Martin E Stryjewski

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc TD-1792 versus vancomycin for treatment of complicated skin and skin structure infections
    Martin E Stryjewski
    Department of Medicine and Division of Infectious Diseases, Centro de Educación Médica e Investigaciones Clínicas CEMIC, Buenos Aires, Argentina
    Antimicrob Agents Chemother 56:5476-83. 2012
  2. doi request reprint Efficacy of telavancin in patients with specific types of complicated skin and skin structure infections
    Martin E Stryjewski
    Department of Medicine and Division of Infectious Diseases, Centro de Educación Médica e Investigaciones Clínicas, Buenos Aires, Argentina
    J Antimicrob Chemother 67:1496-502. 2012
  3. pmc Sepsis, multiple organ failure, and death due to Pandoraea pnomenusa infection after lung transplantation
    Martin E Stryjewski
    Division of Infectious Diseases and International Health, Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA
    J Clin Microbiol 41:2255-7. 2003
  4. ncbi request reprint Expression of antimicrobial peptides in the normal and involved skin of patients with infective cellulitis
    Martin E Stryjewski
    Duke Clinical Research Institute, Durham, NC, USA
    J Infect Dis 196:1425-30. 2007
  5. ncbi request reprint Use of vancomycin or first-generation cephalosporins for the treatment of hemodialysis-dependent patients with methicillin-susceptible Staphylococcus aureus bacteremia
    Martin E Stryjewski
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Clin Infect Dis 44:190-6. 2007
  6. pmc Telavancin versus standard therapy for treatment of complicated skin and skin structure infections caused by gram-positive bacteria: FAST 2 study
    Martin E Stryjewski
    Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA
    Antimicrob Agents Chemother 50:862-7. 2006
  7. doi request reprint Skin and soft-tissue infections caused by community-acquired methicillin-resistant Staphylococcus aureus
    Martin E Stryjewski
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Clin Infect Dis 46:S368-77. 2008
  8. doi request reprint Telavancin versus vancomycin for the treatment of complicated skin and skin-structure infections caused by gram-positive organisms
    Martin E Stryjewski
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Clin Infect Dis 46:1683-93. 2008
  9. doi request reprint Staphylococcus aureus bacteremia among patients with health care-associated fever
    Martin E Stryjewski
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Am J Med 122:281-289.e2. 2009
  10. doi request reprint New treatments for methicillin-resistant Staphylococcus aureus
    Martin E Stryjewski
    Division of Infectious Diseases, Duke Clinical Research Institute, Durham, North Carolina, USA
    Curr Opin Crit Care 15:403-12. 2009

Detail Information

Publications37

  1. pmc TD-1792 versus vancomycin for treatment of complicated skin and skin structure infections
    Martin E Stryjewski
    Department of Medicine and Division of Infectious Diseases, Centro de Educación Médica e Investigaciones Clínicas CEMIC, Buenos Aires, Argentina
    Antimicrob Agents Chemother 56:5476-83. 2012
    ..No patients in the TD-1792 group experienced a serious AE. This study supports further clinical development of TD-1792 in patients with Gram-positive infection...
  2. doi request reprint Efficacy of telavancin in patients with specific types of complicated skin and skin structure infections
    Martin E Stryjewski
    Department of Medicine and Division of Infectious Diseases, Centro de Educación Médica e Investigaciones Clínicas, Buenos Aires, Argentina
    J Antimicrob Chemother 67:1496-502. 2012
    ....
  3. pmc Sepsis, multiple organ failure, and death due to Pandoraea pnomenusa infection after lung transplantation
    Martin E Stryjewski
    Division of Infectious Diseases and International Health, Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA
    J Clin Microbiol 41:2255-7. 2003
    ..Heretofore considered soil bacteria and colonizers that infect patients with chronic lung diseases, Pandoraea species can produce severe infections...
  4. ncbi request reprint Expression of antimicrobial peptides in the normal and involved skin of patients with infective cellulitis
    Martin E Stryjewski
    Duke Clinical Research Institute, Durham, NC, USA
    J Infect Dis 196:1425-30. 2007
    ..Endogenous antimicrobial peptides participate in the innate defense of skin against a variety of pathogens. The systemic expression of these peptides in normal-appearing skin of patients with infective cellulitis is unknown...
