Research Topics
Genomes and GenesSpecies | Ilene SieglerSummaryAffiliation: Duke University Medical Center Country: USA Publications
Research Grants
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Publications
Consistency and timing of marital transitions and survival during midlife: the role of personality and health risk behaviorsIlene C Siegler
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
Ann Behav Med 45:338-47. 2013..Marital status is associated with survival...
Associations among NEO personality assessments and well-being at midlife: facet-level analysesI C Siegler
Behavioral Medicine Research Center, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
Psychol Aging 15:710-4. 2000..The facets within each domain demonstrated different patterns of associations with the well-being measures, indicating that facet-level assessments yield additional information...- Patterns of change in hostility from college to midlife in the UNC Alumni Heart Study predict high-risk statusIlene C Siegler
Department of Psychiatry and Behavioral Sciences and Behavioral Medicine Research Center, Duke University Medical Center, Durham, NC 27710, USA
Psychosom Med 65:738-45. 2003..To examine hostility measured in college and patterns of change in hostility from college to midlife as predictors of high health-related risk later in midlife... - Behavioral medicine and agingIlene C Siegler
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina 27710, USA
J Consult Clin Psychol 70:843-51. 2002..Also discussed are potential problems in age-related research, ways to improve the knowledge base in behavioral medicine and aging, and thoughts about future challenges to enhance work in behavioral medicine and aging... 
Caregiving, residence, race, and depressive symptomsIlene C Siegler
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Aging Ment Health 14:771-8. 2010..To conclude, all the parameters such as race, living arrangements, and the components of depression need to be taken into account to understand the impact of caregiving on the emotional health of caregivers...- Allelic differences in the serotonin transporter-linked polymorphic region in geriatric depressionDavid C Steffens
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
Am J Geriatr Psychiatry 10:185-91. 2002..The findings raise the possibility that this genetic locus may exert differential effects based on gender, increasing risk in men, and increasing risk of recurrence in women... - Psychophysiological mediators of caregiver stress and differential cognitive declinePeter P Vitaliano
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
Psychol Aging 20:402-11. 2005..This is the first study of cognitive decline and mediators in caregivers. This work has implications for caregiver and care-recipient health and for research on cognition, psychophysiology, diabetes, and AD... - Prospective study of perceived stress in cardiac patientsBeverly H Brummett
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
Ann Behav Med 27:22-30. 2004.... - Personality and inflammation: the protective effect of openness to experienceCharles R Jonassaint
Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, USA
Ethn Dis 20:11-4. 2010.... - Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controlsSofia I Iqbal Kring
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
Psychosom Med 72:427-33. 2010..Current evidence supports the hypothesis that gene-environment interactions modulate serum lipid concentrations... - Childhood socioeconomic status and serotonin transporter gene polymorphism enhance cardiovascular reactivity to mental stressRedford B Williams
Department of Psychiatry and Behavioral Sciences, Box 3926, Duke University Medical Center, Durham, NC 27710, USA
Psychosom Med 70:32-9. 2008..We found the long allele associated with larger CVR to mental stress in a preliminary study of 54 normal volunteers... - Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR)Beverly H Brummett
Department of Psychiatry and Behavioral Medicine, Duke University Medical Center, Box 2969, Durham, NC 27710, USA
Behav Genet 38:34-43. 2008..Findings from two independent samples suggest that the association of 5-HTTLPR with depression varies according to gender and stressful life events... - Sleep quality varies as a function of 5-HTTLPR genotype and stressBeverly H Brummett
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Psychosom Med 69:621-4. 2007..A common 44-base pair deletion (s allele) polymorphism in the 5-HTTLPR is associated with reduced 5HTT transcription efficiency and 5HT uptake in vitro... - Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep qualityBeverly H Brummett
