L A Szczech

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. doi Atrial fibrillation: the beat is faster than the answers
    Lynda A Szczech
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Kidney Int 81:432-3. 2012
  2. pmc Sensitivity of International Classification of Diseases codes for hyponatremia among commercially insured outpatients in the United States
    Alisa M Shea
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, PO Box 17969, Durham, North Carolina, USA
    BMC Nephrol 9:5. 2008
  3. ncbi Association between renal disease and outcomes among HIV-infected women receiving or not receiving antiretroviral therapy
    Lynda Anne Szczech
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Infect Dis 39:1199-206. 2004
  4. pmc Microalbuminuria predicts overt proteinuria among patients with HIV infection
    L A Szczech
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    HIV Med 11:419-26. 2010
  5. ncbi Associations between CMS's Clinical Performance Measures project benchmarks, profit structure, and mortality in dialysis units
    L A Szczech
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    Kidney Int 69:2094-100. 2006
  6. ncbi The uncertain significance of anti-glomerular basement membrane antibody among HIV-infected persons with kidney disease
    Lynda Anne Szczech
    Department of Medicine, Division of Nephrology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Kidney Dis 48:e55-9. 2006
  7. ncbi Research in HIV-related renal diseases lags behind their burden to the 'positive' community
    L A Szczech
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Kidney Int 72:1303-5. 2007
  8. doi Chronic kidney disease anemia management: what should be done?
    Lynda Anne Szczech
    Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA
    Blood Purif 31:186-8. 2011
  9. pmc Secondary analysis of the CHOIR trial epoetin-alpha dose and achieved hemoglobin outcomes
    Lynda A Szczech
    Department of Medicine, The Renal Division, Duke University Medical Center, Durham, North Carolina, USA
    Kidney Int 74:791-8. 2008
  10. doi Renal disease: the effects of HIV and antiretroviral therapy and the implications for early antiretroviral therapy initiation
    Lynda Anne Szczech
    Duke University Medical Center, Department of Medicine, Division of Nephrology, Box 3646, Durham, NC 27710, USA
    Curr Opin HIV AIDS 4:167-70. 2009

Detail Information

Publications42

  1. doi Atrial fibrillation: the beat is faster than the answers
    Lynda A Szczech
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Kidney Int 81:432-3. 2012
    ..This Commentary explores gaps in our knowledge of how to treat this vulnerable and sick population...
  2. pmc Sensitivity of International Classification of Diseases codes for hyponatremia among commercially insured outpatients in the United States
    Alisa M Shea
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, PO Box 17969, Durham, North Carolina, USA
    BMC Nephrol 9:5. 2008
    ....
  3. ncbi Association between renal disease and outcomes among HIV-infected women receiving or not receiving antiretroviral therapy
    Lynda Anne Szczech
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Infect Dis 39:1199-206. 2004
    ..The associations of proteinuria and an elevated creatinine level with progression to acquired immunodeficiency syndrome (AIDS) and death in the era of highly antiretroviral therapy (HAART) have not been fully described...
  4. pmc Microalbuminuria predicts overt proteinuria among patients with HIV infection
    L A Szczech
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    HIV Med 11:419-26. 2010
    ..This study examines the association between microalbuminuria and the development of proteinuria among HIV-infected persons...
  5. ncbi Associations between CMS's Clinical Performance Measures project benchmarks, profit structure, and mortality in dialysis units
    L A Szczech
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    Kidney Int 69:2094-100. 2006
    ..This suggests that in the contemporary era, interventions in for-profit dialysis units have not impaired their ability to deliver performance benchmarks and do not affect survival...
  6. ncbi The uncertain significance of anti-glomerular basement membrane antibody among HIV-infected persons with kidney disease
    Lynda Anne Szczech
    Department of Medicine, Division of Nephrology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Kidney Dis 48:e55-9. 2006
    ....
  7. ncbi Research in HIV-related renal diseases lags behind their burden to the 'positive' community
    L A Szczech
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Kidney Int 72:1303-5. 2007
    ..suggests that they remain similar to or worse than outcomes for persons with diabetes mellitus. This study should be used to frame the research resources that we devote to furthering knowledge in this area...
