Affiliation: Duke University Medical Center
- Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic modelJohn D Fryer
Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 25:2803-10. 2005....
- Mortalin is regulated by APOE in hippocampus of AD patients and by human APOE in TR miceCristina Osorio
Neuroproteomics Laboratory, Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
Neurobiol Aging 28:1853-62. 2007..We propose that the differential regulation of mortalin in AD and by the APOE genotype is a cellular defense mechanism responding to increases in oxidative stress...
- Human apolipoprotein E4 targeted replacement mice show increased prevalence of intracerebral hemorrhage associated with vascular amyloid depositionPatrick M Sullivan
Department of Medicine Geriatrics, Duke University Medical Center, Durham, North Carolina, USA
J Stroke Cerebrovasc Dis 17:303-11. 2008....
- Reduced levels of human apoE4 protein in an animal model of cognitive impairmentP M Sullivan
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Neurobiol Aging 32:791-801. 2011..Our findings suggest that a fraction of APOE4-linked AD may be due to insufficient levels of functional apoE required to maintain neuronal health...
- Marked regional differences of brain human apolipoprotein E expression in targeted replacement miceP M Sullivan
Bryan Alzheimer s Disease Research Center and Division of Neurology, Department of Medicine, Duke University Medical Center, Box 2900, Durham, NC 27710, USA
Neuroscience 124:725-33. 2004..Finally, the differences in apoE levels we observed may explain the regional vulnerability of neuronal degeneration in Alzheimer's disease...
- Targeting age-related macular degeneration with Alzheimer's disease based immunotherapies: anti-amyloid-beta antibody attenuates pathologies in an age-related macular degeneration mouse modelJin Dong Ding
Department of Ophthalmology, Duke University Medical Center, Albert Eye Research Institute, Room 5010, Box 3802, Erwin Road, Durham, NC 27710, USA
Vision Res 48:339-45. 2008..These data support the hypothesis that Abeta is a therapeutic target for AMD...
- Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degenerationJin Dong Ding
Department of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 108:E279-87. 2011..They also implicate Aβ in the pathogenesis of AMD and identify Aβ as a viable therapeutic target for its treatment...
- ERG responses and microarray analysis of gene expression in a multifactorial murine model of age-related retinal degenerationGoldis Malek
Department of Ophthalmology, Duke University, Durham NC, USA
Adv Exp Med Biol 613:165-70. 2008
- Initial observations of key features of age-related macular degeneration in APOE targeted replacement miceGoldis Malek
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
Adv Exp Med Biol 572:109-17. 2006
- Apolipoprotein E modifies the CNS response to injury via a histamine-mediated pathwayBrian E Mace
Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
Neurol Res 29:243-50. 2007..These results suggest that apoE modifies secondary neuronal injury caused by histamine release and are consistent with previous observations that apoE affects the CNS inflammatory response in an isoform-specific manner...
- Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasksAlexandra Bour
Laboratoire de Neurosciences Comportementales et Cognitives, Universite Louis Pasteur, CNRS UMR 7191, IFR 37, GDR CNRS 2905, 12 rue Goethe, 67000 Strasbourg, France
Behav Brain Res 193:174-82. 2008..We conclude that the apoE4-TR mice provide an excellent model for understanding the mechanisms underlying apoE4-dependent susceptibility to cognitive decline...
- Abeta42 neurotoxicity in primary co-cultures: effect of apoE isoform and Abeta conformationArlene M Manelli
Department of Medicine, Division of Geriatrics, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201, United States
Neurobiol Aging 28:1139-47. 2007..These in vitro data demonstrate a gain of negative function for apoE4, synergistic with oligomeric Abeta42, in mediating neurotoxicity...