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Psychosom Med 69:396-401. 2007..MAOA-uVNTR genotype has been associated with both psychological and physical measures... - Prediction of all-cause mortality by the Minnesota Multiphasic Personality Inventory Optimism-Pessimism Scale scores: study of a college sample during a 40-year follow-up periodBeverly H Brummett
Department of Psychiatry and Behavioral Sciences, Box 2969, Duke University Medical Center, Durham, NC 27710, USA
Mayo Clin Proc 81:1541-4. 2006..To examine a measure of explanatory style, the Optimism-Pessimism (PSM) scale derived from college-entry Minnesota Multiphasic Personality Inventory scores, as a predictor of all-cause mortality... - Associations among perceptions of social support, negative affect, and quality of sleep in caregivers and noncaregiversBeverly H Brummett
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Health Psychol 25:220-5. 2006..The structural model accounted for approximately 43% of the variance in sleep quality. The present findings may be useful in the development of successful sleep interventions for caregivers... - Personality as a predictor of dietary quality in spouses during midlifeBeverly H Brummett
Duke University Medical Center, Durham, NC 27710, USA
Behav Med 34:5-10. 2008..08-.09). Openness was associated with healthy eating habits--findings that may affect disease prevention during, midlife... - Lipid levels are associated with a regulatory polymorphism of the monoamine oxidase-A gene promoter (MAOA-uVNTR)Beverly H Brummett
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Med Sci Monit 14:CR57-61. 2008..Allelic variation in MAOA-uVNTR has been associated with body mass index (BMI). We extended previous work by examining relations among this polymorphism and serum lipid levels... - Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in menRedford B Williams
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
Psychosom Med 72:601-7. 2010.... - Associations of depressive symptoms, trait hostility, and gender with C-reactive protein and interleukin-6 response after emotion recallBeverly H Brummett
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
Psychosom Med 72:333-9. 2010..Depressive symptoms moderate the effect of trait hostility on circulating levels of CRP and IL-6... - Socioeconomic status moderates associations between CNS serotonin and expression of beta2-integrins CD11b and CD11cBeverly H Brummett
Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
J Psychiatr Res 44:373-7. 2010.... - Hostility and fasting glucose in African American womenAnastasia Georgiades
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina 27710, USA
Psychosom Med 71:642-5. 2009..HOST has been associated with abnormalities in glucose metabolism. Prior studies suggested that this association may be more prevalent in women and in African American (AA) individuals... - 5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusionBeverly H Brummett
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 2969, Durham, NC 27710, USA
Behav Genet 38:476-83. 2008..013), and trended towards predicting anger-hostility (P = .084). Males in the HiHi group had greater increases in negative affect during infusion, compared to all groups except LoLo females, who also showed increased negative affect... - HPA axis function in male caregivers: effect of the monoamine oxidase-A gene promoter (MAOA-uVNTR)Beverly H Brummett
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Biol Psychol 79:250-5. 2008..5/4 repeats) (cortisol p<.043). Individuals with less active MAOA-uVNTR alleles who are under chronic stress may be at increased risk for exhaustion of the HPA response to such stress... - Associations among central nervous system serotonergic function and neuroticism are moderated by genderBeverly H Brummett
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Biol Psychol 78:200-3. 2008..Remaining personality domains were not related to prolactin levels. Findings add to literature suggesting the serotonin system functions differently, in important ways, in males and females... - Neighborhood characteristics moderate effects of caregiving on glucose functioningBeverly H Brummett
Department of Psychiatry and Behavioral Medicine, Duke University Medical Center, Durham, North Carolina, 27710, USA
Psychosom Med 67:752-8. 2005.... - Facets of openness predict mortality in patients with cardiac diseaseCharles R Jonassaint
Department of Psychiatry, Duke University, Durham, North Carolina, USA
