John Simon

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Spectroscopy and photoreactivity of trichochromes: molecular components of pheomelanins
    John D Simon
    Department of Chemistry, Duke University, Durham, NC 27708 0346, USA
    Photochem Photobiol 82:318-23. 2006
  2. ncbi request reprint A2E: a component of ocular lipofuscin
    Laura E Lamb
    Department of Chemistry, Duke University, Durham, NC 27708 0346, USA
    Photochem Photobiol 79:127-36. 2004
  3. doi request reprint The red and the black
    John D Simon
    Department of Chemistry, Duke University, Durham, North Carolina 27705, USA
    Acc Chem Res 43:1452-60. 2010
  4. doi request reprint Introduction to the Symposium-in-Print on Melanins
    John D Simon
    Department of Chemistry, Duke University, Durham, NC, USA
    Photochem Photobiol 84:537-8. 2008
  5. doi request reprint Current challenges in understanding melanogenesis: bridging chemistry, biological control, morphology, and function
    John D Simon
    Department of Chemistry, Duke University, Durham, NC, USA
    Pigment Cell Melanoma Res 22:563-79. 2009
  6. doi request reprint Insights into the thermodynamics of copper association with amyloid-β, α-synuclein and prion proteins
    Lian Hong
    Department of Chemistry, Duke University, Durham, NC 27708, USA
    Metallomics 3:262-6. 2011
  7. pmc Quantification of the binding properties of Cu2+ to the amyloid beta peptide: coordination spheres for human and rat peptides and implication on Cu2+-induced aggregation
    Lian Hong
    Department of Chemistry, Duke University, Durham, North Carolina 27708, USA
    J Phys Chem B 114:11261-71. 2010
  8. ncbi request reprint Comparisons of the structural and chemical properties of melanosomes isolated from retinal pigment epithelium, iris and choroid of newborn and mature bovine eyes
    Yan Liu
    Department of Chemistry, Duke University, Durham, NC 27708 0346, USA
    Photochem Photobiol 81:510-6. 2005
  9. doi request reprint Human iridal stroma melanosomes of varying pheomelanin contents possess a common eumelanic outer surface
    Dana N Peles
    Department of Chemistry, Duke University, Durham, North Carolina 27708, USA
    J Phys Chem B 113:11346-51. 2009
  10. ncbi request reprint Insight into the binding of divalent cations to Sepia eumelanin from IR absorption spectroscopy
    Lian Hong
    Department of Chemistry, Duke University, Durham, NC, USA
    Photochem Photobiol 82:1265-9. 2006

Research Grants

Collaborators

  • Lian Hong
  • S Ito
  • Kazumasa Wakamatsu
  • L Zecca
  • Tadeusz Sarna
  • Warren Warren
  • GLENN MILLHAUSER
  • David Beratan
  • Xin Chen
  • Ziqiang Guan
  • CHRISTIAN RAETZ
  • Dan Ning Hu
  • Richard Manderville
  • Janice Burke
  • Michael C Pirrung
  • Yan Liu
  • Tong Ye
  • Weslyn C Ward
  • William D Bush
  • Dana N Peles
  • Robert J Nemanich
  • Jacob Garguilo
  • Fabio A Zucca
  • Glenn S Edwards
  • Lanying Q Hatcher
  • J Brian Nofsinger
  • Jennifer L Perry
  • Alexander Samokhvalov
  • Laura E Lamb
  • Anna Pawlak
  • Mariusz Zareba
  • Yuri V Il'ichev
  • Chiara Bellei
  • Senli Guo
  • Dan Fu
  • David Sulzer
  • Clifford R Bowers
  • Chi Yuan Cheng
  • Jian Dai
  • Małgorzata Rózanowska
  • Valerie R Kempf
  • Christine Skumatz
  • Nicole M Haralampus-Grynaviski
  • Emily E Weinert
  • Eugene Mosharov
  • David J Burinsky
  • Boris B Akhremitchev
  • Erin C Lamb
  • James Grichnik
  • David Gooden
  • Tessa Carducci
  • Thomas E Matthews
  • Zsolt Talloczy
  • Reza Kordestani
  • Ruggero G Fariello
  • Michele M Henry
  • Melissa A Pasquinelli
  • Trine Christensen
  • Eric J Toone
  • Alberto Albertini
  • Grzegorz Szewczyk
  • T Richard Williams
  • Justin Gorham
  • Michael R Goldsmith
  • Kyle P Radack
  • Bhavin Adhyaru
  • Bhavin B Adhyaru
  • John B Pritchard
  • Mike E Boulton
  • Annie Pfohl-Leszkowicz
  • Virginie Faucet
  • Bartosz Rozanowski
  • Gyungse Park
  • Daniel A J Bow
  • Mark Rudnicki
  • Christine M R Clancy
  • Michael Dockal
  • Florian Ruker

Detail Information

Publications56

  1. ncbi request reprint Spectroscopy and photoreactivity of trichochromes: molecular components of pheomelanins
    John D Simon
    Department of Chemistry, Duke University, Durham, NC 27708 0346, USA
    Photochem Photobiol 82:318-23. 2006
    ..Both trichochromes are efficient quenchers of 1O2, exhibiting a bimolecular rate constant comparable with vitamin C. These results suggest that trichochromes could serve a protective role in pheomelanin pigments...
