Warren D Taylor

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Greater depression severity associated with less improvement in depression-associated cognitive deficits in older subjects
    Warren D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, DUMC 3903, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 10:632-5. 2002
  2. doi request reprint The brain-derived neurotrophic factor VAL66MET polymorphism and cerebral white matter hyperintensities in late-life depression
    Warren D Taylor
    Neuropsychiatric Imaging Research Laboratory, and the Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 16:263-71. 2008
  3. ncbi request reprint Clinical characteristics of magnetic resonance imaging-defined subcortical ischemic depression
    K Ranga Rama Krishnan
    Department of Psychiatry, Duke University Medical Center, DUMC 3950, Durham, NC 27710, USA
    Biol Psychiatry 55:390-7. 2004
  4. pmc Fiber tract-specific white matter lesion severity Findings in late-life depression and by AGTR1 A1166C genotype
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
    Hum Brain Mapp 34:295-303. 2013
  5. ncbi request reprint Orbitofrontal cortex volume in late life depression: influence of hyperintense lesions and genetic polymorphisms
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
    Psychol Med 37:1763-73. 2007
  6. pmc The brain-derived neurotrophic factor Val66Met polymorphism, hippocampal volume, and cognitive function in geriatric depression
    Sophiya Benjamin
    Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
    Am J Geriatr Psychiatry 18:323-31. 2010
  7. ncbi request reprint Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 15:850-7. 2007
  8. ncbi request reprint Lobar distribution of lesion volumes in late-life depression: the Biomedical Informatics Research Network (BIRN)
    James R MacFall
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 31:1500-7. 2006
  9. pmc Negative life stress and longitudinal hippocampal volume changes in older adults with and without depression
    Anthony S Zannas
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    J Psychiatr Res 47:829-34. 2013
  10. pmc AGTR1 gene variation: association with depression and frontotemporal morphology
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Psychiatry Res 202:104-9. 2012

Detail Information

Publications42

  1. ncbi request reprint Greater depression severity associated with less improvement in depression-associated cognitive deficits in older subjects
    Warren D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, DUMC 3903, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 10:632-5. 2002
    ..The authors investigated the relationship of baseline depression severity and cognitive improvement with antidepressant treatment in depressed patients with mild cognitive impairment...
  2. doi request reprint The brain-derived neurotrophic factor VAL66MET polymorphism and cerebral white matter hyperintensities in late-life depression
    Warren D Taylor
    Neuropsychiatric Imaging Research Laboratory, and the Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 16:263-71. 2008
    ....
  3. ncbi request reprint Clinical characteristics of magnetic resonance imaging-defined subcortical ischemic depression
    K Ranga Rama Krishnan
    Department of Psychiatry, Duke University Medical Center, DUMC 3950, Durham, NC 27710, USA
    Biol Psychiatry 55:390-7. 2004
    ..We sought to investigate this diagnosis as a construct by examining differences between depressed subjects with and without magnetic resonance imaging defined subcortical ischemic vascular depression...
  4. pmc Fiber tract-specific white matter lesion severity Findings in late-life depression and by AGTR1 A1166C genotype
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
    Hum Brain Mapp 34:295-303. 2013
    ....
  5. ncbi request reprint Orbitofrontal cortex volume in late life depression: influence of hyperintense lesions and genetic polymorphisms
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
    Psychol Med 37:1763-73. 2007
    ..We hypothesized that smaller OFC volume would be associated with depression, greater hyperintense lesion volume and severity, and APOE epsilon4 or 5HTTLPR short allele carriers...
  6. pmc The brain-derived neurotrophic factor Val66Met polymorphism, hippocampal volume, and cognitive function in geriatric depression
    Sophiya Benjamin
    Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
    Am J Geriatr Psychiatry 18:323-31. 2010
    ..The authors examined the relationship between the BDNF gene and hippocampal volumes in depressed and nondepressed older individuals and its relationship with memory functions mediated by the hippocampus...
