D C Steffens

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Magnetic resonance imaging signal hypointensity and iron content of putamen nuclei in elderly depressed patients
    D C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychiatry Res 83:95-103. 1998
  2. ncbi request reprint Disability in geriatric depression
    D C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 7:34-40. 1999
  3. ncbi request reprint Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging
    C G Lyketsos
    Neuropsychiatry Service, Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Am J Psychiatry 157:708-14. 2000
  4. pmc The COMT Val158Met polymorphism and cognition in depressed and nondepressed older adults
    G G Potter
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710 3925, USA
    Int J Geriatr Psychiatry 24:1127-33. 2009
  5. pmc Impact of BDNF Val66Met and 5-HTTLPR polymorphism variants on neural substrates related to sadness and executive function
    L Wang
    Brain Imaging and Analysis Center, Duke University, Durham, NC, USA
    Genes Brain Behav 11:352-9. 2012
  6. pmc BDNF Val66Met genotype and 6-month remission rates in late-life depression
    W D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Pharmacogenomics J 11:146-54. 2011
  7. pmc Angiotensin receptor gene polymorphisms and 2-year change in hyperintense lesion volume in men
    W D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Mol Psychiatry 15:816-22. 2010
  8. pmc Neuropsychological correlates of magnetic resonance imaging-defined subcortical ischemic depression
    G G Potter
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710 3925, USA
    Int J Geriatr Psychiatry 24:219-25. 2009
  9. ncbi request reprint Does social support buffer functional decline in elderly patients with unipolar depression?
    J C Hays
    Center for the Study of Aging and Human Development, Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Am J Psychiatry 158:1850-5. 2001
  10. ncbi request reprint Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias
    B L Plassman
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Neurology 55:1158-66. 2000

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Magnetic resonance imaging signal hypointensity and iron content of putamen nuclei in elderly depressed patients
    D C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychiatry Res 83:95-103. 1998
    ..Our findings support previous neuroimaging studies linking both changes in the basal ganglia and greater left-sided brain pathology to late-life depression...
  2. ncbi request reprint Disability in geriatric depression
    D C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 7:34-40. 1999
    ..Clinicians should be aware that substantial IADL impairment may accompany mild cognitive impairment associated with depression in older patients...
  3. ncbi request reprint Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging
    C G Lyketsos
    Neuropsychiatry Service, Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Am J Psychiatry 157:708-14. 2000
    ..The authors report findings from a study of 5,092 community residents who constituted 90% of the elderly resident population of Cache County, Utah...
  4. pmc The COMT Val158Met polymorphism and cognition in depressed and nondepressed older adults
    G G Potter
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710 3925, USA
    Int J Geriatr Psychiatry 24:1127-33. 2009
    ..The objective of the current study was to examine the relationship between the COMT Val(158)Met polymorphism and neuropsychological performance in depressed and nondepressed older adults...
  5. pmc Impact of BDNF Val66Met and 5-HTTLPR polymorphism variants on neural substrates related to sadness and executive function
    L Wang
    Brain Imaging and Analysis Center, Duke University, Durham, NC, USA
    Genes Brain Behav 11:352-9. 2012
    ..Our results indicate that the Met allele alone or in combination with 5-HTTLPR S allele may increase reactivity to sad stimuli, which might represent a neural mechanism underlying increased depression vulnerability...
  6. pmc BDNF Val66Met genotype and 6-month remission rates in late-life depression
    W D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Pharmacogenomics J 11:146-54. 2011
    ..Thus in this exploratory analysis, the Met66 allele may be associated with increased odds of remission in older subjects, but also with increased time to remission as there was no 3-month effect...
  7. pmc Angiotensin receptor gene polymorphisms and 2-year change in hyperintense lesion volume in men
    W D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Mol Psychiatry 15:816-22. 2010
    ....
  8. pmc Neuropsychological correlates of magnetic resonance imaging-defined subcortical ischemic depression
    G G Potter
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710 3925, USA
    Int J Geriatr Psychiatry 24:219-25. 2009
    ..The goal of the current study was to examine the neuropsychological profile of magnetic resonance imaging (MRI)-defined subcortical ischemic depression (SID)...
  9. ncbi request reprint Does social support buffer functional decline in elderly patients with unipolar depression?
    J C Hays
    Center for the Study of Aging and Human Development, Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Am J Psychiatry 158:1850-5. 2001
    ..This study tested whether social support protects against functional decline, either generally or selectively, in the most severely depressed elderly patients undergoing treatment for major depressive disorder...
  10. ncbi request reprint Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias
    B L Plassman
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Neurology 55:1158-66. 2000
    ..The association between antecedent head injury and AD is inconsistent...
  11. ncbi request reprint Severity of subcortical gray matter hyperintensity predicts ECT response in geriatric depression
    D C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    J ECT 17:45-9. 2001
    ..To determine the effect of subcortical white and gray matter lesions on ECT outcome...