  2. ncbi request reprint A2E: a component of ocular lipofuscin
    Laura E Lamb
    Department of Chemistry, Duke University, Durham, NC 27708 0346, USA
    Photochem Photobiol 79:127-36. 2004
    ..This article presents the current understanding of the photochemistry of A2E and its involvement as a phototoxic agent in RPE cells...
  3. doi request reprint The red and the black
    John D Simon
    Department of Chemistry, Duke University, Durham, North Carolina 27705, USA
    Acc Chem Res 43:1452-60. 2010
    ..These results suggest that the epidemiological data may simply result from an increased exposure of the underlying tissues to UV light...
  4. doi request reprint Introduction to the Symposium-in-Print on Melanins
    John D Simon
    Department of Chemistry, Duke University, Durham, NC, USA
    Photochem Photobiol 84:537-8. 2008
  5. doi request reprint Current challenges in understanding melanogenesis: bridging chemistry, biological control, morphology, and function
    John D Simon
    Department of Chemistry, Duke University, Durham, NC, USA
    Pigment Cell Melanoma Res 22:563-79. 2009
    ....
  6. doi request reprint Insights into the thermodynamics of copper association with amyloid-β, α-synuclein and prion proteins
    Lian Hong
    Department of Chemistry, Duke University, Durham, NC 27708, USA
    Metallomics 3:262-6. 2011
    ..This current review reconciles the disparate models presented in the literature...
  7. pmc Quantification of the binding properties of Cu2+ to the amyloid beta peptide: coordination spheres for human and rat peptides and implication on Cu2+-induced aggregation
    Lian Hong
    Department of Chemistry, Duke University, Durham, North Carolina 27708, USA
    J Phys Chem B 114:11261-71. 2010
    ..The differences in the coordination geometries for Cu(2+) by the human and rat Abeta are proposed to contribute to the variation in the ability of Cu(2+) to induce aggregation of Abeta peptides...
  8. ncbi request reprint Comparisons of the structural and chemical properties of melanosomes isolated from retinal pigment epithelium, iris and choroid of newborn and mature bovine eyes
    Yan Liu
    Department of Chemistry, Duke University, Durham, NC 27708 0346, USA
    Photochem Photobiol 81:510-6. 2005
    ....
  9. doi request reprint Human iridal stroma melanosomes of varying pheomelanin contents possess a common eumelanic outer surface
    Dana N Peles
    Department of Chemistry, Duke University, Durham, North Carolina 27708, USA
    J Phys Chem B 113:11346-51. 2009
    ..This provides new insights into the potential contribution of iridal stroma melanosomes both to inducing oxidative stress and to accounting for the observed iris-color-dependent epidemiology of uveal melanoma...
  10. ncbi request reprint Insight into the binding of divalent cations to Sepia eumelanin from IR absorption spectroscopy
    Lian Hong
    Department of Chemistry, Duke University, Durham, NC, USA
    Photochem Photobiol 82:1265-9. 2006
    ....
  11. doi request reprint Quantification of the binding constant of copper(II) to the amyloid-beta peptide
    Lanying Q Hatcher
    Department of Chemistry, Duke University, Durham, NC 27708, USA
    J Phys Chem B 112:8160-4. 2008
    ..Several previously reported values can be reconciled with the current measurement by careful consideration of thermodynamics associated with the presence of competing ligands used to solubilize copper...
