P Brian Smith

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi Pharmacokinetics of an elevated dosage of micafungin in premature neonates
    P Brian Smith
    Department of Pediatrics and Duke Clinical Research Institute, Duke University, Durham, NC 27715, USA
    Pediatr Infect Dis J 28:412-5. 2009
  2. ncbi Approach to infants born at 22 to 24 weeks' gestation: relationship to outcomes of more-mature infants
    P Brian Smith
    Department of Pediatrics, Duke University, Durham, North Carolina 27715, USA
    Pediatrics 129:e1508-16. 2012
  3. ncbi Is an increased dwell time of a peripherally inserted catheter associated with an increased risk of bloodstream infection in infants?
    P Brian Smith
    Department of Pediatrics, Duke University, Durham, North Carolina 27715, USA
    Infect Control Hosp Epidemiol 29:749-53. 2008
  4. ncbi Safety monitoring of drugs receiving pediatric marketing exclusivity
    P Brian Smith
    MHS, Duke University Medical Center, Box 3179, Durham, NC 27710, USA
    Pediatrics 122:e628-33. 2008
  5. ncbi Meningitis in preterm neonates: importance of cerebrospinal fluid parameters
    P Brian Smith
    Department of Pediatrics, Duke University, Durham, North Carolina 27710, USA
    Am J Perinatol 25:421-6. 2008
  6. ncbi Safety of placebo controls in pediatric hypertension trials
    P Brian Smith
    Food and Drug Administration, Rockville, MD, USA
    Hypertension 51:829-33. 2008
  7. ncbi Cough in pediatric patients receiving angiotensin-converting enzyme inhibitor therapy or angiotensin receptor blocker therapy in randomized controlled trials
    C M Baker-Smith
    Department of Pediatrics, Duke University, Durham, North Carolina, USA
    Clin Pharmacol Ther 87:668-71. 2010
  8. ncbi Group B streptococcal meningitis: cerebrospinal fluid parameters in the era of intrapartum antibiotic prophylaxis
    Annette K Ansong
    Department of Pediatrics, Duke University, Durham, North Carolina, USA
    Early Hum Dev 85:S5-7. 2009
  9. ncbi Use of the complete blood cell count in late-onset neonatal sepsis
    Christoph P Hornik
    Department of Pediatrics, Duke University, Durham, NC 27715, USA
    Pediatr Infect Dis J 31:803-7. 2012
  10. ncbi Traumatic lumbar punctures in neonates: test performance of the cerebrospinal fluid white blood cell count
    Rachel G Greenberg
    Department of Pediatrics, Duke University, Durham, NC, USA
    Pediatr Infect Dis J 27:1047-51. 2008

Detail Information

Publications60

  1. ncbi Pharmacokinetics of an elevated dosage of micafungin in premature neonates
    P Brian Smith
    Department of Pediatrics and Duke Clinical Research Institute, Duke University, Durham, NC 27715, USA
    Pediatr Infect Dis J 28:412-5. 2009
    ..The primary objective of this study was to assess the safety and pharmacokinetics of an increased (15 mg/kg/d) dose of micafungin...
  2. ncbi Approach to infants born at 22 to 24 weeks' gestation: relationship to outcomes of more-mature infants
    P Brian Smith
    Department of Pediatrics, Duke University, Durham, North Carolina 27715, USA
    Pediatrics 129:e1508-16. 2012
    ..We sought to determine if a center's approach to care of premature infants at the youngest gestational ages (22-24 weeks' gestation) is associated with clinical outcomes among infants of older gestational ages (25-27 weeks' gestation)...
  3. ncbi Is an increased dwell time of a peripherally inserted catheter associated with an increased risk of bloodstream infection in infants?
    P Brian Smith
    Department of Pediatrics, Duke University, Durham, North Carolina 27715, USA
    Infect Control Hosp Epidemiol 29:749-53. 2008
    ..To estimate the risk of bloodstream infection associated with catheter dwell time in infants...
  4. ncbi Safety monitoring of drugs receiving pediatric marketing exclusivity
    P Brian Smith
    MHS, Duke University Medical Center, Box 3179, Durham, NC 27710, USA
    Pediatrics 122:e628-33. 2008
    ..We sought to describe the Pediatric Advisory Committee's recommendations made in response to safety reviews informed by data from the Food and Drug Administration Adverse Event Reporting System in 67 drugs granted exclusivity...
