Patrick Sullivan

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model
    John D Fryer
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 25:2803-10. 2005
  2. ncbi request reprint Mortalin is regulated by APOE in hippocampus of AD patients and by human APOE in TR mice
    Cristina Osorio
    Neuroproteomics Laboratory, Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Neurobiol Aging 28:1853-62. 2007
  3. doi request reprint Human apolipoprotein E4 targeted replacement mice show increased prevalence of intracerebral hemorrhage associated with vascular amyloid deposition
    Patrick M Sullivan
    Department of Medicine Geriatrics, Duke University Medical Center, Durham, North Carolina, USA
    J Stroke Cerebrovasc Dis 17:303-11. 2008
  4. doi request reprint Reduced levels of human apoE4 protein in an animal model of cognitive impairment
    P M Sullivan
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Neurobiol Aging 32:791-801. 2011
  5. ncbi request reprint Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice
    P M Sullivan
    Bryan Alzheimer s Disease Research Center and Division of Neurology, Department of Medicine, Duke University Medical Center, Box 2900, Durham, NC 27710, USA
    Neuroscience 124:725-33. 2004
  6. pmc Targeting age-related macular degeneration with Alzheimer's disease based immunotherapies: anti-amyloid-beta antibody attenuates pathologies in an age-related macular degeneration mouse model
    Jin Dong Ding
    Department of Ophthalmology, Duke University Medical Center, Albert Eye Research Institute, Room 5010, Box 3802, Erwin Road, Durham, NC 27710, USA
    Vision Res 48:339-45. 2008
  7. pmc Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration
    Jin Dong Ding
    Department of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 108:E279-87. 2011
  8. doi request reprint ERG responses and microarray analysis of gene expression in a multifactorial murine model of age-related retinal degeneration
    Goldis Malek
    Department of Ophthalmology, Duke University, Durham NC, USA
    Adv Exp Med Biol 613:165-70. 2008
  9. ncbi request reprint Initial observations of key features of age-related macular degeneration in APOE targeted replacement mice
    Goldis Malek
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Adv Exp Med Biol 572:109-17. 2006
  10. ncbi request reprint Apolipoprotein E modifies the CNS response to injury via a histamine-mediated pathway
    Brian E Mace
    Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Neurol Res 29:243-50. 2007

Research Grants

  1. APOE4 and Loss of Synaptic Integrity
    Patrick Sullivan; Fiscal Year: 2009
  2. APOE4 and Loss of Synaptic Integrity
    Patrick Sullivan; Fiscal Year: 2007

