Ayako Suzuki

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. doi request reprint Drugs associated with hepatotoxicity and their reporting frequency of liver adverse events in VigiBase: unified list based on international collaborative work
    Ayako Suzuki
    Division of Gastroenterology, Duke University, Durham, North Carolina 27710, USA
    Drug Saf 33:503-22. 2010
  2. doi request reprint Serum aminotransferase changes with significant weight loss: sex and age effects
    Ayako Suzuki
    Division of Gastroenterology, Department of Medicine, Duke University, Durham, NC 27710, USA
    Metabolism 59:177-85. 2010
  3. pmc Regional anthropometric measures and hepatic fibrosis in patients with nonalcoholic Fatty liver disease
    Ayako Suzuki
    Duke University, Durham, North Carolina, USA
    Clin Gastroenterol Hepatol 8:1062-9. 2010
  4. doi request reprint Co-medications that modulate liver injury and repair influence clinical outcome of acetaminophen-associated liver injury
    Ayako Suzuki
    Gastroenterology, Duke University, Durham, North Carolina, USA
    Clin Gastroenterol Hepatol 7:882-8. 2009
  5. doi request reprint Nonalcoholic fatty liver disease in women
    Ayako Suzuki
    Division of Gastroenterology and Hepatology, Duke University Medical Center, Durham, NC 27710, USA
    Womens Health (Lond Engl) 5:191-203. 2009
  6. pmc The use of liver biopsy evaluation in discrimination of idiopathic autoimmune hepatitis versus drug-induced liver injury
    Ayako Suzuki
    Division of Gastroenterology, Duke University Medical Center, Durham, NC 27710, USA
    Hepatology 54:931-9. 2011
  7. ncbi request reprint Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease
    Cynthia A Moylan
    Department of Medicine, Duke University, Durham, NC Department of Medicine, Durham Veterans Affairs Medical Center, Durham, NC
    Hepatology 59:471-82. 2014
  8. pmc Hedgehog pathway and pediatric nonalcoholic fatty liver disease
    Marzena Swiderska-Syn
    Division of Gastroenterology and Hepatology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Hepatology 57:1814-25. 2013
  9. pmc Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease
    Cynthia D Guy
    Department of Pathology, Duke University Medical Center, Durham, NC, USA
    Hepatology 55:1711-21. 2012
  10. doi request reprint Does pain predict interference with daily functioning and weight loss in an obese residential treatment-seeking population?
    Amy Wachholtz
    Duke Diet and Fitness Center, Duke University Health System, Durham, NC, USA
    Int J Behav Med 17:118-24. 2010

Detail Information

Publications26

  1. doi request reprint Drugs associated with hepatotoxicity and their reporting frequency of liver adverse events in VigiBase: unified list based on international collaborative work
    Ayako Suzuki
    Division of Gastroenterology, Duke University, Durham, North Carolina 27710, USA
    Drug Saf 33:503-22. 2010
    ..Challenges exist in the clinical diagnosis of drug-induced liver injury (DILI) and in obtaining information on hepatotoxicity in humans...
  2. doi request reprint Serum aminotransferase changes with significant weight loss: sex and age effects
    Ayako Suzuki
    Division of Gastroenterology, Department of Medicine, Duke University, Durham, NC 27710, USA
    Metabolism 59:177-85. 2010
    ..The patterns that we detected may have pathophysiologic significance beyond the practical implications of our findings in clinical practice related to underlying changes in fat metabolism...
  3. pmc Regional anthropometric measures and hepatic fibrosis in patients with nonalcoholic Fatty liver disease
    Ayako Suzuki
    Duke University, Durham, North Carolina, USA
    Clin Gastroenterol Hepatol 8:1062-9. 2010
    ..We investigated whether peripheral and/or abdominal adipose depot size correlates with stage of hepatic fibrosis in patients with NAFLD in sex- and/or menopausal stage-specific manners...
  4. doi request reprint Co-medications that modulate liver injury and repair influence clinical outcome of acetaminophen-associated liver injury
    Ayako Suzuki
    Gastroenterology, Duke University, Durham, North Carolina, USA
    Clin Gastroenterol Hepatol 7:882-8. 2009
    ..We investigated its association with administration of drugs that have been shown to modulate liver injury and/or repair in preclinical studies...
