Judith Voynow

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc NAD(P)H quinone oxidoreductase 1 regulates neutrophil elastase-induced mucous cell metaplasia
    Marisa L Meyer
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 303:L181-8. 2012
  2. doi request reprint Mucins, mucus, and sputum
    Judith A Voynow
    Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA
    Chest 135:505-12. 2009
  3. pmc NAD(P)H quinone oxidoreductase 1 is essential for ozone-induced oxidative stress in mice and humans
    Judith A Voynow
    Division of Pediatric Pulmonary Medicine, Department of Pediatrics, Duke University Medical Center, Box 2994, Durham, NC 27710, USA
    Am J Respir Cell Mol Biol 41:107-13. 2009
  4. pmc Proteases and cystic fibrosis
    Judith A Voynow
    Department of Pediatrics, Duke University Medical Center, Box 2994, Durham, NC 27710, USA
    Int J Biochem Cell Biol 40:1238-45. 2008
  5. ncbi request reprint Regulation of mucin genes in chronic inflammatory airway diseases
    Judith A Voynow
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Cell Mol Biol 34:661-5. 2006
  6. ncbi request reprint Basal-like cells constitute the proliferating cell population in cystic fibrosis airways
    Judith A Voynow
    Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Am J Respir Crit Care Med 172:1013-8. 2005
  7. ncbi request reprint Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells
    J A Voynow
    Division of Pediatric Pulmonary Diseases, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol 276:L835-43. 1999
  8. ncbi request reprint Neutrophil elastase induces mucus cell metaplasia in mouse lung
    Judith A Voynow
    Department of Pediatrics, Duke University Medical Center, Box 2994, Durham, NC 27710, USA
    Am J Physiol Lung Cell Mol Physiol 287:L1293-302. 2004
  9. ncbi request reprint ErbB2 activity is required for airway epithelial repair following neutrophil elastase exposure
    Bernard M Fischer
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    FASEB J 19:1374-6. 2005
  10. ncbi request reprint Neutrophil elastase inhibition of cell cycle progression in airway epithelial cells in vitro is mediated by p27kip1
    Bernard M Fischer
    Division of Pediatric Pulmonary Medicine, Duke Univ Medical Center, Box 2994, Durham, NC 27710, USA
    Am J Physiol Lung Cell Mol Physiol 293:L762-8. 2007

