Warren Taylor

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Fiber tract-specific white matter lesion severity Findings in late-life depression and by AGTR1 A1166C genotype
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
    Hum Brain Mapp 34:295-303. 2013
  2. pmc Angiotensin receptor gene polymorphisms and 2-year change in hyperintense lesion volume in men
    W D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Mol Psychiatry 15:816-22. 2010
  3. ncbi request reprint Greater MRI lesion volumes in elderly depressed subjects than in control subjects
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, DUMC 3903, Durham, NC 27710, USA
    Psychiatry Res 139:1-7. 2005
  4. pmc Frontal white matter anisotropy and antidepressant remission in late-life depression
    Warren D Taylor
    The Department of Psychiatry, Durham, North Carolina, USA
    PLoS ONE 3:e3267. 2008
  5. pmc Social support in older individuals: the role of the BDNF Val66Met polymorphism
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1205-12. 2008
  6. ncbi request reprint Psychiatric disease in the twenty-first century: The case for subcortical ischemic depression
    Warren D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Biol Psychiatry 60:1299-303. 2006
  7. doi request reprint The brain-derived neurotrophic factor VAL66MET polymorphism and cerebral white matter hyperintensities in late-life depression
    Warren D Taylor
    Neuropsychiatric Imaging Research Laboratory, and the Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 16:263-71. 2008
  8. ncbi request reprint Orbitofrontal cortex volume in late life depression: influence of hyperintense lesions and genetic polymorphisms
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
    Psychol Med 37:1763-73. 2007
  9. ncbi request reprint Widespread effects of hyperintense lesions on cerebral white matter structure
    Warren D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, DUMC Box 3903, Durham, NC 27710, USA
    AJR Am J Roentgenol 188:1695-704. 2007
  10. pmc The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Psychiatry Res 155:173-7. 2007

Research Grants

  1. Geriatric Depression Outcomes: Prognostic Factors
    Warren Taylor; Fiscal Year: 2007
  2. Vascular Depression: Longitudinal Changes
    Warren Taylor; Fiscal Year: 2007
  3. Vascular Depression: Longitudinal Changes
    Warren Taylor; Fiscal Year: 2009
  4. Genes and Alterations in Brain Structure and Function in Depression
    Warren D Taylor; Fiscal Year: 2010
  5. Vascular Depression: Longitudinal Changes
    Warren D Taylor; Fiscal Year: 2010

