Research Topics
Species | Cynthia A TothSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Publications
Macular degeneration: the latest in current surgical managementCynthia A Toth
Duke University Eye Center, Durham, North Carolina 27710, USA
Retina 26:S21-5. 2006
Analysis of pars plana vitrectomy for optic pit-related maculopathy with intraoperative optical coherence tomography: a possible connection with the vitreous cavityJustis P Ehlers
Cole Eye Institute, Cleveland, Ohio, USA
Arch Ophthalmol 129:1483-6. 2011..Following aspiration, intraoperative spectral-domain optical coherence tomography demonstrated collapse of the retinoschisis, strongly suggesting a connection between the vitreous cavity and the intraretinal fluid...
Dynamics of human foveal development after premature birthRamiro S Maldonado
Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina 27710, USA
Ophthalmology 118:2315-25. 2011..To determine the dynamic morphologic development of the human fovea in vivo using portable spectral domain-optical coherence tomography (SD-OCT)...
Spectral-domain optical coherence tomographic assessment of severity of cystoid macular edema in retinopathy of prematurityRamiro S Maldonado
Department of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27705, USA
Arch Ophthalmol 130:569-78. 2012....
Extraocular muscle surgery for extorsion after macular translocation surgery new surgical technique and clinical managementSandra Holgado
Duke University Eye Center, Durham, North Carolina 27710, USA
Ophthalmology 113:63-9. 2006....
Subfoveal fluid in healthy full-term newborns observed by handheld spectral-domain optical coherence tomographyMichelle T Cabrera
Department of Ophthalmology, Duke Eye Center, Durham, North Carolina 27710, USA
Am J Ophthalmol 153:167-75.e3. 2012..To report retinal findings for healthy newborn infants imaged with handheld spectral-domain optical coherence tomography (SD OCT)...
Management of ocular torsion and diplopia after macular translocation for age-related macular degeneration: prospective clinical studySharon F Freedman
Duke University Eye Center, Durham, North Carolina 27710, USA
Am J Ophthalmol 136:640-8. 2003..To report the results of a prospective clinical series to evaluate the management of both torsion and diplopia in a large group of patients after full macular translocation (FMT) and extraocular muscle surgery...
Quantitative comparison of drusen segmented on SD-OCT versus drusen delineated on color fundus photographsNieraj Jain
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA
Invest Ophthalmol Vis Sci 51:4875-83. 2010..Areas identified as drusen from semiautomated segmentation of drusen on SD-OCT were compared to those identified from review of digital color fundus photographs (CFPs)...
Macular features from spectral-domain optical coherence tomography as an adjunct to indirect ophthalmoscopy in retinopathy of prematurityAnnie C Lee
Department of Ophthalmology, Duke University Medical Center, Duke University, Durham, North Carolina 27710, USA
Retina 31:1470-82. 2011..To compare vitreoretinal pathology imaged with portable handheld spectral-domain optical coherence tomography (SD-OCT) to conventional indirect ophthalmoscopic examination in neonates undergoing screening for retinopathy of prematurity...
Recurrence of retinal pigment epithelial changes after macular translocation with 360 degrees peripheral retinectomy for geographic atrophyMark T Cahill
Department of Ophthalmology, Duke University Eye Center, Erwin Road, Durham, NC 27710, USA
Arch Ophthalmol 123:935-8. 2005..Further research is needed to assess if the potential for visual recovery in eyes with end-stage nonneovascular AMD is outweighed by the possibility of postoperative recurrence of GA...
Fixation switch and diplopia after full macular translocation surgerySandra Holgado
Duke University Eye Center, Durham, North Carolina 27710, USA
J AAPOS 11:114-9. 2007..We sought to identify and evaluate treatment of patients who switched fixation to the poorer-seeing eye and complained of persistent diplopia 6 to 12 months after full macular translocation surgery (MT360) and extraocular muscle surgery...
