H M Stapleton

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi Polybrominated diphenyl ether flame retardants in the North American environment
    Robert C Hale
    Department of Environmental and Aquatic Animal Health, Virginia Institute of Marine Science, College of William and Mary, 1208 Greate Road, Gloucester Point, VA 23062, USA
    Environ Int 29:771-9. 2003
  2. ncbi Novel and high volume use flame retardants in US couches reflective of the 2005 PentaBDE phase out
    Heather M Stapleton
    Nicholas School of the Environment, Duke University, Durham, North Carolina, USA
    Environ Sci Technol 46:13432-9. 2012
  3. ncbi Serum PBDEs in a North Carolina toddler cohort: associations with handwipes, house dust, and socioeconomic variables
    Heather M Stapleton
    Nicholas School of the Environment, Duke University, Durham, North Carolina 27708, USA
    Environ Health Perspect 120:1049-54. 2012
  4. ncbi Measurement of polybrominated diphenyl ethers on hand wipes: estimating exposure from hand-to-mouth contact
    Heather M Stapleton
    Nicholas School of the Environment and Earth Sciences, Duke University, Durham, North Carolina 27708, USA
    Environ Sci Technol 42:3329-34. 2008
  5. ncbi Serum levels of polybrominated diphenyl ethers (PBDEs) in foam recyclers and carpet installers working in the United States
    Heather M Stapleton
    Nicholas School of the Environment and Earth Sciences, Duke University, LSRC Box 90328, Durham, North Carolina 27708, USA
    Environ Sci Technol 42:3453-8. 2008
  6. ncbi Alternate and new brominated flame retardants detected in U.S. house dust
    Heather M Stapleton
    Nicholas School of the Environment and Earth Sciences, Duke University, Durham, North Carolina, USA
    Environ Sci Technol 42:6910-6. 2008
  7. ncbi Metabolism of polybrominated diphenyl ethers (PBDEs) by human hepatocytes in vitro
    Heather M Stapleton
    Nicholas School of the Environment, Duke University, Durham, North Carolina 27708, USA
    Environ Health Perspect 117:197-202. 2009
  8. ncbi Detection of organophosphate flame retardants in furniture foam and U.S. house dust
    Heather M Stapleton
    Nicholas School of the Environment, Duke University, Durham, North Carolina, USA
    Environ Sci Technol 43:7490-5. 2009
  9. ncbi Identification of flame retardants in polyurethane foam collected from baby products
    Heather M Stapleton
    Nicholas School of the Environment, Duke University, Durham, North Carolina, USA
    Environ Sci Technol 45:5323-31. 2011
  10. ncbi Associations between polybrominated diphenyl ether (PBDE) flame retardants, phenolic metabolites, and thyroid hormones during pregnancy
    Heather M Stapleton
    Nicholas School of the Environment, Duke University, Durham, North Carolina, USA
    Environ Health Perspect 119:1454-9. 2011

Detail Information

Publications28

  1. ncbi Polybrominated diphenyl ether flame retardants in the North American environment
    Robert C Hale
    Department of Environmental and Aquatic Animal Health, Virginia Institute of Marine Science, College of William and Mary, 1208 Greate Road, Gloucester Point, VA 23062, USA
    Environ Int 29:771-9. 2003
    ..This lack of redistribution is likely due to its extremely low volatility and water solubility. Penta-BDE and Deca-BDE products are used in different applications and this may also be a factor controlling their environmental release...
  2. ncbi Novel and high volume use flame retardants in US couches reflective of the 2005 PentaBDE phase out
    Heather M Stapleton
    Nicholas School of the Environment, Duke University, Durham, North Carolina, USA
    Environ Sci Technol 46:13432-9. 2012
    ..Given these results, and the potential for human exposure to FRs, health studies should be conducted on the types of FRs identified here...
  3. ncbi Serum PBDEs in a North Carolina toddler cohort: associations with handwipes, house dust, and socioeconomic variables
    Heather M Stapleton
    Nicholas School of the Environment, Duke University, Durham, North Carolina 27708, USA
    Environ Health Perspect 120:1049-54. 2012
    ..Polybrominated diphenyl ethers (PBDEs) are persistent, bioaccumulative, and endocrine-disrupting chemicals...
  4. ncbi Measurement of polybrominated diphenyl ethers on hand wipes: estimating exposure from hand-to-mouth contact
    Heather M Stapleton
    Nicholas School of the Environment and Earth Sciences, Duke University, Durham, North Carolina 27708, USA
    Environ Sci Technol 42:3329-34. 2008
    ..These estimates are greater than dietary intake rates and suggest hand-to-mouth contact may be a key exposure route for PBDEs...
  5. ncbi Serum levels of polybrominated diphenyl ethers (PBDEs) in foam recyclers and carpet installers working in the United States
    Heather M Stapleton
    Nicholas School of the Environment and Earth Sciences, Duke University, LSRC Box 90328, Durham, North Carolina 27708, USA
    Environ Sci Technol 42:3453-8. 2008
    ..e., carpet padding), have higher body burdens of PBDEs, and thus may be at higher risk from adverse health effects associated with brominated flame retardant exposure...