  5. ncbi Meningitis in preterm neonates: importance of cerebrospinal fluid parameters
    P Brian Smith
    Department of Pediatrics, Duke University, Durham, North Carolina 27710, USA
    Am J Perinatol 25:421-6. 2008
    ..Cerebrospinal fluid parameters used to diagnose meningitis in the absence of dependable cerebrospinal fluid cultures are unreliable. Caution should be employed when interpreting cerebrospinal fluid parameters in the premature neonate...
  6. ncbi Safety of placebo controls in pediatric hypertension trials
    P Brian Smith
    Food and Drug Administration, Rockville, MD, USA
    Hypertension 51:829-33. 2008
    ..Short-term exposure to placebo in pediatric trials of antihypertensive medications appears to be safe...
  7. ncbi Cough in pediatric patients receiving angiotensin-converting enzyme inhibitor therapy or angiotensin receptor blocker therapy in randomized controlled trials
    C M Baker-Smith
    Department of Pediatrics, Duke University, Durham, North Carolina, USA
    Clin Pharmacol Ther 87:668-71. 2010
    ..The incidence of cough in children receiving ACEis (reported cough, 3.2%) was similar to that in children receiving ARBs (reported cough, 1.8%) (P = 0.34). Reports of cough were lower in children than in adults...
  8. ncbi Group B streptococcal meningitis: cerebrospinal fluid parameters in the era of intrapartum antibiotic prophylaxis
    Annette K Ansong
    Department of Pediatrics, Duke University, Durham, North Carolina, USA
    Early Hum Dev 85:S5-7. 2009
    ..Describe cerebrospinal fluid parameters in infants with culture-proven Group B streptococcal meningitis in the era of intrapartum antibiotic prophylaxis...
  9. ncbi Use of the complete blood cell count in late-onset neonatal sepsis
    Christoph P Hornik
    Department of Pediatrics, Duke University, Durham, NC 27715, USA
    Pediatr Infect Dis J 31:803-7. 2012
    ..Diagnosis of late-onset sepsis can be challenging. The complete blood cell count and differential have been previously evaluated as diagnostic tools for late-onset sepsis in small, single-center reports...
  10. ncbi Traumatic lumbar punctures in neonates: test performance of the cerebrospinal fluid white blood cell count
    Rachel G Greenberg
    Department of Pediatrics, Duke University, Durham, NC, USA
    Pediatr Infect Dis J 27:1047-51. 2008
    ..The purpose of this study is to evaluate the diagnostic utility of adjusting CSF white blood cell counts based on CSF and peripheral red blood cell counts...
  11. ncbi Early and late onset sepsis in late preterm infants
    Michael Cohen-Wolkowiez
    Department of Pediatrics, Duke University, Durham, NC 27715, USA
    Pediatr Infect Dis J 28:1052-6. 2009
    ..Early and late onset sepsis results in significant mortality in extremely preterm infants, but little is known about sepsis outcomes in late preterm infants...
  12. ncbi Pharmacokinetics and safety of fluconazole in young infants supported with extracorporeal membrane oxygenation
    Kevin M Watt
    Duke University, Pediatrics, Duke Clinical Research Institute, P O Box 3499, Durham, NC 27710, USA
    Pediatr Infect Dis J 31:1042-7. 2012
    ..The ECMO circuit can alter drug pharmacokinetics; thus, standard fluconazole dosing in children on ECMO may result in suboptimal drug exposure. This study determined the pharmacokinetics of fluconazole in infants on ECMO...
  13. ncbi Predictive value of cerebrospinal fluid parameters in neonates with intraventricular drainage devices
    Robert W Lenfestey
    Department of Pediatrics, Duke University, Durham, North Carolina, USA
    J Neurosurg 107:209-12. 2007
    ..The goal of this study was to determine the normal ranges for cell count parameters in neonates with VP shunts and CSF reservoirs, as well as to determine the predictive value of CSF parameters as markers of infection...
  14. ncbi Very late onset infections in the neonatal intensive care unit
    James L Wynn
    Department of Pediatrics, Duke University, Durham, NC, USA
    Early Hum Dev 88:217-25. 2012
    ..We sought to determine the risk factors, incidence, and mortality of very late onset bacterial infection (blood, urine, or cerebrospinal fluid culture positive occurring after day of life 120) in preterm infants...
  15. ncbi Neonatal meningitis: what is the correlation among cerebrospinal fluid cultures, blood cultures, and cerebrospinal fluid parameters?