  12. doi request reprint Ultra-low temperature oxidation of 5,6-dihydroxyindole: a novel approach to study synthetic melanogenesis
    Lanying Q Hatcher
    Department of Chemistry, Duke University, Durham, NC, USA
    Photochem Photobiol 84:608-12. 2008
    ..MS analysis of the reaction mixture reveals the DHI dimer as well as other extensively oxidized DHI units...
  13. ncbi request reprint Interaction of ochratoxin A with human serum albumin. Binding sites localized by competitive interactions with the native protein and its recombinant fragments
    Yuri V Il'ichev
    Department of Chemistry, Duke University, Durham, NC 27708, USA
    Chem Biol Interact 141:275-93. 2002
    ..9 x 10(5) M(-1), was smaller than the largest constant for HSA by a factor of approximately 7. The binding constant for OTA with D3, 1.1 x 10(5) M(-1), was very close to that of the secondary binding site for HSA...
  14. ncbi request reprint Quantification of Ca(2+) binding to melanin supports the hypothesis that melanosomes serve a functional role in regulating calcium homeostasis
    William D Bush
    Department of Chemistry, Duke University, Durham, NC, USA
    Pigment Cell Res 20:134-9. 2007
    ..Using this binding constant and the data from a fluorescent Ca(2+) displacement assay, the pK(a) of the carboxyl group coordinated to Ca(2+) is determined to be 3.1 +/- 0.1...
  15. ncbi request reprint The differing embryonic origins of retinal and uveal (iris/ciliary body and choroid) melanosomes are mirrored by their phospholipid composition
    Weslyn C Ward
    Department of Chemistry, Duke University, Durham, NC, USA
    Pigment Cell Res 20:61-9. 2007
    ..While the structural and functional roles of melanosomal lipids largely remain to be determined, these different lipid compositions reported herein offer new insights into the roles of melanosomes in the different ocular tissues...
  16. ncbi request reprint Age-dependent photoionization thresholds of melanosomes and lipofuscin isolated from human retinal pigment epithelium cells
    Lian Hong
    Department of Chemistry, Duke University, Durham, NC, USA
    Photochem Photobiol 82:1475-81. 2006
    ..These data suggest that thin deposits of lipofuscin on the surface of retinal pigment epithelium melanosomes are common in the aged eye and that this renders the melanosomes more pro-oxidant...
  17. doi request reprint Insights into melanosomes and melanin from some interesting spatial and temporal properties
    John D Simon
    Department of Chemistry, Duke University, Durham, NC, USA
    J Phys Chem B 112:13201-17. 2008
    ..The article concludes with a brief discussion of important unanswered research questions in this field...
  18. ncbi request reprint Photoionization thresholds of melanins obtained from free electron laser-photoelectron emission microscopy, femtosecond transient absorption spectroscopy and electron paramagnetic resonance measurements of oxygen photoconsumption
    Tong Ye
    Department of Chemistry, Duke University, Durham, NC, USA
    Photochem Photobiol 82:733-7. 2006
    ..The lower ionization potential observed for pheomelanin could be an important part of the explanation for the greater incidence rate of UV-induced skin cancers in red-haired individuals...
  19. pmc Current understanding of the binding sites, capacity, affinity, and biological significance of metals in melanin
    Lian Hong
    Department of Chemistry, Duke University, Durham, North Carolina 27708, USA
    J Phys Chem B 111:7938-47. 2007
    ..This article examines the current state of understanding of this field...
  20. ncbi request reprint Physical and chemical characterization of iris and choroid melanosomes isolated from newborn and mature cows
    Lian Hong
    Department of Chemistry, Duke University, Durham, NC 27708 0346, USA
    Photochem Photobiol 81:517-23. 2005
    ..These tissue-related and age-related chemical differences between samples affected the optic density and metal binding properties of melanosomes, which are believed to be closely associated with the biological functions of melanins...
  21. ncbi request reprint Aggregation of eumelanin mitigates photogeneration of reactive oxygen species
    J Brian Nofsinger
    Department of Chemistry, Duke University Medical Center, Durham, NC 27708 0347, USA
    Free Radic Biol Med 32:720-30. 2002
    ..The effect of aggregation on the photogeneration of ROS serves to provide a foundation for the understanding of the dichotomy of photoprotective and phototoxic properties of melanin...