  5. ncbi request reprint Use of vancomycin or first-generation cephalosporins for the treatment of hemodialysis-dependent patients with methicillin-susceptible Staphylococcus aureus bacteremia
    Martin E Stryjewski
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Clin Infect Dis 44:190-6. 2007
    ..Clinical outcomes resulting from such a therapeutic strategy have not been well defined...
  6. pmc Telavancin versus standard therapy for treatment of complicated skin and skin structure infections caused by gram-positive bacteria: FAST 2 study
    Martin E Stryjewski
    Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA
    Antimicrob Agents Chemother 50:862-7. 2006
    ..These data support the ongoing studies assessing the efficacy and safety of telavancin in the treatment of serious gram-positive infections, particularly involving MRSA...
  7. doi request reprint Skin and soft-tissue infections caused by community-acquired methicillin-resistant Staphylococcus aureus
    Martin E Stryjewski
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Clin Infect Dis 46:S368-77. 2008
    ..Dalbavancin, telavancin, and ceftobiprole are investigational agents that may expand our therapeutic options for the treatment of SSTI caused by MRSA...
  8. doi request reprint Telavancin versus vancomycin for the treatment of complicated skin and skin-structure infections caused by gram-positive organisms
    Martin E Stryjewski
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Clin Infect Dis 46:1683-93. 2008
    ..Telavancin is an investigational, rapidly bactericidal lipoglycopeptide with a multifunctional mechanism of action...
  9. doi request reprint Staphylococcus aureus bacteremia among patients with health care-associated fever
    Martin E Stryjewski
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Am J Med 122:281-289.e2. 2009
    ..aureus bacteremia...
  10. doi request reprint New treatments for methicillin-resistant Staphylococcus aureus
    Martin E Stryjewski
    Division of Infectious Diseases, Duke Clinical Research Institute, Durham, North Carolina, USA
    Curr Opin Crit Care 15:403-12. 2009
    ..The purpose of this manuscript is to provide clinicians with an evidence-based review on new treatments for MRSA...
  11. doi request reprint Gram-negative bloodstream infections
    Martin E Stryjewski
    Division of Infectious Diseases, Department of Medicine, Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno, Buenos Aires, Argentina
    Int J Antimicrob Agents 34:S21-5. 2009
    ..We need therefore to better utilize current antibiotics and undertake rigorous infection control measures to prevent these life-threatening infections...
  12. pmc Presence of genes encoding the panton-valentine leukocidin exotoxin is not the primary determinant of outcome in patients with complicated skin and skin structure infections due to methicillin-resistant Staphylococcus aureus: results of a multinational tr
    In Gyu Bae
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Microbiol 47:3952-7. 2009
    ..05). This contemporary, international study demonstrates that pvl was not the primary determinant of outcome in patients with MRSA cSSSI...
  13. pmc Outcomes of Staphylococcus aureus infection in hemodialysis-dependent patients
    Yanhong Li
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA
    Clin J Am Soc Nephrol 4:428-34. 2009
    ..Staphylococcus aureus is a leading cause of infection in patients with ESRD. Clinical and economic outcomes associated with S. aureus bacteremia and other S. aureus infections in patients with ESRD were examined...
  14. ncbi request reprint Telavancin versus standard therapy for treatment of complicated skin and soft-tissue infections due to gram-positive bacteria
    Martin E Stryjewski
    Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA
    Clin Infect Dis 40:1601-7. 2005
    ..Telavancin is highly active against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-intermediate, and vancomycin-resistant strains...
  15. pmc Associations between the genotypes of Staphylococcus aureus bloodstream isolates and clinical characteristics and outcomes of bacteremic patients
    Tahaniyat Lalani
    Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Microbiol 46:2890-6. 2008
    ..In this study of bloodstream isolates collected as part of a multinational randomized clinical trial, USA 300 and pvl-constitutive MRSA strains were associated with better clinical outcomes...
  16. pmc Genotypic characteristics of Staphylococcus aureus isolates from a multinational trial of complicated skin and skin structure infections
    Steven J Campbell
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Microbiol 46:678-84. 2008
    ..01). S. aureus strains from different geographic regions have different distributions of virulence genes...