- A deficit in astroglial organization causes the impaired reactive sprouting in human apolipoprotein E4 targeted replacement miceJean Francois Blain
Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada H4A 2B4
Neurobiol Dis 21:505-14. 2006..ApoE and beta-amyloid (Abeta) 1-40 accumulated at 30 DPL in hE4 mice. These results suggest that the presence of apoE4 delays the astroglial repair process and indirectly compromises synaptic remodeling...
- The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP miceJohn D Fryer
Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 280:25754-9. 2005....
- ApoB-48 and apoB-100 differentially influence the expression of type-III hyperlipoproteinemia in APOE*2 miceMyron E Hinsdale
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7525, USA
J Lipid Res 43:1520-8. 2002..Apobec(-/-) mice, because apoB-48 and apoB-100 differentially influence the catabolism of lipoproteins...
- ApoE isoform affects LTP in human targeted replacement miceBarbara L Trommer
Department of Pediatrics, Alzheimer s Disease Core Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614, USA
Neuroreport 15:2655-8. 2004..This novel system may be used to investigate the mechanisms of apoE isoform dependent modulation of susceptibility to memory impairment...
- Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathologyChunsheng Wang
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
Neurobiol Dis 18:390-8. 2005..To our knowledge, this is the first study to suggest that cognitive deficits in APOE*4 carriers are due to inherent defects in synaptic function that appear prior to any age-dependent markers of neuropathology...
- Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behaviorJeannette Grootendorst
Laboratoire de Neurosciences Comportementales et Cognitives, Universite Louis Pasteur, CNRS UMR 7521, IFR 37, 12 rue Goethe, 67000 Strasbourg, France
Behav Brain Res 159:1-14. 2005..Deficits occurred predominantly in female h-apoE4 mice, which support the hypothesis that humans carrying h-apoE4, especially women, have impaired spatial memory compared to those carrying h-apoE3...
- Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-betaMasayuki Morikawa
Department of Neurology, Washington University School of Medicine, St Louis, MO 63130, USA
Neurobiol Dis 19:66-76. 2005..These immortalized astrocytes will be useful for studying mechanisms underlying the isoform-specific effects of apoE in the CNS...
- Estradiol enhances long term potentiation in hippocampal slices from aged apoE4-TR miceSung Hwan Yun
Departments of Pediatrics and Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Hippocampus 17:1153-7. 2007..Elucidating the mechanism of this selective enhancement may lead to more informed treatment decisions as well as to the development of safer alternatives to hormone therapy...
- High-fat/high-cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDLMirta Mihovilovic
Deane Laboratory, Duke University Medical Center, Durham, NC 27710, USA
J Lipid Res 48:806-15. 2007....
- APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory responseJohn R Lynch
Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 278:48529-33. 2003....
- ApoE genotype-specific inhibition of apoptosisRobert M Dekroon
Division of Neurology, Duke University Medical Center, Durham, NC 27710, USA
J Lipid Res 44:1566-73. 2003..This ability of APOE4/4 VLDL to inhibit the antiapoptotic effects of HDL presents a potential mechanism by which the expression of several diseases, including atherosclerosis, is enhanced by the APOE4 genotype...
- Apolipoprotein E isoform mediated regulation of nitric oxide releaseCandice M Brown
University Program in Genetics, Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
Free Radic Biol Med 32:1071-5. 2002..These data suggest a potentially novel mechanism for gender-dependent and apoE isoform-dependent immune responses that parallel the genetic susceptibility of APOE4 carriers for the development of Alzheimer's disease...
- APOE4 and Loss of Synaptic IntegrityPatrick Sullivan; Fiscal Year: 2009..A unique animal model will be tested for its effectiveness in portraying APOE-dependent decline in synaptic integrity. Novel mechanisms to explain apoE's function in the brain will be elucidated. ..
- APOE4 and Loss of Synaptic IntegrityPatrick Sullivan; Fiscal Year: 2007..A unique animal model will be tested for its effectiveness in portraying APOE-dependent decline in synaptic integrity. Novel mechanisms to explain apoE's function in the brain will be elucidated. ..