David Steffens

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Impact of symptoms of generalized anxiety disorder on the course of late-life depression
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Division of Geriatric Psychiatry, Duke University Medical Center, Box 3903, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 13:40-7. 2005
  2. pmc Efficacy and safety of adjunctive aripiprazole in major depressive disorder in older patients: a pooled subpopulation analysis
    David C Steffens
    Duke University Medical Center, Durham, NC, USA
    Int J Geriatr Psychiatry 26:564-72. 2011
  3. ncbi request reprint Cholesterol-lowering medication and relapse of depression
    David C Steffens
    Division of Geriatric Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Psychopharmacol Bull 37:92-8. 2003
  4. ncbi request reprint Methodology and preliminary results from the neurocognitive outcomes of depression in the elderly study
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Geriatr Psychiatry Neurol 17:202-11. 2004
  5. ncbi request reprint Establishing diagnostic criteria for vascular depression
    David C Steffens
    Duke University Medical Center, Box 3903, Durham, North Carolina 27710, USA
    J Neurol Sci 226:59-62. 2004
  6. ncbi request reprint Biological and social predictors of long-term geriatric depression outcome
    David C Steffens
    Department of Psychiatry, Duke University Medical Center, Box 3903, Durham, NC 27710, USA
    Int Psychogeriatr 17:41-56. 2005
  7. pmc A multiplicity of approaches to characterize geriatric depression and its outcomes
    David C Steffens
    Division of Geriatric Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Curr Opin Psychiatry 22:522-6. 2009
  8. ncbi request reprint Cognitive impairment and depression outcomes in the IMPACT study
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 14:401-9. 2006
  9. ncbi request reprint Geriatric depression and cognitive impairment
    D C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychol Med 38:163-75. 2008
  10. ncbi request reprint Longitudinal magnetic resonance imaging vascular changes, apolipoprotein E genotype, and development of dementia in the neurocognitive outcomes of depression in the elderly study
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 15:839-49. 2007

Detail Information

Publications80

  1. ncbi request reprint Impact of symptoms of generalized anxiety disorder on the course of late-life depression
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Division of Geriatric Psychiatry, Duke University Medical Center, Box 3903, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 13:40-7. 2005
    ..The authors sought to examine the effect of symptoms of generalized anxiety disorder (GAD) on acute course of depression in a group of older depressed patients...
  2. pmc Efficacy and safety of adjunctive aripiprazole in major depressive disorder in older patients: a pooled subpopulation analysis
    David C Steffens
    Duke University Medical Center, Durham, NC, USA
    Int J Geriatr Psychiatry 26:564-72. 2011
    ....
  3. ncbi request reprint Cholesterol-lowering medication and relapse of depression
    David C Steffens
    Division of Geriatric Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Psychopharmacol Bull 37:92-8. 2003
    ..Future studies of depression outcomes in the elderly will need to include serial examination of cholesterol levels...
  4. ncbi request reprint Methodology and preliminary results from the neurocognitive outcomes of depression in the elderly study
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Geriatr Psychiatry Neurol 17:202-11. 2004
    ..These results are consistent with prior evidence linking depression and later dementia. Future studies are needed to examine neuroimaging and genetic, clinical, and social predictors of neurocognitive decline in depression...
  5. ncbi request reprint Establishing diagnostic criteria for vascular depression
    David C Steffens
    Duke University Medical Center, Box 3903, Durham, North Carolina 27710, USA
    J Neurol Sci 226:59-62. 2004
    ....
  6. ncbi request reprint Biological and social predictors of long-term geriatric depression outcome
    David C Steffens
    Department of Psychiatry, Duke University Medical Center, Box 3903, Durham, NC 27710, USA
    Int Psychogeriatr 17:41-56. 2005
    ..We hypothesized that both presence of vascular brain lesions seen on baseline magnetic resonance imaging (MRI) scans and lower baseline social support measures would be related to worse depression outcome...
