Theodore Slotkin

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi Administration of nicotine to adolescent rats evokes regionally selective upregulation of CNS alpha 7 nicotinic acetylcholine receptors
    Theodore A Slotkin
    Box 3813 DUMC, Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 1030:159-63. 2004
  2. pmc Silver impairs neurodevelopment: studies in PC12 cells
    Christina M Powers
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 118:73-9. 2010
  3. pmc Exposure of neonatal rats to parathion elicits sex-selective reprogramming of metabolism and alters the response to a high-fat diet in adulthood
    T Leon Lassiter
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, USA
    Environ Health Perspect 116:1456-62. 2008
  4. pmc Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 114:1542-6. 2006
  5. pmc Ultraviolet photolysis of chlorpyrifos: developmental neurotoxicity modeled in PC12 cells
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 117:338-43. 2009
  6. pmc Adverse benzo[a]pyrene effects on neurodifferentiation are altered by other neurotoxicant coexposures: interactions with dexamethasone, chlorpyrifos, or nicotine in PC12 cells
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 121:825-31. 2013
  7. pmc Silver nanoparticles compromise neurodevelopment in PC12 cells: critical contributions of silver ion, particle size, coating, and composition
    Christina M Powers
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 119:37-44. 2011
  8. doi Nicotine administration in adolescence reprograms the subsequent response to nicotine treatment and withdrawal in adulthood: Sex-selective effects on cerebrocortical serotonergic function
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA Electronic address
    Brain Res Bull 102:1-8. 2014
  9. pmc An invertebrate model of the developmental neurotoxicity of insecticides: effects of chlorpyrifos and dieldrin in sea urchin embryos and larvae
    G A Buznikov
    N.K. Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia
    Environ Health Perspect 109:651-61. 2001
  10. pmc Prenatal dexamethasone, as used in preterm labor, worsens the impact of postnatal chlorpyrifos exposure on serotonergic pathways
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA Electronic address
    Brain Res Bull 100:44-54. 2014

Research Grants

Collaborators

Detail Information

Publications129 found, 100 shown here

  1. ncbi Administration of nicotine to adolescent rats evokes regionally selective upregulation of CNS alpha 7 nicotinic acetylcholine receptors
    Theodore A Slotkin
    Box 3813 DUMC, Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 1030:159-63. 2004
    ..The present findings reinforce the concept of biologically distinct effects of nicotine in the adolescent brain and provide evidence for a mechanistic involvement of alpha 7 nAChRs in its unique effects during this developmental period...
  2. pmc Silver impairs neurodevelopment: studies in PC12 cells
    Christina M Powers
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 118:73-9. 2010
    ..Exposure to silver is increasing because of silver nanoparticles in consumer products...
  3. pmc Exposure of neonatal rats to parathion elicits sex-selective reprogramming of metabolism and alters the response to a high-fat diet in adulthood
    T Leon Lassiter
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, USA
    Environ Health Perspect 116:1456-62. 2008
    ..Developmental exposures to organophosphate pesticides are virtually ubiquitous. These agents are neurotoxicants, but recent evidence also points to lasting effects on metabolism...
  4. pmc Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 114:1542-6. 2006
    ..In the developing brain, serotonin (5HT) systems are among the most sensitive to disruption by organophosphates...
  5. pmc Ultraviolet photolysis of chlorpyrifos: developmental neurotoxicity modeled in PC12 cells
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 117:338-43. 2009
    ..Ultraviolet photodegradation products from pesticides form both in the field and during water treatment...
  6. pmc Adverse benzo[a]pyrene effects on neurodifferentiation are altered by other neurotoxicant coexposures: interactions with dexamethasone, chlorpyrifos, or nicotine in PC12 cells
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 121:825-31. 2013
    ..Polycyclic aromatic hydrocarbons are suspected developmental neurotoxicants, but human exposures typically occur in combination with other neurotoxic contaminants...