  5. doi request reprint Nonalcoholic fatty liver disease in women
    Ayako Suzuki
    Division of Gastroenterology and Hepatology, Duke University Medical Center, Durham, NC 27710, USA
    Womens Health (Lond Engl) 5:191-203. 2009
    ....
  6. pmc The use of liver biopsy evaluation in discrimination of idiopathic autoimmune hepatitis versus drug-induced liver injury
    Ayako Suzuki
    Division of Gastroenterology, Duke University Medical Center, Durham, NC 27710, USA
    Hepatology 54:931-9. 2011
    ..91 in predicting DILI (CS) versus AIH. Conclusion: Although an overlap of histologic findings exists for AIH and DILI, sufficient differences exist so that pathologists can use the pattern of injury to suggest the correct diagnosis...
  7. ncbi request reprint Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease
    Cynthia A Moylan
    Department of Medicine, Duke University, Durham, NC Department of Medicine, Durham Veterans Affairs Medical Center, Durham, NC
    Hepatology 59:471-82. 2014
    ..Ingenuity Pathway Analysis and IHC confirmed deregulation of metabolic and regenerative pathways in severe NAFLD and revealed overlap among the gene expression patterns of severe NAFLD, cardiovascular disease, and cancer...
  8. pmc Hedgehog pathway and pediatric nonalcoholic fatty liver disease
    Marzena Swiderska-Syn
    Division of Gastroenterology and Hepatology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Hepatology 57:1814-25. 2013
    ..Male gender and prepuberty were also associated with ductular proliferation (P < 0.05), increased numbers of portal Gli2(+) cells (P < 0.017) and portal fibrosis...
  9. pmc Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease
    Cynthia D Guy
    Department of Pathology, Duke University Medical Center, Durham, NC, USA
    Hepatology 55:1711-21. 2012
    ..005), body mass index (P < 0.002), waist circumference (P < 0.0007), homeostatic model assessment of insulin resistance (P < 0.0001), and hypertension (P < 0.02), correlated with hepatic HH activity...
  10. doi request reprint Does pain predict interference with daily functioning and weight loss in an obese residential treatment-seeking population?
    Amy Wachholtz
    Duke Diet and Fitness Center, Duke University Health System, Durham, NC, USA
    Int J Behav Med 17:118-24. 2010
    ..We examined the relationship between pain and (1) interference with daily functioning (DFi) and (2) outcomes in an obese treatment-seeking population...
  11. pmc Association between puberty and features of nonalcoholic fatty liver disease
    Ayako Suzuki
    Division of Gastroenterology, Duke University, Durham, NC 27710, USA
    Clin Gastroenterol Hepatol 10:786-94. 2012
    ..Physiological changes that occur during puberty might affect pathologic features of nonalcoholic fatty liver disease (NAFLD). We investigated associations between pubertal development and clinical and histopathologic features of NAFLD...
  12. doi request reprint Associations of depression, anxiety and antidepressants with histological severity of nonalcoholic fatty liver disease
    Nagy A Youssef
    Department of Psychiatry, Duke University, Durham, NC, USA
    Liver Int 33:1062-70. 2013
    ..Depression and anxiety are common in patients with nonalcoholic fatty liver disease (NAFLD). However, their associations with histological severity of NAFLD are unknown...
  13. pmc Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease
    Susan K Murphy
    Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina
    Gastroenterology 145:1076-87. 2013
    ..We investigated whether DNA methylation profiles can distinguish patients with mild disease from those with advanced NAFLD, and how these patterns are functionally related to hepatic gene expression...
  14. pmc Costaining for keratins 8/18 plus ubiquitin improves detection of hepatocyte injury in nonalcoholic fatty liver disease
    Cynthia D Guy
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Hum Pathol 43:790-800. 2012
    ..Keratin 8/18 plus ubiquitin double immunohistochemical stain improves detection of hepatocyte injury in nonalcoholic fatty liver disease. Thus, it may help differentiate nonalcoholic steatohepatitis from nonalcoholic fatty liver...