Recurrent choroidal neovascularization after macular translocation surgery with 360-degree peripheral retinectomyClaxton A Baer
Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA
Retina 28:1221-7. 2008..To evaluate the pattern of age-related macular degeneration in the new foveal location after macular translocation surgery with 360 degree peripheral retinectomy for neovascular age-related macular degeneration...
Insights into advanced retinopathy of prematurity using handheld spectral domain optical coherence tomography imagingSai H Chavala
Department of Ophthalmology, Duke University Medical Center, Duke University, Durham, North Carolina, USA
Ophthalmology 116:2448-56. 2009..To elucidate the subclinical anatomy of retinopathy of prematurity (ROP) using spectral domain optical coherence tomography (SD OCT)...
Image inversion spectral-domain optical coherence tomography optimizes choroidal thickness and detail through improved contrastPhoebe Lin
Duke Eye Center, Durham, North Carolina, USA
Invest Ophthalmol Vis Sci 53:1874-82. 2012....
Validated automatic segmentation of AMD pathology including drusen and geographic atrophy in SD-OCT imagesStephanie J Chiu
Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
Invest Ophthalmol Vis Sci 53:53-61. 2012....
Drusen ultrastructure imaging with spectral domain optical coherence tomography in age-related macular degenerationAziz A Khanifar
Duke University Medical Center, Department of Ophthalmology, Durham, North Carolina, USA
Ophthalmology 115:1883-90. 2008..To categorize drusen ultrastructure in age-related macular degeneration (AMD) using spectral domain optical coherence tomography (SDOCT) and correlate the tomographic and photographic drusen appearances...
Impact of fluorescein angiographic characteristics of macular lesions on outcomes after macular translocation 360 degree surgery in eyes with age-related macular degenerationPrithvi Mruthyunjaya
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
Retina 25:597-607. 2005..Removal of the subretinal lesion and repositioning of the fovea over a healthier retinal pigment epithelial bed may account for these improvements...
Recovery of the neurosensory retina after macular translocation surgery is independent of preoperative macular sensitivity in neovascular age-related macular degenerationPriyatham S Mettu
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA
Retina 31:1637-49. 2011....
Central and pericentral retinal sensitivity after macular translocation surgeryJanet J Chieh
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA
Retina 28:1522-9. 2008....
Vision-related quality of life in patients with bilateral severe age-related macular degenerationMark T Cahill
Duke University Eye Center, Durham, North Carolina 27710, USA
Ophthalmology 112:152-8. 2005..This inability to perform vision-related daily tasks is not related to general health problems...
Treatment of non-age-related macular degeneration submacular diseases with macular translocation surgeryJustis P Ehlers
Duke Eye Center, Retina Service, Durham, North Carolina 27710, USA
Retina 31:1337-46. 2011..To evaluate the use of macular translocation surgery 360 in blinding submacular diseases other than age-related macular degeneration...
Spectral-domain optical coherence tomography characteristics of intermediate age-related macular degenerationJessica N Leuschen
Duke Eye Center, Durham, North Carolina 27710, USA
Ophthalmology 120:140-50. 2013....
Optimizing hand-held spectral domain optical coherence tomography imaging for neonates, infants, and childrenRamiro S Maldonado
Department of Ophthalmology, Duke University, Durham, NC 27710, USA
Invest Ophthalmol Vis Sci 51:2678-85. 2010..To describe age-related considerations and methods to improve hand-held spectral domain optical coherence tomography (HH-SD OCT) imaging of eyes of neonates, infants, and children...
Quality of life after macular translocation with 360 degrees peripheral retinectomy for age-related macular degenerationMark T Cahill
Duke University Eye Center, Durham, North Carolina 27710, USA
Ophthalmology 112:144-51. 2005..This was not associated with a change in patients' general health...
Quantifying vertical angle kappa after macular translocation surgery: a new use for the synoptophoreSandra Holgado
Duke University Eye Center, Durham, North Carolina 27710, USA
Strabismus 16:139-43. 2008..To report the measurement of vertical angle kappa and its application in patients after full macular translocation (MT360) and extraocular muscle surgery (to correct the resultant large angle torsion), in a prospective study...