Detail Information

Publications18

  1. pmc NAD(P)H quinone oxidoreductase 1 regulates neutrophil elastase-induced mucous cell metaplasia
    Marisa L Meyer
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 303:L181-8. 2012
    ..NQO1 is required for NE-induced inflammation and MCM. This model system demonstrates that NE-induced MCM directly correlates with inflammation, but not with oxidative stress...
  2. doi request reprint Mucins, mucus, and sputum
    Judith A Voynow
    Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA
    Chest 135:505-12. 2009
    ..This review will highlight the most recent insights on mucus biology in health and disease...
  3. pmc NAD(P)H quinone oxidoreductase 1 is essential for ozone-induced oxidative stress in mice and humans
    Judith A Voynow
    Division of Pediatric Pulmonary Medicine, Department of Pediatrics, Duke University Medical Center, Box 2994, Durham, NC 27710, USA
    Am J Respir Cell Mol Biol 41:107-13. 2009
    ..Together, these results demonstrate that NQO1 modulates cellular redox status and influences the biologic and physiologic effects of ozone...
  4. pmc Proteases and cystic fibrosis
    Judith A Voynow
    Department of Pediatrics, Duke University Medical Center, Box 2994, Durham, NC 27710, USA
    Int J Biochem Cell Biol 40:1238-45. 2008
    ..The mechanisms employed by proteases to impact airway function in CF will be reviewed...
  5. ncbi request reprint Regulation of mucin genes in chronic inflammatory airway diseases
    Judith A Voynow
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Cell Mol Biol 34:661-5. 2006
    ....
  6. ncbi request reprint Basal-like cells constitute the proliferating cell population in cystic fibrosis airways
    Judith A Voynow
    Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Am J Respir Crit Care Med 172:1013-8. 2005
    ..Cystic fibrosis airways are recurrently exposed to noxious stimuli, leading to epithelial injury. Previous reports suggest that cystic fibrosis airway epithelia may respond to injury by increasing proliferation...
  7. ncbi request reprint Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells
    J A Voynow
    Division of Pediatric Pulmonary Diseases, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol 276:L835-43. 1999
    ..Neutrophil elastase increased MUC5AC mRNA levels by enhancing mRNA stability. This is the first report of mucin gene regulation by this mechanism...
  8. ncbi request reprint Neutrophil elastase induces mucus cell metaplasia in mouse lung
    Judith A Voynow
    Department of Pediatrics, Duke University Medical Center, Box 2994, Durham, NC 27710, USA
    Am J Physiol Lung Cell Mol Physiol 287:L1293-302. 2004
    ..The addition of AAPV-CMK reduced these measures of inflammation to control levels. These experiments suggest that NE proteolytic activity initiates an inflammatory process leading to goblet cell metaplasia...
  9. ncbi request reprint ErbB2 activity is required for airway epithelial repair following neutrophil elastase exposure
    Bernard M Fischer
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    FASEB J 19:1374-6. 2005
    ..1 microM), an ErbB2-neutralizing antibody, blocked thymidine incorporation only in NE-treated cells. These results suggest ErbB2 is a critical factor for epithelial recovery following NE exposure...
  10. ncbi request reprint Neutrophil elastase inhibition of cell cycle progression in airway epithelial cells in vitro is mediated by p27kip1
    Bernard M Fischer
    Division of Pediatric Pulmonary Medicine, Duke Univ Medical Center, Box 2994, Durham, NC 27710, USA
    Am J Physiol Lung Cell Mol Physiol 293:L762-8. 2007
    ..Our results demonstrate that p27 is regulated by NE and is critical for NE-induced cell cycle arrest...
  11. ncbi request reprint Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species
    Bernard M Fischer
    Division of Pediatric Pulmonary Diseases, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Respir Cell Mol Biol 26:447-52. 2002
    ..NE treatment increased cellular fluorescence in both cell types, indicating generation of intracellular reactive oxygen species. We conclude that NE treatment increases MUC5AC gene expression by an oxidant-dependent mechanism...
  12. pmc MARCKS-related peptide modulates in vivo the secretion of airway Muc5ac
    W Michael Foster
    Division of Pulmonary, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Physiol Lung Cell Mol Physiol 299:L345-52. 2010
    ....
  13. ncbi request reprint Effects of TNFalpha on expression of ICAM-1 in human airway epithelial cells in vitro: oxidant-mediated pathways and transcription factors
    Thomas M Krunkosky
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
    Free Radic Biol Med 35:1158-67. 2003
    ....
  14. pmc Regulation of MUC5AC expression by NAD(P)H:quinone oxidoreductase 1
    Shuo Zheng
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 42:1398-408. 2007
    ..Our results indicate that NQO1 has an important role as a key mediator of NE-regulated oxidant stress and MUC5AC mucin gene expression...
  15. ncbi request reprint Neutrophil elastase increases MUC4 expression in normal human bronchial epithelial cells
    Bernard M Fischer
    Division of Pediatric Pulmonary Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 284:L671-9. 2003
    ..Therefore, airway epithelial cells respond to neutrophil elastase exposure by increasing expression of MUC4, a potential activator of epithelial repair mechanisms...
  16. ncbi request reprint What does mucin have to do with lung disease?
    Judith A Voynow
    Division of Pediatric Pulmonary Diseases, Box 2994, Duke University Medical Center, Durham, NC 27710, USA
    Paediatr Respir Rev 3:98-103. 2002
    ..The insights gleaned from the investigations of mucin function and gene regulation should be useful for elucidating the cellular mechanisms leading to airway remodelling and mucus obstruction...
  17. pmc Neutrophil elastase increases airway epithelial nonheme iron levels
    Bernard M Fischer
    Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Clin Transl Sci 2:333-9. 2009
    ..We demonstrated in vitro that NE increased intracellular non-heme iron levels and degraded ferritin. Our results suggest that NE digests ferritin increasing the extracellular iron pool available for cellular uptake...
  18. ncbi request reprint Respiratory tract mucin genes and mucin glycoproteins in health and disease
    Mary Callaghan Rose
    Research Center for Genetic Medicine, Room 5700, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Physiol Rev 86:245-78. 2006
    ..The underlying premise is that understanding the pathways and processes that lead to mucus overproduction in specific airway diseases will allow circumvention or amelioration of these processes...

Research Grants14

  1. NQO1: Linking Oxidant Stress to Inflammation in Airway Epithelial Cells
    Judith A Voynow; Fiscal Year: 2010
    ..We hypothesize that NQO1 functions as a gate-keeper in airway epithelial cells to transmit ozone-generated oxidant stress to an inflammatory response which causes ozone-triggered airway disease. ..
  2. Mucin Gene Regulation by Elastase and Oxidants
    Judith Voynow; Fiscal Year: 2007
    ..b. To determine whether NE and/or NQO1-generated ROS affect HuR binding to MUC5AC. c. To determine whether HuR binding is sufficient for MUC5AC mRNA stabilization. ..
  3. MUC4 Mucin and Airway Epithelial Regeneration in COPD
    Judith Voynow; Fiscal Year: 2006
    ..Our ultimate goal is to use information from this project to identify new biologic targets for rational therapies to induce normal airway epithelial proliferation and differentiation following injury. ..
  4. REGULATION OF MUCIN GENE EXPRESSION BY ELASTASE
    Judith Voynow; Fiscal Year: 2003
    ..The ultimate goal is to use information from this project to identify new biologic targets for therapeutic interventions to prevent mucus obstruction in chronic inflammatory airway diseases. ..
  5. NQO1: Linking Oxidant Stress to Inflammation in Airway Epithelial Cells
    Judith A Voynow; Fiscal Year: 2011
    ..We hypothesize that NQO1 functions as a gate-keeper in airway epithelial cells to transmit ozone-generated oxidant stress to an inflammatory response which causes ozone-triggered airway disease. ..