  7. pmc Silver nanoparticles compromise neurodevelopment in PC12 cells: critical contributions of silver ion, particle size, coating, and composition
    Christina M Powers
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 119:37-44. 2011
    ..Silver exposures are rising because of the increased use of silver nanoparticles (AgNPs) in consumer products. The monovalent silver ion (Ag+) impairs neurodevelopment in PC12 cells and zebrafish...
  8. doi Nicotine administration in adolescence reprograms the subsequent response to nicotine treatment and withdrawal in adulthood: Sex-selective effects on cerebrocortical serotonergic function
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA Electronic address
    Brain Res Bull 102:1-8. 2014
    ....
  9. pmc An invertebrate model of the developmental neurotoxicity of insecticides: effects of chlorpyrifos and dieldrin in sea urchin embryos and larvae
    G A Buznikov
    N.K. Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia
    Environ Health Perspect 109:651-61. 2001
    ....
  10. pmc Prenatal dexamethasone, as used in preterm labor, worsens the impact of postnatal chlorpyrifos exposure on serotonergic pathways
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA Electronic address
    Brain Res Bull 100:44-54. 2014
    ....
  11. pmc Does thyroid disruption contribute to the developmental neurotoxicity of chlorpyrifos?
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina USA
    Environ Toxicol Pharmacol 36:284-7. 2013
    ..Thus, although chlorpyrifos has the potential to disrupt thyroid status sufficiently to alter brain thyroid hormone levels, the effect is small, and any potential contribution to neurobehavioral abnormalities remains to be proven. ..
  12. pmc BDE99 (2,2',4,4',5-pentabromodiphenyl ether) suppresses differentiation into neurotransmitter phenotypes in PC12 cells
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, 27710, USA
    Neurotoxicol Teratol 37:13-7. 2013
    ..Thus, our results point to interference with neurodifferentiation by specific BDE congeners, distinct from cytotoxic or endocrine mechanisms...
  13. pmc Prenatal dexamethasone augments the sex-selective developmental neurotoxicity of chlorpyrifos: implications for vulnerability after pharmacotherapy for preterm labor
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neurotoxicol Teratol 37:1-12. 2013
    ..Our findings indicate that prior dexamethasone exposure could create a subpopulation that is especially vulnerable to the adverse effects of organophosphates or other developmental neurotoxicants...
  14. pmc Terbutaline impairs the development of peripheral noradrenergic projections: potential implications for autism spectrum disorders and pharmacotherapy of preterm labor
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neurotoxicol Teratol 36:91-6. 2013
    ....
  15. pmc Chlorpyrifos developmental neurotoxicity: interaction with glucocorticoids in PC12 cells
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA
    Neurotoxicol Teratol 34:505-12. 2012
    ....
  16. pmc Does mechanism matter? Unrelated neurotoxicants converge on cell cycle and apoptosis during neurodifferentiation
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA
    Neurotoxicol Teratol 34:395-402. 2012
    ..Our studies suggest that identifying the initial mechanism of action of a developmental neurotoxicant may be strategically less important than focusing on the pathways that converge on common final outcomes such as cell loss...
  17. pmc Developmental neurotoxicity of organophosphates targets cell cycle and apoptosis, revealed by transcriptional profiles in vivo and in vitro
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neurotoxicol Teratol 34:232-41. 2012
    ..Equally important, these effects do not reflect actions on cholinesterase and operate at exposures below the threshold for any detectable inhibition of this enzyme...
  18. pmc Mimicking maternal smoking and pharmacotherapy of preterm labor: fetal nicotine exposure enhances the effect of late gestational dexamethasone treatment on noradrenergic circuits
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813 DUMC, Durham, NC, USA
    Brain Res Bull 86:435-40. 2011
    ..The fact that the combined treatment produced greater effects points to potentially worsened neurobehavioral outcomes after pharmacotherapy of preterm labor in the offspring of smokers...
  19. pmc Developmental exposure to organophosphates triggers transcriptional changes in genes associated with Parkinson's disease in vitro and in vivo
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813 DUMC, Durham, NC 27710, USA
    Brain Res Bull 86:340-7. 2011
    ....
