Research Topics
Genomes and GenesSpecies | Mark Stafford-SmithSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Publications
The association of epsilon-aminocaproic acid with postoperative decrease in creatinine clearance in 1502 coronary bypass patientsM Stafford-Smith
Departments of Anesthesiology and Medicine Division of Nephrology, Duke University Medical Center, Durham, North Carolina 27710, USA
Anesth Analg 91:1085-90. 2000....
Association of genetic polymorphisms with risk of renal injury after coronary bypass graft surgeryMark Stafford-Smith
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
Am J Kidney Dis 45:519-30. 2005..Therefore, we tested the hypothesis that selected gene variants are associated with acute renal injury, reflected by a serum creatinine level increase after cardiac surgery...
Renal medullary hypoxia during experimental cardiopulmonary bypass: a pilot studyMark Stafford-Smith
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
Perfusion 20:53-8. 2005..To determine the effect of cardiopulmonary bypass (CPB) on renal medullary oxygenation...
Evidence-based renal protection in cardiac surgeryMark Stafford-Smith
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
Semin Cardiothorac Vasc Anesth 9:65-76. 2005....
Invited commentaryMark Stafford-Smith
Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA
Ann Thorac Surg 80:2153-4. 2005
Invited commentaryMark Stafford-Smith
Department of Anesthesiology, Duke University Medical Center, Box 3094 DUMC, Durham, NC27710, USA
Ann Thorac Surg 86:11-2. 2008
Invited commentaryMark Stafford-Smith
Department of Anesthesiology, Duke University Medical Center, Box 3094 DUMC, Durham, NC 27710, USA
Ann Thorac Surg 82:1488. 2006
Heart and kidneys: sharing more than just bloodMark Stafford-Smith
Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Curr Opin Anaesthesiol 20:65-9. 2007..To describe the relationship of renal disease and metabolic syndrome with cardiovascular disease and explore the role of toxic solutes retained due to renal impairment as mediators of cardiovascular risk...
The association of lowest hematocrit during cardiopulmonary bypass with acute renal injury after coronary artery bypass surgeryMadhav Swaminathan
Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Ann Thorac Surg 76:784-91; discussion 792. 2003..Therefore we tested the hypothesis that lowest hematocrit during CPB is independently associated with acute renal injury after cardiac surgery...
Alpha-adrenergic mRNA subtype expression in the human nasal turbinateMark Stafford-Smith
Department of Anesthesiology, Duke University Medical Center, DUMC, Durham, NC 27710, USA
Can J Anaesth 54:549-55. 2007..We, therefore, investigated alphaAR subtype expression in human nasal turbinate within epithelial, duct, gland, and vessel cells using in situ hybridization...
Efficacy and safety of heparinase I versus protamine in patients undergoing coronary artery bypass grafting with and without cardiopulmonary bypassMark Stafford-Smith
Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Anesthesiology 103:229-40. 2005..As an alternative to protamine, the authors examined heparinase I reversal of heparin after aortocoronary bypass graft surgery...
Many, but not all, outcome studies support exclusion of female plasma from the blood supplyMark Stafford-Smith
Duke University Medical Center, Box 3094 DUMC, Durham, NC 27710, USA
Expert Rev Hematol 3:551-8. 2010....
Cardiac surgery and acute kidney injury: emerging conceptsMark Stafford-Smith
Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Curr Opin Crit Care 15:498-502. 2009..To review recent advances in understanding of the occurrence, pathophysiology, prophylaxis and treatment of cardiac surgery-associated acute kidney injury (AKI)...
Invited commentaryMark Stafford-Smith
Department of Anesthesiology, Duke University Medical Center, Box 3094 DUMC, Durham, NC 27710, USA
Ann Thorac Surg 86:1165-6. 2008
Acute kidney injury and chronic kidney disease after cardiac surgeryMark Stafford-Smith
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
Adv Chronic Kidney Dis 15:257-77. 2008....
