T F Tedder

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling
    T F Tedder
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Immunol 15:481-504. 1997
  2. ncbi request reprint Leukocyte entry into sites of inflammation requires overlapping interactions between the L-selectin and ICAM-1 pathways
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 163:2176-86. 1999
  3. ncbi request reprint CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation
    M Fujimoto
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 276:44820-7. 2001
  4. ncbi request reprint Structural organization of the human MS4A gene cluster on Chromosome 11q12
    Y Liang
    Department of Immunology, Room 353 Jones Building, Research Drive, Duke University Medical Center, Durham, NC 27710, USA
    Immunogenetics 53:357-68. 2001
  5. ncbi request reprint CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin
    X Li
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Leukoc Biol 69:565-74. 2001
  6. ncbi request reprint A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice
    M Hasegawa
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 167:2469-78. 2001
  7. ncbi request reprint Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop
    M Fujimoto
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Immunity 11:191-200. 1999
  8. ncbi request reprint CD19 can regulate B lymphocyte signal transduction independent of complement activation
    M Hasegawa
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 167:3190-200. 2001
  9. ncbi request reprint CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification
    M Fujimoto
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Immunity 13:47-57. 2000
  10. ncbi request reprint Humoral immune responses in L-selectin-deficient mice
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 157:4899-907. 1996

Collaborators

Detail Information

Publications71

  1. ncbi request reprint CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling
    T F Tedder
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Immunol 15:481-504. 1997
    ..A further understanding of CD22 function is required and may reveal roles for CD22 in disease susceptibility or the development of autoimmunity...
  2. ncbi request reprint Leukocyte entry into sites of inflammation requires overlapping interactions between the L-selectin and ICAM-1 pathways
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 163:2176-86. 1999
    ..Thus, members of the selectin and Ig families function synergistically to mediate optimal leukocyte rolling and entry into tissues, which is essential for the generation of effective inflammatory responses in vivo...
  3. ncbi request reprint CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation
    M Fujimoto
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 276:44820-7. 2001
    ..Other receptors may also utilize a similar strategy to regulate kinase availability and downstream intermolecular signaling...
  4. ncbi request reprint Structural organization of the human MS4A gene cluster on Chromosome 11q12
    Y Liang
    Department of Immunology, Room 353 Jones Building, Research Drive, Duke University Medical Center, Durham, NC 27710, USA
    Immunogenetics 53:357-68. 2001
    ..Like CD20 and FcepsilonRIbeta, the 10 other human MS4A family members are likely to be components of oligomeric cell surface complexes involved in signal transduction in diverse cell lineages...
  5. ncbi request reprint CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin
    X Li
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Leukoc Biol 69:565-74. 2001
    ..These results suggest that CHST1 and CHST2 contribute to the generation of optimal L-selectin ligands in vascular endothelial cells at sites of inflammation...
  6. ncbi request reprint A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice
    M Hasegawa
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 167:2469-78. 2001
    ....
  7. ncbi request reprint Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop
    M Fujimoto
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Immunity 11:191-200. 1999
    ..These data collectively suggest that CD19 activates the CD22/SHP1 inhibitory pathway that then acts primarily on CD19...
  8. ncbi request reprint CD19 can regulate B lymphocyte signal transduction independent of complement activation
    M Hasegawa
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 167:3190-200. 2001
    ....
  9. ncbi request reprint CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification
    M Fujimoto
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Immunity 13:47-57. 2000
    ..Thus, CD19 functions as a specialized adapter protein for the amplification of Src family kinases that is crucial for intrinsic and antigen receptor-induced signal transduction...
  10. ncbi request reprint Humoral immune responses in L-selectin-deficient mice
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 157:4899-907. 1996
    ....
  11. ncbi request reprint L-selectin ligands expressed by human leukocytes are HECA-452 antibody-defined carbohydrate epitopes preferentially displayed by P-selectin glycoprotein ligand-1
    L Tu
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 163:5070-8. 1999
    ..Therefore, the HECA-452-defined carbohydrate determinant displayed on PSGL-1 represented the predominant L-selectin and P-selectin ligand expressed by neutrophils...
  12. ncbi request reprint Regulation of B lymphocyte development and activation by the CD19/CD21/CD81/Leu 13 complex requires the cytoplasmic domain of CD19
    S Sato
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 159:3278-87. 1997
    ..Moreover, expression of the CD19 cytoplasmic domain is required for optimal signaling through the B cell Ag receptor complex...
