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Genomes and GenesSpecies | David SteffensSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Publications
Efficacy and safety of adjunctive aripiprazole in major depressive disorder in older patients: a pooled subpopulation analysisDavid C Steffens
Duke University Medical Center, Durham, NC, USA
Int J Geriatr Psychiatry 26:564-72. 2011....
Cholesterol-lowering medication and relapse of depressionDavid C Steffens
Division of Geriatric Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
Psychopharmacol Bull 37:92-8. 2003..Future studies of depression outcomes in the elderly will need to include serial examination of cholesterol levels...- Methodology and preliminary results from the neurocognitive outcomes of depression in the elderly studyDavid C Steffens
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
J Geriatr Psychiatry Neurol 17:202-11. 2004..These results are consistent with prior evidence linking depression and later dementia. Future studies are needed to examine neuroimaging and genetic, clinical, and social predictors of neurocognitive decline in depression... - Establishing diagnostic criteria for vascular depressionDavid C Steffens
Duke University Medical Center, Box 3903, Durham, North Carolina 27710, USA
J Neurol Sci 226:59-62. 2004.... - Impact of symptoms of generalized anxiety disorder on the course of late-life depressionDavid C Steffens
Department of Psychiatry and Behavioral Sciences, Division of Geriatric Psychiatry, Duke University Medical Center, Box 3903, Durham, NC 27710, USA
Am J Geriatr Psychiatry 13:40-7. 2005..The authors sought to examine the effect of symptoms of generalized anxiety disorder (GAD) on acute course of depression in a group of older depressed patients... - Biological and social predictors of long-term geriatric depression outcomeDavid C Steffens
Department of Psychiatry, Duke University Medical Center, Box 3903, Durham, NC 27710, USA
Int Psychogeriatr 17:41-56. 2005..We hypothesized that both presence of vascular brain lesions seen on baseline magnetic resonance imaging (MRI) scans and lower baseline social support measures would be related to worse depression outcome... 
A multiplicity of approaches to characterize geriatric depression and its outcomesDavid C Steffens
Division of Geriatric Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
Curr Opin Psychiatry 22:522-6. 2009..This review identifies recent progress in the characterization of geriatric depression using a variety of methodologies...- Cognitive impairment and depression outcomes in the IMPACT studyDavid C Steffens
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Am J Geriatr Psychiatry 14:401-9. 2006..The authors examined both of these issues using data from the IMPACT trial... - Geriatric depression and cognitive impairmentD C Steffens
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Psychol Med 38:163-75. 2008..Clinicians are encouraged to develop proactive approaches for treatment, which may include combinations of pharmacological and psychotherapeutic interventions... - Longitudinal magnetic resonance imaging vascular changes, apolipoprotein E genotype, and development of dementia in the neurocognitive outcomes of depression in the elderly studyDavid C Steffens
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Am J Geriatr Psychiatry 15:839-49. 2007..The authors hypothesized that change in subcortical gray matter and white matter hyperintensity volumes would be associated with development of dementia, as would presence of an apolipoprotein E (APOE) epsilon 4 allele... - Spiritual considerations in suicide and depression among the elderlyDavid C Steffens
Division of Geriatric Psychiatry, Duke University Medical Center, Box 3903, Durham, NC 27710, USA
South Med J 100:748-9. 2007 - Short/long heterozygotes at 5HTTLPR and white matter lesions in geriatric depressionDavid C Steffens
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Int J Geriatr Psychiatry 23:244-8. 2008..We examined the relationship between 5HTTLPR genotype and volume of magnetic resonance imaging (MRI) brain lesions... - Structural integrity of the uncinate fasciculus and resting state functional connectivity of the ventral prefrontal cortex in late life depressionDavid C Steffens
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, United States of America