  17. pmc Determination of an inoculum effect with various cephalosporins among clinical isolates of methicillin-susceptible Staphylococcus aureus
    Esteban C Nannini
    Division of Infectious Diseases, Facultad de Ciencias Medicas, Universidad Nacional de Rosario, Rosario, Provincia de Santa Fe, Argentina
    Antimicrob Agents Chemother 54:2206-8. 2010
    ..Since a potential therapeutic effect associated with a cephalosporin inoculum effect has been described, further studies are warranted...
  18. doi request reprint Emergence of coagulase-negative staphylococci as a cause of native valve endocarditis
    Vivian H Chu
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Infect Dis 46:232-42. 2008
    ..Coagulase-negative staphylococci (CoNS) are an infrequent cause of native valve endocarditis (NVE), and our understanding of NVE caused by CoNS is incomplete...
  19. ncbi request reprint Staphylococcus aureus bacteremia in patients with prosthetic devices: costs and outcomes
    Vivian H Chu
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Med 118:1416. 2005
    ..aureus bacteremia on patients with prosthetic devices. This investigation sought to define the clinical outcome, health care resource use, and infection-associated costs of S. aureus bacteremia in patients with prostheses...
  20. ncbi request reprint Risk of endocarditis among patients with prosthetic valves and Staphylococcus aureus bacteremia
    Fadi El-Ahdab
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Med 118:225-9. 2005
    ..However, the risk of endocarditis in patients with a prosthetic valve who develop S. aureus bacteremia is unclear. The aim of this study was to define the risk of prosthetic valve endocarditis in patients with S. aureus bacteremia...
  21. pmc Inoculum effect with cefazolin among clinical isolates of methicillin-susceptible Staphylococcus aureus: frequency and possible cause of cefazolin treatment failure
    Esteban C Nannini
    Division of Infectious Diseases, School of Medicine, Universidad Nacional de Rosario, Rosario, Argentina
    Antimicrob Agents Chemother 53:3437-41. 2009
    ....
  22. ncbi request reprint Persistent bacteremia due to methicillin-resistant Staphylococcus aureus infection is associated with agr dysfunction and low-level in vitro resistance to thrombin-induced platelet microbicidal protein
    Vance G Fowler
    Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    J Infect Dis 190:1140-9. 2004
    ..This investigation examined potential associations between PB with key clinical features and several in vitro bacterial genotypic and phenotypic characteristics, in isolates from 1 institution...
  23. ncbi request reprint Clinical outcomes and costs due to Staphylococcus aureus bacteremia among patients receiving long-term hemodialysis
    John J Engemann
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Infect Control Hosp Epidemiol 26:534-9. 2005
    ..To examine the clinical outcomes and costs associated with Staphylococcus aureus bacteremia among hemodialysis-dependent patients...
  24. pmc A randomized Phase 2 trial of telavancin versus standard therapy in patients with uncomplicated Staphylococcus aureus bacteremia: the ASSURE study
    Martin E Stryjewski
    Department of Medicine, Division of Infectious Diseases, Centro de Educación Médica e Investigaciones Clinicas CEMIC Norberto Quirno, Av, Las Heras 2981, Office 3, Capital Federal C1425ASG, Buenos Aires, Argentina
    BMC Infect Dis 14:289. 2014
    ..aureus (MRSA). We conducted a randomized, double-blind, Phase 2 trial in patients with uncomplicated S. aureus bacteremia...
  25. ncbi request reprint Native valve endocarditis due to coagulase-negative staphylococci: report of 99 episodes from the International Collaboration on Endocarditis Merged Database
    Vivian H Chu
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Clin Infect Dis 39:1527-30. 2004
    ..These results emphasize the importance of CoNS as a cause of NVE and the potential for serious complications with this infection...
  26. ncbi request reprint A new lipoglycopeptide: telavancin
    Esteban C Nannini
    Sanatorio Parque, Division of Infectious Diseases, Argentina
    Expert Opin Pharmacother 9:2197-207. 2008
    ..Telavancin has the potential to become an important therapeutic option to treat serious infections produced by resistant Gram-positive cocci, particularly those caused by methicillin-resistant S. aureus...
