Thomas Tedder

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation
    M Fujimoto
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 276:44820-7. 2001
  2. pmc IL-10-producing regulatory B cells (B10 cells) in autoimmune disease
    Ioannis Kalampokis
    Box 3010, Department of Immunology, Room 353 Jones Building, Research Drive, Duke University Medical Center, Durham, NC 27710, USA
    Arthritis Res Ther 15:S1. 2013
  3. ncbi request reprint CD19 and CD22 regulate a B lymphocyte signal transduction pathway that contributes to autoimmunity
    T F Tedder
    Department of Immunology, Duke University Medical Center, Durham, NC, USA
    Keio J Med 49:1-13. 2000
  4. ncbi request reprint Fcgamma receptor-dependent effector mechanisms regulate CD19 and CD20 antibody immunotherapies for B lymphocyte malignancies and autoimmunity
    Thomas F Tedder
    Department of Immunology, Duke University Medical Center, Box 3010, Room 353 Jones Building, Research Drive, Durham, NC, 27710, USA
    Springer Semin Immunopathol 28:351-64. 2006
  5. ncbi request reprint CD19-CD21 complex regulates an intrinsic Src family kinase amplification loop that links innate immunity with B-lymphocyte intracellular calcium responses
    T F Tedder
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Biochem Soc Trans 30:807-11. 2002
  6. ncbi request reprint The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease: systemic sclerosis as a model system
    Thomas F Tedder
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Curr Dir Autoimmun 8:55-90. 2005
  7. doi request reprint CD19: a promising B cell target for rheumatoid arthritis
    Thomas F Tedder
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Nat Rev Rheumatol 5:572-7. 2009
  8. ncbi request reprint CD19, CD21, and CD22: multifaceted response regulators of B lymphocyte signal transduction
    J C Poe
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Int Rev Immunol 20:739-62. 2001
  9. ncbi request reprint L-selectin is involved in lymphocyte migration to sites of inflammation in the skin: delayed rejection of allografts in L-selectin-deficient mice
    M L Tang
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 158:5191-9. 1997
  10. ncbi request reprint A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice
    M Hasegawa
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 167:2469-78. 2001

Research Grants

  1. CD22 Regulation of B Lymphocyte Function and Survival
    Thomas Tedder; Fiscal Year: 2007
  2. MS4A Family Members in Health and Disease
    Thomas Tedder; Fiscal Year: 2007
  3. CD83 Regulation of Lymphocyte Development and Function
    Thomas Tedder; Fiscal Year: 2007
  4. MOLECULAR ANALYSIS OF B-LYMPHOCYTE RESTRICTED PROTEINS
    Thomas Tedder; Fiscal Year: 2002
  5. REGULATION OF HUMAN LEUKOCYTE RECIRCULATION
    Thomas Tedder; Fiscal Year: 1993
  6. REGULATION OF LEUKOCYTE RECIRCULATION
    Thomas Tedder; Fiscal Year: 2001

Collaborators

Detail Information

Publications100

  1. ncbi request reprint CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation
    M Fujimoto
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 276:44820-7. 2001
    ..Other receptors may also utilize a similar strategy to regulate kinase availability and downstream intermolecular signaling...
  2. pmc IL-10-producing regulatory B cells (B10 cells) in autoimmune disease
    Ioannis Kalampokis
    Box 3010, Department of Immunology, Room 353 Jones Building, Research Drive, Duke University Medical Center, Durham, NC 27710, USA
    Arthritis Res Ther 15:S1. 2013
    ..This review highlights the current knowledge on B10 cells and discusses their potential as novel therapeutic agents in autoimmunity...
  3. ncbi request reprint CD19 and CD22 regulate a B lymphocyte signal transduction pathway that contributes to autoimmunity
    T F Tedder
    Department of Immunology, Duke University Medical Center, Durham, NC, USA
    Keio J Med 49:1-13. 2000
    ..Reciprocally, CD22 is a potent regulator of CD19 function. These observations provide insight into how CD19 and CD22 govern the molecular ordering and intensity of signals transduced in B cells that may contribute to autoimmunity...
