. Control of Medulloblastoma Migration & Survival by Unc5c
    Robert Wechsler Reya; Fiscal Year: 2009
    ..This, in turn, will pave the way for developing new treatments that can be used to fight this devastating disease. ..