  7. ncbi request reprint Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 15:850-7. 2007
    ..The authors examined the relationship between this polymorphism and depression in an elderly sample, hypothesizing that the Met66 allele would be associated with late-life depression...
  8. ncbi request reprint Lobar distribution of lesion volumes in late-life depression: the Biomedical Informatics Research Network (BIRN)
    James R MacFall
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 31:1500-7. 2006
    ..These changes are thought to disrupt neural circuits involved in mood regulation, thus increasing the risk of developing depression...
  9. pmc Negative life stress and longitudinal hippocampal volume changes in older adults with and without depression
    Anthony S Zannas
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    J Psychiatr Res 47:829-34. 2013
    ..Furthermore, these effects may be moderated by genetic polymorphisms in key neurotransmitter systems. These novel findings have important implications for understanding environmental influences on brain aging...
  10. pmc AGTR1 gene variation: association with depression and frontotemporal morphology
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Psychiatry Res 202:104-9. 2012
    ..This supports the idea that genetic variation in AGTR1 is associated with depression and differences in frontotemporal morphology...
  11. ncbi request reprint White matter hyperintensity progression and late-life depression outcomes
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, DUMC 3903, Durham, NC 27710, USA
    Arch Gen Psychiatry 60:1090-6. 2003
    ..Because they are associated with age, they should increase in number and size over time. To our knowledge, this is the first longitudinal, volumetric MRI study of WMHs in depression...
  12. ncbi request reprint Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matter
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, DUMC Box 3903, Durham, NC 277120, USA
    Am J Psychiatry 161:1293-6. 2004
    ..The purpose of this study was to determine whether microstructural abnormalities in the white matter of the dorsolateral prefrontal cortex are associated with late-life depression...
  13. pmc Frontal white matter anisotropy and antidepressant remission in late-life depression
    Warren D Taylor
    The Department of Psychiatry, Durham, North Carolina, USA
    PLoS ONE 3:e3267. 2008
    ..We hypothesized that remission would be associated with higher frontal anisotropy measures, and failure to remit with lower anisotropy...
  14. pmc One-year change in anterior cingulate cortex white matter microstructure: relationship with late-life depression outcomes
    Warren D Taylor
    Departments of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 19:43-52. 2011
    ..To better describe these relationships, the authors examined how 1-year change in DTI measures are related to 1-year course of depression...
  15. pmc Social support in older individuals: the role of the BDNF Val66Met polymorphism
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1205-12. 2008
    ..Further work is needed to determine the generalizability of this finding to the broader population, as well as its significance for clinical outcomes...
  16. ncbi request reprint Medical comorbidity in late-life depression
    Warren D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Int J Geriatr Psychiatry 19:935-43. 2004
    ..Additionally, differences between subgroups of depressed populations, including those with MRI-defined vascular depression and those with late-onset compared with early-onset depression are not well described...
  17. pmc Amygdala volume in late-life depression: relationship with age of onset
    Julie Burke
    Department of Psychiatry, Duke University Medical School, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 19:771-6. 2011
    ..Depression is common in the elderly population. Although numerous neuroimaging studies have examined depressed elders, there is limited research examining how amygdala volume may be related to depression...
  18. ncbi request reprint White matter lesion volumes and caudate volumes in late-life depression
    Jonas Hannestad
    Departments of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Int J Geriatr Psychiatry 21:1193-8. 2006
    ..We additionally hypothesized that this association would be stronger in depressed subjects...
  19. ncbi request reprint Short/long heterozygotes at 5HTTLPR and white matter lesions in geriatric depression
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Int J Geriatr Psychiatry 23:244-8. 2008
    ..We examined the relationship between 5HTTLPR genotype and volume of magnetic resonance imaging (MRI) brain lesions...