PLoS ONE 6:e22697. 2011..In this study we sought to examine the relationship between the uncinate fasciculus, a key fronto-temporal tract and resting state functional connectivity between the ventral prefrontal cortex ((PFC) and limbic and striatal areas... - Antidepressant treatment and worsening white matter on serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health StudyDavid C Steffens
Department of Psychiatry, Duke University Medical Center, Box 3903, Durham, NC 27710, USA
Stroke 39:857-62. 2008..We hypothesized that Cardiovascular Health Study participants taking SSRIs would less often have worsening white matter on serial MRI than participants not on antidepressants... - Outcomes of older cognitively impaired individuals with current and past depression in the NCODE studyDavid C Steffens
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
J Geriatr Psychiatry Neurol 22:52-61. 2009.... - Prevalence of depression among older Americans: the Aging, Demographics and Memory StudyDavid C Steffens
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
Int Psychogeriatr 21:879-88. 2009..The Aging, Demographics and Memory Study (ADAMS) is a population-representative study that included a depression assessment, providing an opportunity to estimate the prevalence of depression in late life in the U.S.A... - Metabolomic differences in heart failure patients with and without major depressionDavid C Steffens
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
J Geriatr Psychiatry Neurol 23:138-46. 2010..It is unclear what role heart failure may have played in these differing concentrations... - Change in hippocampal volume on magnetic resonance imaging and cognitive decline among older depressed and nondepressed subjects in the neurocognitive outcomes of depression in the elderly studyDavid C Steffens
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Am J Geriatr Psychiatry 19:4-12. 2011..previous studies have linked hippocampal volume change and cognitive decline in older adults with dementia. The authors examined hippocampal volume change and cognitive change in older nondemented adults with and without major depression... - Left orbital frontal cortex volume and performance on the benton visual retention test in older depressives and controlsDavid C Steffens
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Neuropsychopharmacology 28:2179-83. 2003..These results add to the literature linking mood and cognitive disturbances to the PFC. Future studies with a larger sample employing functional measures are warranted... - Progression of subcortical ischemic disease from vascular depression to vascular dementiaDavid C Steffens
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham NC 27710, USA
Am J Psychiatry 160:1751-6. 2003 - Sociodemographic and clinical predictors of mortality in geriatric depressionDavid C Steffens
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3903, Durham, NC 27710 0001, USA
Am J Geriatr Psychiatry 10:531-40. 2002..The authors report on prospectively observed mortality in elderly depressed patients, comparing differences in sex and vascular risk... - MRI lesion severity and mortality in geriatric depressionRobert M Levy
Department of Psychaitry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Am J Geriatr Psychiatry 11:678-82. 2003..The authors correlated magnetic resonance imaging (MRI) lesion severity and mortality among depressed elderly patients... - Cerebrovascular disease and evolution of depressive symptoms in the cardiovascular health studyDavid C Steffens
Duke University Medical Center, Department of Psychiatry, Durham, NC 27710, USA
Stroke 33:1636-44. 2002..The Cardiovascular Health Study (CHS) provides an opportunity to examine the relationship between vascular brain pathology seen on neuroimaging and changes in depressive symptoms... - The Duke Somatic Treatment Algorithm for Geriatric Depression (STAGED) approachDavid C Steffens
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3903, Durham, NC 27710, USA
Psychopharmacol Bull 36:58-68. 2002..6% of patients responded, and 65.35% of patients were able to achieve full remission of symptoms. The STAGED approach appears to be a clinically useful method of successfully treating elderly depressed patients... - Hippocampal volume and incident dementia in geriatric depressionDavid C Steffens
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Am J Geriatr Psychiatry 10:62-71. 2002..762). Small left hippocampal size on neuroimaging may be a marker for dementia in depressed patients who have not yet met criteria for a clinical diagnosis of a dementing disorder... - Severity of subcortical gray matter hyperintensity predicts ECT response in geriatric depressionD C Steffens