  20. pmc Developmental neurotoxicity of perfluorinated chemicals modeled in vitro
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 116:716-22. 2008
    ..The widespread detection of perfluoroalkyl acids and their derivatives in wildlife and humans, and their entry into the immature brain, raise increasing concern about whether these agents might be developmental neurotoxicants...
  21. ncbi Anomalous regulation of beta-adrenoceptor signaling in brain regions of the newborn rat
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813 DUMC, Duke Univ Med Ctr, Durham, NC 27710, USA
    Brain Res 1077:54-8. 2006
    ..These effects are likely responsible for the maintenance of betaAR activity associated with neurotrophic input during synaptogenesis but may also contribute to adverse effects of betaAR agonists used in preterm labor...
  22. pmc Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813 DUMC, Durham, NC 27710, USA
    Brain Res Bull 76:424-38. 2008
    ....
  23. pmc Perinatal environmental tobacco smoke exposure in rhesus monkeys: critical periods and regional selectivity for effects on brain cell development and lipid peroxidation
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 114:34-9. 2006
    ....
  24. pmc Exposure of neonatal rats to parathion elicits sex-selective impairment of acetylcholine systems in brain regions during adolescence and adulthood
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 116:1308-14. 2008
    ..Organophosphates elicit developmental neurotoxicity through multiple mechanisms other than their shared property as cholinesterase inhibitors. Accordingly, these agents may differ in their effects on specific brain circuits...
  25. pmc Developmental neurotoxic effects of chlorpyrifos on acetylcholine and serotonin pathways in an avian model
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neurotoxicol Teratol 30:433-9. 2008
    ..These effects in the chick model recapitulate many of the actions of early gestational CPF exposure in rats, and thus suggest that CPF exerts direct actions on the immature brain to compromise the development of ACh and 5HT pathways...
  26. ncbi Imbalances emerge in cardiac autonomic cell signaling after neonatal exposure to terbutaline or chlorpyrifos, alone or in combination
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813 DUMC, Durham, NC 27710, USA
    Brain Res Dev Brain Res 160:219-30. 2005
    ....
  27. pmc Developmental exposure of rats to chlorpyrifos elicits sex-selective hyperlipidemia and hyperinsulinemia in adulthood
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, USA
    Environ Health Perspect 113:1291-4. 2005
    ....
  28. ncbi Critical prenatal and postnatal periods for persistent effects of dexamethasone on serotonergic and dopaminergic systems
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 31:904-11. 2006
    ..Accordingly, adverse neurobehavioral consequences may be inescapable in glucocorticoid therapy of preterm infants...
  29. pmc Unrelated developmental neurotoxicants elicit similar transcriptional profiles for effects on neurotrophic factors and their receptors in an in vitro model
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neurotoxicol Teratol 32:42-51. 2010
    ....
  30. ncbi The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Box 3813 DUMC, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Dev Brain Res 158:115-9. 2005
    ..Our findings at 5 months of age replicate those seen in young adulthood and strongly suggest that the effects of neonatal CPF exposure on 5HT systems are permanent...
  31. pmc Developmental neurotoxicity of low dose diazinon exposure of neonatal rats: effects on serotonin systems in adolescence and adulthood
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Bull 75:640-7. 2008
    ..The effects on 5HT circuits expand the scope of behavioral endpoints that need to be considered in evaluating the developmental neurotoxicity of organophosphates...
  32. ncbi If nicotine is a developmental neurotoxicant in animal studies, dare we recommend nicotine replacement therapy in pregnant women and adolescents?
    Theodore A Slotkin
    Box 3813 DUMC, Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neurotoxicol Teratol 30:1-19. 2008
    ..This review considers the ramifications of the basic science findings of nicotine's effects on brain development for NRT in these populations...
  33. pmc Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology Box 3813, Duke University Medical Center, Durham, NC 27710, USA
    Toxicol Appl Pharmacol 233:211-9. 2008
    ....
  34. pmc Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 114:746-51. 2006
    ..For parathion, the threshold for lethality lies below that necessary for adverse effects on brain development, whereas the opposite is true for chlorpyrifos and diazinon...