  7. pmc A multiplicity of approaches to characterize geriatric depression and its outcomes
    David C Steffens
    Division of Geriatric Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Curr Opin Psychiatry 22:522-6. 2009
    ..This review identifies recent progress in the characterization of geriatric depression using a variety of methodologies...
  8. ncbi request reprint Cognitive impairment and depression outcomes in the IMPACT study
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 14:401-9. 2006
    ..The authors examined both of these issues using data from the IMPACT trial...
  9. ncbi request reprint Geriatric depression and cognitive impairment
    D C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychol Med 38:163-75. 2008
    ..Clinicians are encouraged to develop proactive approaches for treatment, which may include combinations of pharmacological and psychotherapeutic interventions...
  10. ncbi request reprint Longitudinal magnetic resonance imaging vascular changes, apolipoprotein E genotype, and development of dementia in the neurocognitive outcomes of depression in the elderly study
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 15:839-49. 2007
    ..The authors hypothesized that change in subcortical gray matter and white matter hyperintensity volumes would be associated with development of dementia, as would presence of an apolipoprotein E (APOE) epsilon 4 allele...
  11. ncbi request reprint Spiritual considerations in suicide and depression among the elderly
    David C Steffens
    Division of Geriatric Psychiatry, Duke University Medical Center, Box 3903, Durham, NC 27710, USA
    South Med J 100:748-9. 2007
  12. ncbi request reprint Short/long heterozygotes at 5HTTLPR and white matter lesions in geriatric depression
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Int J Geriatr Psychiatry 23:244-8. 2008
    ..We examined the relationship between 5HTTLPR genotype and volume of magnetic resonance imaging (MRI) brain lesions...
  13. pmc Structural integrity of the uncinate fasciculus and resting state functional connectivity of the ventral prefrontal cortex in late life depression
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 6:e22697. 2011
    ..In this study we sought to examine the relationship between the uncinate fasciculus, a key fronto-temporal tract and resting state functional connectivity between the ventral prefrontal cortex ((PFC) and limbic and striatal areas...
  14. doi request reprint Antidepressant treatment and worsening white matter on serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health Study
    David C Steffens
    Department of Psychiatry, Duke University Medical Center, Box 3903, Durham, NC 27710, USA
    Stroke 39:857-62. 2008
    ..We hypothesized that Cardiovascular Health Study participants taking SSRIs would less often have worsening white matter on serial MRI than participants not on antidepressants...
  15. pmc Outcomes of older cognitively impaired individuals with current and past depression in the NCODE study
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Geriatr Psychiatry Neurol 22:52-61. 2009
    ....
  16. pmc Prevalence of depression among older Americans: the Aging, Demographics and Memory Study
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Int Psychogeriatr 21:879-88. 2009
    ..The Aging, Demographics and Memory Study (ADAMS) is a population-representative study that included a depression assessment, providing an opportunity to estimate the prevalence of depression in late life in the U.S.A...
  17. pmc Metabolomic differences in heart failure patients with and without major depression
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    J Geriatr Psychiatry Neurol 23:138-46. 2010
    ..It is unclear what role heart failure may have played in these differing concentrations...
  18. pmc Change in hippocampal volume on magnetic resonance imaging and cognitive decline among older depressed and nondepressed subjects in the neurocognitive outcomes of depression in the elderly study
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 19:4-12. 2011
    ..previous studies have linked hippocampal volume change and cognitive decline in older adults with dementia. The authors examined hippocampal volume change and cognitive change in older nondemented adults with and without major depression...
  19. ncbi request reprint Left orbital frontal cortex volume and performance on the benton visual retention test in older depressives and controls
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 28:2179-83. 2003
    ..These results add to the literature linking mood and cognitive disturbances to the PFC. Future studies with a larger sample employing functional measures are warranted...