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
J ECT 17:45-9. 2001..To determine the effect of subcortical white and gray matter lesions on ECT outcome... - Partial response as a predictor of outcome in geriatric depressionDavid C Steffens
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Am J Geriatr Psychiatry 11:340-8. 2003..Data are lacking on the eventual outcomes of individuals who are partial responders or poor responders to initial treatment... - Subcortical white matter lesions and functional impairment in geriatric depressionDavid C Steffens
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
Depress Anxiety 15:23-8. 2002..We concluded that white matter lesions are independently associated with functional impairment. Further studies are needed to understand how these lesions affect function, e.g., through effects on cognition or motor skills... - Initial evaluation of suspected dementia. Asking the right questionsD C Steffens
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina 27710, USA
Postgrad Med 106:72-6, 79-80, 82-3. 1999..Genetic testing for the APOE epsilon 4 allele can help confirm the diagnosis in patients with late-onset familial or sporadic Alzheimer's disease... - Clinical characteristics of magnetic resonance imaging-defined subcortical ischemic depressionK Ranga Rama Krishnan
Department of Psychiatry, Duke University Medical Center, DUMC 3950, Durham, NC 27710, USA
Biol Psychiatry 55:390-7. 2004..Further research is needed to further characterize this disorder, particularly in regards to cognitive function and treatment implications... - Effects of family history and apolipoprotein E epsilon4 status on cognitive decline in the absence of Alzheimer dementia: the Cache County StudyKathleen M Hayden
Department of Psychiatry and Behavioral Sciences and Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27705, USA
Arch Neurol 66:1378-83. 2009..To evaluate the influences of a family history of Alzheimer dementia (FHxAD) and the apolipoprotein E epsilon4 genotype (APOE epsilon4) on cognitive decline... - Hippocampal volume is associated with physician-reported acute cognitive deficits after electroconvulsive therapyRuby Lekwauwa
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
J Geriatr Psychiatry Neurol 19:21-5. 2006..Although the findings are significant, the sample size in the study is small, so future studies with more complex modeling of key variables that may influence memory are warranted... - Apolipoprotein E genotype and subcortical vascular lesions in older depressed patients and control subjectsDavid C Steffens
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
Biol Psychiatry 54:674-81. 2003..The apolipoprotein E gene (APOE) epsilon 4 allele has been associated with a variety of late-life neuropsychiatric disorders, including Alzheimer's disease, vascular dementia, and depression... - Vascular risk factors and cognitive decline among elderly male twinsGlen L Xiong
Program in Epidemiology of Dementia, Duke University Medical Center, Durham, NC 27701, USA
Neurology 67:1586-91. 2006..CONCLUSION: Based on this study of twin pairs who share similar genetic and early environmental risks for cardiovascular risk factors, diabetes is associated with greater cognitive decline, particularly among the oldest individuals... - Allelic differences in the serotonin transporter-linked polymorphic region in geriatric depressionDavid C Steffens
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
Am J Geriatr Psychiatry 10:185-91. 2002..The findings raise the possibility that this genetic locus may exert differential effects based on gender, increasing risk in men, and increasing risk of recurrence in women... - Cognitive function in late life depression: relationships to depression severity, cerebrovascular risk factors and processing speedYvette I Sheline
Department of Psychiatry, Washington University, St Louis, Missouri, USA
Biol Psychiatry 60:58-65. 2006.... - Ascending digits task as a measure of executive function in geriatric depressionHaris I Sair
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center Box 3903 Durham, NC 27710, USA
J Neuropsychiatry Clin Neurosci 18:117-20. 2006..The ADT may be a good measure of executive function in older adults... - Prefrontal neuropsychological predictors of treatment remission in late-life depressionGuy G Potter
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Neuropsychopharmacology 29:2266-71. 2004..By extension, we suggest that orbitofrontal prefrontal cortex may play a role in sustaining perseverative processing in geriatric depression... - APOE genotype and hippocampal volume change in geriatric depressionDo Hoon Kim
