Ilene Siegler

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Consistency and timing of marital transitions and survival during midlife: the role of personality and health risk behaviors
    Ilene C Siegler
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Ann Behav Med 45:338-47. 2013
  2. ncbi request reprint Associations among NEO personality assessments and well-being at midlife: facet-level analyses
    I C Siegler
    Behavioral Medicine Research Center, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Psychol Aging 15:710-4. 2000
  3. ncbi request reprint Patterns of change in hostility from college to midlife in the UNC Alumni Heart Study predict high-risk status
    Ilene C Siegler
    Department of Psychiatry and Behavioral Sciences and Behavioral Medicine Research Center, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 65:738-45. 2003
  4. ncbi request reprint Behavioral medicine and aging
    Ilene C Siegler
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina 27710, USA
    J Consult Clin Psychol 70:843-51. 2002
  5. pmc Caregiving, residence, race, and depressive symptoms
    Ilene C Siegler
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Aging Ment Health 14:771-8. 2010
  6. ncbi request reprint Allelic differences in the serotonin transporter-linked polymorphic region in geriatric depression
    David C Steffens
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
    Am J Geriatr Psychiatry 10:185-91. 2002
  7. ncbi request reprint Psychophysiological mediators of caregiver stress and differential cognitive decline
    Peter P Vitaliano
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
    Psychol Aging 20:402-11. 2005
  8. ncbi request reprint Prospective study of perceived stress in cardiac patients
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Ann Behav Med 27:22-30. 2004
  9. pmc Personality and inflammation: the protective effect of openness to experience
    Charles R Jonassaint
    Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, USA
    Ethn Dis 20:11-4. 2010
  10. pmc Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls
    Sofia I Iqbal Kring
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Psychosom Med 72:427-33. 2010

