Olga A Timofeeva

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint EEG spectra, behavioral states and motor activity in rats exposed to acetylcholinesterase inhibitor chlorpyrifos
    Olga A Timofeeva
    Curriculum in Toxicology, University of North Carolina Chapel Hill, USA
    Pharmacol Biochem Behav 72:669-79. 2002
  2. doi request reprint Idazoxan blocks the nicotine-induced reversal of the memory impairment caused by the NMDA glutamate receptor antagonist dizocilpine
    Olga A Timofeeva
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Pharmacol Biochem Behav 90:372-81. 2008
  3. pmc Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion
    Olga A Timofeeva
    Department of Psychiatry and Behavioral Sciences, Box 3412, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Bull 77:404-11. 2008
  4. doi request reprint Glutamate and nicotinic receptor interactions in working memory: importance for the cognitive impairment of schizophrenia
    O A Timofeeva
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 104790, Durham, NC 27710, USA
    Neuroscience 195:21-36. 2011
  5. pmc Early postnatal parathion exposure in rats causes sex-selective cognitive impairment and neurotransmitter defects which emerge in aging
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Behav Brain Res 208:319-27. 2010
  6. pmc Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon
    Olga A Timofeeva
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neurotoxicol Teratol 30:38-45. 2008
  7. pmc Hippocampal infusions of MARCKS peptides impair memory of rats on the radial-arm maze
    Olga A Timofeeva
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 1308:147-52. 2010
  8. pmc Developmental diazinon neurotoxicity in rats: later effects on emotional response
    Cindy S Roegge
    WIL Research Laboratories, LLC, 1407 George Road, Ashland, OH 44805, USA
    Brain Res Bull 75:166-72. 2008

Detail Information

Publications8

  1. ncbi request reprint EEG spectra, behavioral states and motor activity in rats exposed to acetylcholinesterase inhibitor chlorpyrifos
    Olga A Timofeeva
    Curriculum in Toxicology, University of North Carolina Chapel Hill, USA
    Pharmacol Biochem Behav 72:669-79. 2002
    ..Increased wakefulness together with reduced motor activity after exposure to CHP seems to be a result of hyperactivity in brain cholinergic neuronal networks...
  2. doi request reprint Idazoxan blocks the nicotine-induced reversal of the memory impairment caused by the NMDA glutamate receptor antagonist dizocilpine
    Olga A Timofeeva
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Pharmacol Biochem Behav 90:372-81. 2008
    ..In subjects with inhibited NMDAR (a model of schizophrenia) alpha(2)-AR agonists attenuate the cognitive impairments. The effect with alpha(2)-AR antagonists remains unclear...
  3. pmc Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion
    Olga A Timofeeva
    Department of Psychiatry and Behavioral Sciences, Box 3412, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Bull 77:404-11. 2008
    ..Our results reinforce the conclusion that low dose exposure to different OPs can have quite different neurotoxic effects, obviously unconnected to their shared property as cholinesterase inhibitors...
  4. doi request reprint Glutamate and nicotinic receptor interactions in working memory: importance for the cognitive impairment of schizophrenia
    O A Timofeeva
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 104790, Durham, NC 27710, USA
    Neuroscience 195:21-36. 2011
    ....
  5. pmc Early postnatal parathion exposure in rats causes sex-selective cognitive impairment and neurotransmitter defects which emerge in aging
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Behav Brain Res 208:319-27. 2010
    ..This study demonstrates the sex-selective, long-term behavioral alterations caused by otherwise nontoxic neonatal exposure to parathion, with effects increasingly expressed with aging...
  6. pmc Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon
    Olga A Timofeeva
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neurotoxicol Teratol 30:38-45. 2008
    ..Both molecular/neurochemical and behavioral effects of developmental OP exposure have been seen at doses below those which cause appreciable cholinesterase inhibition...
  7. pmc Hippocampal infusions of MARCKS peptides impair memory of rats on the radial-arm maze
    Olga A Timofeeva
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 1308:147-52. 2010
    ..Our present behavioral study, together with the earlier in vitro study by Gay et al. (2008), suggests that effector domain MARCKS peptides could play a significant role in memory regulation and impairment...
  8. pmc Developmental diazinon neurotoxicity in rats: later effects on emotional response
    Cindy S Roegge
    WIL Research Laboratories, LLC, 1407 George Road, Ashland, OH 44805, USA
    Brain Res Bull 75:166-72. 2008
    ..The effects show not only some similarities to those of chlorpyrifos but also some differences, in keeping with neurochemical findings comparing the two agents...