  20. ncbi request reprint Cortical white matter microstructural abnormalities in bipolar disorder
    John L Beyer
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Box 3519 DUMC, Durham, NC 27710, USA
    Neuropsychopharmacology 30:2225-9. 2005
    ..Further research is needed to better understand the interaction of microstructural changes and bipolar symptoms and whether these changes are specific to bipolar disorder...
  21. pmc Reduction of dorsolateral prefrontal cortex gray matter in late-life depression
    Cheng Chen Chang
    The Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Psychiatry Res 193:1-6. 2011
    ..Our study confirmed the reduction of dorsolateral prefrontal cortex in elderly depressed subjects, especially in the gray matter. These regional abnormalities may be associated with psychopathological changes in late-life depression...
  22. ncbi request reprint Influence of serotonin transporter promoter region polymorphisms on hippocampal volumes in late-life depression
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Arch Gen Psychiatry 62:537-44. 2005
    ..Recent research demonstrates that specific polymorphisms may be associated with differences in hippocampal volumes in subjects with depression...
  23. ncbi request reprint Widespread effects of hyperintense lesions on cerebral white matter structure
    Warren D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, DUMC Box 3903, Durham, NC 27710, USA
    AJR Am J Roentgenol 188:1695-704. 2007
    ..We hypothesized that hyperintense lesions are associated with alterations in white matter structure beyond the visible lesion boundaries as assessed with diffusion tensor imaging (DTI)...
  24. ncbi request reprint Is there a definition of remission in late-life depression that predicts later relapse?
    Warren D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 29:2272-7. 2004
    ..Definitions of remission that are better associated with longer-term outcomes are needed...
  25. pmc Variability in frontotemporal brain structure: the importance of recruitment of African Americans in neuroscience research
    Nneka Isamah
    The Duke Neuropsychiatric Imaging Research Laboratory, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 5:e13642. 2010
    ....
  26. pmc Association of attentional shift and reversal learning to functional deficits in geriatric depression
    Guy G Potter
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Int J Geriatr Psychiatry 27:1172-9. 2012
    ..The objective of this study is to examine the association between self-reported functional disability in depressed older adults and two types of executive function processes, attentional set shifting and reversal learning...
  27. pmc Structural integrity of the uncinate fasciculus and resting state functional connectivity of the ventral prefrontal cortex in late life depression
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 6:e22697. 2011
    ..In this study we sought to examine the relationship between the uncinate fasciculus, a key fronto-temporal tract and resting state functional connectivity between the ventral prefrontal cortex ((PFC) and limbic and striatal areas...
  28. pmc Hippocampus shape analysis and late-life depression
    Zheen Zhao
    Neuropsychiatric Imaging Research Laboratory, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 3:e1837. 2008
    ..These findings may provide support to other reports of neurogenic effects of antidepressants and their relation to successful treatment for depressive symptoms...
  29. ncbi request reprint Serial MR imaging of volumes of hyperintense white matter lesions in elderly patients: correlation with vascular risk factors
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, DUMC 3903, Durham, NC 27710, USA
    AJR Am J Roentgenol 181:571-6. 2003
    ..Mean change in lesion volume and mean percentage of change were determined between the two time points. Logistic regression models were used to examine the differential effects of age, sex, race, and self-reported medical morbidity...
  30. pmc The COMT Val158Met polymorphism and temporal lobe morphometry in healthy adults
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Psychiatry Res 155:173-7. 2007
    ..5T brain MRI and genotyping. After controlling for demographics, Val158 allele homozygotes exhibited significantly smaller temporal lobe and hippocampal volumes, with a trend for smaller amygdala volumes...
  31. ncbi request reprint Greater MRI lesion volumes in elderly depressed subjects than in control subjects
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, DUMC 3903, Durham, NC 27710, USA
    Psychiatry Res 139:1-7. 2005
    ..Future research should combine similar volumetric techniques with methods of identifying the location of lesions specific to late-life depression...