  15. ncbi request reprint Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation
    Alessia Omenetti
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Lab Invest 87:499-514. 2007
    ..Our findings reveal that adult livers resurrect developmental signaling systems, such as the Hh pathway, to guide remodeling of the biliary epithelia and stroma after cholestatic injury...
  16. pmc Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease
    Manal F Abdelmalek
    Division of Gastroenterology, Duke University, Durham, NC 27710, USA
    Hepatology 51:1961-71. 2010
    ..05 for each). In older adults (age > or = 48 years), daily fructose consumption was associated with increased hepatic inflammation (P < 0.05) and hepatocyte ballooning (P = 0.05)...
  17. ncbi request reprint Light to moderate alcohol consumption is associated with lower frequency of hypertransaminasemia
    Ayako Suzuki
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 102:1912-9. 2007
    ....
  18. pmc Increased production of sonic hedgehog by ballooned hepatocytes
    Fatima Rangwala
    Division of Cellular Therapy, Hematology and Oncology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Pathol 224:401-10. 2011
    ..These results help to explain why fibrosis stage correlates with hepatocyte ballooning in NASH...
  19. doi request reprint Sleep disturbance and pain in an obese residential treatment-seeking population
    Amy Wachholtz
    Duke Diet and Fitness Center, Duke University Health System, Duke University Medical Center, MA 01655, USA
    Clin J Pain 25:584-9. 2009
    ..The relationships between body mass index (BMI) and sleep disturbance, sleep disturbance and pain, and obesity and pain are documented; however, there is a paucity of research exploring how sleep relates to pain in obese populations...
  20. doi request reprint Surveillance for hepatocellular carcinoma in patients with primary biliary cirrhosis
    Marina G Silveira
    Miles and Shirley Fiterman Center for Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
    Hepatology 48:1149-56. 2008
    ..All cases of HCC except one were predicted to be at significant risk for HCC based on age, sex, evidence of portal hypertension, and history of blood transfusion using a previous predictive model...
  21. ncbi request reprint Clinical predictors for hepatocellular carcinoma in patients with primary biliary cirrhosis
    Ayako Suzuki
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Gastroenterol Hepatol 5:259-64. 2007
    ..Optimal selection of PBC patients for HCC screening needs to be determined for effective screening. In this study, we aimed to explore clinical predictors of HCC in PBC patients...
  22. pmc Prevalence and indicators of portal hypertension in patients with nonalcoholic fatty liver disease
    Flavia D Mendes
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Gastroenterol Hepatol 10:1028-33.e2. 2012
    ..Little is known about the prevalence and severity of portal hypertension in patients with nonalcoholic fatty liver disease (NAFLD). We investigated the prevalence and noninvasive predictors of portal hypertension in patients with NAFLD...
  23. ncbi request reprint Values and limitations of serum aminotransferases in clinical trials of nonalcoholic steatohepatitis
    Ayako Suzuki
    Gastroenterology, Duke University Medical Center, Durham, NC, USA
    Liver Int 26:1209-16. 2006
    ..In this study, we assessed diagnostic accuracy of serum aminotransferase changes in predicting histological changes in NASH trials...
  24. doi request reprint A pre-marketing ALT signal predicts post-marketing liver safety
    Cynthia A Moylan
    Division of Gastroenterology and Hepatology, Duke University, Durham, NC 27710, USA
    Regul Toxicol Pharmacol 63:433-9. 2012
    ..A cut-off of 1.2% increase in ALT ≥ 3× ULN in treated versus placebo groups provides an easily calculated method for predicting post-marketing liver safety...
  25. ncbi request reprint Interleukin-15 increases hepatic regenerative activity
    Ayako Suzuki
    Division of Gastroenterology and Department of Medicine, Duke University Medical Center, Durham, NC, USA
    J Hepatol 45:410-8. 2006
    ..It generally inhibits apoptosis and increases cellular proliferation and differentiation. However, IL-15's roles in liver are unknown. We aimed to determine if IL-15 influences hepatic integrity and regenerative activity...
  26. ncbi request reprint Should nonalcoholic fatty liver disease be treated differently in elderly patients?
    Ayako Suzuki
    Gastroenterology Division, Duke University, Durham, NC 27710, USA
    Nat Clin Pract Gastroenterol Hepatol 2:208-9. 2005