    Harmony P Garges
    Pediatrics, Duke University, Durham, North Carolina, USA
    Pediatrics 117:1094-100. 2006
    ..Abnormal cerebrospinal fluid (CSF) parameters are often used to predict neonatal meningitis and determine length and type of antibiotic therapy in neonates with a positive blood culture and negative CSF culture...
  16. ncbi Safety and effectiveness of meropenem in infants with suspected or complicated intra-abdominal infections
    Michael Cohen-Wolkowiez
    Department of Pediatrics, Duke University, Durham, North Carolina 27715, USA
    Clin Infect Dis 55:1495-502. 2012
    ..The purpose of this study was to determine the safety and effectiveness of meropenem in young infants with suspected or complicated intra-abdominal infections...
  17. ncbi Use of the complete blood cell count in early-onset neonatal sepsis
    Christoph P Hornik
    Department of Pediatrics, Duke University, Durham, NC 27715, USA
    Pediatr Infect Dis J 31:799-802. 2012
    ..We evaluated the diagnostic accuracy of the complete blood cell count and differential in EOS in a large, multicenter population of neonates admitted to the neonatal intensive care unit...
  18. ncbi Empiric antifungal therapy and outcomes in extremely low birth weight infants with invasive candidiasis
    Rachel G Greenberg
    Department of Pediatrics, Duke University, Durham, NC, USA
    J Pediatr 161:264-9.e2. 2012
    ..To assess the impact of empiric antifungal therapy for invasive candidiasis on subsequent outcomes in premature infants...
  19. ncbi Antifungal therapy and outcomes in infants with invasive Candida infections
    Simon B Ascher
    Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Pediatr Infect Dis J 31:439-43. 2012
    ..Invasive candidiasis is a leading cause of mortality and morbidity in neonatal intensive care units. Treatment recommendations are limited by a lack of comparative outcomes data...
  20. ncbi Safety and transparency of pediatric drug trials
    Daniel K Benjamin
    Department of Pediatrics, Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA
    Arch Pediatr Adolesc Med 163:1080-6. 2009
    ....
  21. ncbi Center variation in patient age and weight at Fontan operation and impact on postoperative outcomes
    Michelle C Wallace
    Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina 27715, USA
    Ann Thorac Surg 91:1445-52. 2011
    ..We evaluated variation in age, weight, and weight-for-age z-score at Fontan across institutions, and the impact of these variables on postoperative morbidity and mortality...
  22. ncbi Coagulase-negative staphylococcal infections in the neonatal intensive care unit
    Naomi Jean-Baptiste
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Infect Control Hosp Epidemiol 32:679-86. 2011
    ..Coagulase-negative staphylococci (CoNS) are the most commonly isolated pathogens in the neonatal intensive care unit (NICU). CoNS infections are associated with increased morbidity, including neurodevelopmental impairment...
  23. ncbi Pediatric antihypertensive trial failures: analysis of end points and dose range
    Daniel K Benjamin
    Office of Pediatric Therapeutics, US Food and Drug Administration, Rockville, MD, USA
    Hypertension 51:834-40. 2008
    ..More importantly, our ability to combine data across trials allowed us to evaluate and potentially improve trial design...
  24. ncbi Population pharmacokinetics of metronidazole evaluated using scavenged samples from preterm infants
    Michael Cohen-Wolkowiez
    Department of Pediatrics, Duke University, Durham, North Carolina, USA
    Antimicrob Agents Chemother 56:1828-37. 2012
    ..Minimal-risk methods such as scavenged PK sampling provided meaningful information related to development of metronidazole PK models and dosing recommendations...
  25. ncbi Association between thrombosis and bloodstream infection in neonates with peripherally inserted catheters
    Courtney D Thornburg
    Department of Pediatrics, Duke University, Durham, NC, USA
    Thromb Res 122:782-5. 2008
    ..The primary objective of this study was to determine the association between catheter associated blood stream infection (CABSI) and catheter-related thrombosis in the Neonatal Intensive Care Unit...
  26. ncbi Treatment of patent ductus arteriosus with bidirectional flow in neonates
    Patrick N Ethington
    Department of Pediatrics, Duke University, Durham, NC 27710, United States
    Early Hum Dev 87:381-4. 2011
    ..The clinical decision to treat the patent ductus arteriosus is complicated by the lack of evidence available regarding clinical conditions under which closure should be attempted...
  27. ncbi Fluconazole loading dose pharmacokinetics and safety in infants
    Lauren Piper
    Department of Pediatrics and Duke Clinical Research Institute, Duke University, Durham, NC, USA
    Pediatr Infect Dis J 30:375-8. 2011
    ..A loading dose of fluconazole is advised for older patients but has not been evaluated in infants. We sought to determine the pharmacokinetics and safety of a fluconazole loading dose in infants at risk for invasive fungal infection...