  4. ncbi request reprint Fcgamma receptor-dependent effector mechanisms regulate CD19 and CD20 antibody immunotherapies for B lymphocyte malignancies and autoimmunity
    Thomas F Tedder
    Department of Immunology, Duke University Medical Center, Box 3010, Room 353 Jones Building, Research Drive, Durham, NC, 27710, USA
    Springer Semin Immunopathol 28:351-64. 2006
    ....
  5. ncbi request reprint CD19-CD21 complex regulates an intrinsic Src family kinase amplification loop that links innate immunity with B-lymphocyte intracellular calcium responses
    T F Tedder
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Biochem Soc Trans 30:807-11. 2002
    ..This review outlines recent biochemical and genetic studies that characterize the signal transduction pathways utilized by this receptor complex to regulate B-cell intracellular calcium responses...
  6. ncbi request reprint The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease: systemic sclerosis as a model system
    Thomas F Tedder
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Curr Dir Autoimmun 8:55-90. 2005
    ..Thus, chronic B cell activation resulting from augmented CD19 expression or signaling through the CD19 pathway may reveal a prototype autoimmune disease susceptibility pathway in mice and humans...
  7. doi request reprint CD19: a promising B cell target for rheumatoid arthritis
    Thomas F Tedder
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Nat Rev Rheumatol 5:572-7. 2009
    ..CD19-directed immunotherapy could, therefore, offer a new horizon in B-cell depletion for the treatment of multiple autoimmune diseases...
  8. ncbi request reprint CD19, CD21, and CD22: multifaceted response regulators of B lymphocyte signal transduction
    J C Poe
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Int Rev Immunol 20:739-62. 2001
    ....
  9. ncbi request reprint L-selectin is involved in lymphocyte migration to sites of inflammation in the skin: delayed rejection of allografts in L-selectin-deficient mice
    M L Tang
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 158:5191-9. 1997
    ..These findings delineate an important role for L-selectin in lymphocyte recruitment to cutaneous sites of inflammation...
  10. ncbi request reprint A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice
    M Hasegawa
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 167:2469-78. 2001
    ....
  11. ncbi request reprint Humoral immune responses in L-selectin-deficient mice
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 157:4899-907. 1996
    ....
  12. pmc L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites
    T F Tedder
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Exp Med 181:2259-64. 1995
    ..These results demonstrate that L-selectin plays a prominent role in leukocyte homing to nonlymphoid tissues during inflammation and that blocking this process can be beneficial during pathological inflammatory responses...
  13. ncbi request reprint Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop
    M Fujimoto
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Immunity 11:191-200. 1999
    ..These data collectively suggest that CD19 activates the CD22/SHP1 inhibitory pathway that then acts primarily on CD19...
  14. ncbi request reprint CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux
    J C Poe
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 275:17420-7. 2000
    ....
  15. pmc Optimal selectin-mediated rolling of leukocytes during inflammation in vivo requires intercellular adhesion molecule-1 expression
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 95:7562-7. 1998
    ..Thus, members of the selectin and Ig families function synergistically to mediate optimal leukocyte rolling in vivo, which is essential for the generation of effective inflammatory responses...
  16. ncbi request reprint Regulation of B lymphocyte development and activation by the CD19/CD21/CD81/Leu 13 complex requires the cytoplasmic domain of CD19
    S Sato
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 159:3278-87. 1997
    ..Moreover, expression of the CD19 cytoplasmic domain is required for optimal signaling through the B cell Ag receptor complex...
  17. ncbi request reprint CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice
    S Sato
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Immunity 5:551-62. 1996
    ..However, activation of CD22-deficient B lymphocytes by prolonged IgM cross-linking resulted in modest B cell proliferation, demonstrating that CD22 positively regulates antigen receptor signaling in the presence of antigen...
  18. ncbi request reprint Lyphocyte migration in L-selectin-deficient mice. Altered subset migration and aging of the immune system
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 157:1096-106. 1996
    ..Therefore, L-selectin-dependent pathways of lymphocyte migration are important for the normal migration of both naive and memory lymphocytes...
  19. ncbi request reprint CD19 can regulate B lymphocyte signal transduction independent of complement activation
    M Hasegawa
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 167:3190-200. 2001
    ....
  20. ncbi request reprint The selectins: vascular adhesion molecules
    T F Tedder
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    FASEB J 9:866-73. 1995
    ..Future studies are focused on how the selectins interact with the increasing array of other adhesion molecules and inflammatory mediators...