  13. ncbi request reprint CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19
    S Sato
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 158:4662-9. 1997
    ....
  14. ncbi request reprint Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L-selectin and beta7 integrin
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 161:6638-47. 1998
    ....
  15. ncbi request reprint CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux
    J C Poe
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 275:17420-7. 2000
    ....
  16. ncbi request reprint CD19, CD21, and CD22: multifaceted response regulators of B lymphocyte signal transduction
    J C Poe
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Int Rev Immunol 20:739-62. 2001
    ....
  17. ncbi request reprint CD19 and CD22 regulate a B lymphocyte signal transduction pathway that contributes to autoimmunity
    T F Tedder
    Department of Immunology, Duke University Medical Center, Durham, NC, USA
    Keio J Med 49:1-13. 2000
    ..Reciprocally, CD22 is a potent regulator of CD19 function. These observations provide insight into how CD19 and CD22 govern the molecular ordering and intensity of signals transduced in B cells that may contribute to autoimmunity...
  18. ncbi request reprint L-selectin is involved in lymphocyte migration to sites of inflammation in the skin: delayed rejection of allografts in L-selectin-deficient mice
    M L Tang
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 158:5191-9. 1997
    ..These findings delineate an important role for L-selectin in lymphocyte recruitment to cutaneous sites of inflammation...
  19. ncbi request reprint Ligation of L-selectin through conserved regions within the lectin domain activates signal transduction pathways and integrin function in human, mouse, and rat leukocytes
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 159:952-63. 1997
    ..Signaling through L-selectin may enhance leukocyte-endothelial cell interactions by serving as an activation/priming step during rolling, thereby promoting subsequent firm cell-cell adhesion in the presence of inflammatory mediators...
  20. ncbi request reprint Intrinsic differences in L-selectin expression levels affect T and B lymphocyte subset-specific recirculation pathways
    M L Tang
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 160:5113-21. 1998
    ..Thus, the differential migration of T and B lymphocyte subsets to lymphoid tissues is regulated in part by subset-specific differences in L-selectin expression levels...
  21. pmc Optimal selectin-mediated rolling of leukocytes during inflammation in vivo requires intercellular adhesion molecule-1 expression
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 95:7562-7. 1998
    ..Thus, members of the selectin and Ig families function synergistically to mediate optimal leukocyte rolling in vivo, which is essential for the generation of effective inflammatory responses...
  22. ncbi request reprint CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice
    S Sato
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Immunity 5:551-62. 1996
    ..However, activation of CD22-deficient B lymphocytes by prolonged IgM cross-linking resulted in modest B cell proliferation, demonstrating that CD22 positively regulates antigen receptor signaling in the presence of antigen...
  23. ncbi request reprint The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19
    P A Zipfel
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 165:6872-9. 2000
    ..These data suggest a role for c-Abl in the regulation of B cell proliferation downstream of the BCR, possibly through interactions with CD19...
  24. ncbi request reprint CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation
    M Fujimoto
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 162:7088-94. 1999
    ..The absence of this CD19/Src-family kinase amplification loop may account for the hyporesponsive phenotype of CD19-deficient B cells...
  25. pmc The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation
    S Sato
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 92:11558-62. 1995
    ....
  26. ncbi request reprint The selectins: vascular adhesion molecules
    T F Tedder
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    FASEB J 9:866-73. 1995
    ..Future studies are focused on how the selectins interact with the increasing array of other adhesion molecules and inflammatory mediators...
  27. ncbi request reprint Lyphocyte migration in L-selectin-deficient mice. Altered subset migration and aging of the immune system
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 157:1096-106. 1996
    ..Therefore, L-selectin-dependent pathways of lymphocyte migration are important for the normal migration of both naive and memory lymphocytes...
  28. ncbi request reprint Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule
    P Engel
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Immunity 3:39-50. 1995
    ..These experiments indicate that CD19 functions to define signaling thresholds for cell surface receptors that regulate B lymphocyte selection, activation, and differentiation...
  29. pmc Generation of dendritic cells in vitro from peripheral blood mononuclear cells with granulocyte-macrophage-colony-stimulating factor, interleukin-4, and tumor necrosis factor-alpha for use in cancer immunotherapy
    M A Morse
    Division of Hematology Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Surg 226:6-16. 1997
    ....
  30. ncbi request reprint CD19-CD21 complex regulates an intrinsic Src family kinase amplification loop that links innate immunity with B-lymphocyte intracellular calcium responses
    T F Tedder
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Biochem Soc Trans 30:807-11. 2002
    ..This review outlines recent biochemical and genetic studies that characterize the signal transduction pathways utilized by this receptor complex to regulate B-cell intracellular calcium responses...
