George G Somjen

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi Low external NaCl concentration and low osmolarity enhance voltage-gated Ca currents but depress K currents in freshly isolated rat hippocampal neurons
    G G Somjen
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 851:189-97. 1999
  2. ncbi Calcium sensitive non-selective cation current promotes seizure-like discharges and spreading depression in a model neuron
    G G Somjen
    Department of Cell Biology, Duke University Medical Center, Box 3011, Durham, NC 27710, USA
    J Comput Neurosci 26:139-47. 2009
  3. ncbi Computer simulations of neuron-glia interactions mediated by ion flux
    G G Somjen
    Department of Cell Biology, Duke University Medical Center, P O Box 3011, Durham, NC 27710, USA
    J Comput Neurosci 25:349-65. 2008
  4. ncbi Ion regulation in the brain: implications for pathophysiology
    George G Somjen
    Department of Cell Biology and Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neuroscientist 8:254-67. 2002
  5. ncbi Mechanisms of spreading depression and hypoxic spreading depression-like depolarization
    G G Somjen
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Physiol Rev 81:1065-96. 2001
  6. ncbi Potassium-induced enhancement of persistent inward current in hippocampal neurons in isolation and in tissue slices
    G G Somjen
    Department of Cell Biology, Box 3709, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 885:102-10. 2000
  7. ncbi Enhancement of persistent sodium current by internal fluorescence in isolated hippocampal neurons
    G G Somjen
    Department of Cell Biology, Box 3709, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 885:94-101. 2000
  8. ncbi Report of the worldwide survey on teaching physiology
    G G Somjen
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Physiol 277:S6-14. 1999
  9. ncbi Simultaneous monitoring of tissue PO2 and NADH fluorescence during synaptic stimulation and spreading depression reveals a transient dissociation between oxygen utilization and mitochondrial redox state in rat hippocampal slices
    Francesca Galeffi
    Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    J Cereb Blood Flow Metab 31:626-39. 2011
  10. ncbi Two different mechanisms underlie reversible, intrinsic optical signals in rat hippocampal slices
    Dmitriy Fayuk
    Department of Cell Biology, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, North Carolina 27710, USA
    J Neurophysiol 87:1924-37. 2002

Collaborators

Detail Information

Publications12

  1. ncbi Low external NaCl concentration and low osmolarity enhance voltage-gated Ca currents but depress K currents in freshly isolated rat hippocampal neurons
    G G Somjen
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 851:189-97. 1999
    ..Depression of outward currents could also contribute to the irritability of the central nervous system typical of clinical hyponatremia...
  2. ncbi Calcium sensitive non-selective cation current promotes seizure-like discharges and spreading depression in a model neuron
    G G Somjen
    Department of Cell Biology, Duke University Medical Center, Box 3011, Durham, NC 27710, USA
    J Comput Neurosci 26:139-47. 2009
    ..The duration of the AD depended on the amplitude of the NSCC. Similarly, NSCC also enabled the generation of SD. We conclude that NSCC can contribute to the generation of epileptiform events and to spreading depression...
  3. ncbi Computer simulations of neuron-glia interactions mediated by ion flux
    G G Somjen
    Department of Cell Biology, Duke University Medical Center, P O Box 3011, Durham, NC 27710, USA
    J Comput Neurosci 25:349-65. 2008
    ....
  4. ncbi Ion regulation in the brain: implications for pathophysiology
    George G Somjen
    Department of Cell Biology and Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neuroscientist 8:254-67. 2002
    ..Computer simulation confirmed that elevation of [K+]o can lead to such a vicious circle and ignite seizures, spreading depression (SD), or hypoxic SD-like depolarization (anoxic depolarization)...
  5. ncbi Mechanisms of spreading depression and hypoxic spreading depression-like depolarization
    G G Somjen
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Physiol Rev 81:1065-96. 2001
    ..Short bouts of SD and HSD are well tolerated, but prolonged depolarization results in lasting loss of neuron function. Irreversible damage can, however, be avoided if Ca(2+) influx into neurons is prevented...
  6. ncbi Potassium-induced enhancement of persistent inward current in hippocampal neurons in isolation and in tissue slices
    G G Somjen
    Department of Cell Biology, Box 3709, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 885:102-10. 2000
    ..Strong depolarization evoked irregular current fluctuations, which were also augmented in high [K(+)](o). The findings support a role of potassium-mediated positive feedback in the generation of seizures and spreading depression...
  7. ncbi Enhancement of persistent sodium current by internal fluorescence in isolated hippocampal neurons
    G G Somjen
    Department of Cell Biology, Box 3709, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 885:94-101. 2000
    ..With membrane potential clamped to a constant voltage, the laser-induced fluorescence did not evoke a membrane current. It is not certain whether fluorescence-induced I(Na,P) potentiation is related to photodynamic action...
  8. ncbi Report of the worldwide survey on teaching physiology
    G G Somjen
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Physiol 277:S6-14. 1999
    ..Free-ranging, sometimes pithy, comments made by the respondents have been excerpted and are included...
  9. ncbi Simultaneous monitoring of tissue PO2 and NADH fluorescence during synaptic stimulation and spreading depression reveals a transient dissociation between oxygen utilization and mitochondrial redox state in rat hippocampal slices
    Francesca Galeffi
    Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    J Cereb Blood Flow Metab 31:626-39. 2011
    ..In contrast, during SD in 50% O(2), the oxygen levels dropped to a point at which oxidative metabolism in the electron transport chain is limited and the rate of utilization declined...
  10. ncbi Two different mechanisms underlie reversible, intrinsic optical signals in rat hippocampal slices
    Dmitriy Fayuk
    Department of Cell Biology, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, North Carolina 27710, USA
    J Neurophysiol 87:1924-37. 2002
    ..The simultaneous IOS and ISV measurements clearly distinguish these two mechanisms of optical signal generation...
  11. ncbi Differences in O2 availability resolve the apparent discrepancies in metabolic intrinsic optical signals in vivo and in vitro
    Dennis A Turner
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Trends Neurosci 30:390-8. 2007
    ..Although oxygen is abundant in vivo, it is diffusion-limited in vitro. The disparities in mitochondrial and tissue oxygen availability account for the different redox responses...
  12. ncbi Is spreading depression bad for you? Focus on "repetitive normoxic spreading depression-like events result in cell damage in juvenile hippocampal slice cultures"
    George G Somjen
    J Neurophysiol 95:16-7. 2006