  21. ncbi request reprint CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19
    S Sato
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 158:4662-9. 1997
    ....
  22. ncbi request reprint The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19
    P A Zipfel
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 165:6872-9. 2000
    ..These data suggest a role for c-Abl in the regulation of B cell proliferation downstream of the BCR, possibly through interactions with CD19...
  23. ncbi request reprint CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification
    M Fujimoto
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Immunity 13:47-57. 2000
    ..Thus, CD19 functions as a specialized adapter protein for the amplification of Src family kinases that is crucial for intrinsic and antigen receptor-induced signal transduction...
  24. ncbi request reprint Intrinsic differences in L-selectin expression levels affect T and B lymphocyte subset-specific recirculation pathways
    M L Tang
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 160:5113-21. 1998
    ..Thus, the differential migration of T and B lymphocyte subsets to lymphoid tissues is regulated in part by subset-specific differences in L-selectin expression levels...
  25. ncbi request reprint Leukocyte entry into sites of inflammation requires overlapping interactions between the L-selectin and ICAM-1 pathways
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 163:2176-86. 1999
    ..Thus, members of the selectin and Ig families function synergistically to mediate optimal leukocyte rolling and entry into tissues, which is essential for the generation of effective inflammatory responses in vivo...
  26. ncbi request reprint CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation
    M Fujimoto
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 162:7088-94. 1999
    ..The absence of this CD19/Src-family kinase amplification loop may account for the hyporesponsive phenotype of CD19-deficient B cells...
  27. ncbi request reprint Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L-selectin and beta7 integrin
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 161:6638-47. 1998
    ....
  28. ncbi request reprint CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling
    T F Tedder
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Immunol 15:481-504. 1997
    ..A further understanding of CD22 function is required and may reveal roles for CD22 in disease susceptibility or the development of autoimmunity...
  29. ncbi request reprint The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity
    T F Tedder
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Immunity 6:107-18. 1997
  30. ncbi request reprint Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule
    P Engel
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Immunity 3:39-50. 1995
    ..These experiments indicate that CD19 functions to define signaling thresholds for cell surface receptors that regulate B lymphocyte selection, activation, and differentiation...
  31. ncbi request reprint CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin
    X Li
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Leukoc Biol 69:565-74. 2001
    ..These results suggest that CHST1 and CHST2 contribute to the generation of optimal L-selectin ligands in vascular endothelial cells at sites of inflammation...
  32. ncbi request reprint The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen
    P Engel
    Department of Immunology, Duke University Medical Center, Durham, NC 27710
    Blood 84:1402-7. 1994
    ..The FUN-1 monoclonal antibody also completely blocked the costimulatory activity of B7-2/B70 in functional assays. Therefore, the serologically defined CD86 differentiation antigen is the B7-2/B70 molecule...
  33. ncbi request reprint Ligation of L-selectin through conserved regions within the lectin domain activates signal transduction pathways and integrin function in human, mouse, and rat leukocytes
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 159:952-63. 1997
    ..Signaling through L-selectin may enhance leukocyte-endothelial cell interactions by serving as an activation/priming step during rolling, thereby promoting subsequent firm cell-cell adhesion in the presence of inflammatory mediators...
  34. ncbi request reprint CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization
    X Li
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genomics 55:345-7. 1999
    ..Thus, this study identified two sulfotransferases expressed by vascular endothelial cells that may contribute to the generation of L-selectin ligands during inflammatory responses...
  35. ncbi request reprint L-selectin ligands expressed by human leukocytes are HECA-452 antibody-defined carbohydrate epitopes preferentially displayed by P-selectin glycoprotein ligand-1
    L Tu
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 163:5070-8. 1999
    ..Therefore, the HECA-452-defined carbohydrate determinant displayed on PSGL-1 represented the predominant L-selectin and P-selectin ligand expressed by neutrophils...
  36. ncbi request reprint L-Selectin is required for the development of airway hyperresponsiveness but not airway inflammation in a murine model of asthma
    L C Fiscus
    University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA
    J Allergy Clin Immunol 107:1019-24. 2001
    ..CONCLUSION: L-selectin plays a crucial role in the development of AHR but not allergic inflammation in an animal model of asthma. L-selectin represents a potential target for novel asthma therapies specifically aimed at controlling AHR...