  27. pmc Telavancin for hospital-acquired pneumonia: clinical response and 28-day survival
    G Ralph Corey
    Department of Medicine, Duke Clinical Research Institute, Durham, North Carolina, USA
    Antimicrob Agents Chemother 58:2030-7. 2014
    ..Telavancin should be administered to patients with moderate-to-severe renal impairment only if treatment benefit outweighs the risk or if no suitable alternatives are available. ..
  28. ncbi request reprint Increasing rates of cardiac device infections among Medicare beneficiaries: 1990-1999
    Christopher H Cabell
    Divisions of Division of Cardiology, Duke University Medical Center, and Duke Clinical Research Institute, Durham, NC 27715, USA
    Am Heart J 147:582-6. 2004
    ....
  29. doi request reprint Healthcare personnel infected with novel influenza A H1N1 virus in university hospitals in Buenos Aires, Argentina
    Marcia Querci
    Division of Infectious Diseases, Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno CEMIC, Buenos Aires, Argentina
    Scand J Infect Dis 43:70-4. 2011
    ..A high proportion of HCP with an ILI were infected with H1N1. Complication rates were relatively low. Prior prophylaxis with oseltamivir was associated with a lower risk of developing H1N1...
  30. ncbi request reprint Telavancin's interactions with the bacterial cell membrane
    Esteban C Nannini
    Division of Infectious Diseases, School of Medicine, Universidad Nacional de Rosario, Rosario, Argentina
    Future Microbiol 5:355-8. 2010
    ..This study takes a significant step forward in our understanding of the concentration-dependent bactericidal activity of telavancin, a drug recently approved for use in skin and skin structure infections caused by Gram-positive cocci...
  31. doi request reprint Short-course therapy for bloodstream infections in immunocompetent adults
    G Ralph Corey
    Division of Infectious Diseases, Duke Clinical Research Institute, 2400 Pratt Street, Durham, NC 27705, USA
    Int J Antimicrob Agents 34:S47-51. 2009
    ..7 days. Patients with bloodstream infections treated with short-course therapy must be followed carefully for occult complications, and should ideally be under the care of an infectious diseases physician...
  32. doi request reprint Nephrotoxicity associated with the use of intravenous colistin
    Cecilia Santamaría
    Centro de Educación Médica e Investigaciones Clínicas CEMIC, Division of Infectious Diseases, Buenos Aires, Argentina
    Scand J Infect Dis 41:767-9. 2009
    ..At the end of therapy 6/54 patients (11%) suffered renal impairment. Renal impairment associated with the use of colistin is less frequent than initially reported...
  33. doi request reprint Methicillin-resistant Staphylococcus aureus: an evolving pathogen
    Martin E Stryjewski
    Department of Medicine and Division of Infectious Diseases, Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno CEMIC, Buenos Aires, Argentina
    Clin Infect Dis 58:S10-9. 2014
    ..These resistance trends for newer therapies highlight the ongoing need for new and more potent antimicrobial therapies. ..
  34. doi request reprint New rules for clinical trials of patients with acute bacterial skin and skin-structure infections: do not let the perfect be the enemy of the good
    G Ralph Corey
    Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA
    Clin Infect Dis 52:S469-76. 2011
    ..Thus, we hope that as the FDA and FNIH move forward they will strike a balance between "The Perfect" statistical solution and "The Good" practical clinical realities...
  35. ncbi request reprint Costs and outcomes among hemodialysis-dependent patients with methicillin-resistant or methicillin-susceptible Staphylococcus aureus bacteremia
    Shelby D Reed
    Center for Clinical and Genetic Economics, USA
    Infect Control Hosp Epidemiol 26:175-83. 2005
    ..We compared costs and outcomes of methicillin resistance in patients with S. aureus bacteremia and a single chronic condition...
  36. ncbi request reprint Selective decontamination of digestive tract in intensive care
    Martin E Stryjewski
    Lancet 362:2118; author reply 2119-20. 2003
  37. ncbi request reprint Osteoblasts produce monocyte chemoattractant protein-1 in a murine model of Staphylococcus aureus osteomyelitis and infected human bone tissue
    Ian Marriott
    Department of Biology, University of North Carolina at Charlotte, 9201 University City Boulevard, Charlotte, NC 28223, USA
    Bone 37:504-12. 2005
    ....