  35. pmc Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 115:1306-13. 2007
    ..Organophosphate developmental neurotoxicity involves multiple mechanisms converging on neural cell replication and differentiation...
  36. pmc Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickel
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 115:93-101. 2007
    ..In light of the large number of chemicals that are potential developmental neurotoxicants, there is a need to develop rapid screening techniques...
  37. pmc Developmental neurotoxicity of parathion: progressive effects on serotonergic systems in adolescence and adulthood
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, USA
    Neurotoxicol Teratol 31:11-7. 2009
    ....
  38. pmc Comparative developmental neurotoxicity of organophosphates in vivo: transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Bull 72:232-74. 2007
    ..The approach used here demonstrates how planned comparisons with microarrays can be used to screen for developmental neurotoxicity...
  39. ncbi Lasting effects of nicotine treatment and withdrawal on serotonergic systems and cell signaling in rat brain regions: separate or sequential exposure during fetal development and adulthood
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813 DUMC, Durham, NC 27710, USA
    Brain Res Bull 73:259-72. 2007
    ..These effects may contribute to lifelong vulnerability to readdiction...
  40. doi Development of glucocorticoid receptor regulation in the rat forebrain: implications for adverse effects of glucocorticoids in preterm infants
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Bull 76:531-5. 2008
    ..Since this developmental phase in the rat corresponds to the critical period in which glucocorticoids are used in preterm infants, adverse effects on brain development may be inescapable...
  41. ncbi Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic hyperactivity at adolescence: critical periods for regional and sex-selective effects
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813 DUMC, Durham, NC 27710, USA
    Reprod Toxicol 23:421-7. 2007
    ..Similar, but lesser effects were seen for dopamine turnover in the same regions. These results indicate that, in a critical developmental period, apparently subtoxic exposures to CPF produce long-term activation of 5HT systems...
  42. pmc Developmental exposure to terbutaline and chlorpyrifos, separately or sequentially, elicits presynaptic serotonergic hyperactivity in juvenile and adolescent rats
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Bull 73:301-9. 2007
    ..Equally importantly, the interaction between terbutaline and chlorpyrifos suggests that tocolytic therapy may alter the subsequent susceptibility to common environmental toxicants...
  43. ncbi Permanent, sex-selective effects of prenatal or adolescent nicotine exposure, separately or sequentially, in rat brain regions: indices of cholinergic and serotonergic synaptic function, cell signaling, and neural cell number and size at 6 months of age
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 32:1082-97. 2007
    ....
  44. pmc Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 115:909-16. 2007
    ..The fibroblast growth factor (FGF) superfamily of neurotrophic factors plays critical roles in neural cell development, brain assembly, and recovery from neuronal injury...
  45. ncbi Separate or sequential exposure to nicotine prenatally and in adulthood: persistent effects on acetylcholine systems in rat brain regions
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Bull 74:91-103. 2007
    ..These effects may contribute to lifelong vulnerability to readdiction...
  46. ncbi A unique role for striatal serotonergic systems in the withdrawal from adolescent nicotine administration
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology Duke University Medical Center Durham, Box 3813 DUMC, NC 27710, USA
    Neurotoxicol Teratol 29:10-6. 2007
    ....
  47. pmc Transcriptional profiles reveal similarities and differences in the effects of developmental neurotoxicants on differentiation into neurotransmitter phenotypes in PC12 cells
    Theodore Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Centre, Durham, NC 27710, USA
    Brain Res Bull 78:211-25. 2009
    ....
  48. ncbi Alterations of serotonin synaptic proteins in brain regions of neonatal Rhesus monkeys exposed to perinatal environmental tobacco smoke
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 1111:30-5. 2006
    ..These results reinforce the need to reduce ETS exposure of pregnant women and young children...
  49. doi Nicotine exposure in adolescence alters the response of serotonin systems to nicotine administered subsequently in adulthood
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Dev Neurosci 31:58-70. 2009
    ..Our results thus provide mechanistic evidence that nicotine exposure, during the period in which nearly all smokers begin to use tobacco, reprograms the future response of 5-HT systems to nicotine...