Association of the 98T ELAM-1 polymorphism with increased bleeding after cardiac surgeryIan J Welsby
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
J Cardiothorac Vasc Anesth 24:427-33. 2010..The authors tested the hypothesis that genetic polymorphisms of inflammatory mediators and cellular adhesion molecules are associated with bleeding after cardiac surgery...
Preliminary report on the interaction of apolipoprotein E polymorphism with aortic atherosclerosis and acute nephropathy after CABGG Burkhard Mackensen
Division of Cardiothoracic Anesthesia and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
Ann Thorac Surg 78:520-6. 2004..We hypothesized that patients with and without the epsilon4 allele (E4/non-E4) would have different associations between atheroma burden and postoperative renal dysfunction...
Cognitive function after major noncardiac surgery, apolipoprotein E4 genotype, and biomarkers of brain injuryDavid L McDonagh
Department of Anesthesiology and Medicine, Division of Cardiothoracic Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Anesthesiology 112:852-9. 2010..Identified risk factors are largely limited to demographic characteristics. We hypothesized that POCD was associated with apolipoprotein E4 (APOE4) genotype and plasma biomarkers of brain injury and inflammation...
Increasing healthcare resource utilization after coronary artery bypass graft surgery in the United StatesMadhav Swaminathan
Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
Circ Cardiovasc Qual Outcomes 2:305-12. 2009..Our objective was to determine patterns of discharge disposition after CABG surgery in the United States...
Genetic variants in P-selectin and C-reactive protein influence susceptibility to cognitive decline after cardiac surgeryJoseph P Mathew
Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina
J Am Coll Cardiol 49:1934-42. 2007....
Predictors of cognitive recovery after cardiac surgeryMonique T Fontes
MHSC, Duke University Medical Center, Division of Cardiothoracic Anesthesiology and Critical Care Medicine, P O Box 3094, Durham, NC 27710
Anesth Analg 116:435-42. 2013..Although predictors of cognitive injury have been well examined, factors that modulate recovery have not. We sought to determine the predictors of cognitive recovery after initial injury following cardiac surgery...
Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in menRedford B Williams
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
Psychosom Med 72:601-7. 2010....
Glycosylated hemoglobin levels and outcome in non-diabetic cardiac surgery patientsChristopher C C Hudson
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
Can J Anaesth 57:565-72. 2010..Therefore, in a cohort of non-diabetic patients, we tested the hypothesis that preoperative HbA1c is associated with early mortality risk after cardiac surgery...
The effect of aprotinin on outcome after coronary-artery bypass graftingAndrew D Shaw
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27516, USA
N Engl J Med 358:784-93. 2008..Aprotinin has recently been associated with adverse outcomes in patients undergoing cardiac surgery. We reviewed our experience with this agent in patients undergoing cardiac surgery at Duke University Medical Center...
Impact of early renal recovery on survival after cardiac surgery-associated acute kidney injuryMadhav Swaminathan
Division of Cardiothoracic Anesthesiology, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Ann Thorac Surg 89:1098-104. 2010..Although some early recovery is common, its effect on long-term outcomes is unclear. We tested the hypothesis that early renal recovery after CSA-AKI is independently associated with improved long-term survival...
Intraoperative systolic blood pressure variability predicts 30-day mortality in aortocoronary bypass surgery patientsSolomon Aronson
Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA parallel
Anesthesiology 113:305-12. 2010..We tested the hypothesis that intraoperative systolic blood pressure variability outside a targeted blood pressure range predicts 30-day mortality in patients undergoing cardiac surgery...
Mortality trends associated with acute renal failure requiring dialysis after CABG surgery in the United StatesAlina Nicoara
Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, N C 27710, USA
Blood Purif 28:359-63. 2009..We examined a large nationwide database from 1988 to 2003 and hypothesized that mortality in CABG-associated acute renal failure needing dialysis (ARF-D) had declined during this period...