  6. ncbi Alternate and new brominated flame retardants detected in U.S. house dust
    Heather M Stapleton
    Nicholas School of the Environment and Earth Sciences, Duke University, Durham, North Carolina, USA
    Environ Sci Technol 42:6910-6. 2008
    ..This study highlights the fact that numerous types of brominated flame retardants are present in indoor environments, raising questions about exposure to mixtures of these contaminants...
  7. ncbi Metabolism of polybrominated diphenyl ethers (PBDEs) by human hepatocytes in vitro
    Heather M Stapleton
    Nicholas School of the Environment, Duke University, Durham, North Carolina 27708, USA
    Environ Health Perspect 117:197-202. 2009
    ..Concentrations of PBDEs in human tissues have increased recently, and body burdens in the U.S. and Canadian populations are higher than in any other region...
  8. ncbi Detection of organophosphate flame retardants in furniture foam and U.S. house dust
    Heather M Stapleton
    Nicholas School of the Environment, Duke University, Durham, North Carolina, USA
    Environ Sci Technol 43:7490-5. 2009
    ..The high prevalence of these chemicals in foam and the high concentrations measured in dust (as high as 1.8 mg/g) warrant further studies to evaluate potential health effects from dust exposure, particularly for children...
  9. ncbi Identification of flame retardants in polyurethane foam collected from baby products
    Heather M Stapleton
    Nicholas School of the Environment, Duke University, Durham, North Carolina, USA
    Environ Sci Technol 45:5323-31. 2011
    ..Future studies are therefore warranted to specifically measure infants exposure to these flame retardants from intimate contact with these products and to determine if there are any associated health concerns...
  10. ncbi Associations between polybrominated diphenyl ether (PBDE) flame retardants, phenolic metabolites, and thyroid hormones during pregnancy
    Heather M Stapleton
    Nicholas School of the Environment, Duke University, Durham, North Carolina, USA
    Environ Health Perspect 119:1454-9. 2011
    ..Polybrominated diphenyl ethers (PBDEs) are chemical additives used as flame retardants in commercial products. PBDEs are bioaccumulative and persistent and have been linked to several adverse health outcomes...
  11. ncbi Photodegradation of decabromodiphenyl ether in house dust by natural sunlight
    Heather M Stapleton
    Duke University, Nicholas School of the Environment and Earth Sciences, Durham, NC 27708, USA
    Environ Toxicol Chem 27:306-12. 2008
    ..The ratio of BDE 197 to BDE 201 may also be indicative of BDE 209 degradation. as the ratio of these two congeners appeared to reach a steady-state value (~1) in both exposure scenarios in the present study...
  12. ncbi In vivo and in vitro debromination of decabromodiphenyl ether (BDE 209) by juvenile rainbow trout and common carp
    Heather M Stapleton
    Duke University, Nicholas School of the Environment and Earth Sciences, Durham, North Carolina, USA
    Environ Sci Technol 40:4653-8. 2006
    ..In contrast, carp liver microsomes biotransformed up to 65% of the BDE 209 mass, primarily down to hexaBDE congeners. These microsomal incubations confirm a metabolic pathway for BDE 209 debromination...
  13. ncbi Determination of polybrominated diphenyl ethers in indoor dust standard reference materials
    Heather M Stapleton
    Analytical Chemistry Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    Anal Bioanal Chem 384:791-800. 2006
    ..These SRMs are the first reference materials with certified concentrations for PBDEs, which will aid in validating future measurements of PBDEs in house dust and other similar matrices...
  14. ncbi Determination of HBCD, PBDEs and MeO-BDEs in California sea lions (Zalophus californianus) stranded between 1993 and 2003
    H M Stapleton
    Analytical Chemistry Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    Mar Pollut Bull 52:522-31. 2006
    ..In addition, HBCD concentrations appear to be increasing in California sea lion populations, whereas PBDE concentrations, between 1993 and 2003, were highly variable...
  15. ncbi Polybrominated diphenyl ethers in house dust and clothes dryer lint
    Heather M Stapleton
    National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA
    Environ Sci Technol 39:925-31. 2005
    ..This study demonstrates that PBDEs are prevalent at relatively high concentrations within homes where people, and particularly young children, may be susceptible to exposure...
  16. ncbi Ultraviolet treatment and biodegradation of dibenzothiophene: Identification and toxicity of products
    Ellen M Cooper
    Duke University Nicholas School of the Environment, Durham, North Carolina 27708, USA
    Environ Toxicol Chem 29:2409-16. 2010
    ..The novel approach of combined biodegradation/UV treatment is promising, although further research is needed to reduce toxicity in the case of DBT...
  17. ncbi Certification of SRM 1589a PCBs, pesticides, PBDEs, and dioxins/furans in human serum
    Michele M Schantz
    Analytical Chemistry Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    Anal Bioanal Chem 389:1201-8. 2007
    ....