  28. ncbi Mortality and neurodevelopmental outcome after Staphylococcus aureus bacteremia in infants
    Michael Cohen Wolkowiez
    Department of Pediatrics, Duke University, Durham, NC, USA
    Pediatr Infect Dis J 26:1159-61. 2007
    ..Infants with methicillin-resistant S. aureus infection had a longer median duration of bacteremia (4.5 versus 1 day, P = 0.01), but no difference in length of hospital stay, mortality, or neurodevelopmental impairment...
  29. ncbi Protocolized approach to the management of congenital diaphragmatic hernia: benefits of reducing variability in care
    Elisabeth T Tracy
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Pediatr Surg 45:1343-8. 2010
    ..Our institution developed a comprehensive evidence-based protocol to standardize the management of CDH infants. This report reviews patient outcomes before and after the implementation of the protocol...
  30. ncbi Outcomes of catheter-associated infections in pediatric patients with short bowel syndrome
    Rachel G Greenberg
    Department of Pediatrics, Duke Clinical Research Institute, Duke University, Durham, NC, USA
    J Pediatr Gastroenterol Nutr 50:460-2. 2010
    ..We conducted a retrospective observational study in children with short bowel syndrome to compare outcomes of catheter-associated infections treated with catheter removal plus antibiotic therapy versus antibiotic therapy alone...
  31. ncbi Outcomes following candiduria in extremely low birth weight infants
    James L Wynn
    Department of Pediatrics, Duke University, Durham, NC 27715, USA
    Clin Infect Dis 54:331-9. 2012
    ..Candidiasis carries a significant risk of death or neurodevelopmental impairment (NDI) in extremely low birth weight infants (ELBW; <1000 g). We sought to determine the impact of candiduria in ELBW preterm infants...
  32. ncbi Prediction of bronchopulmonary dysplasia by postnatal age in extremely premature infants
    Matthew M Laughon
    Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina 27599 7596, USA
    Am J Respir Crit Care Med 183:1715-22. 2011
    ....
  33. ncbi Effect of methicillin-resistant Staphylococcus aureus colonization in the neonatal intensive care unit on total hospital cost
    Eric D Schultz
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA
    Infect Control Hosp Epidemiol 30:383-5. 2009
    ..We determined the economic impact of isolating and cohorting MRSA-colonized neonates on total hospital cost at a 49-bed, level III-IV neonatal intensive care unit...
  34. ncbi Risk Factors for Invasive Candidiasis in Infants >1500 g Birth Weight
    Jan Hau Lee
    From the Department of Pediatrics, Duke University Medical Center Duke Clinical Research Institute, Duke University Medical Center, Durham, NC Department of Pediatric Subspecialties, KK Women s and Children s Hospital, Singapore Department of Biostatistics, University of North Carolina, Chapel Hill, NC and Pediatrix Medical Group, Sunrise, FL
    Pediatr Infect Dis J 32:222-6. 2013
    ..We describe the incidence, risk factors and outcomes of invasive candidiasis in infants >1500 g birth weight...
  35. ncbi Pharmacokinetics and tolerability of single-dose daptomycin in young infants
    Michael Cohen-Wolkowiez
    Department of Pediatrics, Duke University Medical Center, and Duke Clinical Research Institute, Durham, NC 27715, USA
    Pediatr Infect Dis J 31:935-7. 2012
    ..Daptomycin is approved for the treatment of complicated skin and skin-structure infections and Staphylococcus aureus bacteremia. We sought to characterize daptomycin single-dose pharmacokinetics and tolerability in young infants...
  36. ncbi Very low birth weight neonates who survive early-onset sepsis do not have an increased risk of developing late-onset sepsis
    Cheryl B Lin
    Duke University National University of Singapore, Singapore
    Early Hum Dev 88:905-9. 2012
    ..In critically ill children and adults, sepsis increases subsequent infection risk. It is unknown whether sepsis modifies the risk of subsequent infection in VLBWs...
  37. ncbi Population pharmacokinetics of meropenem in plasma and cerebrospinal fluid of infants with suspected or complicated intra-abdominal infections
    P Brian Smith
    Department of Pediatrics, Duke University, Durham, NC, USA
    Pediatr Infect Dis J 30:844-9. 2011
    ..The purpose of this study was to determine the pharmacokinetics (PK) of meropenem in young infants as a basis for optimizing dosing and minimizing adverse events...