  37. pmc The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation
    S Sato
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 92:11558-62. 1995
    ....
  38. ncbi request reprint Structural organization of the human MS4A gene cluster on Chromosome 11q12
    Y Liang
    Department of Immunology, Room 353 Jones Building, Research Drive, Duke University Medical Center, Durham, NC 27710, USA
    Immunogenetics 53:357-68. 2001
    ..Like CD20 and FcepsilonRIbeta, the 10 other human MS4A family members are likely to be components of oligomeric cell surface complexes involved in signal transduction in diverse cell lineages...
  39. ncbi request reprint Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily
    L J Zhou
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 154:3821-35. 1995
    ..Thus, CD83 serves as a useful and specific marker for this unique population of human blood dendritic cells...
  40. ncbi request reprint Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse
    Y Liang
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genomics 72:119-27. 2001
    ..1 along with CD20, FcepsilonRIbeta, and HTm4. Thus, like CD20 and FcepsilonRIbeta, the other MS4A family members are likely to be components of oligomeric cell surface complexes that serve diverse signal transduction functions...
  41. ncbi request reprint CD83 expression is a sensitive marker of activation required for B cell and CD4+ T cell longevity in vivo
    Charlene M Prazma
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 179:4550-62. 2007
    ....
  42. pmc B Lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse
    Noriko Asano
    Department of Regenerative Medicine, Research Institute, International Medical Center of Japan, Tokyo, Japan
    Am J Pathol 165:641-50. 2004
    ....
  43. ncbi request reprint CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms
    Jonathan C Poe
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Immunol 5:1078-87. 2004
    ..These observations resolve longstanding questions regarding the physiological importance of CD22 ligand binding in the regulation of B cell function in vivo...
  44. ncbi request reprint Altered B lymphocyte function induces systemic autoimmunity in systemic sclerosis
    Shinichi Sato
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Mol Immunol 41:1123-33. 2004
    ..Thus, chronic B cell activation resulting from augmented CD19 signaling leads to skin fibrosis possibly through IL-6 overproduction, as well as autoantibody production, in tight-skin mice and SSc patients...
  45. ncbi request reprint Humoral autoimmunity in mice overexpressing B cell surface CD19: vital role for MHC class II
    William Stohl
    Division of Rheumatology and Immunology, Department of Medicine, University of Southern California Keck School of Medicine, 2001 Zonal Avenue HMR 711, Los Angeles, CA 90033, USA
    Clin Immunol 116:257-64. 2005
    ..This raises the possibility that MHCII affects B cells in a manner that, at least in part, is independent of helper T cell function...
  46. pmc Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease
    Norihito Yazawa
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 102:15178-83. 2005
    ..These results demonstrate clinical utility for the treatment of diverse B cell malignancies, autoimmune disease, and humoral transplant rejection...
  47. ncbi request reprint Complement component C3d-antigen complexes can either augment or inhibit B lymphocyte activation and humoral immunity in mice depending on the degree of CD21/CD19 complex engagement
    Youngkyun Lee
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 175:8011-23. 2005
    ..Therefore, C3d may enhance or inhibit Ag-specific humoral immune responses through both CD21-dependent and -independent mechanisms depending on the concentration and nature of the Ag-C3d complexes...
  48. ncbi request reprint New prospects for autoimmune disease therapy: B cells on deathwatch
    E William St Clair
    Arthritis Rheum 54:1-9. 2006
  49. pmc B lymphocytes: how they develop and function
    Tucker W Lebien
    Department of Laboratory Medicine Pathology, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Blood 112:1570-80. 2008
    ..Despite the significant advances that have been made at the cellular and molecular levels, there is much more to learn, and cross-disciplinary studies in hematology and immunology will continue to pave the way for new discoveries...
  50. pmc B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Japan
    Am J Pathol 169:954-66. 2006
    ..Thereby, B-cell depletion during disease onset suppressed skin fibrosis, indicating that B cells contribute to the initiation of systemic sclerosis pathogenesis in tight-skin mice but are not required for disease maintenance...
  51. pmc CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma
    Ayumi Yoshizaki
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Am J Pathol 172:1650-63. 2008
    ....