  8. doi Chronic kidney disease anemia management: what should be done?
    Lynda Anne Szczech
    Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA
    Blood Purif 31:186-8. 2011
    ..The renal community now must struggle with how to incentivize quality care and maximize patient quality of life while minimizing the real safety signal of which we are now aware...
  9. pmc Secondary analysis of the CHOIR trial epoetin-alpha dose and achieved hemoglobin outcomes
    Lynda A Szczech
    Department of Medicine, The Renal Division, Duke University Medical Center, Durham, North Carolina, USA
    Kidney Int 74:791-8. 2008
    ..Prospective studies are needed to confirm this relationship and determine safe dosing algorithms for patients unable to achieve target hemoglobin...
  10. doi Renal disease: the effects of HIV and antiretroviral therapy and the implications for early antiretroviral therapy initiation
    Lynda Anne Szczech
    Duke University Medical Center, Department of Medicine, Division of Nephrology, Box 3646, Durham, NC 27710, USA
    Curr Opin HIV AIDS 4:167-70. 2009
    ..This review will summarize the relevant literature supporting the early initiation of antiretroviral therapy among persons with HIV and kidney disease...
  11. pmc A secondary analysis of the CHOIR trial shows that comorbid conditions differentially affect outcomes during anemia treatment
    Lynda A Szczech
    Renal Division, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Kidney Int 77:239-46. 2010
    ..These differential outcomes underscore the need for dedicated trials in these subpopulations...
  12. doi Acute kidney injury and cardiovascular outcomes in acute severe hypertension
    Lynda A Szczech
    Department of Medicine, Division of Nephrology, Duke University Medical Center, Box 3646, Durham, NC 27710, USA
    Circulation 121:2183-91. 2010
    ....
  13. doi Randomized evaluation of efficacy and safety of ferric carboxymaltose in patients with iron deficiency anaemia and impaired renal function (REPAIR-IDA): rationale and study design
    Lynda A Szczech
    Renal Division, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Nephrol Dial Transplant 25:2368-75. 2010
    ..Ferric carboxymaltose (FCM) is a novel IV iron formulation designed to permit larger infusions compared to currently available IV standards such as Venofer(R) (iron sucrose)...
  14. doi Getting the urine to the lab: time to think outside of the specimen cup
    Lynda A Szczech
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Kidney Int 79:145-7. 2011
    ..Implications of these associations as well as the mechanisms supporting them are explored...
  15. ncbi The clinical epidemiology and course of the spectrum of renal diseases associated with HIV infection
    Lynda Anne Szczech
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Kidney Int 66:1145-52. 2004
    ..This study was undertaken to compare HIVAN to the spectrum of other kidney diseases seen among HIV-infected patients...
  16. ncbi Protease inhibitors are associated with a slowed progression of HIV-related renal diseases
    L A Szczech
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Clin Nephrol 57:336-41. 2002
    ..This study describes the clinical course of HIV-related renal diseases and the effect of protease inhibitors on their progression...
  17. ncbi Key concepts in biostatistics: using statistics to answer the question "is there a difference?"
    Lynda Anne Szczech
    Institute for Renal Outcomes and Health Policy Research, Duke University Medical Center, Durham, North Carolina 27710, USA
    Semin Dial 15:347-51. 2002
    ..These concepts are integral to the design and analysis of clinical studies. An understanding of their advantages and applications will enhance the reader's ability to understand and evaluate the literature...
  18. ncbi Predictors of proteinuria and renal failure among women with HIV infection
    Lynda Anne Szczech
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Kidney Int 61:195-202. 2002
    ..This study examines the risk factors for proteinuria and renal failure in a large cohort of HIV-infected women not selected for the presence of renal disease...
  19. ncbi An introduction to epidemiology and biostatistics and issues in interpretation of studies
    Lynda Anne Szczech
    Institute for Renal Outcomes and Health Policy Research, Duke University Medical Center, Durham, North Carolina 27710, USA
    Semin Dial 15:60-5. 2002
    ..This series of articles will help the reader to weigh methods and study designs to understand the appropriate conclusions that may be drawn from any data...