  22. ncbi request reprint Metal-ion interactions and the structural organization of Sepia eumelanin
    Yan Liu
    Department of Chemistry, Duke University, Durham, NC, USA
    Pigment Cell Res 18:42-8. 2005
    ....
  23. ncbi request reprint Establishing structure-function relationships for eumelanin
    J Brian Nofsinger
    Department of Chemistry, Duke University, Durham, North Carolina 27708, USA
    Biopolymers 67:302-5. 2002
    ....
  24. doi request reprint Binding of Cu(II) to human alpha-synucleins: comparison of wild type and the point mutations associated with the familial Parkinson's disease
    Lian Hong
    Department of Chemistry, Duke University, Durham, NC 27708, USA
    J Phys Chem B 113:9551-61. 2009
    ..g., small oligomeric species, such as dimers and trimers) relative to WT and A53T. Thus, we propose that the high affinity site is attributed to the binding of Cu(II) to those small oligomeric species...
  25. ncbi request reprint Isolation and biophysical studies of natural eumelanins: applications of imaging technologies and ultrafast spectroscopy
    Yan Liu
    Department of Chemistry, Duke University, Durham, NC 27708, USA
    Pigment Cell Res 16:606-18. 2003
    ..Ultrafast laser spectroscopy studies of melanins are providing insights into the time scales and mechanisms by which melanin dissipates absorbed light energy...
  26. doi request reprint The ultraviolet absorption coefficient of melanosomes decreases with increasing pheomelanin content
    Dana N Peles
    Department of Chemistry, Duke University, Durham, North Carolina 27708, USA
    J Phys Chem B 114:9677-83. 2010
    ..2). On the basis of the reported optical properties of synthetic models, this result suggests that the absorption of pheomelanin is less than eumelanin at wavelengths of biological relevance ( approximately 315-400 nm)...
  27. ncbi request reprint Ion-exchange and adsorption of Fe(III) by Sepia melanin
    Yan Liu
    Department of Chemistry, Duke University, Durham, NC, USA
    Pigment Cell Res 17:262-9. 2004
    ..These observations imply the existence of channels within the melanin granules that can serve to transport metal ions...
  28. ncbi request reprint Binding of metal ions to melanin and their effects on the aerobic reactivity
    Lian Hong
    Department of Chemistry, Duke University, Durham, NC 27708 0346, USA
    Photochem Photobiol 80:477-81. 2004
    ..Cu(II)- and Fe(III)-enriched melanins induce the most damage. Hydroxyl radical, *OH, is proposed to be one of the reactive oxygen species responsible...
  29. doi request reprint Surface elastic properties of human retinal pigment epithelium melanosomes
    Senli Guo
    Department of Chemistry, Duke University, Durham, NC, USA
    Photochem Photobiol 84:671-8. 2008
    ..This suggestion indicates that part of the difference in photochemical properties between the old and young melanosomes originates from surface lipofuscin...
  30. ncbi request reprint The effect of preparation procedures on the morphology of melanin from the ink sac of Sepia officinalis
    Yan Liu
    Department of Chemistry, Duke University, Durham, NC 27708 0346, USA
    Pigment Cell Res 16:72-80. 2003
    ..The implications of these results on quantifying photochemical properties and kinetic reaction rate constants of melanin are discussed...
  31. ncbi request reprint Ultrafast absorption and photothermal studies of decarboxytrichochrome C in solution
    Tong Ye
    Department of Chemistry, Duke University, Durham, NC 27708, USA
    Photochem Photobiol Sci 2:821-3. 2003
    ..The combination of ultrafast absorption and photoacoustic data suggest photoexcitation produces a long-lived intermediate and the energy of this species is at least 133 kJ mol(-1) above the ground state of the dTC molecule...
  32. ncbi request reprint The surface oxidation potential of melanosomes measured by free electron laser-photoelectron emission microscopy
    Jacob Garguilo
    Department of Physics, North Carolina State University, Raleigh, NC, USA
    Photochem Photobiol 83:692-7. 2007
    ..This result is discussed in relation to the age-dependent accumulation of iron in human melanosomes in both the eye and brain...