  31. ncbi request reprint The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity
    T F Tedder
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Immunity 6:107-18. 1997
  32. ncbi request reprint CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity
    S Sato
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 157:4371-8. 1996
    ....
  33. ncbi request reprint Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse
    Y Liang
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genomics 72:119-27. 2001
    ..1 along with CD20, FcepsilonRIbeta, and HTm4. Thus, like CD20 and FcepsilonRIbeta, the other MS4A family members are likely to be components of oligomeric cell surface complexes that serve diverse signal transduction functions...
  34. ncbi request reprint Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily
    L J Zhou
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 154:3821-35. 1995
    ..Thus, CD83 serves as a useful and specific marker for this unique population of human blood dendritic cells...
  35. ncbi request reprint CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization
    X Li
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genomics 55:345-7. 1999
    ..Thus, this study identified two sulfotransferases expressed by vascular endothelial cells that may contribute to the generation of L-selectin ligands during inflammatory responses...
  36. ncbi request reprint CD20: a regulator of cell-cycle progression of B lymphocytes
    T F Tedder
    Dept of Immunology, Duke University Medical Center, Durham, NC 27710
    Immunol Today 15:450-4. 1994
    ..Here, Thomas Tedder and Pablo Engel discuss the suggestion that CD20 is a regulator of transmembrane Ca2+ conductance and plays an important functional role in B-cell activation, proliferation and differentiation...
  37. ncbi request reprint Isolation and generation of human dendritic cells
    T F Tedder
    Duke University Medical Center, Durham, North Carolina, USA
    Curr Protoc Immunol . 2001
    ..In addition, a negative selection approach is provided that may be employed to generate cell preparations that have been depleted of dendritic cells to be used for comparison in functional studies...
  38. ncbi request reprint The CD19/CD21 signal transduction complex of B lymphocytes
    T F Tedder
    Dept of Immunology, Duke University Medical Center, Durham, NC 27710
    Immunol Today 15:437-42. 1994
    ..Current studies, reviewed here by Thomas Tedder, Liang-Ji Zhou and Pablo Engel, indicate an important biological role for this protein complex in the regulation of B-cell development and activation...
  39. pmc Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function
    D J Dilillo
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Leukemia 27:170-82. 2013
    ..Thus, malignant IL-10-competent CLL cells exhibit regulatory functions comparable to normal B10 cells that may contribute to the immunosuppression observed in patients and TCL1-Tg mice...
  40. ncbi request reprint The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen
    P Engel
    Department of Immunology, Duke University Medical Center, Durham, NC 27710
    Blood 84:1402-7. 1994
    ..The FUN-1 monoclonal antibody also completely blocked the costimulatory activity of B7-2/B70 in functional assays. Therefore, the serologically defined CD86 differentiation antigen is the B7-2/B70 molecule...
  41. pmc L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites
    T F Tedder
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Exp Med 181:2259-64. 1995
    ..These results demonstrate that L-selectin plays a prominent role in leukocyte homing to nonlymphoid tissues during inflammation and that blocking this process can be beneficial during pathological inflammatory responses...
  42. ncbi request reprint Structure and domain organization of the CD19 antigen of human, mouse, and guinea pig B lymphocytes. Conservation of the extensive cytoplasmic domain
    L J Zhou
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115 6084
    J Immunol 147:1424-32. 1991
    ..Thus, CD19 appears to be well conserved in structure and expression through recent mammalian evolution and the highly conserved cytoplasmic domains may play a critical role in the transduction of CD19-mediated signals...
  43. ncbi request reprint A role for CD21/CD35 and CD19 in responses to acute septic peritonitis: a potential mechanism for mast cell activation
    J L Gommerman
    Department of Pathology, Center for Blood Research and Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 165:6915-21. 2000
    ..Taken together, these findings suggest that the engagement of complement receptors CD21/CD35 along with CD19 on the mast cell surface by C3 fragments may be necessary for the full expression of mast cell activation in the CLP model...
  44. ncbi request reprint Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds
    Y Qian
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 166:2412-9. 2001
    ..These results suggest a differentiation scheme in which peripheral ignorance to Sm is maintained in mice by the differentiation of anti-Sm B cells to B-1 cells that have increased activation thresholds...