  20. ncbi request reprint Progression of subcortical ischemic disease from vascular depression to vascular dementia
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham NC 27710, USA
    Am J Psychiatry 160:1751-6. 2003
  21. ncbi request reprint Sociodemographic and clinical predictors of mortality in geriatric depression
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3903, Durham, NC 27710 0001, USA
    Am J Geriatr Psychiatry 10:531-40. 2002
    ..The authors report on prospectively observed mortality in elderly depressed patients, comparing differences in sex and vascular risk...
  22. ncbi request reprint MRI lesion severity and mortality in geriatric depression
    Robert M Levy
    Department of Psychaitry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 11:678-82. 2003
    ..The authors correlated magnetic resonance imaging (MRI) lesion severity and mortality among depressed elderly patients...
  23. ncbi request reprint Cerebrovascular disease and evolution of depressive symptoms in the cardiovascular health study
    David C Steffens
    Duke University Medical Center, Department of Psychiatry, Durham, NC 27710, USA
    Stroke 33:1636-44. 2002
    ..The Cardiovascular Health Study (CHS) provides an opportunity to examine the relationship between vascular brain pathology seen on neuroimaging and changes in depressive symptoms...
  24. ncbi request reprint The Duke Somatic Treatment Algorithm for Geriatric Depression (STAGED) approach
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3903, Durham, NC 27710, USA
    Psychopharmacol Bull 36:58-68. 2002
    ..6% of patients responded, and 65.35% of patients were able to achieve full remission of symptoms. The STAGED approach appears to be a clinically useful method of successfully treating elderly depressed patients...
  25. ncbi request reprint Hippocampal volume and incident dementia in geriatric depression
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 10:62-71. 2002
    ..762). Small left hippocampal size on neuroimaging may be a marker for dementia in depressed patients who have not yet met criteria for a clinical diagnosis of a dementing disorder...
  26. ncbi request reprint Severity of subcortical gray matter hyperintensity predicts ECT response in geriatric depression
    D C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    J ECT 17:45-9. 2001
    ..To determine the effect of subcortical white and gray matter lesions on ECT outcome...
  27. ncbi request reprint Partial response as a predictor of outcome in geriatric depression
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 11:340-8. 2003
    ..Data are lacking on the eventual outcomes of individuals who are partial responders or poor responders to initial treatment...
  28. ncbi request reprint Subcortical white matter lesions and functional impairment in geriatric depression
    David C Steffens
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Depress Anxiety 15:23-8. 2002
    ..We concluded that white matter lesions are independently associated with functional impairment. Further studies are needed to understand how these lesions affect function, e.g., through effects on cognition or motor skills...
  29. ncbi request reprint Initial evaluation of suspected dementia. Asking the right questions
    D C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina 27710, USA
    Postgrad Med 106:72-6, 79-80, 82-3. 1999
    ..Genetic testing for the APOE epsilon 4 allele can help confirm the diagnosis in patients with late-onset familial or sporadic Alzheimer's disease...
  30. ncbi request reprint Clinical characteristics of magnetic resonance imaging-defined subcortical ischemic depression
    K Ranga Rama Krishnan
    Department of Psychiatry, Duke University Medical Center, DUMC 3950, Durham, NC 27710, USA
    Biol Psychiatry 55:390-7. 2004
    ..We sought to investigate this diagnosis as a construct by examining differences between depressed subjects with and without magnetic resonance imaging defined subcortical ischemic vascular depression...
  31. pmc Effects of family history and apolipoprotein E epsilon4 status on cognitive decline in the absence of Alzheimer dementia: the Cache County Study
    Kathleen M Hayden
    Department of Psychiatry and Behavioral Sciences and Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27705, USA
    Arch Neurol 66:1378-83. 2009
    ..To evaluate the influences of a family history of Alzheimer dementia (FHxAD) and the apolipoprotein E epsilon4 genotype (APOE epsilon4) on cognitive decline...