Imaging the infant retina with a hand-held spectral-domain optical coherence tomography deviceAdrienne W Scott
Department of Ophthalmology, Albert Eye Research Institute, Duke University Eye Center, Duke University Medical Center, Durham, North Carolina
Am J Ophthalmol 147:364-373.e2. 2009..To evaluate and treat infant retina through the use of a hand-held spectral-domain optical coherence tomography (SD OCT) device in selected cases of Shaken Baby syndrome (SBS)...
Abnormal foveal morphology in ocular albinism imaged with spectral-domain optical coherence tomographyGabriel T Chong
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
Arch Ophthalmol 127:37-44. 2009..To evaluate the spectrum of foveal architecture in pediatric albinism and to assess the utility of spectral-domain optical coherence tomography (OCT) in ocular imaging of children with nystagmus...
Change in visual function after macular translocation with 360 degrees retinectomy for neovascular age-related macular degenerationPrithvi Mruthyunjaya
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA
Ophthalmology 111:1715-24. 2004..Macular translocation with 360 degrees retinectomy is an effective treatment option for patients with vision loss in their second eye resulting from neovascular AMD...
Maturation of the human fovea: correlation of spectral-domain optical coherence tomography findings with histologyLejla Vajzovic
Department of Ophthalmology, Duke University Eye Center, Durham, NC 27710, USA
Am J Ophthalmol 154:779-789.e2. 2012..To correlate human foveal development visualized by spectral-domain optical coherence tomography (SDOCT) with histologic specimens...
Spatial correlation between hyperpigmentary changes on color fundus photography and hyperreflective foci on SDOCT in intermediate AMDFrancisco A Folgar
Duke University Eye Center, Duke University, Durham, North Carolina, USA
Invest Ophthalmol Vis Sci 53:4626-33. 2012..The purpose of this study was to accurately correlate hyperpigmentary changes with spectral domain optical coherence tomography (SDOCT) hyperreflective foci in eyes with non-advanced AMD...
Macular translocation with 360 degrees peripheral retinectomy for geographic atrophyMark T Cahill
Duke University Eye Center, Room 107, Erwin Road, PO Box 3802, Durham, NC 27710, USA
Arch Ophthalmol 121:132-3. 2003
Integration of a spectral domain optical coherence tomography system into a surgical microscope for intraoperative imagingJustis P Ehlers
Duke Eye Center, Duke University Medical Center, Durham, North Carolina 27710, USA
Invest Ophthalmol Vis Sci 52:3153-9. 2011..To demonstrate an operating microscope-mounted spectral domain optical coherence tomography (MMOCT) system for human retinal and model surgery imaging...
Correlation of pathologic features in spectral domain optical coherence tomography with conventional retinal studiesMarcin Stopa
Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710, USA
Retina 28:298-308. 2008....
Spectral domain optical coherence tomography imaging of geographic atrophy marginsSrilaxmi Bearelly
The Duke Center for Macular Diseases and Albert Eye Research Institute, Duke University Eye Center, Erwin Road, Durham, NC 27710, USA
Ophthalmology 116:1762-9. 2009....
Automatic segmentation of seven retinal layers in SDOCT images congruent with expert manual segmentationStephanie J Chiu
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
Opt Express 18:19413-28. 2010..Results show that this method accurately segments eight retinal layer boundaries in normal adult eyes more closely to an expert grader as compared to a second expert grader...
Developing SDOCT to assess donor human eyes prior to tissue sectioning for researchNinita H Brown
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
Graefes Arch Clin Exp Ophthalmol 247:1069-80. 2009..To establish the utility of SDOCT for localizing pathology in the posterior eyecup, for identifying ocular disease in donor eyes, or for directing subsequent sectioning of retinal lesions for research...