Psychiatry and Behavioral Sciences, Durham, North Carolina 27710, USA
Biol Psychiatry 51:426-9. 2002..In this study, we examined the role of apolipoprotein E and hippocampal volume change in 45 older nondemented depressed subjects. All had baseline and 2-year magnetic resonance imaging scans... - Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trialYvette I Sheline
Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Box 8134, St Louis, MO 63110, USA
Arch Gen Psychiatry 67:277-85. 2010..Research on vascular depression has used 2 approaches to subtype late-life depression, based on executive dysfunction or white matter hyperintensity severity... - Amyloid-associated depression: a prodromal depression of Alzheimer disease?Xiaoyan Sun
Department of Psychiatry, Tufts New England Medical Center, Campus Box 1007, 750 Washington St, Boston, MA 02111, USA
Arch Gen Psychiatry 65:542-50. 2008..In a previous study, we reported that depression is also associated with low plasma Abeta(42) levels in the elderly population... - Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County StudyMartin Steinberg
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Int J Geriatr Psychiatry 23:170-7. 2008..Neuropsychiatric symptoms are nearly universal in dementia, yet little is known about their longitudinal course in the community... - Neuropsychological performance in advanced age: influences of demographic factors and Apolipoprotein E: findings from the Cache County Memory StudyKatheen A Welsh-Bohmer
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
Clin Neuropsychol 23:77-99. 2009..Among elderly without dementia or other cognitive impairment, APOE does not appear to exert any major effects on cognition once other demographic influences are controlled... - Statin use and hippocampal volumes in elderly subjects at risk for Alzheimer's disease: a pilot observational studyP Murali Doraiswamy
Department of Psychiatry and Medicine (Geriatrics, Duke University Medical Center, Durham, North Carolina, USA
Am J Alzheimers Dis Other Demen 19:275-8. 2004..Prospective studies in both nondemented and AD subjects may provide more conclusive answers... - Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjectsJennifer C Naylor
VA Mid Atlantic Mental Illness, Research and Clinical Center MIRECC, Durham, NC, USA
Biochim Biophys Acta 1801:951-9. 2010..In addition, the APOE4 allele is associated with reduced allopregnanolone levels. Neurosteroids may be relevant to the neurobiology and therapeutics of AD... - Prevalence and clinical correlates of neuropsychiatric symptoms in dementiaDavid C Steffens
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, USA
Am J Alzheimers Dis Other Demen 20:367-73. 2005..Our results may also shed light on mechanisms that underlie neuropsychiatric symptoms... - Differential patterns of cognitive decline in anterior and posterior white matter hyperintensity progressionMaria J Marquine
Departments of Neurology, the American Stroke Association Bugher Foundation Center for Stroke Prevention Research, Duke University Medical Center, Durham, NC 27705, USA
Stroke 41:1946-50. 2010..The present study sought to determine patterns of cognitive decline associated with anterior and posterior WMH progression... - Association of AGTR1 with 18-month treatment outcome in late-life depressionDouglas G Kondo
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Am J Geriatr Psychiatry 15:564-72. 2007..This study investigated the association of AGTR1 genotype on 18-month treatment outcome in late-life depression... - Head injury in early adulthood and the lifetime risk of depressionTracey Holsinger
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
Arch Gen Psychiatry 59:17-22. 2002..The lifetime risk of depression increased with severity of the head injury. CONCLUSION: The risk of depression remains elevated for decades following head injury and seems to be highest in those who have had a severe head injury... - Perspectives on depression, mild cognitive impairment, and cognitive declineDavid C Steffens
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
Arch Gen Psychiatry 63:130-8. 2006.... - Smaller orbital frontal cortex volumes associated with functional disability in depressed eldersWarren D Taylor
Department of Psychiatry and Behavioral Medicine at Duke University Medical Center, Durham, North Carolina 27710, USA