  32. ncbi request reprint Hippocampal volume is associated with physician-reported acute cognitive deficits after electroconvulsive therapy
    Ruby Lekwauwa
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Geriatr Psychiatry Neurol 19:21-5. 2006
    ..Although the findings are significant, the sample size in the study is small, so future studies with more complex modeling of key variables that may influence memory are warranted...
  33. ncbi request reprint Apolipoprotein E genotype and subcortical vascular lesions in older depressed patients and control subjects
    David C Steffens
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Biol Psychiatry 54:674-81. 2003
    ..The apolipoprotein E gene (APOE) epsilon 4 allele has been associated with a variety of late-life neuropsychiatric disorders, including Alzheimer's disease, vascular dementia, and depression...
  34. ncbi request reprint Vascular risk factors and cognitive decline among elderly male twins
    Glen L Xiong
    Program in Epidemiology of Dementia, Duke University Medical Center, Durham, NC 27701, USA
    Neurology 67:1586-91. 2006
    ..The co-twin control method improves on traditional case-control approaches by controlling for within-twin pair similarities of genetic and early environmental influences...
  35. ncbi request reprint Allelic differences in the serotonin transporter-linked polymorphic region in geriatric depression
    David C Steffens
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
    Am J Geriatr Psychiatry 10:185-91. 2002
    ..The findings raise the possibility that this genetic locus may exert differential effects based on gender, increasing risk in men, and increasing risk of recurrence in women...
  36. ncbi request reprint Cognitive function in late life depression: relationships to depression severity, cerebrovascular risk factors and processing speed
    Yvette I Sheline
    Department of Psychiatry, Washington University, St Louis, Missouri, USA
    Biol Psychiatry 60:58-65. 2006
    ....
  37. ncbi request reprint Ascending digits task as a measure of executive function in geriatric depression
    Haris I Sair
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center Box 3903 Durham, NC 27710, USA
    J Neuropsychiatry Clin Neurosci 18:117-20. 2006
    ..The ADT may be a good measure of executive function in older adults...
  38. ncbi request reprint Prefrontal neuropsychological predictors of treatment remission in late-life depression
    Guy G Potter
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 29:2266-71. 2004
    ..By extension, we suggest that orbitofrontal prefrontal cortex may play a role in sustaining perseverative processing in geriatric depression...
  39. ncbi request reprint APOE genotype and hippocampal volume change in geriatric depression
    Do Hoon Kim
    Psychiatry and Behavioral Sciences, Durham, North Carolina 27710, USA
    Biol Psychiatry 51:426-9. 2002
    ..In this study, we examined the role of apolipoprotein E and hippocampal volume change in 45 older nondemented depressed subjects. All had baseline and 2-year magnetic resonance imaging scans...
  40. pmc Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Box 8134, St Louis, MO 63110, USA
    Arch Gen Psychiatry 67:277-85. 2010
    ..Research on vascular depression has used 2 approaches to subtype late-life depression, based on executive dysfunction or white matter hyperintensity severity...
  41. pmc Amyloid-associated depression: a prodromal depression of Alzheimer disease?
    Xiaoyan Sun
    Department of Psychiatry, Tufts New England Medical Center, Campus Box 1007, 750 Washington St, Boston, MA 02111, USA
    Arch Gen Psychiatry 65:542-50. 2008
    ..In a previous study, we reported that depression is also associated with low plasma Abeta(42) levels in the elderly population...
  42. pmc Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study
    Martin Steinberg
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Int J Geriatr Psychiatry 23:170-7. 2008
    ..Neuropsychiatric symptoms are nearly universal in dementia, yet little is known about their longitudinal course in the community...
  43. pmc Neuropsychological performance in advanced age: influences of demographic factors and Apolipoprotein E: findings from the Cache County Memory Study
    Katheen A Welsh-Bohmer
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Clin Neuropsychol 23:77-99. 2009
    ..Among elderly without dementia or other cognitive impairment, APOE does not appear to exert any major effects on cognition once other demographic influences are controlled...