Research Grants

Detail Information

Publications50

  1. pmc Consistency and timing of marital transitions and survival during midlife: the role of personality and health risk behaviors
    Ilene C Siegler
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Ann Behav Med 45:338-47. 2013
    ..Marital status is associated with survival...
  2. ncbi request reprint Associations among NEO personality assessments and well-being at midlife: facet-level analyses
    I C Siegler
    Behavioral Medicine Research Center, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Psychol Aging 15:710-4. 2000
    ..The facets within each domain demonstrated different patterns of associations with the well-being measures, indicating that facet-level assessments yield additional information...
  3. ncbi request reprint Patterns of change in hostility from college to midlife in the UNC Alumni Heart Study predict high-risk status
    Ilene C Siegler
    Department of Psychiatry and Behavioral Sciences and Behavioral Medicine Research Center, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 65:738-45. 2003
    ..To examine hostility measured in college and patterns of change in hostility from college to midlife as predictors of high health-related risk later in midlife...
  4. ncbi request reprint Behavioral medicine and aging
    Ilene C Siegler
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina 27710, USA
    J Consult Clin Psychol 70:843-51. 2002
    ..Also discussed are potential problems in age-related research, ways to improve the knowledge base in behavioral medicine and aging, and thoughts about future challenges to enhance work in behavioral medicine and aging...
  5. pmc Caregiving, residence, race, and depressive symptoms
    Ilene C Siegler
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Aging Ment Health 14:771-8. 2010
    ..To conclude, all the parameters such as race, living arrangements, and the components of depression need to be taken into account to understand the impact of caregiving on the emotional health of caregivers...
  6. ncbi request reprint Allelic differences in the serotonin transporter-linked polymorphic region in geriatric depression
    David C Steffens
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
    Am J Geriatr Psychiatry 10:185-91. 2002
    ..The findings raise the possibility that this genetic locus may exert differential effects based on gender, increasing risk in men, and increasing risk of recurrence in women...
  7. ncbi request reprint Psychophysiological mediators of caregiver stress and differential cognitive decline
    Peter P Vitaliano
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
    Psychol Aging 20:402-11. 2005
    ..This is the first study of cognitive decline and mediators in caregivers. This work has implications for caregiver and care-recipient health and for research on cognition, psychophysiology, diabetes, and AD...
  8. ncbi request reprint Prospective study of perceived stress in cardiac patients
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Ann Behav Med 27:22-30. 2004
    ..Although the study of stress CAD samples has received considerable attention, few studies have examined the effects of gender and age, had multiple follow-ups over an extended period, and had extensive baseline assessment batteries...
  9. pmc Personality and inflammation: the protective effect of openness to experience
    Charles R Jonassaint
    Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, USA
    Ethn Dis 20:11-4. 2010
    ....
  10. pmc Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls
    Sofia I Iqbal Kring
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Psychosom Med 72:427-33. 2010
    ..Current evidence supports the hypothesis that gene-environment interactions modulate serum lipid concentrations...
  11. ncbi request reprint Childhood socioeconomic status and serotonin transporter gene polymorphism enhance cardiovascular reactivity to mental stress
    Redford B Williams
    Department of Psychiatry and Behavioral Sciences, Box 3926, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 70:32-9. 2008
    ..We found the long allele associated with larger CVR to mental stress in a preliminary study of 54 normal volunteers...
  12. pmc Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR)
    Beverly H Brummett
    Department of Psychiatry and Behavioral Medicine, Duke University Medical Center, Box 2969, Durham, NC 27710, USA
    Behav Genet 38:34-43. 2008
    ..Findings from two independent samples suggest that the association of 5-HTTLPR with depression varies according to gender and stressful life events...
  13. pmc Sleep quality varies as a function of 5-HTTLPR genotype and stress
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 69:621-4. 2007
    ..A common 44-base pair deletion (s allele) polymorphism in the 5-HTTLPR is associated with reduced 5HTT transcription efficiency and 5HT uptake in vitro...
  14. pmc Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 69:396-401. 2007
    ..MAOA-uVNTR genotype has been associated with both psychological and physical measures...
  15. ncbi request reprint Prediction of all-cause mortality by the Minnesota Multiphasic Personality Inventory Optimism-Pessimism Scale scores: study of a college sample during a 40-year follow-up period
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Box 2969, Duke University Medical Center, Durham, NC 27710, USA
    Mayo Clin Proc 81:1541-4. 2006
    ..To examine a measure of explanatory style, the Optimism-Pessimism (PSM) scale derived from college-entry Minnesota Multiphasic Personality Inventory scores, as a predictor of all-cause mortality...
  16. ncbi request reprint Associations among perceptions of social support, negative affect, and quality of sleep in caregivers and noncaregivers
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Health Psychol 25:220-5. 2006
    ..The structural model accounted for approximately 43% of the variance in sleep quality. The present findings may be useful in the development of successful sleep interventions for caregivers...
  17. pmc Personality as a predictor of dietary quality in spouses during midlife
    Beverly H Brummett
    Duke University Medical Center, Durham, NC 27710, USA
    Behav Med 34:5-10. 2008
    ..08-.09). Openness was associated with healthy eating habits--findings that may affect disease prevention during, midlife...
  18. pmc Lipid levels are associated with a regulatory polymorphism of the monoamine oxidase-A gene promoter (MAOA-uVNTR)