  38. ncbi Cardiovascular abnormalities in late-onset Pompe disease and response to enzyme replacement therapy
    Daniel Forsha
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27715, USA
    Genet Med 13:625-31. 2011
    ..We evaluated the prevalence of cardiovascular abnormalities and the efficacy and safety of enzyme replacement therapy in patients with late-onset Pompe disease...
  39. ncbi Population pharmacokinetics of fluconazole in young infants
    K C Wade
    Department of Pediatrics, Division of Neonatology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Antimicrob Agents Chemother 52:4043-9. 2008
    ..This population PK model of fluconazole discriminated the impact of BGA, PNA, and creatinine on drug CL. Our data suggest that dosing in young infants will require adjustment for BGA and PNA to achieve targeted systemic drug exposures...
  40. ncbi The use of antifungal therapy in neonatal intensive care
    Daniela Testoni
    Duke Clinical Research Institute, Duke University Medical Center, 2400 Pratt Street, Durham, NC 27705, USA
    Clin Perinatol 39:83-98. 2012
    ..We conclude that more studies are required for antifungals to be used safely and effectively in infants...
  41. ncbi Cytokine gene polymorphisms and the outcome of invasive candidiasis: a prospective cohort study
    Melissa D Johnson
    Duke University Medical Center, Durham, North Carolina, USA
    Clin Infect Dis 54:502-10. 2012
    ..Although clinical and microbiological factors affecting prognosis have been identified, the impact of genetic variation in the innate immune responses mediated by cytokines on outcomes of infection remains to be studied...
  42. ncbi Dynamic change of fecal calprotectin in very low birth weight infants during the first month of life
    Qing Yang
    Department of Pediatrics, Division of Neonatology, Duke University Medical Center, Durham, NC, USA
    Neonatology 94:267-71. 2008
    ..Calprotectin is a cytosolic component of neutrophils. Fecal calprotectin (FC) level is a useful marker for exacerbation of inflammatory bowel disease in children. FC may be a useful marker for necrotizing enterocolitis (NEC)...
  43. ncbi Performance of the AST-to-platelet ratio index as a noninvasive marker of fibrosis in pediatric patients with chronic viral hepatitis
    Katherine E McGoogan
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    J Pediatr Gastroenterol Nutr 50:344-6. 2010
    ..Further research into APRI and the other noninvasive markers of fibrosis in children with chronic viral hepatitis is warranted...
  44. ncbi Quantification of 1,3-beta-D-glucan levels in children: preliminary data for diagnostic use of the beta-glucan assay in a pediatric setting
    P Brian Smith
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Vaccine Immunol 14:924-5. 2007
    ..We found higher 1,3-beta-D-glucan levels in children than those previously reported in adults...
  45. ncbi Globalization of pediatric research: analysis of clinical trials completed for pediatric exclusivity
    Sara K Pasquali
    Duke University Medical Center, Department of Pediatrics, Division of Cardiology, PO Box 17969, Durham, NC 27715, USA
    Pediatrics 126:e687-92. 2010
    ..We evaluated the setting of published studies conducted under the US Pediatric Exclusivity Provision, which provides economic incentives to pharmaceutical companies to conduct drug studies with children...
  46. ncbi Anidulafungin: a new echinocandin for the treatment of fungal infections
    Michael Cohen-Wolkowiez
    Department of Pediatrics, Miami Children's Hospital, Florida, USA
    Drugs Today (Barc) 42:533-44. 2006
    ..In February 2006, the U.S. Food and Drug Administration approved the echinocandin anidulafungin for the treatment of patients with candidemia, peritonitis, intra-abdominal abscesses and esophageal candidiasis...
  47. ncbi The (1,3){beta}-D-glucan test as an aid to early diagnosis of invasive fungal infections following lung transplantation
    Barbara D Alexander
    Division of Infectious Diseases and International Health, Department of Medicine, Clinical Microbiology Laboratory, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Microbiol 48:4083-8. 2010
    ..Although the NPV of the BG test is high, the low PPV limits its utility as a screening tool for early diagnosis of IFI...
  48. ncbi Isoflurane for life-threatening bronchospasm: a 15-year single-center experience
    David A Turner
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, Duke Children s Hospital, Duke University Medical Center, Durham, NC 27710, USA
    Respir Care 57:1857-64. 2012
    ..We hypothesized that isoflurane is safe and would lead to improved gas exchange in children with life-threatening bronchospasm refractory to conventional therapy...