  44. ncbi request reprint Statin use and hippocampal volumes in elderly subjects at risk for Alzheimer's disease: a pilot observational study
    P Murali Doraiswamy
    Department of Psychiatry and Medicine Geriatrics, Duke University Medical Center, Durham, North Carolina, USA
    Am J Alzheimers Dis Other Demen 19:275-8. 2004
    ..Prospective studies in both nondemented and AD subjects may provide more conclusive answers...
  45. pmc Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjects
    Jennifer C Naylor
    VA Mid Atlantic Mental Illness, Research and Clinical Center MIRECC, Durham, NC, USA
    Biochim Biophys Acta 1801:951-9. 2010
    ..In addition, the APOE4 allele is associated with reduced allopregnanolone levels. Neurosteroids may be relevant to the neurobiology and therapeutics of AD...
  46. ncbi request reprint Prevalence and clinical correlates of neuropsychiatric symptoms in dementia
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, USA
    Am J Alzheimers Dis Other Demen 20:367-73. 2005
    ..Our results may also shed light on mechanisms that underlie neuropsychiatric symptoms...
  47. pmc Differential patterns of cognitive decline in anterior and posterior white matter hyperintensity progression
    Maria J Marquine
    Departments of Neurology, the American Stroke Association Bugher Foundation Center for Stroke Prevention Research, Duke University Medical Center, Durham, NC 27705, USA
    Stroke 41:1946-50. 2010
    ..The present study sought to determine patterns of cognitive decline associated with anterior and posterior WMH progression...
  48. ncbi request reprint Association of AGTR1 with 18-month treatment outcome in late-life depression
    Douglas G Kondo
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 15:564-72. 2007
    ..This study investigated the association of AGTR1 genotype on 18-month treatment outcome in late-life depression...
  49. ncbi request reprint Head injury in early adulthood and the lifetime risk of depression
    Tracey Holsinger
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Arch Gen Psychiatry 59:17-22. 2002
    ..Head injury can also have long-term cognitive effects, but little is known about the long-term risk of depression associated with head injury. We investigated the lifetime rates of depressive illness 50 years after closed head injury...
  50. ncbi request reprint Perspectives on depression, mild cognitive impairment, and cognitive decline
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
    Arch Gen Psychiatry 63:130-8. 2006
    ....
  51. ncbi request reprint Smaller orbital frontal cortex volumes associated with functional disability in depressed elders
    Warren D Taylor
    Department of Psychiatry and Behavioral Medicine at Duke University Medical Center, Durham, North Carolina 27710, USA
    Biol Psychiatry 53:144-9. 2003
    ..Recent evidence has linked the orbital frontal cortex (OFC) with depression. We examined the relationship between OFC volumes in older subjects and impairment in the basic (BADL) and instrumental (IADL) activities of daily living...
  52. ncbi request reprint White matter lesion volumes and caudate volumes in late-life depression
    Jonas Hannestad
    Departments of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Int J Geriatr Psychiatry 21:1193-8. 2006
    ..We additionally hypothesized that this association would be stronger in depressed subjects...
  53. ncbi request reprint Influence of serotonin transporter promoter region polymorphisms on hippocampal volumes in late-life depression
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Arch Gen Psychiatry 62:537-44. 2005
    ..Recent research demonstrates that specific polymorphisms may be associated with differences in hippocampal volumes in subjects with depression...
  54. pmc Hippocampus shape analysis and late-life depression
    Zheen Zhao
    Neuropsychiatric Imaging Research Laboratory, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 3:e1837. 2008
    ..These findings may provide support to other reports of neurogenic effects of antidepressants and their relation to successful treatment for depressive symptoms...
  55. ncbi request reprint Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 15:850-7. 2007
    ..The authors examined the relationship between this polymorphism and depression in an elderly sample, hypothesizing that the Met66 allele would be associated with late-life depression...