  52. ncbi request reprint Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase
    Yuichi Aiba
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama, Japan
    Blood 111:1497-503. 2008
    ..Together, our data suggest that BCAP and CD19 have complementary roles in BCR-mediated PI3K activation, thereby, at least in part, contributing to B-cell development...
  53. pmc CD19 expression in B cells is important for suppression of contact hypersensitivity
    Rei Watanabe
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Am J Pathol 171:560-70. 2007
    ..Thus, CD19 expression in B cells is critical for termination of CHS responses, possibly through the function of regulatory B cells...
  54. ncbi request reprint Severely impaired B lymphocyte proliferation, survival, and induction of the c-Myc:Cullin 1 ubiquitin ligase pathway resulting from CD22 deficiency on the C57BL/6 genetic background
    Jonathan C Poe
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 172:2100-10. 2004
    ..Moreover, this study defines CD22 and CD40 as the first examples of lymphocyte coreceptors that influence induction of the c-Myc:CUL1 ubiquitin ligase pathway...
  55. ncbi request reprint Association of a functional CD19 polymorphism with susceptibility to systemic sclerosis
    Naoyuki Tsuchiya
    Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Arthritis Rheum 50:4002-7. 2004
    ..In this study, we examined whether CD19 polymorphisms are associated with genetic susceptibility to SSc...
  56. ncbi request reprint Anti-CD22 ligand-blocking antibody HB22.7 has independent lymphomacidal properties and augments the efficacy of 90Y-DOTA-peptide-Lym-1 in lymphoma xenografts
    Joseph M Tuscano
    Department of Internal Medicine, University of California, Davis Medical Center, Sacramento 95817, USA
    Blood 101:3641-7. 2003
    ..7 was added to RIT. Thus the anti-CD22 ligand-blocking antibody HB22.7 has independent lymphomacidal properties and augments the efficacy of (90)Y-DOTA-peptide-Lym-1 in lymphoma xenografts without significant toxicity...
  57. ncbi request reprint Complementary roles for CD19 and Bruton's tyrosine kinase in B lymphocyte signal transduction
    Manabu Fujimoto
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 168:5465-76. 2002
    ....
  58. ncbi request reprint CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes
    Norihito Yazawa
    Department of Regenerative Medicine, Research Institute, International Medical Center of Japan, Tokyo
    Blood 102:1374-80. 2003
    ..Thus, signaling through the B-cell-specific LPS receptor RP105 is uniquely regulated by the B-cell-specific signaling component, Lyn/CD19/Vav complex...
  59. ncbi request reprint B lymphocytes contribute to autoimmune disease pathogenesis: current trends and clinical implications
    Joseph M Tuscano
    Department of Internal Medicine, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Autoimmun Rev 2:101-8. 2003
    ..This promises an arsenal of highly targeted, less toxic therapies focused on restoring normal B cell function that will eliminate pathogenic autoantibodies and replace the current use of immunosuppressive drugs...
  60. ncbi request reprint The tetraspanin CD81 regulates the expression of CD19 during B cell development in a postendoplasmic reticulum compartment
    Tsipi Shoham
    Department of Medicine, Division of Oncology, Stanford University Medical Center, CA 94305 5151, USA
    J Immunol 171:4062-72. 2003
    ....
  61. pmc CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse
    Eriko Saito
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Clin Invest 109:1453-62. 2002
    ..CD19 deficiency also inhibited IL-6 production by TSK/+ B cells. Thus, chronic B cell activation resulting from augmented CD19 signaling in TSK/+ mice leads to skin sclerosis possibly through IL-6 overproduction as well as autoimmunity...
  62. ncbi request reprint Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1
    Toru Yukami
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1, Takara machi, Kanazawa 920 8641, Japan
    J Leukoc Biol 82:519-31. 2007
    ..These results indicate that skin wound healing is regulated cooperatively by all selectins and ICAM-1 and may provide critical information for the therapy of skin wounds...
  63. ncbi request reprint Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice
    Yukiyo Matsushita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Immunol 179:698-707. 2007
    ..Thus, our findings indicate that ICAM-1 expression contributes to the development of skin fibrosis in TSK/+ mice, especially via ICAM-1 expressed on skin fibroblasts...