  50. pmc Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 117:587-96. 2009
    ..Oxidative stress and excitotoxicity underlie the developmental neurotoxicity of numerous chemicals...
  51. ncbi Ontogenesis of beta-adrenoceptor signaling: implications for perinatal physiology and for fetal effects of tocolytic drugs
    Theodore A Slotkin
    Dept of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Pharmacol Exp Ther 306:1-7. 2003
    ..At the same time, however, the inability to restrict betaAR function may underlie adverse effects of betaAR-agonist tocolytics that are used in the treatment of preterm labor...
  52. ncbi Glucocorticoid-targeting of the adenylyl cyclase signaling pathway in the cerebellum of young vs. aged rats
    T A Slotkin
    Box 3813, Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 800:236-44. 1998
    ..Given the high incidence of HPA axis dysregulation in the elderly, and particularly in elderly depression, effects of glucocorticoids on cell signaling may contribute to disrupted function and to altered drug reactivity...
  53. ncbi Nicotine and the adolescent brain: insights from an animal model
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813 DUMC, Durham, NC 27710, USA
    Neurotoxicol Teratol 24:369-84. 2002
    ..Effects of nicotine on critical components of reward pathways and circuits involved in learning, memory and mood are likely to contribute to increased addictive properties and long-term behavioral problems seen in adolescent smokers...
  54. ncbi Perinatal exposure to environmental tobacco smoke upregulates nicotinic cholinergic receptors in monkey brain
    T A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Dev Brain Res 133:175-9. 2002
    ..These results indicate that perinatal ETS exposes the fetus and neonate to quantities of nicotine that are sufficient to alter brain development...
  55. ncbi Functional alterations in CNS catecholamine systems in adolescence and adulthood after neonatal chlorpyrifos exposure
    T A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813 DUMC, Durham, NC 27710, USA
    Brain Res Dev Brain Res 133:163-73. 2002
    ..The effects seen here are likely to contribute to alterations in behavioral performance that persist or emerge long after the termination of CPF exposure...
  56. ncbi Heroin neuroteratogenicity: targeting adenylyl cyclase as an underlying biochemical mechanism
    T A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Dev Brain Res 132:69-79. 2001
    ....
  57. ncbi Beta-adrenoceptor signaling in the developing brain: sensitization or desensitization in response to terbutaline
    T A Slotkin
    Box 3813 DUMC, Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Dev Brain Res 131:113-25. 2001
    ..The inability to desensitize betaAR responses may lead to disruption of neural cell development as a consequence of tocolytic therapy...
  58. ncbi Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure
    T A Slotkin
    Department of Pharmacology and Cancer Biology, Box 3813 DUMC, Duke University Medical Center, 27710, Durham, NC, USA
    Brain Res 902:229-43. 2001
    ..The effects are likely to contribute to gender-selective alterations in behavioral performance that persist or emerge long after the termination of exposure and well after the restoration of cholinesterase activity...
  59. ncbi Antimitotic and cytotoxic effects of theophylline in MDA-MB-231 human breast cancer cells
    T A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Breast Cancer Res Treat 64:259-67. 2000
    ..The multiple pharmacologic properties of theophylline, producing mitotic inhibition, cytotoxicity and altered signaling in MDA-MB-231 cells, may provide insight into novel therapeutic strategies...
  60. ncbi Neonatal polyamine depletion by alpha-difluoromethylornithine: effects on adenylyl cyclase cell signaling are separable from effects on brain region growth
    T A Slotkin
    Department of Pharmacology and Cancer Biology, Box 3813, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 887:16-22. 2000
    ....
  61. ncbi Perinatal exposure to environmental tobacco smoke alters cell signaling in a primate model: autonomic receptors and the control of adenylyl cyclase activity in heart and lung
    T A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Dev Brain Res 124:53-8. 2000
    ..These data indicate that perinatal ETS exposure evokes changes in cells signaling that they are selective for the lung and that may ultimately reflect adverse effects at the level of physiological function...