Detail Information

Publications38

  1. pmc Fiber tract-specific white matter lesion severity Findings in late-life depression and by AGTR1 A1166C genotype
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
    Hum Brain Mapp 34:295-303. 2013
    ....
  2. pmc Angiotensin receptor gene polymorphisms and 2-year change in hyperintense lesion volume in men
    W D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Mol Psychiatry 15:816-22. 2010
    ....
  3. ncbi request reprint Greater MRI lesion volumes in elderly depressed subjects than in control subjects
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, DUMC 3903, Durham, NC 27710, USA
    Psychiatry Res 139:1-7. 2005
    ..Future research should combine similar volumetric techniques with methods of identifying the location of lesions specific to late-life depression...
  4. pmc Frontal white matter anisotropy and antidepressant remission in late-life depression
    Warren D Taylor
    The Department of Psychiatry, Durham, North Carolina, USA
    PLoS ONE 3:e3267. 2008
    ..We hypothesized that remission would be associated with higher frontal anisotropy measures, and failure to remit with lower anisotropy...
  5. pmc Social support in older individuals: the role of the BDNF Val66Met polymorphism
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1205-12. 2008
    ..Further work is needed to determine the generalizability of this finding to the broader population, as well as its significance for clinical outcomes...
  6. ncbi request reprint Psychiatric disease in the twenty-first century: The case for subcortical ischemic depression
    Warren D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Biol Psychiatry 60:1299-303. 2006
    ..Subcortical ischemic depression affects clinical presentation, long-term outcomes, and response to antidepressant therapy, arguing that it is a valid diagnostic entity worth further study...
  7. doi request reprint The brain-derived neurotrophic factor VAL66MET polymorphism and cerebral white matter hyperintensities in late-life depression
    Warren D Taylor
    Neuropsychiatric Imaging Research Laboratory, and the Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 16:263-71. 2008
    ....
  8. ncbi request reprint Orbitofrontal cortex volume in late life depression: influence of hyperintense lesions and genetic polymorphisms
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
    Psychol Med 37:1763-73. 2007
    ..We hypothesized that smaller OFC volume would be associated with depression, greater hyperintense lesion volume and severity, and APOE epsilon4 or 5HTTLPR short allele carriers...
  9. ncbi request reprint Widespread effects of hyperintense lesions on cerebral white matter structure
    Warren D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, DUMC Box 3903, Durham, NC 27710, USA
    AJR Am J Roentgenol 188:1695-704. 2007
    ..We hypothesized that hyperintense lesions are associated with alterations in white matter structure beyond the visible lesion boundaries as assessed with diffusion tensor imaging (DTI)...
  10. pmc The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Psychiatry Res 155:173-7. 2007
    ..5T brain MRI and genotyping. After controlling for demographics, Val158 allele homozygotes exhibited significantly smaller temporal lobe and hippocampal volumes, with a trend for smaller amygdala volumes...
  11. ncbi request reprint Medical comorbidity in late-life depression
    Warren D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Int J Geriatr Psychiatry 19:935-43. 2004
    ..Additionally, differences between subgroups of depressed populations, including those with MRI-defined vascular depression and those with late-onset compared with early-onset depression are not well described...
  12. ncbi request reprint Is there a definition of remission in late-life depression that predicts later relapse?
    Warren D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 29:2272-7. 2004
    ..Definitions of remission that are better associated with longer-term outcomes are needed...
  13. pmc One-year change in anterior cingulate cortex white matter microstructure: relationship with late-life depression outcomes
    Warren D Taylor
    Departments of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 19:43-52. 2011
    ..To better describe these relationships, the authors examined how 1-year change in DTI measures are related to 1-year course of depression...
  14. ncbi request reprint Localization of age-associated white matter hyperintensities in late-life depression
    Warren D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, DUMC 3903, Durham, NC 27710, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:539-44. 2003
    ..Deep white matter hyperintense lesions are associated with advanced age and late-life depression. The authors examined where age-related cerebral lesions occurred in elderly depressed and healthy control subjects...
  15. pmc BDNF Val66Met genotype and 6-month remission rates in late-life depression
    W D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Pharmacogenomics J 11:146-54. 2011
    ..Thus in this exploratory analysis, the Met66 allele may be associated with increased odds of remission in older subjects, but also with increased time to remission as there was no 3-month effect...
