Laura Svetkey

..Few other variables other than initial weight loss and dietary pattern were predictive. Future research should identify additional modifiable influences on long-term maintenance after a modest weight loss...

..The chronic care model suggests that blood pressure control can be achieved by improving how patients and physicians address patient self-care...

..In conclusion, diverse groups of people can adopt multiple lifestyle changes that can lead to improved BP control and reduced CVD risk...

..BP became normal or optimal in 71% of persons consuming the control/lower sodium diet and 77% of persons consuming the DASH/lower sodium diet. Both the DASH diet and reduced sodium intake improved BP control...

..To describe PREMIER, a randomized trial to determine the effects of multi-component lifestyle interventions on blood pressure (BP)...

..Behavioral weight loss interventions achieve short-term success, but re-gain is common...

..Differences between treatment groups did not persist at 18 months. Combined physician and patient interventions lowers blood pressure; future research should focus on enhancing effectiveness and sustainability of these interventions...

..The purpose of this study was to identify genes that modulate BP response to dietary interventions...

..The angiotensin converting enzyme (ACE) gene was also tested...

..006). Evidence for linkage was significant at the .05 level after adjustment for the number of phenotypic traits examined...

..Evaluating a randomized controlled trial involving a tailored behavioral intervention conducted to improve blood pressure control...

..Corresponding heritability estimates were 0.26 to 0.84, 0.26 to 0.74, and 0.004 to 0.24, respectively. These data strongly suggest a heritable component of salt sensitivity...

..This study describes the clinical course of HIV-related renal diseases and the effect of protease inhibitors on their progression...

..This study examines the association between microalbuminuria and the development of proteinuria among HIV-infected persons...

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..The choice of antihypertensive agent may also be important. Further investigation is needed into the mechanisms accounting for the observed sex and race differences...

..Our results indicate that the DASH diet, which is rich in fruits, vegetables, and low-fat dairy foods, is effective as first-line therapy in stage 1 ISH...

..In contrast, the DASH diet had no significant effect on markers of fibrinolysis in whites or African-Americans...

..These results demonstrate that the DASH combination diet provides significant round-the-clock reduction in BP, especially in hypertensive participants...

..Captopril stimulated peripheral renin and postcaptopril renography are not useful as screening tools for the diagnosis of renovascular disease in blacks. Blacks at high risk should be evaluated with angiography...

..This pattern was supported by differences in the ANOVA. African American acculturation is related to dietary intake. These findings have implications for the design of cancer-related public health messages targeted to African Americans...

..To identify unique cultural variables for African Americans that might limit the effectiveness of behavioral interventions in clinical trials...

..We tested the hypothesis that consumption of a healthy diet rich in fruits and vegetables and reduced in saturated fat, total fat, and cholesterol will concomitantly reduce oxidative stress and Ab-oxLDL...

..Results from this study will expand our knowledge of the biology of obesity and weight regulation and may lead to targeted strategies for its treatment and control...

..CONCLUSIONS: Over 18 months, persons with prehypertension and stage 1 hypertension can sustain multiple lifestyle modifications that improve control of blood pressure and could reduce the risk for chronic disease...

..To assess contributions of individual lifestyle changes on systolic blood pressure (SBP) changes...

..Our data suggest that strategies for lowering BP in individuals with metabolic syndrome may be enhanced by recommendations to adopt the DASH dietary pattern...

..We tested the hypothesis that AA who participate in all AA weight loss intervention groups will lose more weight than AA who participate in mixed race groups...

..Eating the DASH diet, however, is more expensive in high-SES communities. Increased information, food availability, and affordability are likely to lead to more widespread adoption of the DASH diet...

..Despite the damaging impact of hypertension and the availability of evidence-based target values for blood pressure, interventions to improve blood pressure control have had limited success...

..This study examines the risk factors for proteinuria and renal failure in a large cohort of HIV-infected women not selected for the presence of renal disease...

..In addition, investigators must understand how to effectively address relevant biases of African Americans without challenging their ethnic identity. Steps to decrease biases are described...

..5+/-3.4 vs 64.9+/-13.1 [mmol/d]/mm Hg, P=0.0002) without significantly shifting the x-intercept (94.1+/-0.5 vs 93.2+/-0.6 mm Hg, NS) of the relationship. These data suggest a natriuretic action of the DASH diet...

..We conducted a clinical trial to assess the BP response to the DASH diet with an antihypertensive medication, losartan, in participants with essential hypertension...

..The Dietary Approaches to Stop Hypertension (DASH) diet also lowers BP. To date, no trial has evaluated the effects of simultaneously implementing these lifestyle recommendations...

..The purpose of this report is to describe the process, results, and implications in the phone recruitment of African Americans through church rosters for a survey of diet-and blood pressure-related awareness and hypertension prevalence...

..Further exploration of attitudes and socioeconomic factors in assessing health awareness and HTN prevalence in this population is recommended...

..04 for three-way interaction among diet, time of visit, and sodium). CONCLUSIONS: After the feeding intervention, DASH diet participants ate more fruits/vegetables and had sustained reductions in BP despite increased sodium intake...

..However, several nonpharmacologic interventions reduce BP to a greater degree in hypertensives and African-Americans...

..This study was undertaken to compare HIVAN to the spectrum of other kidney diseases seen among HIV-infected patients...

..001) compared with a decrease to 26% in the advice-only group. The PREMIER trial demonstrated that persons with above-optimal BP and stage 1 hypertension can make multiple lifestyle changes leading to better control of BP...

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..This paper describes methods and results for the initial 6-month weight-loss program (Phase I)...

..This ancillary study of PREMIER sought to determine the effects on insulin sensitivity of a comprehensive behavioral intervention for hypertension with and without the Dietary Approaches to Stop Hypertension (DASH) dietary pattern...

..The DASH diet should be promoted, along with maintaining healthy weight, reducing sodium intake, increasing regular physical activity, and limiting alcohol intake, for lowering blood pressure and reducing the risk of CVD...

..A reduced sodium intake reduced calcium excretion in both diet groups and serum OC in the DASH group. The DASH diet and reduced sodium intake may have complementary, beneficial effects on bone health...

..There were no significant interactions between the effects of sodium and the DASH diet on serum lipids. In conclusion, changes in dietary sodium intake over the range of 50 to 150 mmol/d did not affect blood lipid concentrations...

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..The purpose of this proposal is to develop and test two such interventions, which, if effective, should complement ongoing efforts to stem the obesity epidemic and ultimately prevent obesity-related CVD. ..

..The purpose of this proposal is to develop and test two such interventions, which, if effective, should complement ongoing efforts to stem the obesity epidemic and ultimately prevent obesity-related CVD. ..

..3 for the primary outcome. The HIP study will test practical interventions for improving hypertension control that can be broadly implemented and reduce CVD risk. ..

..Ultimately, increased understanding of these mechanisms will lead to improved strategies for prevention and control, both nutritional and pharmacologic, of high BP. ..

..Results from PREMIER will provide the scientific rationale for routinely implementing comprehensive lifestyle intervention programs to control BP and ultimately prevent BP related cardiovascular disease. ..

..3 for the primary outcome. The HIP study will test practical interventions for improving hypertension control that can be broadly implemented and reduce CVD risk. ..