Relationship of genetic variability and depressive symptoms to adverse events after coronary artery bypass graft surgeryBarbara Phillips-Bute
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
Psychosom Med 70:953-9. 2008..To assess genetic variability in two serotonin-related gene polymorphisms (MAOA-uVNTR and 5HTTLPR) and their relationships to depression and adverse cardiac events in a sample of patients undergoing coronary artery bypass surgery...
Randomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgeryJoseph P Mathew
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
Stroke 40:880-7. 2009..Based on experimental and clinical evidence, this study assessed the potential of intravenously administered lidocaine to reduce postoperative cognitive dysfunction after cardiac surgery using cardiopulmonary bypass...
The relationship of plasma transfusion from female and male donors with outcome after cardiac surgeryIan J Welsby
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
J Thorac Cardiovasc Surg 140:1353-60. 2010..We examined whether plasma donor gender is related to postcardiac surgery pulmonary dysfunction and death or prolonged hospitalization...
Effects of extreme hemodilution during cardiac surgery on cognitive function in the elderlyJoseph P Mathew
Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Anesthesiology 107:577-84. 2007....
Preoperative statin therapy does not reduce cognitive dysfunction after cardiopulmonary bypassJoseph P Mathew
Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
J Cardiothorac Vasc Anesth 19:294-9. 2005....
Trends in cardiac surgery-associated acute renal failure in the United States: a disproportionate increase after heart transplantationSusan M Martinelli
Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Ren Fail 31:633-40. 2009..The disproportionate increase in ARF burden after heart transplantation is a concern due to its strong association with chronic kidney disease and mortality...
Preliminary report on the use of high-fidelity simulation in the training of study coordinators conducting a clinical research protocolJeffrey M Taekman
Department of Anesthesia, Box 3094, Duke University Medical Center, Durham, NC 27710, USA
Anesth Analg 99:521-7, table of contents. 2004..Simulation exercises should be considered when training study coordinators for clinical research trials...
Postcardiac surgery complications: association of acute renal dysfunction and atrial fibrillationMaher J Albahrani
Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Anesth Analg 96:637-43, table of contents. 2003..This interaction suggests that a common etiology for these two complications may be more important in younger patients...
Transcranial Doppler emboli count predicts rise in creatinine after coronary artery bypass graft surgeryGautam M Sreeram
Department of Anesthesiology, Duke Heart Center, Duke University Medical Center, Durham, NC, USA
J Cardiothorac Vasc Anesth 18:548-51. 2004..To examine the correlation between transcranial Doppler ultrasonography-detected emboli during coronary artery bypass graft surgery with cardiopulmonary bypass and renal dysfunction as determined by the postoperative change in creatinine...
Utility of concomitant tricuspid valve procedures for patients undergoing implantation of a continuous-flow left ventricular deviceValentino Piacentino
Division of Cardiac and Thoracic Surgery, Duke University Medical Center, Durham, NC, USA
J Thorac Cardiovasc Surg 144:1217-21. 2012..The objective of this report is to examine early clinical benefits of concomitant tricuspid surgery for these patients...
Serotonin-related gene polymorphisms and central nervous system serotonin functionRedford B Williams
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3926, Durham, NC 27710, USA
Neuropsychopharmacology 28:533-41. 2003....
Pulse pressure and long-term survival after coronary artery bypass graft surgeryNikolay M Nikolov
Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Anesth Analg 110:335-40. 2010..We therefore assessed long-term survival in patients with increased PP at the time of presentation for CABG surgery...
A prospective, double-blind, randomized clinical feasibility trial of controlling the storage age of red blood cells for transfusion in cardiac surgical patientsElliott Bennett-Guerrero
Department of Anesthesiology, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
Transfusion 49:1375-83. 2009..We studied the feasibility of two different schemes for categorizing and randomizing age of RBC units transfused in cardiac surgical patients...
Utility of a simple algorithm to grade diastolic dysfunction and predict outcome after coronary artery bypass graft surgeryMadhav Swaminathan
Department of Anesthesiology, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
Ann Thorac Surg 91:1844-50. 2011....