Biol Psychiatry 53:144-9. 2003..Further studies are needed to determine how smaller OFC volumes are related to other MRI abnormalities associated with depression and functional impairment... - White matter lesion volumes and caudate volumes in late-life depressionJonas Hannestad
Departments of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Int J Geriatr Psychiatry 21:1193-8. 2006..This study demonstrates one mechanism by which WMLs may disrupt frontostriatal circuits... - Influence of serotonin transporter promoter region polymorphisms on hippocampal volumes in late-life depressionWarren D Taylor
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
Arch Gen Psychiatry 62:537-44. 2005..Recent research demonstrates that specific polymorphisms may be associated with differences in hippocampal volumes in subjects with depression... - Hippocampus shape analysis and late-life depressionZheen Zhao
Neuropsychiatric Imaging Research Laboratory, Duke University Medical Center, Durham, North Carolina, United States of America
PLoS ONE 3:e1837. 2008..These findings may provide support to other reports of neurogenic effects of antidepressants and their relation to successful treatment for depressive symptoms... - Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depressionWarren D Taylor
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
Am J Geriatr Psychiatry 15:850-7. 2007..The authors examined the relationship between this polymorphism and depression in an elderly sample, hypothesizing that the Met66 allele would be associated with late-life depression... - Depressive state- and disease-related alterations in neural responses to affective and executive challenges in geriatric depressionLihong Wang
Brain Imaging and Analysis Center, Duke University Medical Center, PO Box 3918, Rm 163, Bell Building, Durham, NC 27710, USA
Am J Psychiatry 165:863-71. 2008..Identifying both depressive state-related and disease-related alterations in brain regions associated with emotion and cognitive function could provide useful diagnostic information in geriatric depression... - Social support in older individuals: the role of the BDNF Val66Met polymorphismWarren D Taylor
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Med Genet B Neuropsychiatr Genet 147:1205-12. 2008..Further work is needed to determine the generalizability of this finding to the broader population, as well as its significance for clinical outcomes... - Widespread effects of hyperintense lesions on cerebral white matter structureWarren D Taylor
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, DUMC Box 3903, Durham, NC 27710, USA
AJR Am J Roentgenol 188:1695-704. 2007..We hypothesized that hyperintense lesions are associated with alterations in white matter structure beyond the visible lesion boundaries as assessed with diffusion tensor imaging (DTI)... - Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matterWarren D Taylor
Department of Psychiatry, Duke University Medical Center, DUMC Box 3903, Durham, NC 277120, USA
Am J Psychiatry 161:1293-6. 2004..The purpose of this study was to determine whether microstructural abnormalities in the white matter of the dorsolateral prefrontal cortex are associated with late-life depression... - Review of evidence for genetic testing for CYP450 polymorphisms in management of patients with nonpsychotic depression with selective serotonin reuptake inhibitorsMugdha Thakur
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
Genet Med 9:826-35. 2007..The purpose of this study was 2-fold: to systematically review the literature for evidence supporting CYP450 genotyping to guide SSRI treatment for major depression, and, where evidence is inadequate, to suggest future research... - Social support and locus of control as predictors of adherence to antidepressant medication in an elderly populationCorrine I Voils
Center for Health Services Research in Primary Care, and Health Services Research and Development, Building 16, Room 70, Durham Veterans Affairs Medical Center 152, 508 Fulton St, Durham, NC 27705, USA
Am J Geriatr Psychiatry 13:157-65. 2005..The authors examined whether social support and locus of control (LOC), either individually or jointly, would be associated with subsequent self-reported medication adherence and treatment barriers in a sample of depressed elderly patients... - Localization of age-associated white matter hyperintensities in late-life depressionWarren D Taylor
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, DUMC 3903, Durham, NC 27710, USA
