Affiliation: Duke University Medical Center
- Effect of bupropion extended release on negative emotion processing in major depressive disorder: a pilot functional magnetic resonance imaging studyBrigitte Robertson
Clinical Pharmacology and Discovery Medicine, GlaxoSmithKline, Research Triangle Park
J Clin Psychiatry 68:261-7. 2007..This study examined the effect of bupropion XL, an extended release formulation of the nonserotonergic antidepressant agent bupropion, using a paradigm that investigated both negative emotional response and attentional processing...
- Prefrontal mechanisms for executive control over emotional distraction are altered in major depressionLihong Wang
Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, USA
Psychiatry Res 163:143-55. 2008..The results provide direct evidence of an alteration in the neural systems that interplay cognition with mood in MDD...
- Depressive state- and disease-related alterations in neural responses to affective and executive challenges in geriatric depressionLihong Wang
Brain Imaging and Analysis Center, Duke University Medical Center, PO Box 3918, Rm 163, Bell Building, Durham, NC 27710, USA
Am J Psychiatry 165:863-71. 2008..Identifying both depressive state-related and disease-related alterations in brain regions associated with emotion and cognitive function could provide useful diagnostic information in geriatric depression...
- Neural correlates associated with cognitive decline in late-life depressionLihong Wang
Duke UNC Brain Imaging and Analysis Center, Department of Psychiatry and Behavioral Sciences, Duke University, Durham, USA
Am J Geriatr Psychiatry 20:653-63. 2012..Persistent cognitive impairment (PCI) after remission of depressive symptoms is a major adverse outcome of late-life depression (LLD). The purpose of this study was to examine neural substrates associated with PCI in LLD...
- The effect of acute tryptophan depletion on emotional distraction and subsequent memoryLihong Wang
Brain Imaging and Analysis Center, Duke University Medical Center, 2424 Erwin Road, Suite 501 Durham, NC 27705, USA
Soc Cogn Affect Neurosci 4:357-68. 2009..These findings highlight the importance of serotonin in negative memory with implications for mood disorders...
- Frontoparietal attentional network activation differs between smokers and nonsmokers during affective cognitionBrett Froeliger
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
Psychiatry Res 211:57-63. 2013..These findings suggests that chronic nicotine use may reduce inhibitory control and conflict resolution of emotional distraction, and result in recruiting additional attentional resources during emotional interference on cognition...
- Opposing influences of emotional and non-emotional distracters upon sustained prefrontal cortex activity during a delayed-response working memory taskFlorin Dolcos
Duke UNC Brain Imaging and Analysis Center, Duke University, Durham, NC, USA
Neuropsychologia 46:326-35. 2008....
- Mood alters amygdala activation to sad distractors during an attentional taskLihong Wang
Brain Imaging and Analysis Center, Duke University, Durham, NC 27710, USA
Biol Psychiatry 60:1139-46. 2006..There is little evidence showing that the amygdala's response to sad sensory stimuli is functionally modulated by mood state, however...
- Smoking abstinence and depressive symptoms modulate the executive control system during emotional information processingBrett Froeliger
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
Addict Biol 17:668-79. 2012..Reactivity to emotional stimuli and the interfering effects on cognition are moderated by the magnitude of smoking state-dependent negative affect and baseline depressive symptoms...
- Role of the inferior frontal cortex in coping with distracting emotionsFlorin Dolcos
Duke UNC Brain Imaging and Analysis Center, Duke University, Durham, North Carolina 27710, USA
Neuroreport 17:1591-4. 2006..controlling the subjective feeling of being distracted (right hemisphere)...
- Functional imaging of emotion reactivity in opiate-dependent borderline personality disorderMoria J Smoski
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Personal Disord 2:230-41. 2011..Future studies that also include BPD-only and OD-only groups are necessary to help clarify the individual and potentially synergistic effects of these two conditions...
- Prognostic value of posteromedial cortex deactivation in mild cognitive impairmentJeffrey R Petrella
Alzheimer Imaging Research Laboratory and Brain Imaging and Analysis Center, Department of Radiology, Duke University Medical Center, Durham, North Carolina, United States of America
PLoS ONE 2:e1104. 2007..The goal of this study was to prospectively determine the prognostic significance of PMC deactivation in mild cognitive impairment (MCI)...
- Neural substrates for processing task-irrelevant sad images in adolescentsLihong Wang
Duke UNC Brain Imaging and Analysis Center, Duke University Medical Center, USA
Dev Sci 11:23-32. 2008..The pattern of activation to task-irrelevant emotional distraction suggests a possible immaturity of brain function in cognitive control over emotional distraction in adolescents...