Renal artery stenosis is not associated with the development of acute renal failure following coronary artery bypass graftingPeter J Conlon
Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
Ren Fail 27:81-6. 2005..We hypothesized that renal artery stenosis (RAS), causing occult renal ischemia, may be an important factor contributing to development of ARF after CABG surgery...
Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunctionMadhav Swaminathan
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
Anesth Analg 95:1-8, table of contents. 2002..Factors responsible for subtle postoperative cognitive dysfunction do not appear to be associated with clinically important renal effects...
A clinical prediction tool to estimate the number of units of red blood cells needed in primary elective coronary artery bypass surgeryIan Welsby
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
Transfusion 50:2337-43. 2010..We hypothesized that a clinical prediction tool could be developed to estimate the number of units of RBCs needed for coronary artery bypass grafting (CABG) surgery...
Efficacy of single-dose, multilevel paravertebral nerve blockade for analgesia after thoracoscopic proceduresSteven E Hill
Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Anesthesiology 104:1047-53. 2006..The purpose of this trial was to compare the efficacy of analgesia from preoperative bupivacaine paravertebral nerve blockade with that from placebo injections...
Emerging concepts in acute kidney injury following cardiac surgeryChristopher Hudson
Department of Anesthesiology Duke University Medical Center, Durham, North Carolina 27710, USA
Semin Cardiothorac Vasc Anesth 12:320-30. 2008..In this review, the focus will be on advances in risk stratification, evolving definitions and improving early diagnosis of AKI, identification of effective individualized therapies, and future directions...
Hemodynamic changes after protamine administration: association with mortality after coronary artery bypass surgeryIan J Welsby
Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA
Anesthesiology 102:308-14. 2005..Although randomized trials are necessary to address causality, this evidence suggests that strategies that avoid or attenuate these reactions may improve patient care...
Cardiac surgery-associated acute kidney injury: putting together the pieces of the puzzleAndrew Shaw
Division of Cardiothoracic Anesthesia and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
Nephron Physiol 109:p55-60. 2008..In this paper, we discuss those aspects of AKI that are particular to cardiac surgery-associated AKI (CSA-AKI), with emphasis on recent advances in the field...
Trends in acute renal failure associated with coronary artery bypass graft surgery in the United StatesMadhav Swaminathan
Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA
Crit Care Med 35:2286-91. 2007..Based on similar observations in other clinical settings, we tested the hypothesis that the diagnosis of acute renal failure associated with coronary artery bypass graft surgery is increasing in the United States...
The association between duration of storage of transfused red blood cells and morbidity and mortality after reoperative cardiac surgerySukhjeewan Basran
Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, USA
Anesth Analg 103:15-20, table of contents. 2006..The duration of storage of RBCs is associated with adverse outcome after repeat sternotomy for cardiac surgery. The clinical significance of this finding should be investigated in a large, randomized, blinded clinical trial...
Activated clotting time systems vary in precision and bias and are not interchangeable when following heparin management protocols during cardiopulmonary bypassIan J Welsby
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
J Clin Monit Comput 17:287-92. 2002..A secondary objective was to evaluate the potential impact of any change in ACT measurement on heparin requirements during cardiopulmonary bypass (CPB)...
Mitral valve surgery and acute renal injury: port access versus median sternotomyBrian J McCreath
Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Ann Thorac Surg 75:812-9. 2003..Our findings suggest that a port access minithoracotomy approach to mitral valve surgery may be preferable to conventional methods for patients with high renal risk...
ABO blood group and bleeding after coronary artery bypass graft surgeryIan J Welsby
Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA
Blood Coagul Fibrinolysis 18:781-5. 2007..In conclusion, although we identified clinical and procedural factors that were independently associated with bleeding, blood group was not one of these factors...
Symmetry aortic connector devices and acute renal injury: a comparison of renal dysfunction after three different aortocoronary bypass surgery techniquesStephanie S F Fischer
Cardiothoracic Division, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Anesth Analg 102:25-31. 2006..We could not find evidence that OPCAB surgery using ACDs reduces acute renal injury compared with standard OPCAB or CABG surgery...