  62. ncbi Beta-adrenoceptor signaling and its control of cell replication in MDA-MB-231 human breast cancer cells
    T A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Breast Cancer Res Treat 60:153-66. 2000
    ..Novel pharmacologic strategies that focus on cell surface receptors operating through adenylyl cyclase may offer opportunities to combat cancers that are unresponsive to hormonal agents, or that have developed multidrug resistance...
  63. ncbi Modeling geriatric depression in animals: biochemical and behavioral effects of olfactory bulbectomy in young versus aged rats
    T A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, USA
    J Pharmacol Exp Ther 289:334-45. 1999
    ..OBX may provide a useful animal model with which to test therapeutic interventions for geriatric depression...
  64. ncbi Cholinergic receptors in heart and brainstem of rats exposed to nicotine during development: implications for hypoxia tolerance and perinatal mortality
    T A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Dev Brain Res 113:1-12. 1999
    ....
  65. ncbi Effects of aging and glucocorticoid treatment on monoamine oxidase subtypes in rat cerebral cortex: therapeutic implications
    T A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Bull 47:345-8. 1998
    ..These distinctions may influence the etiology and therapy of depression, while at the same time providing potential biomarkers (such as platelet MAO) that may serve to predict successful treatment outcome in patient subpopulations...
  66. ncbi Heroin neuroteratogenicity: delayed-onset deficits in catecholaminergic synaptic activity
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Box 3813 DUMC, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 984:189-97. 2003
    ..These results may explain why apparently unrelated developmental neurotoxicants may ultimately produce a common set of neurochemical and behavioral anomalies...
  67. ncbi Glucocorticoid administration alters nuclear transcription factors in fetal rat brain: implications for the use of antenatal steroids
    T A Slotkin
    Box 3813, Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Dev Brain Res 111:11-24. 1998
    ..These results indicate that even a single, low dose of glucocorticoids used in late gestation, can disrupt the transcription factors that regulate brain cell differentiation...
  68. pmc Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity?
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, DUMC, Duke University Medical Center, Durham, NC 27710, USA
    Reprod Toxicol 31:297-301. 2011
    ..These studies show how common insecticides may contribute to the increased worldwide incidence of obesity and diabetes...
  69. pmc Nonenzymatic role of acetylcholinesterase in neuritic sprouting: regional changes in acetylcholinesterase and choline acetyltransferase after neonatal 6-hydroxydopamine lesions
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, 27710, USA
    Neurotoxicol Teratol 31:183-6. 2009
    ..Further, the results for choline acetyltransferase indicate that early depletion of norepinephrine compromises development of acetylcholine systems, consistent with a trophic role for this neurotransmitter...
  70. pmc Benzo[a]pyrene impairs neurodifferentiation in PC12 cells
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Bull 80:17-21. 2009
    ..BaP thus has direct actions on developing neuronal cells that could contribute to the adverse neurodevelopmental effects seen with in vivo exposures...
  71. pmc Consumption of a high-fat diet in adulthood ameliorates the effects of neonatal parathion exposure on acetylcholine systems in rat brain regions
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 117:916-22. 2009
    ..We are seeking interventions that can ameliorate or reverse the effects later in life...
  72. pmc Neonatal parathion exposure disrupts serotonin and dopamine synaptic function in rat brain regions: modulation by a high-fat diet in adulthood
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neurotoxicol Teratol 31:390-9. 2009
    ..Thus, dietary factors may produce similar synaptic changes as do developmental neurotoxicants, potentially contributing to the increasing incidence of neurodevelopmental disorders...
  73. ncbi Alpha7 nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: nicotine and chlorpyrifos
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813 DUMC, Durham, NC 27710, USA
    Brain Res Bull 64:227-35. 2004
    ..The present findings reinforce the mechanistic involvement of alpha7 nAChRs in the actions of developmental neurotoxicants, and its biomarker potential for neuroteratogens that target neuritic outgrowth...