  64. ncbi request reprint B cell depletion delays collagen-induced arthritis in mice: arthritis induction requires synergy between humoral and cell-mediated immunity
    Koichi Yanaba
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 179:1369-80. 2007
    ....
  65. ncbi request reprint CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cells
    Yoshihiro Kuwano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Int Immunol 19:977-92. 2007
    ..These studies further emphasize a role for CD83 in lymphocyte development and immune regulation and reveal an unexpected role for CD83 expression in influencing cell-surface MHC class II turnover...
  66. ncbi request reprint Stromal complement receptor CD21/35 facilitates lymphoid prion colonization and pathogenesis
    Mark D Zabel
    Institute for Neuropathology, University Hospital of Zurich, Zurich, Switzerland
    J Immunol 179:6144-52. 2007
    ..Because both PrP(C) and CD21/35 are highly expressed on follicular dendritic cells, CD21/35 appears to be involved in targeting prions to follicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions...
  67. pmc B-lymphocyte depletion ameliorates Sjögren's syndrome in Id3 knockout mice
    Ikuko Hayakawa
    Department of Immunology, Duke University Medical Center, Durham, NC, USA
    Immunology 122:73-9. 2007
    ..This study establishes a new animal model for immunotherapy of Sjögren's symptoms and suggests a possible link between immunoglobulin G3 and disease pathology in Id3 knockout mice...
  68. ncbi request reprint CD83: a regulatory molecule of the immune system with great potential for therapeutic application
    Yoko Fujimoto
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Japan
    J Med Dent Sci 53:85-91. 2006
    ..Because of these immuno-regulatory functions, the therapeutic application of CD83 is highly anticipated in many pathological states including malignancy and autoimmune disease...
  69. pmc Dendritic cell CD83: a therapeutic target or innocent bystander?
    Charlene M Prazma
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Immunol Lett 115:1-8. 2008
    ....
  70. pmc Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice
    Jean David Bouaziz
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 104:20878-83. 2007
    ..These results provide direct evidence that B cells contribute to T cell activation and expansion in vivo and offer insights into the mechanism of action for B cell depletion therapy in the treatment of autoimmunity...
  71. ncbi request reprint L-selectin is not required for T cell-mediated autoimmune diabetes
    Randall H Friedline
    Department of Microbiology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 168:2659-66. 2002
    ..scid recipients. In conclusion, CD62L expression is not essential for the development of type 1 diabetes in NOD mice...
  72. pmc Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression
    Takashi Matsushita
    Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA
    J Clin Invest 118:3420-30. 2008
    ..The therapeutic effect of B cell depletion for the treatment of autoimmunity may therefore depend on the relative contributions and the timing of these opposing B cell activities during the course of disease initiation and pathogenesis...
  73. doi request reprint Regulatory B cells as inhibitors of immune responses and inflammation
    Jean David Bouaziz
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Immunol Rev 224:201-14. 2008
    ..This review focuses on the recent progress in this field and the exciting opportunities for understanding how this unique B-cell subset influences diverse immune functions...
  74. ncbi request reprint The cutaneous reverse Arthus reaction requires intercellular adhesion molecule 1 and L-selectin expression
    Yuko Kaburagi
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Immunol 168:2970-8. 2002
    ....
  75. ncbi request reprint L-selectin dimerization enhances tether formation to properly spaced ligand
    Oren Dwir
    Department of Immunology, Weizmann Institute of Science, Rehovot, 76100 Israel
    J Biol Chem 277:21130-9. 2002
    ..This is the first indication that shear stress augments effective selectin ligand density at local contact sites by promoting L-selectin encounter of immobilized ligand...
  76. ncbi request reprint B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions
    Yan Xiu
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 180:2863-75. 2008
    ..Moreover, this study defines a new, clinically relevant approach whereby B cell depletion early in the course of disease development may prevent diabetes or delay progression of disease...
  77. ncbi request reprint CD22 regulates time course of both B cell division and antibody response
    Taishi Onodera
    Laboratory of Immunology, School of Biomedical Science, Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, Japan
    J Immunol 180:907-13. 2008
    ..quot;..