  56. doi request reprint Depressive state- and disease-related alterations in neural responses to affective and executive challenges in geriatric depression
    Lihong Wang
    Brain Imaging and Analysis Center, Duke University Medical Center, PO Box 3918, Rm 163, Bell Building, Durham, NC 27710, USA
    Am J Psychiatry 165:863-71. 2008
    ..Identifying both depressive state-related and disease-related alterations in brain regions associated with emotion and cognitive function could provide useful diagnostic information in geriatric depression...
  57. pmc Social support in older individuals: the role of the BDNF Val66Met polymorphism
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1205-12. 2008
    ..Further work is needed to determine the generalizability of this finding to the broader population, as well as its significance for clinical outcomes...
  58. ncbi request reprint Widespread effects of hyperintense lesions on cerebral white matter structure
    Warren D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, DUMC Box 3903, Durham, NC 27710, USA
    AJR Am J Roentgenol 188:1695-704. 2007
    ..We hypothesized that hyperintense lesions are associated with alterations in white matter structure beyond the visible lesion boundaries as assessed with diffusion tensor imaging (DTI)...
  59. ncbi request reprint Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matter
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, DUMC Box 3903, Durham, NC 277120, USA
    Am J Psychiatry 161:1293-6. 2004
    ..The purpose of this study was to determine whether microstructural abnormalities in the white matter of the dorsolateral prefrontal cortex are associated with late-life depression...
  60. ncbi request reprint Review of evidence for genetic testing for CYP450 polymorphisms in management of patients with nonpsychotic depression with selective serotonin reuptake inhibitors
    Mugdha Thakur
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genet Med 9:826-35. 2007
    ..The purpose of this study was 2-fold: to systematically review the literature for evidence supporting CYP450 genotyping to guide SSRI treatment for major depression, and, where evidence is inadequate, to suggest future research...
  61. ncbi request reprint Social support and locus of control as predictors of adherence to antidepressant medication in an elderly population
    Corrine I Voils
    Center for Health Services Research in Primary Care, and Health Services Research and Development, Building 16, Room 70, Durham Veterans Affairs Medical Center 152, 508 Fulton St, Durham, NC 27705, USA
    Am J Geriatr Psychiatry 13:157-65. 2005
    ..The authors examined whether social support and locus of control (LOC), either individually or jointly, would be associated with subsequent self-reported medication adherence and treatment barriers in a sample of depressed elderly patients...
  62. ncbi request reprint Localization of age-associated white matter hyperintensities in late-life depression
    Warren D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, DUMC 3903, Durham, NC 27710, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:539-44. 2003
    ..Deep white matter hyperintense lesions are associated with advanced age and late-life depression. The authors examined where age-related cerebral lesions occurred in elderly depressed and healthy control subjects...
  63. pmc The brain-derived neurotrophic factor Val66Met polymorphism, hippocampal volume, and cognitive function in geriatric depression
    Sophiya Benjamin
    Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
    Am J Geriatr Psychiatry 18:323-31. 2010
    ..The authors examined the relationship between the BDNF gene and hippocampal volumes in depressed and nondepressed older individuals and its relationship with memory functions mediated by the hippocampus...
  64. ncbi request reprint Orbitofrontal cortex volume in late life depression: influence of hyperintense lesions and genetic polymorphisms
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
    Psychol Med 37:1763-73. 2007
    ..We hypothesized that smaller OFC volume would be associated with depression, greater hyperintense lesion volume and severity, and APOE epsilon4 or 5HTTLPR short allele carriers...
  65. ncbi request reprint Vascular nutritional correlates of late-life depression
    Martha E Payne
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Am J Geriatr Psychiatry 14:787-95. 2006
    ..The authors sought to examine the association of vascular nutritional factors and depression in an elderly cohort of depression (currently and recently depressed) and comparison (never depressed) subjects...