Association of leukocyte-depleted blood transfusions with infectious complications after cardiac surgeryAjeet D Sharma
Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA
Surg Infect (Larchmt) 3:127-33. 2002..However, an increased incidence of postoperative infections was observed to be associated with blood transfusions in general...
The genetic determinants of renal impairment following cardiac surgeryRobert B Yates
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
Semin Cardiothorac Vasc Anesth 10:314-26. 2006..Emphasizing the importance of using genetics to elucidate molecular mechanisms of this disease, this article reviews the current literature on genetic polymorphisms and post cardiac surgery-related renal dysfunction...
Changing systems for measuring activated clotting times: impact on the clinical practice of heparin anticoagulation during cardiac surgeryMathew Patteril
Department of Cardiothoracic Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA
Clin Chim Acta 356:218-24. 2005..Prospective study to determine the effect of Actalyke ACT system monitoring on hemostasis after cardiac surgery is merited...
Clinical impact of concomitant tricuspid valve procedures during left ventricular assist device implantationValentino Piacentino
Duke University Medical Center, Durham, NC, USA
Ann Thorac Surg 92:1414-8; discussion 1418-9. 2011..Preoperative TR is associated with negative outcomes but the clinical benefit of concomitant tricuspid valve procedures has not been extensively studied...
Right ventricular rupture during off-pump coronary bypass surgeryMadhav Swaminathan
Division of Cardiothoracic Anesthesia and Critical Care, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
J Cardiothorac Vasc Anesth 17:87-9. 2003
The use of high-fidelity human patient simulation as an evaluative tool in the development of clinical research protocols and proceduresMelanie C Wright
Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA
Contemp Clin Trials 26:646-59. 2005..Human patient simulation can provide a context for informal expert evaluation of clinical protocol design and for formal "rehearsal" to evaluate the efficacy of procedures and support tools...
Suitability of the lumbar test dose for the thoracic epidural spaceH Mayumi Homi
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
J Cardiothorac Vasc Anesth 20:700-3. 2006
An unexpected intraoperative findingGeorge N Djaiani
Departments of Cardiothoracic Anesthesia, Surgery, and Radiology, Duke University Medical Center, Durham, NC 27710, USA
J Cardiothorac Vasc Anesth 16:382-3. 2002
Monitoring direct thrombin inhibitors: time for standardizationIan J Welsby
Anesthesiology 101:1048-9. 2004
Perioperative blood transfusion and blood conservation in cardiac surgery: the Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists clinical practice guidelineVictor A Ferraris
Ann Thorac Surg 83:S27-86. 2007....
Longitudinal change in the BODE index predicts mortality in severe emphysemaFernando J Martinez
Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0360, USA
Am J Respir Crit Care Med 178:491-9. 2008..We hypothesized that decrease in a modified BODE (mBODE) would predict survival in National Emphysema Treatment Trial (NETT) patients...
End-stage renal disease and intensive care unit prognosis: are current tools good enough?Mark Stafford-Smith
Crit Care Med 36:2939-40. 2008
Lower endotoxin immunity predicts increased cognitive dysfunction in elderly patients after cardiac surgeryJoseph P Mathew
Department of Anesthesiology
Stroke 34:508-13. 2003..Interventions that increase IgM EndoCAb levels might improve cognitive function after cardiac surgery...
Continuous oxygen use in nonhypoxemic emphysema patients identifies a high-risk subset of patients: retrospective analysis of the National Emphysema Treatment TrialMichael B Drummond
Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Chest 134:497-506. 2008..Little is known regarding the clinical characteristics and survival of nonhypoxemic emphysema patients using continuous oxygen. Analysis of data from the National Emphysema Treatment Trial (NETT) offers insight into this population...
Protamine contributes to myocardial ischemiaIan J Welsby
Anesthesiology 103:669; author reply 669-70. 2005
