Laurent Verkoczy

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Induction of HIV-1 broad neutralizing antibodies in 2F5 knock-in mice: selection against membrane proximal external region-associated autoreactivity limits T-dependent responses
    Laurent Verkoczy
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 191:2538-50. 2013
  2. pmc Rescue of HIV-1 broad neutralizing antibody-expressing B cells in 2F5 VH x VL knockin mice reveals multiple tolerance controls
    Laurent Verkoczy
    Department of Medicine, Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 187:3785-97. 2011
  3. pmc Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies
    Laurent Verkoczy
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, USA
    Curr Opin Immunol 23:383-90. 2011
  4. pmc Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance
    Laurent Verkoczy
    Duke Human Vaccine Institute and Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 107:181-6. 2010
  5. pmc Functional, non-clonal IgMa-restricted B cell receptor interactions with the HIV-1 envelope gp41 membrane proximal external region
    Laurent Verkoczy
    Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 4:e7215. 2009
  6. pmc Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10
    Yao Chen
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 191:1260-75. 2013
  7. pmc Enhanced antibody responses to an HIV-1 membrane-proximal external region antigen in mice reconstituted with cultured lymphocytes
    T Matt Holl
    Department of Immunology, Duke University, Durham, NC 27710
    J Immunol 192:3269-79. 2014
  8. pmc Modulation of Nonneutralizing HIV-1 gp41 Responses by an MHC-Restricted TH Epitope Overlapping Those of Membrane Proximal External Region Broadly Neutralizing Antibodies
    Jinsong Zhang
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710
    J Immunol 192:1693-706. 2014
  9. pmc Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitution
    Xiaoying Shen
    Department of Surgery, Duke Human Vaccine Institute, Duke University, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 107:5972-7. 2010
  10. pmc Antibody polyspecificity and neutralization of HIV-1: a hypothesis
    Barton F Haynes
    Duke Human Vaccine Institute, Duke University School of Medicine, Durham NC 27710, USA
    Hum Antibodies 14:59-67. 2005

Collaborators

Detail Information

Publications14

  1. pmc Induction of HIV-1 broad neutralizing antibodies in 2F5 knock-in mice: selection against membrane proximal external region-associated autoreactivity limits T-dependent responses
    Laurent Verkoczy
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 191:2538-50. 2013
    ....
  2. pmc Rescue of HIV-1 broad neutralizing antibody-expressing B cells in 2F5 VH x VL knockin mice reveals multiple tolerance controls
    Laurent Verkoczy
    Department of Medicine, Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 187:3785-97. 2011
    ....
  3. pmc Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies
    Laurent Verkoczy
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, USA
    Curr Opin Immunol 23:383-90. 2011
    ....
  4. pmc Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance
    Laurent Verkoczy
    Duke Human Vaccine Institute and Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 107:181-6. 2010
    ..These features are consistent with elimination of 2F5 HC autoreactivity by additional negative selection mechanism(s) in the periphery...
  5. pmc Functional, non-clonal IgMa-restricted B cell receptor interactions with the HIV-1 envelope gp41 membrane proximal external region
    Laurent Verkoczy
    Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 4:e7215. 2009
    ..These data suggest that low avidity, non-paratopic interactions between the gp41 MPER and membrane Ig on naïve B cells may interfere with or divert bnAb responses...
  6. pmc Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10
    Yao Chen
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 191:1260-75. 2013
    ..e., and not 4E10 BCR(+) B cells) with those mimicked by its gp41 neutralization epitope. ..
  7. pmc Enhanced antibody responses to an HIV-1 membrane-proximal external region antigen in mice reconstituted with cultured lymphocytes
    T Matt Holl
    Department of Immunology, Duke University, Durham, NC 27710
    J Immunol 192:3269-79. 2014
    ....
  8. pmc Modulation of Nonneutralizing HIV-1 gp41 Responses by an MHC-Restricted TH Epitope Overlapping Those of Membrane Proximal External Region Broadly Neutralizing Antibodies
    Jinsong Zhang
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710
    J Immunol 192:1693-706. 2014
    ..Moreover, the proximity of TH and B cell epitopes in this restriction may have to be considered in redesigning minimal MPER immunogens aimed at exclusively binding BnAb epitopes and triggering MPER(+) BnAbs. ..
  9. pmc Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitution
    Xiaoying Shen
    Department of Surgery, Duke Human Vaccine Institute, Duke University, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 107:5972-7. 2010
    ..These data suggest that a major contribution to the L669S mutant virus phenotype of enhanced susceptibility to MPER mAbs is prolonged exposure of the MPER neutralizing epitope during viral entry...
  10. pmc Antibody polyspecificity and neutralization of HIV-1: a hypothesis
    Barton F Haynes
    Duke Human Vaccine Institute, Duke University School of Medicine, Durham NC 27710, USA
    Hum Antibodies 14:59-67. 2005
    ....
  11. pmc HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design
    Mattia Bonsignori
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
    Trends Microbiol 20:532-9. 2012
    ..Strategies are being developed for the analysis of infection and vaccine candidate-induced antibodies, their gene usage, and their maturation pathways such that this information can be used to attempt to guide rational vaccine design...
  12. pmc Differential reactivity of germ line allelic variants of a broadly neutralizing HIV-1 antibody to a gp41 fusion intermediate conformation
    S Munir Alam
    Human Vaccine Institute, Duke University Medical Center, 2 Genome Court, P O Box 103020, Durham, NC 27710, USA
    J Virol 85:11725-31. 2011
    ..Thus, these data demonstrate a genetically determined trait that may affect host responses to HIV-1 envelope epitopes recognized by broadly neutralizing antibodies and has implications for unmutated ancestor-based immunogen design...
  13. pmc B cell responses to HIV-1 infection and vaccination: pathways to preventing infection
    Barton F Haynes
    Duke Human Vaccine Institute and the Duke Center for AIDS Research, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA
    Trends Mol Med 17:108-16. 2011
    ....
  14. ncbi request reprint Autoreactivity in HIV-1 broadly neutralizing antibodies: implications for their function and induction by vaccination
    Laurent Verkoczy
    aDuke Human Vaccine Institute, Duke University Medical Center, Durham bNational Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Curr Opin HIV AIDS 9:224-34. 2014
    ..This review discusses progress in understanding the impact of immune tolerance on inducing broadly neutralizing antibodies (bnAbs), and how such knowledge can be incorporated into novel immunization approaches...