  18. ncbi Characterizing the in vitro hepatic biotransformation of the flame retardant BDE 99 by common carp
    Pamela D Noyes
    Duke University, Nicholas School of the Environment, Integrated Toxicology and Environmental Health Program, Durham, NC, USA
    Aquat Toxicol 97:142-50. 2010
    ..Further studies are needed to evaluate metabolic activity in other species and tissues that contain these enzymes...
  19. ncbi Persistent organic pollutants in two dolphin species with focus on toxaphene and polybrominated diphenyl ethers
    Karen J S Tuerk
    National Institute of Standards and Technology, Hollings Marine Laboratory, Charleston, South Carolina 29412, USA
    Environ Sci Technol 39:692-8. 2005
    ..acutus or that concentrations have already peaked in this species prior to the first collection in 1993...
  20. ncbi Photodegradation pathways of nonabrominated diphenyl ethers, 2-ethylhexyltetrabromobenzoate and di(2-ethylhexyl)tetrabromophthalate: identifying potential markers of photodegradation
    Elizabeth F Davis
    Duke University, Nicholas School of the Environment, Durham, North Carolina 27708, USA
    Environ Sci Technol 43:5739-46. 2009
    ..Both TBB and TBPH underwent photolysis more slowly than nonaBDEs (half-lives ranging from 85.70 to 220.17 min) and primarily formed debrominated products...
  21. ncbi Analysis of the flame retardant metabolites bis(1,3-dichloro-2-propyl) phosphate (BDCPP) and diphenyl phosphate (DPP) in urine using liquid chromatography-tandem mass spectrometry
    E M Cooper
    Nicholas School of the Environment, Duke University, Durham, NC 27708, USA
    Anal Bioanal Chem 401:2123-32. 2011
    ..The presented method is simple and sufficiently sensitive to detect these FR metabolites in humans and may be applied to future studies to increase our understanding of exposure to and potential health effects from FRs...
  22. ncbi Dietary accumulation and metabolism of polybrominated diphenyl ethers by juvenile carp (Cyprinus carpio)
    Heather M Stapleton
    Chesapeake Biological Laboratory, University of Maryland Center for Environmental Science, Solomons, Maryland 20688, USA
    Environ Toxicol Chem 23:1939-46. 2004
    ..This study suggests that BDEs have significantly different fate dynamics relative to PCBs in wild carp and likely other species of fish...
  23. ncbi Debromination of the flame retardant decabromodiphenyl ether by juvenile carp (Cyprinus carpio) following dietary exposure
    Heather M Stapleton
    Chesapeake Biological Laboratory, University of Maryland Center for Environmental Science, Solomons, Maryland 20688, USA
    Environ Sci Technol 38:112-9. 2004
    ..Although exposure of carp to BDE 209 did not result in the accumulation of BDE 209 in carp tissues, our results indicate evidence of limited BDE 209 bioavailability from food in the form of lower brominated metabolites...
  24. ncbi Debromination of polybrominated diphenyl ether congeners BDE 99 and BDE 183 in the intestinal tract of the common carp (Cyprinus carpio)
    Heather M Stapleton
    Chesapeake Biological Laboratory, University of Maryland, Center for Environmental Science, Solomons, Maryland 20688, USA
    Environ Sci Technol 38:1054-61. 2004
    ..Reactions occurring within the gut transform BDE congeners to other products that may accumulate or be excreted. Further studies are needed to identify and determine the effects of these BDE metabolites...
  25. ncbi Personal exposure to polybrominated diphenyl ethers (PBDEs) in residential indoor air
    Joseph G Allen
    Department of Environmental Health, Boston University School of Public Health, 715 Albany Street, Boston, Massachusetts 02118, USA
    Environ Sci Technol 41:4574-9. 2007
    ..045) and BDE 209 (r = 0.58, p = 0.008). Use of personal air concentrations increased estimates of inhalation exposure over those previously reported. Inhalation may account for up to 22% of the total BDE 209 exposure in U.S. adults...
  26. ncbi Linking PBDEs in house dust to consumer products using X-ray fluorescence
    Joseph G Allen
    Environmental Health and Engineering, Inc, 117 Fourth Avenue, Needham, Massachusetts 02494, USA
    Environ Sci Technol 42:4222-8. 2008
    ..005), a potential surrogate for television usage...
  27. ncbi Comparative absorption and bioaccumulation of polybrominated diphenyl ethers following ingestion via dust and oil in male rats
    Janice K Huwe
    United States Department of Agriculture, Agricultural Research Service Biosciences Research Laboratory, Fargo, North Dakota 58105, USA
    Environ Sci Technol 42:2694-700. 2008
    ..The present study shows that PBDEs in dust are readily bioavailable and are biologically active, as indicated by increased transcription of hepatic enzymes...
  28. ncbi Debromination of polybrominated diphenyl ether-99 (BDE-99) in carp (Cyprinus carpio) microflora and microsomes
    Rae T Benedict
    University of Maryland Center for Environmental Science, Chesapeake Biological Laboratory, P O Box 38, Solomons, MD 20688, USA
    Chemosphere 69:987-93. 2007
    ....