W J Strittmatter

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Bathing the brain
    Warren J Strittmatter
    Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 123:1013-5. 2013
  2. ncbi request reprint Molecular biology of apolipoprotein E
    Warren J Strittmatter
    Deane Laboratory, Division of Neurology, Duke Medical Center, Durham, North Carolina 27710, USA
    Curr Opin Lipidol 13:119-23. 2002
  3. ncbi request reprint Apolipoprotein E and Alzheimer's disease
    W J Strittmatter
    Division of Neurology, Duke University Medical Center 2900, Durham, North Carolina 27710, USA
    Ann N Y Acad Sci 924:91-2. 2000
  4. ncbi request reprint Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism
    A D Roses
    Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann N Y Acad Sci 777:146-57. 1996
  5. pmc Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease
    W J Strittmatter
    Department of Medicine Neurology, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710
    Proc Natl Acad Sci U S A 91:11183-6. 1994
  6. ncbi request reprint Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    E H Corder
    Department of Medicine, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710
    Science 261:921-3. 1993
  7. ncbi request reprint Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study
    S H Han
    Department of Medicine Neurology, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710
    J Neuropathol Exp Neurol 53:535-44. 1994
  8. ncbi request reprint Impairment of the blood-nerve and blood-brain barriers in apolipoprotein e knockout mice
    S M Fullerton
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, 27710, USA
    Exp Neurol 169:13-22. 2001
  9. ncbi request reprint The role of apolipoprotein E in Alzheimer's disease: pharmacogenomic target selection
    A M Saunders
    Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Biochim Biophys Acta 1502:85-94. 2000
  10. ncbi request reprint Apolipoprotein E binds to and potentiates the biological activity of ciliary neurotrophic factor
    C R Gutman
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 17:6114-21. 1997