  45. ncbi request reprint L-selectin and intercellular adhesion molecule 1 mediate lymphocyte migration to the inflamed airway/lung during an allergic inflammatory response in an animal model of asthma
    E Keramidaris
    Department of Immunology, Royal Children's Hospital, Flemington Rd, Parkville, VIC 3052, Australia
    J Allergy Clin Immunol 107:734-8. 2001
    ..8% +/- 1.8%, P =.002). These findings demonstrate clear roles for both L-selectin and ICAM-1 in lymphocyte migration to the lung during an allergic inflammatory response, with ICAM-1 playing a greater role...
  46. pmc Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19
    A K Matsumoto
    Division of Molecular and Clinical Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Exp Med 173:55-64. 1991
    ....
  47. ncbi request reprint The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules
    L E Bradbury
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115 6084
    J Immunol 149:2841-50. 1992
    ..Together, these data suggest that TAPA-1 and Leu-13 are broadly expressed members of a signal transduction complex in which lineage-specific proteins, such as CD19 and CD21, provide cell-specific functions...
  48. pmc Regulation of local and metastatic host-mediated anti-tumour mechanisms by L-selectin and intercellular adhesion molecule-1
    M Yamada
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Clin Exp Immunol 143:216-27. 2006
    ..The results indicate that L-selectin and ICAM-1 contribute co-operatively to the anti-tumour reaction by regulating lymphocyte infiltration to the tumour...
  49. ncbi request reprint A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily
    L J Zhou
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115 6084
    J Immunol 149:735-42. 1992
    ..Thus, the HB15 glycoprotein represents a newly identified member of the Ig superfamily that may play a significant role in Ag presentation or the cellular interactions that follow lymphocyte activation...
  50. ncbi request reprint Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes
    L J Zhou
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA
    Immunogenetics 35:102-11. 1992
    ..The high level of conservation of nucleotide sequences between species in all exons and 5' and 3' UT suggests that expression of the CD19 gene may be regulated in a similar fashion in human and mouse...
  51. ncbi request reprint Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils
    D C Ord
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, Massachusetts 02115
    J Biol Chem 265:7760-7. 1990
    ..Therefore, the usage of exons II through X results in the generation of a single major LAM-1 protein product expressed by lymphocytes and neutrophils...
  52. pmc Delayed wound healing in the absence of intercellular adhesion molecule-1 or L-selectin expression
    T Nagaoka
    Department of Dermatology, Kanazawa University School of Medicine, Ishikawa, Japan
    Am J Pathol 157:237-47. 2000
    ..These results demonstrate a distinct role of ICAM-1 and L-selectin in wound healing and that the delayed wound healing in the absence of these molecules is likely because of decreased leukocyte accumulation into the wound site...
  53. pmc A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase
    A B Satterthwaite
    Department of Microbiology, Immunology, and Molecular Genetics, and Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 97:6687-92. 2000
    ..A transgenic system creating a reduction in dosage of Btk can therefore be used to identify modifier loci that affect B cell responses and quantitatively rank their contribution to Btk-mediated processes...
  54. ncbi request reprint The mouse Cd83 gene: structure, domain organization, and chromosome localization
    C J Twist
    Division of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney St, Boston, MA 02115 6084, USA
    Immunogenetics 48:383-93. 1998
    ..The isolation and characterization of the mCD83 cDNA and gene provides important information and tools that will facilitate the study of CD83 and dendritic cell function in a mouse model system...
  55. ncbi request reprint The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches
    E J Kunkel
    Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville 22908, USA
    J Immunol 161:2449-56. 1998
    ..In situ, beta 7 integrins and L-selectin account for all lymphocyte homing to Peyer's patches, but P-selectin-dependent rolling, as induced by minimal trauma, may support trafficking of effector T lymphocytes to Peyer's patches...
  56. pmc Neutrophil margination, sequestration, and emigration in the lungs of L-selectin-deficient mice
    N A Doyle
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Clin Invest 99:526-33. 1997
    ..coli-induced pneumonia, and in the accumulation of neutrophils within noncapillary microvessels when induced by either intravascular complement fragments or..
  57. ncbi request reprint L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes
    N Wagner
    Institute for Genetics, University of Cologne, Germany
    Eur J Immunol 28:3832-9. 1998
    ..We conclude that the combination of both molecules, L-selectin and beta7 integrin, is indispensable for MLN formation and that these molecules may mediate lymphocyte migration to MLN in a sequential and synergistical manner...