  20. ncbi The clinical characteristics and antiretroviral dosing patterns of HIV-infected patients receiving dialysis
    Lynda Anne Szczech
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Kidney Int 63:2295-301. 2003
    ..This study describes the clinical characteristics and antiretroviral dosing patterns of HIV-infected patients receiving dialysis to define the clinical needs of this growing population...
  21. ncbi Outcomes of patients with chronic renal insufficiency in the bypass angioplasty revascularization investigation
    L A Szczech
    Duke University Medical Center, Division of Nephrology, Durham, NC 27710, USA
    Circulation 105:2253-8. 2002
    ..Although severe chronic kidney disease (CKD) is an independent predictor of mortality among patients with coronary artery disease, the impact of mild CKD on morbidity and mortality has not been fully defined...
  22. ncbi Differential survival after coronary revascularization procedures among patients with renal insufficiency
    L A Szczech
    Division of Nephrology, Department of Medicine, Duke Institute for Renal Outcomes Research and Health Policy, and Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Kidney Int 60:292-9. 2001
    ....
  23. ncbi Renal diseases associated with human immunodeficiency virus infection: epidemiology, clinical course, and management
    L A Szczech
    Department of Medicine, Division of Nephrology, Duke University Medical Center, Durham, NC 27710, USA
    Clin Infect Dis 33:115-9. 2001
    ..Future research should focus on gaining a better understanding of the distribution and determinants of renal disease among HIV-infected patients as well as on performing controlled studies to test treatment strategies...
  24. ncbi Changing hemodialysis thresholds for optimal survival
    L A Szczech
    Duke Institute for Renal Outcomes Research and Health Policy, Duke University Medical Center, Durham, North Carolina 27710, USA
    Kidney Int 59:738-45. 2001
    ..Because of new hemodialysis technologies and evolving demographics of the hemodialysis population, the relationship between the amount of hemodialysis and mortality was examined in contemporary cohorts...
  25. ncbi Study designs and their potential influence on conclusions
    Lynda Anne Szczech
    Institute for Renal Outcomes and Health Policy Research, Duke University Medical Center, Durham, North Carolina 27710, USA
    Semin Dial 15:207-11. 2002
    ..Through the examination of these methods, the reader will be able to rigorously examine study methods and understand how design affects study conclusions and their application to patient care...
  26. ncbi Hypertension and medication-related renal dysfunction in the HIV-infected patient
    L A Szczech
    Duke Institute of Renal Outcomes Research and Health Policy, Duke University Medical Center, Durham, NC 27710, USA
    Semin Nephrol 21:386-93. 2001
    ..Knowledge of these interactions and side effects is essential toward caring for the patient with HIV-infection...
  27. ncbi Long-term outcomes of revascularization for peripheral vascular disease in end-stage renal disease patients
    D N Reddan
    Duke Institute of Renal Outcomes Research and Health Policy, Division of Nephrology, Duke University Medical Center, Durham, NC, USA
    Am J Kidney Dis 38:57-63. 2001
    ..Patient-related variables (eg, increased prevalence of hypertension and cardiovascular disease) and/or provider-specific factors (eg, timing of surgery in the course of PVD) may be responsible for poorer outcomes...
  28. ncbi The predictive value of self-report scales compared with physician diagnosis of depression in hemodialysis patients
    S S Hedayati
    Department of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Kidney Int 69:1662-8. 2006
    ..When used for screening, the threshold for depression should be higher for ESRD compared with non-ESRD patients. Identifying depression using physician interview is important, given the low -LR of self-report scales...
  29. pmc Association of intradialytic blood pressure changes with hospitalization and mortality rates in prevalent ESRD patients
    J K Inrig
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27705, USA
    Kidney Int 71:454-61. 2007
    ..Further research should attempt to elucidate the mechanisms behind these findings...