  66. ncbi request reprint Psychiatric disease in the twenty-first century: The case for subcortical ischemic depression
    Warren D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Biol Psychiatry 60:1299-303. 2006
    ..Subcortical ischemic depression affects clinical presentation, long-term outcomes, and response to antidepressant therapy, arguing that it is a valid diagnostic entity worth further study...
  67. ncbi request reprint Duke Twins Study of Memory in Aging in the NAS-NRC Twin Registry
    Brenda L Plassman
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27701, USA
    Twin Res Hum Genet 9:950-7. 2006
    ..We provide an overview of the study's methodology and describe the focus of recent research...
  68. pmc Cognitive performance and informant reports in the diagnosis of cognitive impairment and dementia in African Americans and whites
    Guy G Potter
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Alzheimers Dement 5:445-53. 2009
    ..This study compared direct testing and informant reports of cognition with clinical diagnoses of cognitive impairment and dementia between African Americans and whites...
  69. ncbi request reprint Time-to-remission from geriatric depression: psychosocial and clinical factors
    Hayden B Bosworth
    Health Services Research and Development, Building 16, Room 70, Durham Veterans Affairs Medical Center 152, 508 Fulton Street, Durham NC 27705, USA
    Am J Geriatr Psychiatry 10:551-9. 2002
    ..The authors examined psychosocial and clinical predictors of time-to-remission in a sample of initially clinically depressed elderly patients...
  70. ncbi request reprint Implementing a disease management intervention for depression in primary care: a random work sampling study
    Linda H Harpole
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Gen Hosp Psychiatry 25:238-45. 2003
    ..This information will be helpful to those who may wish to implement this disease management strategy...
  71. ncbi request reprint Hippocampal volume and antidepressant response in geriatric depression
    Ming Hong Hsieh
    Chung Shan Medical and Dental College Hospital, Taiwan
    Int J Geriatr Psychiatry 17:519-25. 2002
    ..While most imaging studies have focused on cerebrovascular disease, evidence is growing that the hippocampus may play a role in depression, particularly geriatric depression...
  72. ncbi request reprint The incidence of mental and behavioral disturbances in dementia: the cache county study
    Martin Steinberg
    Johns Hopkins Hospital, Baltimore, MD 21287, USA
    J Neuropsychiatry Clin Neurosci 15:340-5. 2003
    ..These results argue for a routine assessment of psychiatric disturbances in all patients with dementia, even among those who have never experienced symptoms of mental or behavioral disturbances...
  73. ncbi request reprint Population-based study of medical comorbidity in early dementia and "cognitive impairment, no dementia (CIND)": association with functional and cognitive impairment: The Cache County Study
    Constantine G Lyketsos
    Division of Geriatric Psychiatry and Neuropsychiatry, Dept of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Am J Geriatr Psychiatry 13:656-64. 2005
    ..Authors investigated medical comorbidity in persons with dementia and "Cognitive Impairment, No Dementia" (CIND)...
  74. ncbi request reprint The Aging, Demographics, and Memory Study: study design and methods
    Kenneth M Langa
    Division of General Medicine, Department of Medicine, University of Michigan Health System, 300 North Ingalls Building, Rm 7E01, Box 4029, Ann Arbor, MI 48109, USA
    Neuroepidemiology 25:181-91. 2005
    ..We also illustrate potential uses of the ADAMS data and provide information to interested researchers on obtaining ADAMS and HRS data...
  75. ncbi request reprint White matter and subcortical gray matter lesion volume changes and late-life depression outcome: a 4-year magnetic resonance imaging study
    Po See Chen
    Institute of Basic Medical Sciences and Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Int Psychogeriatr 18:445-56. 2006
    ..In a longitudinal analysis, we examined changes in deep WMLs and subcortical GMLs in older depressed and nondepressed subjects over a 4-year period...