- Cortical deactivation in mild cognitive impairment: high-field-strength functional MR imagingJeffrey R Petrella
Department of Radiology, Duke University Medical Center, 1527 Hosp North, Box 3808, Durham, NC 27710, USA
Radiology 245:224-35. 2007....
- Psychological and neural mechanisms of trait mindfulness in reducing depression vulnerabilityNatalie A Paul
Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC 27705, USA
Soc Cogn Affect Neurosci 8:56-64. 2013..Based on these results, mindfulness could reduce vulnerability to depression in at least two ways: (i) by buffering against trait rumination and negative bias and (ii) by reducing automatic emotional responding via the insula...
- Nicotine withdrawal modulates frontal brain function during an affective Stroop taskBrett Froeliger
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 2608 Erwin Road, Lake View Pavilion East Suite 300, Durham, NC 27705 4596, USA
Psychopharmacology (Berl) 220:707-18. 2012..In this study, functional magnetic resonance imaging (fMRI) was used to investigate smoking abstinence effects on emotion-cognition interactions...
- Amygdala activation to sad pictures during high-field (4 tesla) functional magnetic resonance imagingLihong Wang
Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, USA
Emotion 5:12-22. 2005..In contrast, oddball targets engaged dorsal sectors of frontal, parietal, and cingulate cortices. The amygdala's role in emotional evaluation thus extends to images of grief and despair as well as to those depicting violence and threat...
- Scan-rescan reliability of subcortical brain volumes derived from automated segmentationRajendra A Morey
Duke UNC Brain Imaging and Analysis Center, Duke University, Durham, North Carolina 27705, USA
Hum Brain Mapp 31:1751-62. 2010..Thus, longitudinal research requires a careful analysis of sample size and choice of segmentation method combined with a consideration of the brain structure(s) of interest and the magnitude of the anticipated effects...
- Structural integrity of the uncinate fasciculus and resting state functional connectivity of the ventral prefrontal cortex in late life depressionDavid C Steffens
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, United States of America
PLoS ONE 6:e22697. 2011..In this study we sought to examine the relationship between the uncinate fasciculus, a key fronto-temporal tract and resting state functional connectivity between the ventral prefrontal cortex ((PFC) and limbic and striatal areas...
- Ventromedial prefrontal cortex encodes emotional valueAmy Winecoff
Center for Cognitive Neuroscience, Duke University, Durham, North Carolina 27708, USA
J Neurosci 33:11032-9. 2013..These results suggest that the vmPFC encodes a domain-general value signal that tracks the value of not only external rewards, but also emotional stimuli. ..
- Loss of sustained activity in the ventromedial prefrontal cortex in response to repeated stress in individuals with early-life emotional abuse: implications for depression vulnerabilityLihong Wang
Center for Biomedical Research Imaging, Tsinghua University, Beijing, China Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, USA Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC, USA
Front Psychol 4:320. 2013..This pilot study warrants future investigation to clarify the stress-related neural activity pattern dynamically to identify depression vulnerability at an individual level...
- Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han populationLihong Wang
Department of Immunology, Harbin Medical University, Harbin 150081, China
BMC Cancer 7:173. 2007..To evaluate the potential influences of CTLA-4 gene polymorphisms on breast cancer risk, a case-control study was conducted in Han women of Northeast China...
- Analysis of FLT3 internal tandem duplication and D835 mutations in Chinese acute leukemia patientsLihong Wang
State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, PR China
Leuk Res 29:1393-8. 2005..Early detection of FLT3 mutations and an intensification of induction therapy might thus be useful for this group of patients to overcome the poor prognosis...
- Visual event-related potentials under different interstimulus intervals in Parkinson's disease: relation to motor disability, WAIS-R, and regional cerebral blood flowMei Li
Department of Neurology, Graduate School of Medicine, Yokohama City University, 3 9 Fukuura, Yokohama 236 0004, Japan
Parkinsonism Relat Disord 11:209-19. 2005..Both P300 latency and reaction time during task O showed significantly longer latency in longer ISI condition. Our results revealed 'ISI' influence on ERPs during task S and significant correlation between ERPs and rCBF in task S...
- Early sensory information processes are enhanced on visual oddball and S1-S2 tasks in Parkinson's disease: a visual event-related potentials studyMei Li
Department of Neurology, School of Medicine, Yokohama City University, 3 9 Fukuura, Kanazawa Ku, 236 0004 Yokohama, Japan
Parkinsonism Relat Disord 9:329-40. 2003..We surmise overactive aspects or failed inhibitory modulation of sensory information processing in the early ERP stage and deficient cognitive information processing during the late ERP stage in PD...