  33. doi request reprint Neuromelanins isolated from different regions of the human brain exhibit a common surface photoionization threshold
    William D Bush
    Department of Chemistry, Duke University, Durham, NC, USA
    Photochem Photobiol 85:387-90. 2009
    ..5 +/- 0.2 eV (-0.1 +/- 0.2 V vs NHE). All neuromelanins exhibit a common low surface oxidation potential, reflecting their eumelanic component and their inability to trigger redox processes with neurotoxic effect...
  34. doi request reprint Neuromelanins in various regions of human brain are associated with native and oxidized isoprenoid lipids
    Weslyn C Ward
    Department of Chemistry, Duke University, Durham, NC 27708, USA
    Arch Biochem Biophys 484:94-9. 2009
    ..Oxidized and reduced dolichol-related species were identified and determined to be region-dependent...
  35. ncbi request reprint Comparison of the structural and physical properties of human hair eumelanin following enzymatic or acid/base extraction
    Yan Liu
    Department of Chemistry, Duke University, Durham, NC 27708, USA
    Pigment Cell Res 16:355-65. 2003
    ..The enzymatically extracted hair melanin, on the contrary, retains the morphology of intact melanosomes and is an excellent source of human melanin...
  36. doi request reprint Direct measurement of the ultraviolet absorption coefficient of single retinal melanosomes
    Dana N Peles
    Department of Chemistry, Duke University, Durham, NC, USA
    Photochem Photobiol 86:279-81. 2010
    ....
  37. doi request reprint Quantification of naturally occurring pyrrole acids in melanosomes
    Weslyn C Ward
    Department of Chemistry, Duke University, Durham, NC, USA
    Photochem Photobiol 84:700-5. 2008
    ..This work also establishes that PTeCA is a naturally occurring pyrrole acid in melanosomes...
  38. doi request reprint Probing skin pigmentation changes with transient absorption imaging of eumelanin and pheomelanin
    Dan Fu
    Princeton University, Department of Chemistry, Princeton, New Jersey 08544, USA
    J Biomed Opt 13:054036. 2008
    ..This difference should enable us to map out their respective distribution in tissue samples with subcellular resolution. This technique could provide valuable information in diagnosing the malignant transformation of melanocytes...
  39. pmc Spectroscopic and morphological studies of human retinal lipofuscin granules
    Nicole M Haralampus-Grynaviski
    Department of Chemistry, Duke University, Durham, NC 27708, USA
    Proc Natl Acad Sci U S A 100:3179-84. 2003
    ....
  40. ncbi request reprint Ultrafast energy transfer from bound tetra(4-N,N,N,N-trimethylanilinium)porphyrin to synthetic dopa and cysteinyldopa melanins
    Tong Ye
    Department of Chemistry, Duke University, Durham, NC 27708 0346, USA
    Photochem Photobiol 77:1-4. 2003
    ..These results are consistent with previous photoacoustic studies, which revealed that the TAP-melanin complex behaves like a supermolecular system liberating heat as a whole...
  41. ncbi request reprint The action spectrum for generation of the primary intermediate revealed by ultrafast absorption spectroscopy studies of pheomelanin
    Tong Ye
    Department of Chemistry, Duke University, Durham, NC 27708 0346, USA
    Photochem Photobiol 77:41-5. 2003
    ....
  42. ncbi request reprint Characterization of the Fe(III)-binding site in Sepia eumelanin by resonance Raman confocal microspectroscopy
    Alexander Samokhvalov
    Department of Chemistry, Duke University, Durham, NC 27708 0346, USA
    Photochem Photobiol 80:84-8. 2004
    ..The 580 and 1470 cm(-1) bands are assigned to Fe-OR stretching and ring deformation modes, respectively. These data further substantiate that the Fe(III)-melanin-binding site in melanin is composed of CAT-like structural units...
  43. ncbi request reprint Oxidation potentials of human eumelanosomes and pheomelanosomes
    Alexander Samokhvalov
    Department of Chemistry, Duke University, Durham, NC 27708, USA
    Photochem Photobiol 81:145-8. 2005
    ..The FEL-PEEM experiment offers to be an important new approach for quantifying the effects of age, oxidation and metal accumulation on the oxidation potentials of intact melanosomes...