  76. ncbi request reprint Three-year incidence of first-onset depressive syndrome in a population sample of older adults: the Cache County study
    Maria C Norton
    Department of Family, Consumer and Human Development, Utah State University, Logan, 84322, USA
    Am J Geriatr Psychiatry 14:237-45. 2006
    ....
  77. ncbi request reprint Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression
    Jae Nam Bae
    Department of Psychiatry, Inha University Hospital, Incheon, South Korea
    Biol Psychiatry 60:1356-63. 2006
    ..This study used diffusion tensor imaging to examine for white matter microstructural abnormalities of these regions and of central white matter structures in late-life depression...
  78. ncbi request reprint Persistent mild cognitive impairment in geriatric depression
    Jung Sik Lee
    Yong In Mental Hospital, Yong In, Korea
    Int Psychogeriatr 19:125-35. 2007
    ....
  79. ncbi request reprint Are microvascular abnormalities in the retina associated with depression symptoms? The Cardiovascular Health Study
    Cong Sun
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
    Am J Geriatr Psychiatry 15:335-43. 2007
    ..Depression has been linked with vascular risk factors and stroke. The authors examined the relationship between retinal microvascular abnormalities and depression symptoms in an elderly population...
  80. pmc Hippocampal volumes and depression subtypes
    Daniel L Greenberg
    Psychology Research, VA Boston Healthcare System, Boston, MA 02130, USA
    Psychiatry Res 163:126-32. 2008
    ..We conducted cross-sectional and longitudinal analyses of hippocampal volumes in atypical depressive, melancholic depressive, and control subjects. We found no effect of depression subtype on hippocampal volume or memory performance...

Research Grants17

  1. Midcareer Investigator Award in Geriatric Depression
    David Steffens; Fiscal Year: 2007
    This application seeks funding for a K24 Career Award in Patient-Oriented Research. The candidate, Dr. David Steffens, is Associate Professor of Psychiatry and Medicine at Duke University Medical Center, where he serves as the Head of the ..
  2. Geriatric Depression: Risk Factors for Adverse Outcomes
    David C Steffens; Fiscal Year: 2010
    ..Finally, it will be the first prospective longitudinal study in depression to correlate clinical in vivo data on well characterized patients with subsequent post-mortem morphometric analyses. ..
  3. Geriatric Depression: Risk Factors for Adverse Outcomes
    David Steffens; Fiscal Year: 2009
    ..Finally, it will be the first prospective longitudinal study in depression to correlate clinical in vivo data on well characterized patients with subsequent post-mortem morphometric analyses. ..
  4. Tryptophan Metabolism, Genes, and Major Depression
    David Steffens; Fiscal Year: 2007
    ..Results from this study will help inform future treatment studies using genetics and metabolomic technology. ..
  5. PREMIER Mental Health Interventions Training Program
    David Steffens; Fiscal Year: 2007
    ..By the end of two years of training, each fellow will have extensive experience and training in clinical trials that will enable them to obtain appointments as junior faculty. ..
  6. Geriatric Depression: Risk Factors for Adverse Outcomes
    David Steffens; Fiscal Year: 2007
    ..Finally, it will be the first prospective longitudinal study in depression to correlate clinical in vivo data on well characterized patients with subsequent post-mortem morphometric analyses. ..
  7. Geriatric Depression: Risk Factors for Adverse Outcomes
    David Steffens; Fiscal Year: 2006
    ..abstract_text> ..
  8. GERIATRIC DEPRESSION--RISK FACTORS FOR ADVERSE OUTCOME
    David Steffens; Fiscal Year: 2000
    ..Results in this clinical population will be valuable for comparison with epidemiological data. This project benefits from the resources of the Duke Mental Health Clinical Research Center for essential support. ..
  9. Geriatric Depression: Risk Factors for Adverse Outcomes
    David C Steffens; Fiscal Year: 2011
    ..Finally, it will be the first prospective longitudinal study in depression to correlate clinical in vivo data on well characterized patients with subsequent post-mortem morphometric analyses. ..