  78. ncbi request reprint Maintenance of long-lived plasma cells and serological memory despite mature and memory B cell depletion during CD20 immunotherapy in mice
    David J DiLillo
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 180:361-71. 2008
    ..Thereby, depleting mature and memory B cells does not have a dramatic negative effect on preexisting Ab levels...
  79. ncbi request reprint CD25+CD4+ regulatory T cell migration requires L-selectin expression: L-selectin transcriptional regulation balances constitutive receptor turnover
    Guglielmo M Venturi
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 178:291-300. 2007
    ....
  80. ncbi request reprint A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo
    LiLi Tu
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 169:2034-43. 2002
    ..These results suggest that sL-selectin influences lymphocyte migration in vivo and that the increased sL-selectin levels present in certain pathologic conditions may adversely affect leukocyte migration...
  81. pmc Relative contributions of selectins and intercellular adhesion molecule-1 to tissue injury induced by immune complex deposition
    Koichi Yanaba
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Am J Pathol 162:1463-73. 2003
    ....
  82. ncbi request reprint Role of the CD19 and CD21/35 receptor complex in innate immunity, host defense and autoimmunity
    Karen M Haas
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Adv Exp Med Biol 560:125-39. 2005
  83. ncbi request reprint The peritoneal cavity provides a protective niche for B1 and conventional B lymphocytes during anti-CD20 immunotherapy in mice
    Yasuhito Hamaguchi
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 174:4389-99. 2005
    ..Thus, the majority of CD20(+) cells and B cell subsets within lymphoid tissues and the peritoneum could be depleted efficiently in vivo through Fc-dependent, but C-independent pathways during anti-CD20 immunotherapy...
  84. ncbi request reprint CD83 expression influences CD4+ T cell development in the thymus
    Yoko Fujimoto
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Cell 108:755-67. 2002
    ..Thereby, CD83 expression represents an additional regulatory component for CD4+ T cell development in the thymus...
  85. ncbi request reprint Ultraviolet light exposure suppresses contact hypersensitivity by abrogating endothelial intercellular adhesion molecule-1 up-regulation at the elicitation site
    Kazuhiro Komura
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    J Immunol 171:2855-62. 2003
    ..These results indicate that UV exposure inhibits CHS by abrogating up-regulation of endothelial ICAM-1 expression after Ag challenge at elicitation sites...
  86. pmc The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy
    Junji Uchida
    Department of Immunology, Box 3010, Room 353 Jones Building, Research Drive, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Med 199:1659-69. 2004
    ..That the innate monocyte network depletes B cells through FcgammaR-dependent pathways during anti-CD20 immunotherapy has important clinical implications for anti-CD20 and other antibody-based therapies...
  87. ncbi request reprint Cutting edge: C3d functions as a molecular adjuvant in the absence of CD21/35 expression
    Karen M Haas
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 172:5833-7. 2004
    ..Thus, C3d can function as a molecular adjuvant in the absence of CD21/35 expression...
  88. pmc L-selectin shedding does not regulate constitutive T cell trafficking but controls the migration pathways of antigen-activated T lymphocytes
    Elena Galkina
    Division of Cellular Immunology, National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    J Exp Med 198:1323-35. 2003
    ..These results suggest that the ability to shed L-selectin is not required for T cell recirculation and homing to PLNs. However, L-selectin shedding from antigen-activated T cells prevents reentry into PLNs...
  89. ncbi request reprint CD molecules 2005: human cell differentiation molecules
    Heddy Zola
    Child Health Research Institute, 72 King William Rd, North Adelaide 5006, South Australia, Australia
    Blood 106:3123-6. 2005
    ....
  90. ncbi request reprint B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae
    Karen M Haas
    Department of Immunology, Box 3010, Duke University Medical Center, Durham, North Carolina 27710, USA
    Immunity 23:7-18. 2005
    ..This reciprocal contribution of B-1a and B-1b subsets to innate and acquired immunity reveals an unexpected division of labor within the B-1 compartment that is normally balanced by their coordinated development...
  91. ncbi request reprint L-selectin or ICAM-1 deficiency reduces an immediate-type hypersensitivity response by preventing mast cell recruitment in repeated elicitation of contact hypersensitivity
    Yuka Shimada
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Immunol 170:4325-34. 2003
    ....