  30. ncbi Interactions between dialysis-related volume exposures, nutritional surrogates and mortality among ESRD patients
    Lynda Anne Szczech
    Department of Medicine, Division of Nephrology, Institute for Renal Outcomes Research and Health Policy, Duke University Medical Center, Durham, NC 27705, USA
    Nephrol Dial Transplant 18:1585-91. 2003
    ..This analysis characterizes the association between dialysis-related volume expansion and mortality in the context of its interaction with nutritional surrogates...
  31. ncbi Nondialytic management of hyperkalemia and pulmonary edema among end-stage renal disease patients: an evaluation of the evidence
    Kimberley Evans
    Department of Medicine, Division of Nephrology, Duke University Medical Center, Durham, North Carolina 27705, USA
    Semin Dial 17:22-9. 2004
    ..Therefore, whether or not nondialytic management alone is appropriate remains a matter of individual judgment that should be decided on a case-by-case basis...
  32. pmc Cystatin C level as a marker of kidney function in human immunodeficiency virus infection: the FRAM study
    Michelle C Odden
    Department of Medicine, San FranciscoVeterans Affairs Medical Center 4150 Clement Street, San Francisco, CA 94121, USA
    Arch Intern Med 167:2213-9. 2007
    ..Cystatin C measurement may be more sensitive than creatinine for detecting impaired kidney function in persons with HIV...
  33. pmc Microalbuminuria in HIV infection
    Lynda Anne Szczech
    Duke University Medical Center, Department of Medicine, Division of Nephrology, Durham, North Carolina, USA
    AIDS 21:1003-9. 2007
    ..Microalbuminuria is associated with increased risk of cardiovascular disease and mortality. The objective of the study was to evaluate if HIV infection was an independent risk factor for microalbuminuria...
  34. ncbi Intradialytic blood volume monitoring in ambulatory hemodialysis patients: a randomized trial
    Donal N Reddan
    Duke University Medical Center, Box 3646, Durham, NC 27710, USA
    J Am Soc Nephrol 16:2162-9. 2005
    ..The atypically low hospitalization and mortality rates for the conventional monitoring group suggest that these findings should be generalized to the US hemodialysis population with caution...
  35. ncbi HIV-associated nephropathy: a review of the epidemiology and clinical course in the HAART era
    S Susan Hedayati
    Department of Medicine, Division of Nephrology, Duke University Medical Center, Durham, North Carolina 27710, USA
    AIDS Patient Care STDS 17:57-63. 2003
  36. ncbi The evaluation of underlying cardiovascular disease among patients with end-stage renal disease
    S Susan Hedayati
    Duke University Medical Center, Department of Medicine, Division of Nephrology, Durham, NC 27710, USA
    Adv Chronic Kidney Dis 11:246-53. 2004
    ....
  37. ncbi HIV and the kidneys. How to know when something is wrong and why it is important
    Lynda Anne Szczech
    Duke University Medical Center, Durham, North Carolina, USA
    Posit Aware 17:32-5. 2006
  38. ncbi Chronic kidney disease, mortality, and treatment strategies among patients with clinically significant coronary artery disease
    Donal N Reddan
    Duke Institute for Renal Outcomes Research and Health Policy, Division of Nephrology, Duke Clinical Research Institute, Duke University Medical Center, Duke University Medical Center, Durham, North Carolina, USA
    J Am Soc Nephrol 14:2373-80. 2003
    ..Among patients with severe CKD, PCI was not associated with improved survival. CABG is associated with greater mortality reduction than PCI in severe CKD...
  39. ncbi Renal complications of HIV/AIDS
    Lynda Anne Szczech
    BETA 19:27-34. 2007
    ..This article explains how kidney function is assessed, describes the renal complications that are most commonly seen in HIV positive people, and outlines treatment options...
  40. doi Tenofovir nephrotoxicity: focusing research questions and putting them into clinical context
    Lynda Anne Szczech
    J Infect Dis 197:7-9. 2008
  41. ncbi The impact of antiretroviral therapy on HIVAN
    Lynda Anne Szczech
    Kidney Int 65:1114; author reply 1115. 2004
  42. ncbi Definition of proteinuria among women with HIV infection
    Lynda Anne Szczech
    Kidney Int 65:1519. 2004