Optical coherence tomography reader agreement in neovascular age-related macular degenerationNanfei Zhang
Duke University Eye Center and the OCT Reading Center at Duke, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Ophthalmol 144:37-44. 2007..To determine the interreader and intrareader agreement at the Optical Coherence Tomography (OCT) Reading Center at Duke for images produced for an interventional neovascular age-related macular degeneration (AMD) clinical trial...
Clinicopathologic studies of eyes that were obtained postmortem from four patients who were enrolled in the submacular surgery trials: SST Report No. 16Hans E Grossniklaus
Department of Ophthalmology, Emory University School of Medicine, 428 Emory Eye Center, 1365 Clifton Road, Atlanta, GA 30322, USA
Am J Ophthalmol 141:93-104. 2006..To compare the fundus photographic and fluorescein angiographic features with the histologic findings in eyes from patients enrolled in the Submacular Surgery Trials (SST)...
Improvement in near visual function after macular translocation surgery with 360-degree peripheral retinectomyCynthia A Toth
Department of Ophthalmology, Duke University Medical Center, Box 3802, Durham, NC 27701, USA
Graefes Arch Clin Exp Ophthalmol 242:541-8. 2004..Information is limited on how specific near-vision skills are impacted by therapies such as macular translocation surgery with 360-degree retinectomy (MT360) for age-related macular degeneration (AMD)...
Intraoperative use of handheld spectral domain optical coherence tomography imaging in macular surgeryPouya N Dayani
Department of Ophthalmology, Duke University Eye Center, Durham, NC 27710, USA
Retina 29:1457-68. 2009..To describe the intraoperative use of handheld spectral domain optical coherence tomography (SDOCT) imaging in macular surgery...
Photoreceptor layer thinning over drusen in eyes with age-related macular degeneration imaged in vivo with spectral-domain optical coherence tomographyStefanie G Schuman
Duke University Medical Center, Department of Ophthalmology, Durham, North Carolina 27710, USA
Ophthalmology 116:488-496.e2. 2009..Quantitative imaging biomarkers may aid in defining risk of disease progression...
Macular translocation surgery with 360-degree peripheral retinectomy following ocular photodynamic therapy of choroidal neovascularizationCarl H Park
Vitreoretinal Service, Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Ophthalmol 136:830-5. 2003..MTS360 appears to be effective in stabilizing vision, especially in patients who had previously undergone only one OPT session. Further studies are indicated to evaluate the efficacy of MTS360 in this current era of OPT...
Histologic development of the human fovea from midgestation to maturityAnita Hendrickson
Department of Ophthalmology, University of Washington, Seattle, WA, USA
Am J Ophthalmol 154:767-778.e2. 2012..To describe the histologic development of the human central retina from fetal week (Fwk) 22 to 13 years...
Unprocessed real-time imaging of vitreoretinal surgical maneuvers using a microscope-integrated spectral-domain optical coherence tomography systemPaul Hahn
Department of Ophthalmology, Duke University Eye Center, Durham, NC 27710, USA
Graefes Arch Clin Exp Ophthalmol 251:213-20. 2013..In this report, we explore the capability of MIOCT to acquire real-time video imaging of vitreoretinal surgical maneuvers without post-processing modifications...
Dislocation of the donor graft to the posterior segment in descemet stripping automated endothelial keratoplastyNatalie A Afshari
Duke Eye Center, Durham, North Carolina 27710, USA
Am J Ophthalmol 153:638-42, 642.e1-2. 2012..To report a series of dislocations of the donor graft into the posterior segment associated with Descemet stripping endothelial keratoplasty (DSAEK) and to identify possible risk factors for dislocation and clinical outcomes...
The use of optical coherence tomography in intraoperative ophthalmic imagingPaul Hahn
Departments of Ophthalmology and Biomedical Engineering, Duke University, Durham, North Carolina, USA
Ophthalmic Surg Lasers Imaging 42:S85-94. 2011..This article reviews intraoperative imaging of the posterior and anterior segment using the handheld SD-OCT and recent advances toward real-time microscope-mounted intrasurgical imaging...