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model
    John D Fryer
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 25:2803-10. 2005
    ....
  2. ncbi request reprint Mortalin is regulated by APOE in hippocampus of AD patients and by human APOE in TR mice
    Cristina Osorio
    Neuroproteomics Laboratory, Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Neurobiol Aging 28:1853-62. 2007
    ..We propose that the differential regulation of mortalin in AD and by the APOE genotype is a cellular defense mechanism responding to increases in oxidative stress...
  3. doi request reprint Human apolipoprotein E4 targeted replacement mice show increased prevalence of intracerebral hemorrhage associated with vascular amyloid deposition
    Patrick M Sullivan
    Department of Medicine Geriatrics, Duke University Medical Center, Durham, North Carolina, USA
    J Stroke Cerebrovasc Dis 17:303-11. 2008
    ....
  4. doi request reprint Reduced levels of human apoE4 protein in an animal model of cognitive impairment
    P M Sullivan
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Neurobiol Aging 32:791-801. 2011
    ..Our findings suggest that a fraction of APOE4-linked AD may be due to insufficient levels of functional apoE required to maintain neuronal health...
  5. ncbi request reprint Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice
    P M Sullivan
    Bryan Alzheimer s Disease Research Center and Division of Neurology, Department of Medicine, Duke University Medical Center, Box 2900, Durham, NC 27710, USA
    Neuroscience 124:725-33. 2004
    ..Finally, the differences in apoE levels we observed may explain the regional vulnerability of neuronal degeneration in Alzheimer's disease...
  6. pmc Targeting age-related macular degeneration with Alzheimer's disease based immunotherapies: anti-amyloid-beta antibody attenuates pathologies in an age-related macular degeneration mouse model
    Jin Dong Ding
    Department of Ophthalmology, Duke University Medical Center, Albert Eye Research Institute, Room 5010, Box 3802, Erwin Road, Durham, NC 27710, USA
    Vision Res 48:339-45. 2008
    ..These data support the hypothesis that Abeta is a therapeutic target for AMD...
  7. pmc Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration
    Jin Dong Ding
    Department of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 108:E279-87. 2011
    ..They also implicate Aβ in the pathogenesis of AMD and identify Aβ as a viable therapeutic target for its treatment...
  8. doi request reprint ERG responses and microarray analysis of gene expression in a multifactorial murine model of age-related retinal degeneration
    Goldis Malek
    Department of Ophthalmology, Duke University, Durham NC, USA
    Adv Exp Med Biol 613:165-70. 2008
  9. ncbi request reprint Initial observations of key features of age-related macular degeneration in APOE targeted replacement mice
    Goldis Malek
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Adv Exp Med Biol 572:109-17. 2006
  10. ncbi request reprint Apolipoprotein E modifies the CNS response to injury via a histamine-mediated pathway
    Brian E Mace
    Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Neurol Res 29:243-50. 2007
    ..These results suggest that apoE modifies secondary neuronal injury caused by histamine release and are consistent with previous observations that apoE affects the CNS inflammatory response in an isoform-specific manner...
  11. doi request reprint Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks
    Alexandra Bour
    Laboratoire de Neurosciences Comportementales et Cognitives, Universite Louis Pasteur, CNRS UMR 7191, IFR 37, GDR CNRS 2905, 12 rue Goethe, 67000 Strasbourg, France
    Behav Brain Res 193:174-82. 2008
    ..We conclude that the apoE4-TR mice provide an excellent model for understanding the mechanisms underlying apoE4-dependent susceptibility to cognitive decline...
  12. pmc Abeta42 neurotoxicity in primary co-cultures: effect of apoE isoform and Abeta conformation
    Arlene M Manelli
    Department of Medicine, Division of Geriatrics, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201, United States
    Neurobiol Aging 28:1139-47. 2007
    ..These in vitro data demonstrate a gain of negative function for apoE4, synergistic with oligomeric Abeta42, in mediating neurotoxicity...
  13. ncbi request reprint A deficit in astroglial organization causes the impaired reactive sprouting in human apolipoprotein E4 targeted replacement mice
    Jean Francois Blain
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada H4A 2B4
    Neurobiol Dis 21:505-14. 2006
    ..ApoE and beta-amyloid (Abeta) 1-40 accumulated at 30 DPL in hE4 mice. These results suggest that the presence of apoE4 delays the astroglial repair process and indirectly compromises synaptic remodeling...
  14. ncbi request reprint The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice
    John D Fryer
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 280:25754-9. 2005
    ....
  15. ncbi request reprint ApoB-48 and apoB-100 differentially influence the expression of type-III hyperlipoproteinemia in APOE*2 mice
    Myron E Hinsdale
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7525, USA
    J Lipid Res 43:1520-8. 2002
    ..Apobec(-/-) mice, because apoB-48 and apoB-100 differentially influence the catabolism of lipoproteins...
  16. ncbi request reprint ApoE isoform affects LTP in human targeted replacement mice
    Barbara L Trommer
    Department of Pediatrics, Alzheimer s Disease Core Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614, USA
    Neuroreport 15:2655-8. 2004
    ..This novel system may be used to investigate the mechanisms of apoE isoform dependent modulation of susceptibility to memory impairment...
  17. ncbi request reprint Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology
    Chunsheng Wang
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neurobiol Dis 18:390-8. 2005
    ..To our knowledge, this is the first study to suggest that cognitive deficits in APOE*4 carriers are due to inherent defects in synaptic function that appear prior to any age-dependent markers of neuropathology...
  18. ncbi request reprint Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior
    Jeannette Grootendorst
    Laboratoire de Neurosciences Comportementales et Cognitives, Universite Louis Pasteur, CNRS UMR 7521, IFR 37, 12 rue Goethe, 67000 Strasbourg, France
    Behav Brain Res 159:1-14. 2005
    ..Deficits occurred predominantly in female h-apoE4 mice, which support the hypothesis that humans carrying h-apoE4, especially women, have impaired spatial memory compared to those carrying h-apoE3...
  19. ncbi request reprint Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-beta
    Masayuki Morikawa
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63130, USA
    Neurobiol Dis 19:66-76. 2005
    ..These immortalized astrocytes will be useful for studying mechanisms underlying the isoform-specific effects of apoE in the CNS...
  20. ncbi request reprint Estradiol enhances long term potentiation in hippocampal slices from aged apoE4-TR mice
    Sung Hwan Yun
    Departments of Pediatrics and Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Hippocampus 17:1153-7. 2007
    ..Elucidating the mechanism of this selective enhancement may lead to more informed treatment decisions as well as to the development of safer alternatives to hormone therapy...
  21. ncbi request reprint High-fat/high-cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDL
    Mirta Mihovilovic
    Deane Laboratory, Duke University Medical Center, Durham, NC 27710, USA
    J Lipid Res 48:806-15. 2007
    ....
  22. ncbi request reprint APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response
    John R Lynch
    Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 278:48529-33. 2003
    ....
  23. ncbi request reprint ApoE genotype-specific inhibition of apoptosis
    Robert M Dekroon
    Division of Neurology, Duke University Medical Center, Durham, NC 27710, USA
    J Lipid Res 44:1566-73. 2003
    ..This ability of APOE4/4 VLDL to inhibit the antiapoptotic effects of HDL presents a potential mechanism by which the expression of several diseases, including atherosclerosis, is enhanced by the APOE4 genotype...
  24. ncbi request reprint Apolipoprotein E isoform mediated regulation of nitric oxide release
    Candice M Brown
    University Program in Genetics, Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 32:1071-5. 2002
    ..These data suggest a potentially novel mechanism for gender-dependent and apoE isoform-dependent immune responses that parallel the genetic susceptibility of APOE4 carriers for the development of Alzheimer's disease...

Research Grants4

  1. APOE4 and Loss of Synaptic Integrity
    Patrick Sullivan; Fiscal Year: 2009
    ..A unique animal model will be tested for its effectiveness in portraying APOE-dependent decline in synaptic integrity. Novel mechanisms to explain apoE's function in the brain will be elucidated. ..
  2. APOE4 and Loss of Synaptic Integrity
    Patrick Sullivan; Fiscal Year: 2007
    ..A unique animal model will be tested for its effectiveness in portraying APOE-dependent decline in synaptic integrity. Novel mechanisms to explain apoE's function in the brain will be elucidated. ..