Psychosom Med 69:319-22. 2007..To examine the NEO Personality Inventory (NEO PI) Openness to Experience (O) domain and its facets as predictors of cardiac deaths and all-cause mortality... - Effect of smoking and sedentary behavior on the association between depressive symptoms and mortality from coronary heart diseaseBeverly H Brummett
Department of Psychiatry and Behavioral Sciences, Durham, North Carolina 27710, USA
Am J Cardiol 92:529-32. 2003..Results indicated that smoking and/or sedentary behavior may partially mediate the relation between depressive symptoms and mortality. No evidence for moderation was found... - Serotonin-related gene polymorphisms and central nervous system serotonin functionRedford B Williams
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3926, Durham, NC 27710, USA
Neuropsychopharmacology 28:533-41. 2003.... - Associations among the NEO Personality Inventory, Revised and the serotonin transporter gene-linked polymorphic region in elders: effects of depression and genderBeverly H Brummett
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
Psychiatr Genet 13:13-8. 2003..We attempted to replicate findings suggesting a positive relation between the short allele variant of 5-HTTLPR and Neuroticism, and a negative association between the short allele variant and Agreeableness... - Coping styles and personality domains related to menopausal stressHayden B Bosworth
Department of Medicine, Division of General Internal Medicine, Duke University, Durham, North Carolina, USA
Womens Health Issues 13:32-8. 2003.... - Evaluating participants' use of a hormone replacement therapy decision-making interventionLori A Bastian
Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, 508 Fulton Street 152, Durham, NC 27705, USA
Patient Educ Couns 48:283-91. 2002.... - Alcoholic beverage preference, diet, and health habits in the UNC Alumni Heart StudyJohn C Barefoot
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Am J Clin Nutr 76:466-72. 2002..Moderate alcohol intake is related to better health, and additional benefits may be associated with wine. However, beverage preference may be confounded by lifestyle factors related to health... - A tailored intervention to aid decision-making about hormone replacement therapyColleen M McBride
The Comprehensive Cancer Center, Duke University Medical Center, Durham, NC 27710-2949, USA
Am J Public Health 92:1112-4. 2002 - Terminal change in cognitive function: an updated review of longitudinal studiesHayden B Bosworth
Health Services Research and Development, Veterans Affairs Medical Center, Department of Psychiatry and Behavioral Science, Behavioral Medicine Research Center, Duke University Medical Center, Durham, North Carolina, USA
Exp Aging Res 28:299-315. 2002.... - Predictors of smoking cessation in patients with a diagnosis of coronary artery diseaseBeverly H Brummett
Behavioral Medicine Research Center and the Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
J Cardiopulm Rehabil 22:143-7. 2002..This study aimed to examine demographic, psychosocial, and clinical variables as predictors of smoking cessation in patients with coronary artery disease... - Associations among social support, income, and symptoms of depression in an educated sample: the UNC Alumni Heart StudyBeverly H Brummett
Duke University Medical Center, Durham, NC 27710, USA
Int J Behav Med 10:239-50. 2003..The present results extend previous work regarding the moderating effect of income to a sample of relatively high education and income level... - Hostility, race, and glucose metabolism in nondiabetic individualsRichard S Surwit
Department of Psychiatry, Duke University School of Medicine, Durham, North Carolina 27710, USA
Diabetes Care 25:835-9. 2002..The present study was designed to determine whether hostility is differentially related to measures of glucose metabolism in African-Americans and Caucasians... - Hostility, age, and mortality in a sample of cardiac patientsStephen H Boyle
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, USA
Am J Cardiol 96:64-6. 2005..After controlling for disease severity, there was a significant interaction between age and hostility. Hostility was significantly associated with poorer survival but only in younger (<61.2 years) patients... - Hostility as a predictor of survival in patients with coronary artery diseaseStephen H Boyle
Department of Psychiatry, Duke University Medical Center, Box 2969, Durham, NC, USA