  49. ncbi Antibiotic use and misuse in the neonatal intensive care unit
    Nidhi Tripathi
    Duke University Medical Center, Durham, NC 27710, USA
    Clin Perinatol 39:61-8. 2012
    ....
  50. ncbi Bias flow does not affect ventilation during high-frequency oscillatory ventilation in a pediatric animal model of acute lung injury
    David A Turner
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, Duke Children s Hospital, Duke University Medical Center, Durham, NC, USA
    Pediatr Crit Care Med 13:e108-12. 2012
    ..We hypothesize that in a swine model of acute lung injury, increased bias flow rates will not affect CO(2) elimination...
  51. ncbi Neonatal candidiasis
    P Brian Smith
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Infect Dis Clin North Am 19:603-15. 2005
    ..Although some pharmacokinetic data for some products are available for term and near-term infants, optimal product choice, closing, and other treatment strategies also are unknown in this older age group...
  52. ncbi Safety and effectiveness of indomethacin versus ibuprofen for treatment of patent ductus arteriosus
    Lakshmi I Katakam
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA
    Am J Perinatol 27:425-9. 2010
    ..The decision to use one agent over the other should be based on dose schedule preference and the currently published clinical trials until more safety and effectiveness data are available...
  53. ncbi Risk factors and prevention of late-onset sepsis in premature infants
    L Corbin Downey
    Department of Pediatrics, Children s Hospital of the King s Daughters, Norfolk, VA, USA
    Early Hum Dev 86:7-12. 2010
    ..In this review, we will outline the risk factors for development of late-onset sepsis and evidence supporting methods for prevention of late-onset sepsis in premature infants...
  54. ncbi Prevalence of iron deficiency in children with Down syndrome
    Natalia E Dixon
    Department of Pediatrics, Hematology Oncology, Duke University Medical Center, Durham, NC, USA
    J Pediatr 157:967-971.e1. 2010
    ..To determine the prevalence of iron deficiency (ID) and iron deficiency anemia (IDA) in a sample of children with Down syndrome (DS) and to evaluate the effect of macrocytosis on the diagnosis of ID/IDA in these children...
  55. ncbi Excess costs of hospital care associated with neonatal candidemia
    P Brian Smith
    Department of Pediatrics, 3179 Duke University Medical Center, Durham NC, 27710, USA
    Pediatr Infect Dis J 26:197-200. 2007
    ..Candida is an increasingly important nosocomial pathogen within intensive care nurseries. The purpose of this study was to determine the attributable cost of candidemia in neonates...
  56. ncbi Preliminary observations of the use of high-frequency jet ventilation as rescue therapy in infants with congenital diaphragmatic hernia
    Michael A Kuluz
    Department of Pediatrics, Duke University, Durham, NC, USA
    J Pediatr Surg 45:698-702. 2010
    ..Several investigators have reported outcomes from centers using high-frequency oscillatory ventilation in their management of CDH, but there are no recent reports on use of high-frequency jet ventilation...
  57. ncbi Duration of empirical antibiotic therapy for infants suspected of early-onset sepsis
    C Michael Cotten
    Division of Neonatology, Department of Pediatrics, Duke University, Durham, North Carolina 27710, USA
    Curr Opin Pediatr 25:167-71. 2013
    ..Our purpose is to review current opinions and evidence influencing clinicians' choices for duration of empirically initiated antibiotics in newborns with sterile cultures...
  58. ncbi Regional variation in late preterm births in North Carolina
    Sofia R Aliaga
    Department of Pediatrics, University of North Carolina, 101 Manning Drive, Chapel Hill, NC 27599, USA
    Matern Child Health J 17:33-41. 2013
    ..We speculate that provider practice variation might explain some of the remaining difference. This is an area where policy changes and quality improvement efforts can help reduce variation, and potentially decrease LPT births...
  59. ncbi Targeted interventions improve shared agreement of daily goals in the pediatric intensive care unit
    Kyle J Rehder
    Division of Pediatric Critical Care Medicine, Duke University Medical Center, Durham, NC, USA
    Pediatr Crit Care Med 13:6-10. 2012
    ..To improve communication during daily rounds using sequential interventions...
  60. ncbi Vasopressin for refractory hypotension in extremely low birth weight infants
    Margarita Bidegain
    Division of Neonatal Perinatal Medicine, Jean and George Brumley, Jr, Neonatal Perinatal Research Institute, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    J Pediatr 157:502-4. 2010
    ..002) and allowed weaning of catecholamines in a group of extremely low birth weight infants with refractory hypotension...