  12. ncbi request reprint Neuropsychiatric disturbance in Alzheimer's disease clusters into three groups: the Cache County study
    C G Lyketsos
    Neuropsychiatry Service, Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, USA
    Int J Geriatr Psychiatry 16:1043-53. 2001
    ..We investigated the frequency and inter-relationship of neuropsychiatric disturbances in a population sample of persons suffering from Alzheimer's disease (AD)...
  13. ncbi request reprint MRI correlates of suicide attempt history in unipolar depression
    E P Ahearn
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham 900 Ridgefield Drive, Raleigh, North Carolina 27609, USA
    Biol Psychiatry 50:266-70. 2001
    ..Gray matter hyperintensities in the basal ganglia may be especially associated with risk for suicide attempts...
  14. ncbi request reprint Relation of subjective and received social support to clinical and self-report assessments of depressive symptoms in an elderly population
    B H Brummett
    Department of Psychiatry and Behavioral Sciences Duke University Medical Center, Box 2969, 27710, Durham, NC, USA
    J Affect Disord 61:41-50. 2000
    ..The present study also used a multi-measure approach to assess both depressive symptomatology and social support...
  15. pmc A review of racial differences in geriatric depression: implications for care and clinical research
    D C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Natl Med Assoc 89:731-6. 1997
    ..Future attempts at both treatment and clinical research recruitment efforts are needed to address these possibilities...
  16. ncbi request reprint Evidence of white matter tract disruption in MRI hyperintensities
    W D Taylor
    Department of Psychiatry, Duke University, Durham, North Carolina 27710, USA
    Biol Psychiatry 50:179-83. 2001
    ..CONCLUSIONS: Hyperintensities damage the structure of brain tissue, and do so comparably in depressed subjects and control subjects...
  17. pmc A functional alternative splicing mutation in human tryptophan hydroxylase-2
    X Zhang
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Mol Psychiatry 16:1169-76. 2011
    ..However, in combination with other gene variants linked to 5-HT homeostasis, this variant may exhibit important epistatic influences...
  18. ncbi request reprint Bupropion SR in the naturalistic treatment of elderly patients with major depression
    D C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Int J Geriatr Psychiatry 16:862-5. 2001
    ..Controlled randomized studies to establish the long-term efficacy and optimal dose of the newer antidepressants in geriatric depression are urgently needed...
  19. ncbi request reprint Performance feedback deficit in geriatric depression
    D C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Biol Psychiatry 50:358-63. 2001
    ..CONCLUSIONS: These results extend previous findings suggesting a performance feedback deficit in geriatric depression. The findings support previous studies linking the orbital frontal cortex and depression...
  20. ncbi request reprint Initial evaluation of suspected dementia. Asking the right questions
    D C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina 27710, USA
    Postgrad Med 106:72-6, 79-80, 82-3. 1999
    ..Genetic testing for the APOE epsilon 4 allele can help confirm the diagnosis in patients with late-onset familial or sporadic Alzheimer's disease...
  21. pmc Prevalence of dementia in the United States: the aging, demographics, and memory study
    B L Plassman
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27701, USA
    Neuroepidemiology 29:125-32. 2007
    ..To estimate the prevalence of Alzheimer's disease (AD) and other dementias in the USA using a nationally representative sample...
  22. ncbi request reprint Age effects of coronary artery bypass graft on cognitive status change among elderly male twins
    G G Potter
    Department of Psychiatry and Behavioral Sciences, Duke University, Program in Epidemiology of Dementia, 905 W Main St, Box 41 Suite 25 D, Durham, NC 27701, USA
    Neurology 63:2245-9. 2004
    ..Research regarding long-term cognitive outcome following coronary artery bypass graft (CABG) is inconsistent, which may be due in part to differential genetic and environmental influences within most study samples...
  23. ncbi request reprint Risk factors for neuropsychiatric symptoms in dementia: the Cache County Study
    M Steinberg
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Int J Geriatr Psychiatry 21:824-30. 2006
    ..To investigate the probability of individual neuropsychiatric symptoms in dementia patients as a function of eight risk factors...
  24. ncbi request reprint Geriatric depression and cognitive impairment
    D C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychol Med 38:163-75. 2008
    ..Clinicians are encouraged to develop proactive approaches for treatment, which may include combinations of pharmacological and psychotherapeutic interventions...
  25. ncbi request reprint Apolipoprotein E genotype and major depression in a community of older adults. The Cache County Study
    D C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychol Med 33:541-7. 2003
    ..The role of allelic variation in APOE, the genetic locus for apolipoprotein E, in geriatric depression is poorly understood. There are conflicting reports as to an association between the epsilon4 allele and depression in late life...