Reversible retinal edema in an infant with neonatal hemochromatosis and liver failureRamiro S Maldonado
Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina 27010, USA
J AAPOS 15:91-3. 2011..Both the clinical retinal appearance and the anatomic abnormalities observed on spectral domain optical coherence tomography resolved after successful liver transplant...
Measurement of ocular torsion after macular translocation: disc fovea angle and Maddox rodSharon F Freedman
Duke University Eye Center, Durham, NC 27710, USA
J AAPOS 7:103-7. 2003..This study verifies the reproducibility of MR to measure large angles of torsion and offers DFA as a simple corroborative test for measuring ocular torsion in patients with poor vision or cooperation...
Intraoperative spectral domain optical coherence tomography for vitreoretinal surgeryYuankai K Tao
Department of Biomedical Engineering, Duke University, 136 Hudson Hall, Durham, North Carolina 27708, USA
Opt Lett 35:3315-7. 2010..We experimentally quantify the axial and lateral resolution of the MMOCT and demonstrate fundus imaging at a 20Hz frame rate...
A method to free retina and vitreous from intraoperative incarceration in the sclerotomyMarcin Stopa
Duke University Eye Center, Durham, NC 27710, USA
Retina 26:1070-1. 2006
Visual outcomes following macular translocation with 360-degree peripheral retinectomyJames C Lai
Department of Ophthalmology, VitreoretinalService, Duke University Medical Center, Durham, NC 27710, USA
Arch Ophthalmol 120:1317-24. 2002....
Mutational hot spot potential of a novel base pair mutation of the CSPG2 gene in a family with Wagner syndromeShawn M Ronan
Duke University Eye Center, Durham, NC 27710, USA
Arch Ophthalmol 127:1511-9. 2009..11-q13.2, with associated COL2A1 gene mutations. Wagner syndrome maps to chromosome 5q13-q14 and is associated with mutations in CSPG2 encoding versican, a proteoglycan present in human vitreous...
Effect of INS37217, a P2Y(2) receptor agonist, on experimental retinal detachment and electroretinogram in adult rabbitsCarsten H Meyer
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
Invest Ophthalmol Vis Sci 43:3567-74. 2002....
RGD peptide-assisted vitrectomy to facilitate induction of a posterior vitreous detachment: a new principle in pharmacological vitreolysisLeonardo B Oliveira
Department of Ophthalmology, Duke University Medical Center, NC 27710, USA
Curr Eye Res 25:333-40. 2002....
Radial optic neurotomy in the porcine eye without retinal vein occlusionMarcin P Czajka
Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA
Arch Ophthalmol 122:1185-9. 2004..Clinical Relevance Radial optic neurotomy remains a controversial method of treatment for central retinal vein occlusion. To our knowledge, this is the first study in the literature describing the histopathologic findings after RON...
Strabismus surgery for large-angle cyclotorsion after macular translocation surgerySharon F Freedman
Duke University, Durham, North Carolina, USA
J AAPOS 6:154-62. 2002..CONCLUSION: The strabismus surgery described is effective at reducing the large degree of cyclotorsion (>or= 20 degrees) often resulting from macular translocation surgery, but does not allow reestablishment of binocular function...
Decreased visual acuity associated with cystoid macular edema in neovascular age-related macular degenerationT Daniel Ting
Department of Ophthalmology, Duke University Medical Center, Box 3802, Erwin Road, Durham, NC 27710, USA
Arch Ophthalmol 120:731-7. 2002..The OCT is a useful test to detect the presence of CME in these patients since CME may be difficult to identify on fluorescein angiogram...
Surgical removal vs observation for subfoveal choroidal neovascularization, either associated with the ocular histoplasmosis syndrome or idiopathic: I. Ophthalmic findings from a randomized clinical trial: Submacular Surgery Trials (SST) Group H Trial: SSBarbara S Hawkins
Arch Ophthalmol 122:1597-611. 2004....