Prog Neuropsychopharmacol Biol Psychiatry 27:539-44. 2003..Deep white matter hyperintense lesions are associated with advanced age and late-life depression. The authors examined where age-related cerebral lesions occurred in elderly depressed and healthy control subjects... - The brain-derived neurotrophic factor Val66Met polymorphism, hippocampal volume, and cognitive function in geriatric depressionSophiya Benjamin
Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
Am J Geriatr Psychiatry 18:323-31. 2010..The authors examined the relationship between the BDNF gene and hippocampal volumes in depressed and nondepressed older individuals and its relationship with memory functions mediated by the hippocampus... - Orbitofrontal cortex volume in late life depression: influence of hyperintense lesions and genetic polymorphismsWarren D Taylor
Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
Psychol Med 37:1763-73. 2007..We hypothesized that smaller OFC volume would be associated with depression, greater hyperintense lesion volume and severity, and APOE epsilon4 or 5HTTLPR short allele carriers... - Vascular nutritional correlates of late-life depressionMartha E Payne
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
Am J Geriatr Psychiatry 14:787-95. 2006..The authors sought to examine the association of vascular nutritional factors and depression in an elderly cohort of depression (currently and recently depressed) and comparison (never depressed) subjects... - Psychiatric disease in the twenty-first century: The case for subcortical ischemic depressionWarren D Taylor
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
Biol Psychiatry 60:1299-303. 2006..Subcortical ischemic depression affects clinical presentation, long-term outcomes, and response to antidepressant therapy, arguing that it is a valid diagnostic entity worth further study... - Duke Twins Study of Memory in Aging in the NAS-NRC Twin RegistryBrenda L Plassman
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27701, USA
Twin Res Hum Genet 9:950-7. 2006..We provide an overview of the study's methodology and describe the focus of recent research... - Cognitive performance and informant reports in the diagnosis of cognitive impairment and dementia in African Americans and whitesGuy G Potter
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
Alzheimers Dement 5:445-53. 2009..This study compared direct testing and informant reports of cognition with clinical diagnoses of cognitive impairment and dementia between African Americans and whites... - Time-to-remission from geriatric depression: psychosocial and clinical factorsHayden B Bosworth
Health Services Research and Development, Building 16, Room 70, Durham Veterans Affairs Medical Center 152, 508 Fulton Street, Durham NC 27705, USA
Am J Geriatr Psychiatry 10:551-9. 2002..The authors examined psychosocial and clinical predictors of time-to-remission in a sample of initially clinically depressed elderly patients... - Implementing a disease management intervention for depression in primary care: a random work sampling studyLinda H Harpole
Department of Medicine, Duke University Medical Center, Durham, NC, USA
Gen Hosp Psychiatry 25:238-45. 2003..This information will be helpful to those who may wish to implement this disease management strategy... - Hippocampal volume and antidepressant response in geriatric depressionMing-Hong Hsieh
Chung Shan Medical and Dental College Hospital, Taiwan
Int J Geriatr Psychiatry 17:519-25. 2002.... - The incidence of mental and behavioral disturbances in dementia: the cache county studyMartin Steinberg
Johns Hopkins Hospital, Baltimore, MD 21287, USA
J Neuropsychiatry Clin Neurosci 15:340-5. 2003..These results argue for a routine assessment of psychiatric disturbances in all patients with dementia, even among those who have never experienced symptoms of mental or behavioral disturbances... - Population-based study of medical comorbidity in early dementia and "cognitive impairment, no dementia (CIND)": association with functional and cognitive impairment: The Cache County StudyConstantine G Lyketsos
Division of Geriatric Psychiatry and Neuropsychiatry, Dept of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Johns Hopkins Hospital, Baltimore, MD 21287, USA
Am J Geriatr Psychiatry 13:656-64. 2005..Authors investigated medical comorbidity in persons with dementia and "Cognitive Impairment, No Dementia" (CIND)... - The Aging, Demographics, and Memory Study: study design and methodsKenneth M Langa
Division of General Medicine, Department of Medicine, University of Michigan Health System, 300 North Ingalls Building, Rm 7E01, Box 4029, Ann Arbor, MI 48109, USA