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Med Sci Monit 14:CR57-61. 2008
    ..Allelic variation in MAOA-uVNTR has been associated with body mass index (BMI). We extended previous work by examining relations among this polymorphism and serum lipid levels...
  19. pmc Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in men
    Redford B Williams
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 72:601-7. 2010
    ....
  20. pmc Associations of depressive symptoms, trait hostility, and gender with C-reactive protein and interleukin-6 response after emotion recall
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Psychosom Med 72:333-9. 2010
    ..Depressive symptoms moderate the effect of trait hostility on circulating levels of CRP and IL-6...
  21. pmc Socioeconomic status moderates associations between CNS serotonin and expression of beta2-integrins CD11b and CD11c
    Beverly H Brummett
    Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    J Psychiatr Res 44:373-7. 2010
    ....
  22. pmc Hostility and fasting glucose in African American women
    Anastasia Georgiades
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina 27710, USA
    Psychosom Med 71:642-5. 2009
    ..HOST has been associated with abnormalities in glucose metabolism. Prior studies suggested that this association may be more prevalent in women and in African American (AA) individuals...
  23. pmc 5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 2969, Durham, NC 27710, USA
    Behav Genet 38:476-83. 2008
    ..013), and trended towards predicting anger-hostility (P = .084). Males in the HiHi group had greater increases in negative affect during infusion, compared to all groups except LoLo females, who also showed increased negative affect...
  24. pmc HPA axis function in male caregivers: effect of the monoamine oxidase-A gene promoter (MAOA-uVNTR)
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Biol Psychol 79:250-5. 2008
    ..5/4 repeats) (cortisol p<.043). Individuals with less active MAOA-uVNTR alleles who are under chronic stress may be at increased risk for exhaustion of the HPA response to such stress...
  25. pmc Associations among central nervous system serotonergic function and neuroticism are moderated by gender
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Biol Psychol 78:200-3. 2008
    ..Remaining personality domains were not related to prolactin levels. Findings add to literature suggesting the serotonin system functions differently, in important ways, in males and females...
  26. ncbi request reprint Neighborhood characteristics moderate effects of caregiving on glucose functioning
    Beverly H Brummett
    Department of Psychiatry and Behavioral Medicine, Duke University Medical Center, Durham, North Carolina, 27710, USA
    Psychosom Med 67:752-8. 2005
    ....
  27. ncbi request reprint Facets of openness predict mortality in patients with cardiac disease
    Charles R Jonassaint
    Department of Psychiatry, Duke University, Durham, North Carolina, USA
    Psychosom Med 69:319-22. 2007
    ..To examine the NEO Personality Inventory (NEO PI) Openness to Experience (O) domain and its facets as predictors of cardiac deaths and all-cause mortality...
  28. ncbi request reprint Effect of smoking and sedentary behavior on the association between depressive symptoms and mortality from coronary heart disease
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Durham, North Carolina 27710, USA
    Am J Cardiol 92:529-32. 2003
    ..Results indicated that smoking and/or sedentary behavior may partially mediate the relation between depressive symptoms and mortality. No evidence for moderation was found...
  29. ncbi request reprint Serotonin-related gene polymorphisms and central nervous system serotonin function
    Redford B Williams
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3926, Durham, NC 27710, USA
    Neuropsychopharmacology 28:533-41. 2003
    ....
  30. ncbi request reprint Associations among the NEO Personality Inventory, Revised and the serotonin transporter gene-linked polymorphic region in elders: effects of depression and gender
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Psychiatr Genet 13:13-8. 2003
    ..We attempted to replicate findings suggesting a positive relation between the short allele variant of 5-HTTLPR and Neuroticism, and a negative association between the short allele variant and Agreeableness...
  31. ncbi request reprint Coping styles and personality domains related to menopausal stress
    Hayden B Bosworth
    Department of Medicine, Division of General Internal Medicine, Duke University, Durham, North Carolina, USA
    Womens Health Issues 13:32-8. 2003
    ....
  32. ncbi request reprint Evaluating participants' use of a hormone replacement therapy decision-making intervention
    Lori A Bastian
    Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, 508 Fulton Street 152, Durham, NC 27705, USA
    Patient Educ Couns 48:283-91. 2002
    ....
  33. ncbi request reprint Alcoholic beverage preference, diet, and health habits in the UNC Alumni Heart Study
    John C Barefoot
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Am J Clin Nutr 76:466-72. 2002
    ..Moderate alcohol intake is related to better health, and additional benefits may be associated with wine. However, beverage preference may be confounded by lifestyle factors related to health...
  34. pmc A tailored intervention to aid decision-making about hormone replacement therapy
    Colleen M McBride
    The Comprehensive Cancer Center, Duke University Medical Center, Durham, NC 27710 2949, USA
    Am J Public Health 92:1112-4. 2002
  35. ncbi request reprint Terminal change in cognitive function: an updated review of longitudinal studies
    Hayden B Bosworth
    Health Services Research and Development, Veterans Affairs Medical Center, Department of Psychiatry and Behavioral Science, Behavioral Medicine Research Center, Duke University Medical Center, Durham, North Carolina, USA
    Exp Aging Res 28:299-315. 2002
    ....
  36. ncbi request reprint Predictors of smoking cessation in patients with a diagnosis of coronary artery disease
    Beverly H Brummett
    Behavioral Medicine Research Center and the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiopulm Rehabil 22:143-7. 2002
    ..This study aimed to examine demographic, psychosocial, and clinical variables as predictors of smoking cessation in patients with coronary artery disease...