  92. ncbi request reprint Leukocyte rolling velocities and migration are optimized by cooperative L-selectin and intercellular adhesion molecule-1 functions
    Takafumi Kadono
    Department of Immunology, Duke University Medical Center, Durham, NC 27710
    J Immunol 169:4542-50. 2002
    ..Thus, in addition to mediating leukocyte firm adhesion, CD18 integrin/ICAM-1 interactions regulate leukocyte rolling velocities and thereby optimize L-selectin-mediated leukocyte rolling...
  93. ncbi request reprint CD22 ligand binding regulates normal and malignant B lymphocyte survival in vivo
    Karen M Haas
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 177:3063-73. 2006
    ..These data demonstrate that inhibition of CD22 ligand binding can disrupt normal and malignant B cell survival in vivo and suggest a novel mechanism of action for therapeutics targeting CD22 ligand binding domains...
  94. pmc Intercellular adhesion molecule-1 and L-selectin regulate bleomycin-induced lung fibrosis
    Yasuhito Hamaguchi
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    Am J Pathol 161:1607-18. 2002
    ..This suggests that these adhesion molecules are potential therapeutic targets for inhibiting human pulmonary fibrosis...
  95. pmc Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy
    Yasuhito Hamaguchi
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Med 203:743-53. 2006
    ..Thus, isotype-specific mAb interactions with distinct FcgammaRs contribute significantly to the effectiveness of CD20 mAbs in vivo, which may have important clinical implications for CD20 and other mAb-based therapies...
  96. pmc Inhibitory role of CD19 in the progression of experimental autoimmune encephalomyelitis by regulating cytokine response
    Takashi Matsushita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Am J Pathol 168:812-21. 2006
    ..Thus, CD19 modulates the Th1/Th2 cytokine balance in B cells and plays a critical role as a suppressive molecule in the development of EAE...
  97. ncbi request reprint L-selectin and intercellular adhesion molecule-1 regulate the development of Concanavalin A-induced liver injury
    Ayako Kawasuji
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1, Takara machi, Kanazawa, 920 8641, Japan
    J Leukoc Biol 79:696-705. 2006
    ..These results indicate that L-selectin and ICAM-1 contribute cooperatively to the development of Con A-induced hepatitis by regulating leukocyte infiltration and subsequent cytokine production...
  98. ncbi request reprint B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation
    Manabu Fujimoto
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 176:873-9. 2006
    ..Thus, CD22 phosphorylation is not only quantitatively but also qualitatively regulated by different stimulations, which may determine the outcome of B cell signaling...
  99. ncbi request reprint Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses
    Karen M Haas
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Immunity 17:713-23. 2002
    ..Thus, CD21/35 expression is critical for early protective antibody responses to lethal pathogens that rapidly multiply and quickly overwhelm the immune system...
  100. ncbi request reprint Mouse CD20 expression and function
    Junji Uchida
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Int Immunol 16:119-29. 2004
    ..Thus, mouse and human CD20 share similar patterns of expression and function. These studies thereby provide an animal model for studying CD20 function in vivo and the molecular mechanisms that influence anti-CD20 immunotherapy...

Research Grants27

  1. CD22 Regulation of B Lymphocyte Function and Survival
    Thomas Tedder; Fiscal Year: 2007
    ....
  2. MS4A Family Members in Health and Disease
    Thomas Tedder; Fiscal Year: 2007
    ..abstract_text> ..
  3. CD83 Regulation of Lymphocyte Development and Function
    Thomas Tedder; Fiscal Year: 2007
    ..an important regulatory checkpoint for helper T cell development, understanding its function may provide mechanisms for modulating humoral immunity and for the treatment of immunodeficiency, autoimmunity and malignancies ..
  4. MOLECULAR ANALYSIS OF B-LYMPHOCYTE RESTRICTED PROTEINS
    Thomas Tedder; Fiscal Year: 2002
    ..Determining how these B cell-restricted proteins regulate B cell function may also provide new methods for treatment of B cell malignancies, autoimmunity and immunodeficiency. ..
  5. REGULATION OF HUMAN LEUKOCYTE RECIRCULATION
    Thomas Tedder; Fiscal Year: 1993
    ....
  6. REGULATION OF LEUKOCYTE RECIRCULATION
    Thomas Tedder; Fiscal Year: 2001
    ....