  58. ncbi request reprint Overlapping roles for L-selectin and P-selectin in antigen-induced immune responses in the microvasculature
    S Kanwar
    Immunology Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    J Immunol 162:2709-16. 1999
    ..In conclusion, leukocyte rolling is L-selectin-dependent post-Ag challenge with L-selectin and P-selectin sharing overlapping functions...
  59. ncbi request reprint CD19 maps to a region of conservation between human chromosome 16 and mouse chromosome 7
    D C Ord
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA
    Immunogenetics 39:322-8. 1994
    ..Multiple genes with a lymphocyte-related function also map to this conserved region including genes encoding the IL-4 receptor, CD11a, CD11b, CD11c, CD43 (leukosialin), and protein kinase C beta polypeptide...
  60. pmc Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins
    T F Tedder
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, Massachusetts
    J Exp Med 170:123-33. 1989
    ..The LAM-1 gene is located on chromosome 1q23-25, as is another member of this adhesion family, suggesting that this new family of proteins may be encoded by a cluster of "adhesion protein" loci...
  61. ncbi request reprint Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily
    T F Tedder
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    J Immunol 143:712-7. 1989
    ....
  62. ncbi request reprint Isolation and characterization of a bovine cDNA encoding a functional homolog of human P-selectin
    N A Strubel
    Surgical Research Laboratory, Children s Hospital, Boston, Massachusetts
    Biochem Biophys Res Commun 192:338-44. 1993
    ..The bovine P-selectin bound the myeloid cells in a manner similar to human P-selectin, indicating that the altered domain structure of bovine P-selectin does not affect P-selectin function in this in vitro cell adhesion assay...
  63. pmc Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes
    J K Bubien
    Department of Medicine, University of Alabama, Birmingham 35294
    J Cell Biol 121:1121-32. 1993
    ....
  64. ncbi request reprint Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22
    J M Tuscano
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1876, USA
    Eur J Immunol 26:1246-52. 1996
    ..This study further substantiates the importance of CD22 as a B lymphocyte signaling molecule and begins to unravel the mechanisms by which CD22 cross-linking can alter B cell function...
  65. ncbi request reprint Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice
    M L Arbones
    Cell Genesys, Incorporated, Foster City, California 94404
    Immunity 1:247-60. 1994
    ..Thus, L-selectin plays an essential role in leukocyte homing to lymphoid tissues and sites of inflammation...
  66. ncbi request reprint Cloning of a complementary DNA encoding a new mouse B lymphocyte differentiation antigen, homologous to the human B1 (CD20) antigen, and localization of the gene to chromosome 19
    T F Tedder
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    J Immunol 141:4388-94. 1988
    ..These results suggest that only B cells express this heretofore undescribed murine cell-surface protein that is structurally homologous with the membrane-embedded human B1 Ag...
  67. pmc Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes
    T F Tedder
    Division of Tumor Immunology, Dana Faber Cancer Institute, Boston, MA
    Proc Natl Acad Sci U S A 85:208-12. 1988
    ..The deduced B1 amino acid sequence shows no significant homology with other known proteins...
  68. ncbi request reprint Structure of the gene encoding the human B lymphocyte differentiation antigen CD20 (B1)
    T F Tedder
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    J Immunol 142:2560-8. 1989
    ..The 5' splice site following exon V was found to be divergent from the consensus splice sequence. A relationship between the individual peptides encoded by the six exons and structurally distinct regions of the CD20 protein is likely...
  69. ncbi request reprint The gene that encodes the human CD20 (B1) differentiation antigen is located on chromosome 11 near the t(11;14)(q13;q32) translocation site
    T F Tedder
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    J Immunol 142:2555-9. 1989
    ..These results raise the possibility that alterations in the expression of the CD20 gene may result after the t(11;14) chromosomal alteration...
  70. pmc The HB-6, CDw75, and CD76 differentiation antigens are unique cell-surface carbohydrate determinants generated by the beta-galactoside alpha 2,6-sialyltransferase
    B J Bast
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, Massachusetts
    J Cell Biol 116:423-35. 1992
    ..Thus, expression of a single ST can result in the generation of multiple distinct antigenic determinants on the cell surface which can be distinguished by mAb and may have regulatory roles in lymphocyte function...
  71. ncbi request reprint L-Selectin is required for the development of airway hyperresponsiveness but not airway inflammation in a murine model of asthma
    L C Fiscus
    University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA
    J Allergy Clin Immunol 107:1019-24. 2001
    ..CONCLUSION: L-selectin plays a crucial role in the development of AHR but not allergic inflammation in an animal model of asthma. L-selectin represents a potential target for novel asthma therapies specifically aimed at controlling AHR...