Detail Information

Publications22

  1. pmc Bathing the brain
    Warren J Strittmatter
    Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 123:1013-5. 2013
    ....
  2. ncbi request reprint Molecular biology of apolipoprotein E
    Warren J Strittmatter
    Deane Laboratory, Division of Neurology, Duke Medical Center, Durham, North Carolina 27710, USA
    Curr Opin Lipidol 13:119-23. 2002
    ....
  3. ncbi request reprint Apolipoprotein E and Alzheimer's disease
    W J Strittmatter
    Division of Neurology, Duke University Medical Center 2900, Durham, North Carolina 27710, USA
    Ann N Y Acad Sci 924:91-2. 2000
    ..Isoform-specific interactions of apolipoprotein E with other molecules determine the outcome from other neurologic disorders and may provide more tractable model systems...
  4. ncbi request reprint Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism
    A D Roses
    Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann N Y Acad Sci 777:146-57. 1996
    ..These data are supported by recent data from APOE knock-out mice demonstrating dendritic alterations leading to synaptic simplification similar to that observed in AD...
  5. pmc Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease
    W J Strittmatter
    Department of Medicine Neurology, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710
    Proc Natl Acad Sci U S A 91:11183-6. 1994
    ..Isoform-specific interactions of apoE with tau may regulate intraneuronal tau metabolism in Alzheimer disease and alter the rate of formation of paired helical filaments and neurofibrillary tangles...
  6. ncbi request reprint Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    E H Corder
    Department of Medicine, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710
    Science 261:921-3. 1993
    ..Thus APOE-epsilon 4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-epsilon 4 was virtually sufficient to cause AD by age 80...
  7. ncbi request reprint Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study
    S H Han
    Department of Medicine Neurology, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710
    J Neuropathol Exp Neurol 53:535-44. 1994
    ..Isoform-specific interactions with microtubule-associated proteins, such as tau or MAP2C, could influence the rate of pathology in neurodegenerative diseases such as Alzheimer's disease...
  8. ncbi request reprint Impairment of the blood-nerve and blood-brain barriers in apolipoprotein e knockout mice
    S M Fullerton
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, 27710, USA
    Exp Neurol 169:13-22. 2001
    ..These observations support a role for apoE in maintaining the integrity of the BNB/BBB and suggest a novel relationship between apoE and neural injury...
  9. ncbi request reprint The role of apolipoprotein E in Alzheimer's disease: pharmacogenomic target selection
    A M Saunders
    Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Biochim Biophys Acta 1502:85-94. 2000
    ..This review summarizes part of an experimental approach to identify biological pathways influenced by the different APOE polymorphisms that are relevant to the pathogenesis of AD...
  10. ncbi request reprint Apolipoprotein E binds to and potentiates the biological activity of ciliary neurotrophic factor
    C R Gutman
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 17:6114-21. 1997
    ....
  11. pmc Apolipoprotein E and Alzheimer disease
    W J Strittmatter
    Department of Medicine Neurology, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 92:4725-7. 1995
    ....
  12. ncbi request reprint Human apolipoprotein E accelerates microtubule polymerization in vitro
    B L Scott
    Department of Medicine Neurology, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 245:105-8. 1998
    ....
  13. ncbi request reprint Amino acid sequence requirements of peptides that inhibit polyglutamine-protein aggregation and cell death
    H Ren
    Deane Laboratory, Duke University Medical Center, Durham, North Carolina 27710, USA
    Biochem Biophys Res Commun 288:703-10. 2001
    ..Polyglutamine binding peptides targeted for intracellular delivery by fusion to TAT retain the ability to inhibit polyglutamine aggregation and cell death in transfected COS 7 cells...
  14. ncbi request reprint Disrupted spermine homeostasis: a novel mechanism in polyglutamine-mediated aggregation and cell death
    C A Colton
    Deane Laboratory, Division of Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 24:7118-27. 2004
    ..Inhibition of ODC by difluoromethylornithine prevented basal and induced cell death in Q57 cells, demonstrating a central role for polyamines in this process...
  15. ncbi request reprint Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH
    J R Burke
    Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Med 2:347-50. 1996
    ..We sought to identify proteins in the brain that selectively interact with polyglutamine-domain proteins, hypothesizing that the polyglutamine domain may determine protein-protein interactions...
  16. ncbi request reprint Peripheral sensory nerve defects in apolipoprotein E knockout mice
    S M Fullerton
    Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Exp Neurol 153:156-63. 1998
    ..Consistent with these morphological findings, apoE KO mice display reduced sensitivity to noxious thermal stimuli. These data provide in vivo support for the hypothesis that apoE promotes neuronal health and survival...
  17. doi request reprint Apolipoprotein E genotype as a determinant of survival in chronic lymphocytic leukemia
    J B Weinberg
    Department of Medicine, Duke University and VA Medical Centers, Durham, NC 27705, USA
    Leukemia 22:2184-92. 2008
    ....
  18. ncbi request reprint Apolipoprotein E and neuromuscular disease: a critical review of the literature
    R S Bedlack
    PO Box 3403, Duke University Medical Center, Durham, NC 27710, USA
    Arch Neurol 57:1561-5. 2000
    ..The effect of various APOE alleles on neuromuscular diseases therefore parallels their influence on central nervous system diseases. Arch Neurol. 2000;57:1561-1565..
  19. ncbi request reprint Effect of tissue transglutaminase on the solubility of proteins containing expanded polyglutamine repeats
    T S Lai
    Department of Medicine Hematology Neurology Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurochem 88:1253-60. 2004
    ..Furthermore, the effectiveness of a primary amine substrate at inhibiting formation of insoluble inclusions may be related to their ability to inhibit intermolecular cross-linking by TTG...
  20. ncbi request reprint ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation
    D Y Huang
    Department of Medicine Neurology, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 192:209-12. 1995
    ..Understanding the molecular mechanisms of the high avidity, isoform-specific interactions of ApoE with tau may help in developing approaches for disease intervention...
  21. ncbi request reprint Interaction of apolipoprotein E with laminin increases neuronal adhesion and alters neurite morphology
    D Y Huang
    Department of Neurobiology, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Exp Neurol 136:251-7. 1995
    ..ApoE may be important in the development and maintenance of neurons in the central nervous system by regulating interactions between the neuron and the extracellular matrix...
  22. ncbi request reprint Differential binding of apolipoprotein E isoforms to tau and other cytoskeletal proteins
    L M Fleming
    Department of Psychiatry, University of Alabama, Birmingham, 35294 0017, USA
    Exp Neurol 138:252-60. 1996
    ..The more avid interaction results in the formation of complexes which are SDS stable and occurs almost exclusively with apoE3, while the other interactions between apoE and cytoskeletal proteins are specific for apoE3...