  32. pmc Biochemical abnormalities of the medial temporal lobe and medial prefrontal cortex in late-life depression
    Talaignair N Venkatraman
    The Departments of Radiology, Duke University Medical Center, Durham, NC, United States
    Psychiatry Res 172:49-54. 2009
    ..In contrast, elevated NAA and myo-inositol concentrations in the left medial temporal lobe could be associated with neuronal and glial cell changes in the amygdala...
  33. ncbi request reprint Diffusion tensor imaging: background, potential, and utility in psychiatric research
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, DUMC Box 3903, Durham, NC 27710, USA
    Biol Psychiatry 55:201-7. 2004
    ..It is only beginning to be utilized in psychiatric research. This article reviews the theory behind diffusion tensor imaging, its potential to map fiber tracts in the brain, and its recent use in psychiatric research...
  34. ncbi request reprint Localization of age-associated white matter hyperintensities in late-life depression
    Warren D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, DUMC 3903, Durham, NC 27710, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:539-44. 2003
    ..Deep white matter hyperintense lesions are associated with advanced age and late-life depression. The authors examined where age-related cerebral lesions occurred in elderly depressed and healthy control subjects...
  35. ncbi request reprint Psychiatric disease in the twenty-first century: The case for subcortical ischemic depression
    Warren D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Biol Psychiatry 60:1299-303. 2006
    ..Subcortical ischemic depression affects clinical presentation, long-term outcomes, and response to antidepressant therapy, arguing that it is a valid diagnostic entity worth further study...
  36. pmc Stressful life events, perceived stress, and 12-month course of geriatric depression: direct effects and moderation by the 5-HTTLPR and COMT Val158Met polymorphisms
    Anthony S Zannas
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Stress 15:425-34. 2012
    ..Moreover, changes in these stress measures over time correlate with depression outcomes. 5-HTTLPR S carriers appear to be more susceptible to both the effects of enduring stress and the benefit of interval stress reduction...
  37. ncbi request reprint A systematic review of antidepressant placebo-controlled trials for geriatric depression: limitations of current data and directions for the future
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 29:2285-99. 2004
    ..Large simple studies are urgently needed to address the unmet needs for data on safety and efficacy of antidepressants in this population...
  38. ncbi request reprint Smaller orbital frontal cortex volumes associated with functional disability in depressed elders
    Warren D Taylor
    Department of Psychiatry and Behavioral Medicine at Duke University Medical Center, Durham, North Carolina 27710, USA
    Biol Psychiatry 53:144-9. 2003
    ..Recent evidence has linked the orbital frontal cortex (OFC) with depression. We examined the relationship between OFC volumes in older subjects and impairment in the basic (BADL) and instrumental (IADL) activities of daily living...
  39. ncbi request reprint Neuroimaging in late-life depression
    Sandeep Vaishnavi
    Duke South Hospital, Duke University Medical Center, Durham, USA
    Int Rev Psychiatry 18:443-51. 2006
    ..Neuroimaging may potentially be utilized at some point as a biomarker for late-life depression, thus helping with diagnosis and guiding treatment...
  40. ncbi request reprint Progression of subcortical ischemic disease from vascular depression to vascular dementia
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham NC 27710, USA
    Am J Psychiatry 160:1751-6. 2003
  41. ncbi request reprint Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression
    Jae Nam Bae
    Department of Psychiatry, Inha University Hospital, Incheon, South Korea
    Biol Psychiatry 60:1356-63. 2006
    ..This study used diffusion tensor imaging to examine for white matter microstructural abnormalities of these regions and of central white matter structures in late-life depression...
  42. ncbi request reprint Translational research in late-life mood disorders: implications for future intervention and prevention research
    Gwenn S Smith
    PET Centre, Centre for Addiction and Mental Health, Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Neuropsychopharmacology 32:1857-75. 2007
    ..Geriatric depression could serve as a model for translational research integrating basic and clinical neuroscience approaches that would have implications for the study of other neuropsychiatric disorders...