  37. ncbi request reprint Associations among social support, income, and symptoms of depression in an educated sample: the UNC Alumni Heart Study
    Beverly H Brummett
    Duke University Medical Center, Durham, NC 27710, USA
    Int J Behav Med 10:239-50. 2003
    ..The present results extend previous work regarding the moderating effect of income to a sample of relatively high education and income level...
  38. ncbi request reprint Hostility, race, and glucose metabolism in nondiabetic individuals
    Richard S Surwit
    Department of Psychiatry, Duke University School of Medicine, Durham, North Carolina 27710, USA
    Diabetes Care 25:835-9. 2002
    ..The present study was designed to determine whether hostility is differentially related to measures of glucose metabolism in African-Americans and Caucasians...
  39. ncbi request reprint Hostility, age, and mortality in a sample of cardiac patients
    Stephen H Boyle
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 96:64-6. 2005
    ..After controlling for disease severity, there was a significant interaction between age and hostility. Hostility was significantly associated with poorer survival but only in younger (<61.2 years) patients...
  40. ncbi request reprint Hostility as a predictor of survival in patients with coronary artery disease
    Stephen H Boyle
    Department of Psychiatry, Duke University Medical Center, Box 2969, Durham, NC, USA
    Psychosom Med 66:629-32. 2004
    ..This study examined the ability of the total CMHS and an abbreviated form of the CMHS (ACM) to predict survival in a sample of patients with documented coronary artery disease (CAD) with increased statistical power...
  41. ncbi request reprint Perceived social support as a predictor of mortality in coronary patients: effects of smoking, sedentary behavior, and depressive symptoms
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 2969, Durham, NC 27710, USA
    Psychosom Med 67:40-5. 2005
    ....
  42. ncbi request reprint Initiation and discontinuation of hormone therapy for menopausal symptoms: results from a community sample
    Hayden B Bosworth
    Center for Health Services Research in Primary Care, Durham VAMC, Durham, North Carolina, USA
    J Behav Med 28:105-14. 2005
    ..These findings highlight the importance of physicians discussing HT with their patients, particularly because of recent clinical trial developments...
  43. ncbi request reprint Ratings of positive and depressive emotion as predictors of mortality in coronary patients
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Int J Cardiol 100:213-6. 2005
    ..An extensive body of research has demonstrated an association between negative affective states and health outcomes. Positive emotions may also influence physical health, however, their examination has received far less attention...
  44. ncbi request reprint Discrimination, dispositions, and cardiovascular responses to stress
    Laura Smart Richman
    Department of Psychology and Neuroscience, Duke University, Flower Drive, Durham, NC 27708, USA
    Health Psychol 26:675-83. 2007
    ..The authors examined how race and trait levels of hostility and optimism interact with past exposure to discrimination to predict physiological reactivity and recovery during an anger recall task...
  45. ncbi request reprint Does personality at college entry predict number of reported pain conditions at mid-life? A longitudinal study
    Katherine L Applegate
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27708, USA
    J Pain 6:92-7. 2005
    ..The study is important because it is the first to examine how personality assessed in younger adults relates to the number of chronic pain conditions reported 30 years later...
  46. ncbi request reprint Community recruitment process by race, gender, and SES gradient: lessons learned from the Community Health and Stress Evaluation (CHASE) Study experience
    Angela R Burroughs
    RTI International, Durham, NC, USA
    J Community Health 28:421-37. 2003
    ..We present an evaluation of the community recruitment component, why we think differences occurred, and the lessons learned from the experiences that may be applied to similar studies...
  47. ncbi request reprint Prospective associations between sedentary lifestyle and BMI in midlife
    Laust H Mortensen
    National Institute of Public Health, Øster Farimagsgade 5, 1399 Copenhagen K, Denmark
    Obesity (Silver Spring) 14:1462-71. 2006
    ..However, it has been questioned whether high BMI is a determinant or a consequence of a sedentary lifestyle...
  48. ncbi request reprint Another round in the mammography controversy
    Helen I Meissner
    Applied Cancer Screening Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland 20892 7331, USA
    J Womens Health (Larchmt) 12:261-76. 2003
    ..We conducted a national survey in March 2002 to provide information about women's perspectives on the issues, including the evidence regarding the efficacy of mammography and, ultimately, their intentions to continue screening...
  49. ncbi request reprint A path model of chronic stress, the metabolic syndrome, and coronary heart disease
    Peter P Vitaliano
    Departments of Psychiatry and Behavioral Sciences and Medicine, University of Washington, Seattle, Washington 98195 6560, USA
    Psychosom Med 64:418-35. 2002
    ....
  50. ncbi request reprint Effect of race on cultural justifications for caregiving
    Peggye Dilworth-Anderson
    Center for Aging and Diversity, University of North Carolina Institute on Aging, 720 Airport Road, Suite 100, CB 1030, Chapel Hill, NC 27599 1030, USA
    J Gerontol B Psychol Sci Soc Sci 60:S257-62. 2005
    ..Our objective in this study was to explore the effects of caregiver characteristics on cultural reasons given for providing care to dependent elderly family members...

Research Grants9

  1. SURVEILLANCE AND ANALYSIS OF THE UNC ALUMNI HEART STUDY
    Ilene Siegler; Fiscal Year: 2000
    ..In particular, we will analyze data already in hand in order to test hypotheses about the role of psychosocial factors in weight parameters, dietary practices and the contribution of spouse hostility to coronary risk. ..
  2. SURVEILLANCE AND ANALYSIS OF THE UNC ALUMNI HEART STUDY
    Ilene Siegler; Fiscal Year: 2004
    ..Adding additional measures to the present rich data base, places the UNC Alumni Heart Study in an excellent position to help fill these gaps in the next 5 years, as these members of the early Baby Boom Cohort approach age 60. ..