  16. ncbi request reprint White matter hyperintensity progression and late-life depression outcomes
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, DUMC 3903, Durham, NC 27710, USA
    Arch Gen Psychiatry 60:1090-6. 2003
    ..Because they are associated with age, they should increase in number and size over time. To our knowledge, this is the first longitudinal, volumetric MRI study of WMHs in depression...
  17. ncbi request reprint Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matter
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, DUMC Box 3903, Durham, NC 277120, USA
    Am J Psychiatry 161:1293-6. 2004
    ..The purpose of this study was to determine whether microstructural abnormalities in the white matter of the dorsolateral prefrontal cortex are associated with late-life depression...
  18. ncbi request reprint A systematic review of antidepressant placebo-controlled trials for geriatric depression: limitations of current data and directions for the future
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 29:2285-99. 2004
    ..Large simple studies are urgently needed to address the unmet needs for data on safety and efficacy of antidepressants in this population...
  19. ncbi request reprint Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 15:850-7. 2007
    ..The authors examined the relationship between this polymorphism and depression in an elderly sample, hypothesizing that the Met66 allele would be associated with late-life depression...
  20. ncbi request reprint Clinical characteristics of magnetic resonance imaging-defined subcortical ischemic depression
    K Ranga Rama Krishnan
    Department of Psychiatry, Duke University Medical Center, DUMC 3950, Durham, NC 27710, USA
    Biol Psychiatry 55:390-7. 2004
    ..We sought to investigate this diagnosis as a construct by examining differences between depressed subjects with and without magnetic resonance imaging defined subcortical ischemic vascular depression...
  21. ncbi request reprint White matter lesion volumes and caudate volumes in late-life depression
    Jonas Hannestad
    Departments of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Int J Geriatr Psychiatry 21:1193-8. 2006
    ..We additionally hypothesized that this association would be stronger in depressed subjects...
  22. pmc Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Box 8134, St Louis, MO 63110, USA
    Arch Gen Psychiatry 67:277-85. 2010
    ..Research on vascular depression has used 2 approaches to subtype late-life depression, based on executive dysfunction or white matter hyperintensity severity...
  23. pmc Temporal lobe volume in bipolar disorder: relationship with diagnosis and antipsychotic medication use
    Lindsay D Jones
    The Neuropsychiatric Imaging Research Laboratory, Duke University, Durham, North Carolina, United States
    J Affect Disord 114:50-7. 2009
    ..We tested for differences in temporal lobe volume in bipolar disorder and the relationship between these volumes and psychotropic medication use...
  24. pmc Hippocampus shape analysis and late-life depression
    Zheen Zhao
    Neuropsychiatric Imaging Research Laboratory, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 3:e1837. 2008
    ..These findings may provide support to other reports of neurogenic effects of antidepressants and their relation to successful treatment for depressive symptoms...
  25. pmc The brain-derived neurotrophic factor Val66Met polymorphism, hippocampal volume, and cognitive function in geriatric depression
    Sophiya Benjamin
    Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
    Am J Geriatr Psychiatry 18:323-31. 2010
    ..The authors examined the relationship between the BDNF gene and hippocampal volumes in depressed and nondepressed older individuals and its relationship with memory functions mediated by the hippocampus...
  26. ncbi request reprint Short/long heterozygotes at 5HTTLPR and white matter lesions in geriatric depression
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Int J Geriatr Psychiatry 23:244-8. 2008
    ..We examined the relationship between 5HTTLPR genotype and volume of magnetic resonance imaging (MRI) brain lesions...
  27. ncbi request reprint Greater depression severity associated with less improvement in depression-associated cognitive deficits in older subjects
    Warren D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, DUMC 3903, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 10:632-5. 2002
    ..The authors investigated the relationship of baseline depression severity and cognitive improvement with antidepressant treatment in depressed patients with mild cognitive impairment...
  28. ncbi request reprint Serial MR imaging of volumes of hyperintense white matter lesions in elderly patients: correlation with vascular risk factors
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, DUMC 3903, Durham, NC 27710, USA
    AJR Am J Roentgenol 181:571-6. 2003
    ..Mean change in lesion volume and mean percentage of change were determined between the two time points. Logistic regression models were used to examine the differential effects of age, sex, race, and self-reported medical morbidity...
  29. ncbi request reprint Lobar distribution of lesion volumes in late-life depression: the Biomedical Informatics Research Network (BIRN)