Neuroepidemiology 25:181-91. 2005..We also illustrate potential uses of the ADAMS data and provide information to interested researchers on obtaining ADAMS and HRS data... - White matter and subcortical gray matter lesion volume changes and late-life depression outcome: a 4-year magnetic resonance imaging studyPo See Chen
Institute of Basic Medical Sciences and Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Int Psychogeriatr 18:445-56. 2006..The mechanisms that produce these progressive lesion changes remain unclear. Treatments aimed at arresting lesion progression may play a role in the management of late-life depression... - Three-year incidence of first-onset depressive syndrome in a population sample of older adults: the Cache County studyMaria C Norton
Department of Family, Consumer and Human Development, Utah State University, Logan, 84322, USA
Am J Geriatr Psychiatry 14:237-45. 2006.... - Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depressionJae Nam Bae
Department of Psychiatry, Inha University Hospital, Incheon, South Korea
Biol Psychiatry 60:1356-63. 2006..These findings support the hypothesis that altered connectivity between brain regions contributes to the risk of depression... - Persistent mild cognitive impairment in geriatric depressionJung Sik Lee
Yong In Mental Hospital, Yong In, Korea
Int Psychogeriatr 19:125-35. 2007.... - Are microvascular abnormalities in the retina associated with depression symptoms? The Cardiovascular Health StudyCong Sun
Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
Am J Geriatr Psychiatry 15:335-43. 2007..Depression has been linked with vascular risk factors and stroke. The authors examined the relationship between retinal microvascular abnormalities and depression symptoms in an elderly population... - Hippocampal volumes and depression subtypesDaniel L Greenberg
Psychology Research, VA Boston Healthcare System, Boston, MA 02130, USA
Psychiatry Res 163:126-32. 2008..We conducted cross-sectional and longitudinal analyses of hippocampal volumes in atypical depressive, melancholic depressive, and control subjects. We found no effect of depression subtype on hippocampal volume or memory performance...
Research Grants
- Midcareer Investigator Award in Geriatric DepressionDavid Steffens; Fiscal Year: 2007This application seeks funding for a K24 Career Award in Patient-Oriented Research. The candidate, Dr. David Steffens, is Associate Professor of Psychiatry and Medicine at Duke University Medical Center, where he serves as the Head of the ..
- Geriatric Depression: Risk Factors for Adverse OutcomesDavid C Steffens; Fiscal Year: 2010..Finally, it will be the first prospective longitudinal study in depression to correlate clinical in vivo data on well characterized patients with subsequent post-mortem morphometric analyses. ..
- Geriatric Depression: Risk Factors for Adverse OutcomesDavid Steffens; Fiscal Year: 2009..Finally, it will be the first prospective longitudinal study in depression to correlate clinical in vivo data on well characterized patients with subsequent post-mortem morphometric analyses. ..
- Tryptophan Metabolism, Genes, and Major DepressionDavid Steffens; Fiscal Year: 2007..Results from this study will help inform future treatment studies using genetics and metabolomic technology. ..
- PREMIER Mental Health Interventions Training ProgramDavid Steffens; Fiscal Year: 2007..By the end of two years of training, each fellow will have extensive experience and training in clinical trials that will enable them to obtain appointments as junior faculty. ..
- Geriatric Depression: Risk Factors for Adverse OutcomesDavid Steffens; Fiscal Year: 2007..Finally, it will be the first prospective longitudinal study in depression to correlate clinical in vivo data on well characterized patients with subsequent post-mortem morphometric analyses. ..
- Geriatric Depression: Risk Factors for Adverse OutcomesDavid Steffens; Fiscal Year: 2006..abstract_text> ..
- GERIATRIC DEPRESSION--RISK FACTORS FOR ADVERSE OUTCOMEDavid Steffens; Fiscal Year: 2000..Results in this clinical population will be valuable for comparison with epidemiological data. This project benefits from the resources of the Duke Mental Health Clinical Research Center for essential support. ..
- Geriatric Depression: Risk Factors for Adverse OutcomesDavid C Steffens; Fiscal Year: 2011..Finally, it will be the first prospective longitudinal study in depression to correlate clinical in vivo data on well characterized patients with subsequent post-mortem morphometric analyses. ..