Psychosom Med 66:629-32. 2004..This study examined the ability of the total CMHS and an abbreviated form of the CMHS (ACM) to predict survival in a sample of patients with documented coronary artery disease (CAD) with increased statistical power... - Perceived social support as a predictor of mortality in coronary patients: effects of smoking, sedentary behavior, and depressive symptomsBeverly H Brummett
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 2969, Durham, NC 27710, USA
Psychosom Med 67:40-5. 2005.... - Initiation and discontinuation of hormone therapy for menopausal symptoms: results from a community sampleHayden B Bosworth
Center for Health Services Research in Primary Care, Durham VAMC, Durham, North Carolina, USA
J Behav Med 28:105-14. 2005..These findings highlight the importance of physicians discussing HT with their patients, particularly because of recent clinical trial developments... - Ratings of positive and depressive emotion as predictors of mortality in coronary patientsBeverly H Brummett
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Int J Cardiol 100:213-6. 2005..An extensive body of research has demonstrated an association between negative affective states and health outcomes. Positive emotions may also influence physical health, however, their examination has received far less attention... - Discrimination, dispositions, and cardiovascular responses to stressLaura Smart Richman
Department of Psychology and Neuroscience, Duke University, Flower Drive, Durham, NC 27708, USA
Health Psychol 26:675-83. 2007..The authors examined how race and trait levels of hostility and optimism interact with past exposure to discrimination to predict physiological reactivity and recovery during an anger recall task... - Does personality at college entry predict number of reported pain conditions at mid-life? A longitudinal studyKatherine L Applegate
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27708, USA
J Pain 6:92-7. 2005..The study is important because it is the first to examine how personality assessed in younger adults relates to the number of chronic pain conditions reported 30 years later... - Community recruitment process by race, gender, and SES gradient: lessons learned from the Community Health and Stress Evaluation (CHASE) Study experienceAngela R Burroughs
RTI International, Durham, NC, USA
J Community Health 28:421-37. 2003..We present an evaluation of the community recruitment component, why we think differences occurred, and the lessons learned from the experiences that may be applied to similar studies... - Prospective associations between sedentary lifestyle and BMI in midlifeLaust H Mortensen
National Institute of Public Health, Øster Farimagsgade 5, 1399 Copenhagen K, Denmark
Obesity (Silver Spring) 14:1462-71. 2006..However, it has been questioned whether high BMI is a determinant or a consequence of a sedentary lifestyle... - Another round in the mammography controversyHelen I Meissner
Applied Cancer Screening Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland 20892 7331, USA
J Womens Health (Larchmt) 12:261-76. 2003..We conducted a national survey in March 2002 to provide information about women's perspectives on the issues, including the evidence regarding the efficacy of mammography and, ultimately, their intentions to continue screening... - A path model of chronic stress, the metabolic syndrome, and coronary heart diseasePeter P Vitaliano
Departments of Psychiatry and Behavioral Sciences and Medicine, University of Washington, Seattle, Washington 98195 6560, USA
Psychosom Med 64:418-35. 2002.... - Effect of race on cultural justifications for caregivingPeggye Dilworth-Anderson
Center for Aging and Diversity, University of North Carolina Institute on Aging, 720 Airport Road, Suite 100, CB 1030, Chapel Hill, NC 27599 1030, USA
J Gerontol B Psychol Sci Soc Sci 60:S257-62. 2005..Our objective in this study was to explore the effects of caregiver characteristics on cultural reasons given for providing care to dependent elderly family members...
Research Grants
- SURVEILLANCE AND ANALYSIS OF THE UNC ALUMNI HEART STUDYIlene Siegler; Fiscal Year: 2000..In particular, we will analyze data already in hand in order to test hypotheses about the role of psychosocial factors in weight parameters, dietary practices and the contribution of spouse hostility to coronary risk. ..
- SURVEILLANCE AND ANALYSIS OF THE UNC ALUMNI HEART STUDYIlene Siegler; Fiscal Year: 2004..Adding additional measures to the present rich data base, places the UNC Alumni Heart Study in an excellent position to help fill these gaps in the next 5 years, as these members of the early Baby Boom Cohort approach age 60. ..