  74. doi Additive and synergistic effects of fetal nicotine and dexamethasone exposure on cholinergic synaptic function in adolescence and adulthood: Implications for the adverse consequences of maternal smoking and pharmacotherapy of preterm delivery
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Bull 81:552-60. 2010
    ..Our results thus point to potentially worse neurobehavioral outcomes of the pharmacotherapy of preterm labor in the offspring of smokers...
  75. ncbi Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin C: neurotransmitter receptors, cell signaling and cell development biomarkers in fetal brain regions of rhesus monkeys
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 30:129-44. 2005
    ....
  76. ncbi Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Toxicol Appl Pharmacol 198:132-51. 2004
    ..Novel in vitro and in vivo exposure models are being developed to uncover heretofore unsuspected mechanisms and targets for developmental neurotoxicants...
  77. pmc Oxidative stress from diverse developmental neurotoxicants: antioxidants protect against lipid peroxidation without preventing cell loss
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology Duke University Medical Center Durham, North Carolina 27710, USA
    Neurotoxicol Teratol 32:124-31. 2010
    ..Instead, additional mechanisms for each agent may provide alternative routes to neurotoxicity, or may be additive or synergistic with oxidative stress...
  78. doi Mimicking maternal smoking and pharmacotherapy of preterm labor: interactions of fetal nicotine and dexamethasone on serotonin and dopamine synaptic function in adolescence and adulthood
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Bull 82:124-34. 2010
    ..The fact that the combined treatment produced greater effects for many parameters points to potentially worse neurobehavioral outcomes after pharmacotherapy of preterm labor in the offspring of smokers...
  79. pmc Transcriptional profiles for glutamate transporters reveal differences between organophosphates but similarities with unrelated neurotoxicants
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Bull 83:76-83. 2010
    ....
  80. pmc Diverse neurotoxicants converge on gene expression for neuropeptides and their receptors in an in vitro model of neurodifferentiation: effects of chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 1353:36-52. 2010
    ....
  81. ncbi Disruption of rat forebrain development by glucocorticoids: critical perinatal periods for effects on neural cell acquisition and on cell signaling cascades mediating noradrenergic and cholinergic neurotransmitter/neurotrophic responses
    Marisa L Kreider
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
    Neuropsychopharmacology 30:1841-55. 2005
    ..These results indicate that, during a critical developmental period, Dex administration leads to widespread interference with forebrain development, likely contributing to eventual, adverse neurobehavioral outcomes...
  82. ncbi Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood
    Dan Qiao
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813 DUMC Rm c162, LSRC Building Research Drive, Durham, NC 27710, USA
    Brain Res Dev Brain Res 148:43-52. 2004
    ....
  83. ncbi Lasting effects of developmental dexamethasone treatment on neural cell number and size, synaptic activity, and cell signaling: critical periods of vulnerability, dose-effect relationships, regional targets, and sex selectivity
    Marisa L Kreider
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA
    Neuropsychopharmacology 31:12-35. 2006
    ..These results indicate that, during critical developmental periods, Dex administration evokes lasting alterations in neural cell numbers and synaptic function in forebrain regions, even at doses below those used in preterm infants...
  84. ncbi Gestational dexamethasone treatment elicits sex-dependent alterations in locomotor activity, reward-based memory and hippocampal cholinergic function in adolescent and adult rats
    Marisa L Kreider
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 30:1617-23. 2005
    ....
  85. ncbi Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos
    Dan Qiao
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813 DUMC, Durham, NC 27710, USA
    Brain Res Dev Brain Res 147:183-90. 2003
    ..At the same time, nicotine promotes trophic actions that protect against neurotoxicants that work through other mechanisms...
  86. pmc Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression
    Justin E Aldridge
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27701, USA
    Environ Health Perspect 113:527-31. 2005
    ..Our results indicate that neonatal CPF exposures, classically thought to be subtoxic, produce lasting changes in 5HT-related behaviors that resemble animal models of depression...
  87. ncbi Modeling the developmental neurotoxicity of nicotine in vitro: cell acquisition, growth and viability in PC12 cells
    Yael Abreu-Villaça
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813 DUMC, Durham, NC 27710, USA
    Brain Res Dev Brain Res 154:239-46. 2005
    ..g., differentiation state) in which exposure occurs...