    James R MacFall
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 31:1500-7. 2006
    ..These changes are thought to disrupt neural circuits involved in mood regulation, thus increasing the risk of developing depression...
  30. ncbi request reprint Cortical white matter microstructural abnormalities in bipolar disorder
    John L Beyer
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Box 3519 DUMC, Durham, NC 27710, USA
    Neuropsychopharmacology 30:2225-9. 2005
    ..Further research is needed to better understand the interaction of microstructural changes and bipolar symptoms and whether these changes are specific to bipolar disorder...
  31. ncbi request reprint Progression of subcortical ischemic disease from vascular depression to vascular dementia
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham NC 27710, USA
    Am J Psychiatry 160:1751-6. 2003
  32. ncbi request reprint Influence of serotonin transporter promoter region polymorphisms on hippocampal volumes in late-life depression
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Arch Gen Psychiatry 62:537-44. 2005
    ..Recent research demonstrates that specific polymorphisms may be associated with differences in hippocampal volumes in subjects with depression...
  33. ncbi request reprint Diffusion tensor imaging: background, potential, and utility in psychiatric research
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, DUMC Box 3903, Durham, NC 27710, USA
    Biol Psychiatry 55:201-7. 2004
    ..It is only beginning to be utilized in psychiatric research. This article reviews the theory behind diffusion tensor imaging, its potential to map fiber tracts in the brain, and its recent use in psychiatric research...
  34. ncbi request reprint Smaller orbital frontal cortex volumes associated with functional disability in depressed elders
    Warren D Taylor
    Department of Psychiatry and Behavioral Medicine at Duke University Medical Center, Durham, North Carolina 27710, USA
    Biol Psychiatry 53:144-9. 2003
    ..Recent evidence has linked the orbital frontal cortex (OFC) with depression. We examined the relationship between OFC volumes in older subjects and impairment in the basic (BADL) and instrumental (IADL) activities of daily living...
  35. pmc Biochemical abnormalities of the medial temporal lobe and medial prefrontal cortex in late-life depression
    Talaignair N Venkatraman
    The Departments of Radiology, Duke University Medical Center, Durham, NC, United States
    Psychiatry Res 172:49-54. 2009
    ..In contrast, elevated NAA and myo-inositol concentrations in the left medial temporal lobe could be associated with neuronal and glial cell changes in the amygdala...
  36. ncbi request reprint Neuroimaging in late-life depression
    Sandeep Vaishnavi
    Duke South Hospital, Duke University Medical Center, Durham, USA
    Int Rev Psychiatry 18:443-51. 2006
    ..Neuroimaging may potentially be utilized at some point as a biomarker for late-life depression, thus helping with diagnosis and guiding treatment...
  37. ncbi request reprint Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression
    Jae Nam Bae
    Department of Psychiatry, Inha University Hospital, Incheon, South Korea
    Biol Psychiatry 60:1356-63. 2006
    ..This study used diffusion tensor imaging to examine for white matter microstructural abnormalities of these regions and of central white matter structures in late-life depression...
  38. ncbi request reprint Translational research in late-life mood disorders: implications for future intervention and prevention research
    Gwenn S Smith
    PET Centre, Centre for Addiction and Mental Health, Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Neuropsychopharmacology 32:1857-75. 2007
    ..Geriatric depression could serve as a model for translational research integrating basic and clinical neuroscience approaches that would have implications for the study of other neuropsychiatric disorders...

Research Grants8

  1. Geriatric Depression Outcomes: Prognostic Factors
    Warren Taylor; Fiscal Year: 2007
    ..Discussion: These findings will better describe the role of neural connectivity and striatofrontal dysfunction in geriatric depression. ..
  2. Vascular Depression: Longitudinal Changes
    Warren Taylor; Fiscal Year: 2007
    ..The proposal will provide important new data on neuroradiologic and neuropsychological factors contributing to recurrent or chronic depression in older individuals. ..
  3. Vascular Depression: Longitudinal Changes
    Warren Taylor; Fiscal Year: 2009
    ..The proposal will provide important new data on neuroradiologic and neuropsychological factors contributing to recurrent or chronic depression in older individuals. ..
  4. Genes and Alterations in Brain Structure and Function in Depression
    Warren D Taylor; Fiscal Year: 2010
    ..This study will advance our understanding of how genes affect the brain, which in turn will provide important information on the causes of depression. ..
  5. Vascular Depression: Longitudinal Changes
    Warren D Taylor; Fiscal Year: 2010
    ..The proposal will provide important new data on neuroradiologic and neuropsychological factors contributing to recurrent or chronic depression in older individuals. ..