  44. ncbi request reprint Comparison of structural and chemical properties of black and red human hair melanosomes
    Yan Liu
    Department of Chemistry, Duke University, Durham, NC 27708, USA
    Photochem Photobiol 81:135-44. 2005
    ..Excellent agreement is observed between these spectral results and the chemical degradation data...
  45. ncbi request reprint Molecular aspects of the transport and toxicity of ochratoxin a
    Jian Dai
    Department of Chemistry, Wake Forest University, Winston Salem, North Carolina 27106, USA
    Acc Chem Res 37:874-81. 2004
    ..These studies are beginning to provide a detailed chemical model for the trans-port, accumulation, and genotoxic and carcinogenic effects of OTA...
  46. ncbi request reprint Binding of warfarin influences the acid-base equilibrium of H242 in sudlow site I of human serum albumin
    Jennifer L Perry
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Photochem Photobiol 82:1365-9. 2006
    ..30+/-0.02 protons from the solvent. This measurement suggests that the binding of W- is stabilized by an ion-pair interaction between protonated H242 and the phenoxide group of W-...
  47. pmc The surface oxidation potential of human neuromelanin reveals a spherical architecture with a pheomelanin core and a eumelanin surface
    William D Bush
    Department of Chemistry, Duke University, Durham, NC 27708, USA
    Proc Natl Acad Sci U S A 103:14785-9. 2006
    ..Such a kinetic model would predict a structural motif with pheomelanin at the core and eumelanin at the surface, which is consistent with the measured surface oxidation potential of the approximately 30-nm constituents of NM granules...
  48. ncbi request reprint Identification and quantification of dolichol and dolichoic acid in neuromelanin from substantia nigra of the human brain
    Weslyn C Ward
    Department of Chemistry, Duke University, Durham, NC, USA
    J Lipid Res 48:1457-62. 2007
    ..The distribution of dol-CA chains lengths in NM also differed from that of dol, suggesting that the enzyme(s) responsible for the conversion of dol to dol-CA prefer a dolichol substrate containing 19 isoprene units...
  49. ncbi request reprint Mechanistic studies on the photochemical deprotection of 3',5'-dimethoxybenzoin esters
    Michael C Pirrung
    Department of Chemistry, University of California, Riverside, CA 92521 0403 USA
    Photochem Photobiol 82:1258-64. 2006
    ..In this multistep reaction, benzofuran formation by a final deprotonation is slower than alpha-ketocation generation...
  50. doi request reprint Perspectives on the structure and function of melanin
    John D Simon
    Pigment Cell Melanoma Res 21:346-7. 2008
  51. doi request reprint Role of ocular melanin in ophthalmic physiology and pathology
    Dan Ning Hu
    Tissue Culture Center, Department of Pathology, The New York Eye and Ear Infirmary and New York Medical College, New York, NY, USA
    Photochem Photobiol 84:639-44. 2008
    ....
  52. ncbi request reprint Age-related changes in the photoreactivity of retinal lipofuscin granules: role of chloroform-insoluble components
    Małgorzata Rózanowska
    Department of Biophysics, Faculty of Biotechnology, Krakow, Poland School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
    Invest Ophthalmol Vis Sci 45:1052-60. 2004
    ..As the composition, absorption, and fluorescence of lipofuscin undergo age-related changes, the purpose of this study was to determine whether photoreactivity of lipofuscin granules also changes with the donor age...
  53. doi request reprint Different molecular constituents in pheomelanin are responsible for emission, transient absorption and oxygen photoconsumption
    Tong Ye
    Department of Neurobiology, University of Alabama, Birmingham, AL, USA
    Photochem Photobiol 84:437-43. 2008
    ..This raises concern about comparing the results from different photochemical methodologies for melanin, which is a specific case of comparing data on systems where molecular constituents are not well defined...
  54. ncbi request reprint Effects of photodegradation on the physical and antioxidant properties of melanosomes isolated from retinal pigment epithelium
    Mariusz Zareba
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, USA
    Photochem Photobiol 82:1024-9. 2006
    ....
  55. ncbi request reprint Melanin structure and the potential functions of uveal melanosomes
    Lian Hong
    Pigment Cell Res 19:465-6. 2006
  56. doi request reprint Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease
    David Sulzer
    Department of Neurology, Columbia University, New York, NY 10036, USA
    J Neurochem 106:24-36. 2008
    ....

Research Grants5