  88. ncbi Does prenatal nicotine exposure sensitize the brain to nicotine-induced neurotoxicity in adolescence?
    Yael Abreu-Villaça
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 29:1440-50. 2004
    ....
  89. ncbi Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions
    Justin E Aldridge
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Toxicol Appl Pharmacol 203:132-44. 2005
    ..Our results indicate that 5HT systems represent a target for otherwise unrelated neuroteratogens...
  90. ncbi Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation
    Laura M Icenogle
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neurotoxicol Teratol 26:95-101. 2004
    ..The resemblance of these findings to those of late gestational or neonatal CPF exposure indicates a prolonged window of vulnerability of brain development to CPF...
  91. ncbi Prenatal nicotine exposure alters the response to nicotine administration in adolescence: effects on cholinergic systems during exposure and withdrawal
    Yael Abreu-Villaça
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 29:879-90. 2004
    ....
  92. ncbi Quantitative morphological assessment reveals neuronal and glial deficits in hippocampus after a brief subtoxic exposure to chlorpyrifos in neonatal rats
    Tara Sankar Roy
    Department of Pharmacology and Cancer Biology, Box 3813 DUMC, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Dev Brain Res 155:71-80. 2005
    ..The simultaneous targeting of neurons and glia by CPF is likely to play an important role in its developmental neurotoxicant effects...
  93. pmc Neonatal organophosphorus pesticide exposure alters the developmental trajectory of cell-signaling cascades controlling metabolism: differential effects of diazinon and parathion
    Abayomi A Adigun
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 118:210-5. 2010
    ..Organophosphorus pesticides (OPs) are developmental neurotoxicants but also produce lasting effects on metabolism...
  94. ncbi Developmental toxicity of terbutaline: critical periods for sex-selective effects on macromolecules and DNA synthesis in rat brain, heart, and liver
    Melissa C Garofolo
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Bull 59:319-29. 2003
    ..These effects may contribute to neuropsychiatric, cognitive, cardiovascular, and metabolic abnormalities reported in the offspring of women treated with beta-agonist tocolytics...
  95. pmc Neonatal dexamethasone treatment leads to alterations in cell signaling cascades controlling hepatic and cardiac function in adulthood
    Abayomi A Adigun
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neurotoxicol Teratol 32:193-9. 2010
    ....
  96. pmc Neonatal parathion exposure and interactions with a high-fat diet in adulthood: Adenylyl cyclase-mediated cell signaling in heart, liver and cerebellum
    Abayomi A Adigun
    Department of Pharmacology and Cancer Biology, Durham, NC 27710, USA
    Brain Res Bull 81:605-12. 2010
    ....
  97. ncbi Does pharmacotherapy for preterm labor sensitize the developing brain to environmental neurotoxicants? Cellular and synaptic effects of sequential exposure to terbutaline and chlorpyrifos in neonatal rats
    Melissa C Rhodes
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Toxicol Appl Pharmacol 195:203-17. 2004
    ....
  98. pmc Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling
    Justin E Aldridge
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 112:148-55. 2004
    ..These effects are likely to contribute to neurobehavioral teratology of CPF...
  99. pmc Disparate developmental neurotoxicants converge on the cyclic AMP signaling cascade, revealed by transcriptional profiles in vitro and in vivo
    Abayomi A Adigun
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, Box 3813 DUMC, Duke Univ Med Ctr, Durham, NC 27710, USA
    Brain Res 1316:1-16. 2010
    ....
  100. pmc Organophosphate exposure during a critical developmental stage reprograms adenylyl cyclase signaling in PC12 cells
    Abayomi A Adigun
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 1329:36-44. 2010
    ....
  101. pmc Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cells
    Ruth R Jameson
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 114:667-72. 2006
    ....

Research Grants37

  1. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....
  2. DRUGS AND DEVELOPMENT OF ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 1980
    ....
  3. MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY
    Theodore Slotkin; Fiscal Year: 2004
    ..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
  4. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  5. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 1992
    ....