ASHOK KUMAR SHETTY

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi Progenitor cells from the CA3 region of the embryonic day 19 rat hippocampus generate region-specific neuronal phenotypes in vitro
    Ashok K Shetty
    Division of Neurosurgery, Department of Surgery, Duke University Medical Center Medical Research Service, Durham Veterans Affairs Medical Center, Durham, North Carolina 27710, USA
    Hippocampus 14:595-614. 2004
  2. pmc Predictable chronic mild stress improves mood, hippocampal neurogenesis and memory
    V K Parihar
    Medical Research and Surgery Services, Veterans Affairs Medical Center, Durham, NC, USA
    Mol Psychiatry 16:171-83. 2011
  3. pmc Issues to ponder when correlating hippocampal neurogenesis to a hippocampal-dependent memory function
    Ashok K Shetty
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA
    Neurobiol Aging 31:2181-4. 2010
  4. ncbi Aging in the rat hippocampus is associated with widespread reductions in the number of glutamate decarboxylase-67 positive interneurons but not interneuron degeneration
    Dirk P Stanley
    Medical Research Service, Veterans Affairs Medical Center, Durham, North Carolina 27710, USA
    J Neurochem 89:204-16. 2004
  5. ncbi Hippocampal neurotrophin levels after injury: Relationship to the age of the hippocampus at the time of injury
    Ashok K Shetty
    Medical Research Service, Veterans Affairs Medical Center, Durham, North Carolina 27710, USA
    J Neurosci Res 78:520-32. 2004
  6. ncbi Stem/progenitor cell proliferation factors FGF-2, IGF-1, and VEGF exhibit early decline during the course of aging in the hippocampus: role of astrocytes
    Ashok K Shetty
    Department of Surgery, Division of Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Glia 51:173-86. 2005
  7. pmc Concise review: prospects of stem cell therapy for temporal lobe epilepsy
    Ashok K Shetty
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Stem Cells 25:2396-407. 2007
  8. ncbi Repair of the injured adult hippocampus through graft-mediated modulation of the plasticity of the dentate gyrus in a rat model of temporal lobe epilepsy
    Ashok K Shetty
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 25:8391-401. 2005
  9. pmc Restoration of calbindin after fetal hippocampal CA3 cell grafting into the injured hippocampus in a rat model of temporal lobe epilepsy
    Ashok K Shetty
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Hippocampus 17:943-56. 2007
  10. pmc Promise of resveratrol for easing status epilepticus and epilepsy
    Ashok K Shetty
    Medical Research and Surgery Services, Veterans Affairs Medical Center, Durham, NC 27705, USA
    Pharmacol Ther 131:269-86. 2011

Collaborators

Detail Information

Publications51

  1. ncbi Progenitor cells from the CA3 region of the embryonic day 19 rat hippocampus generate region-specific neuronal phenotypes in vitro
    Ashok K Shetty
    Division of Neurosurgery, Department of Surgery, Duke University Medical Center Medical Research Service, Durham Veterans Affairs Medical Center, Durham, North Carolina 27710, USA
    Hippocampus 14:595-614. 2004
    ....
  2. pmc Predictable chronic mild stress improves mood, hippocampal neurogenesis and memory
    V K Parihar
    Medical Research and Surgery Services, Veterans Affairs Medical Center, Durham, NC, USA
    Mol Psychiatry 16:171-83. 2011
    ..Collectively, these findings reveal that PCMS is beneficial to adult brain function, which is exemplified by increased hippocampal neurogenesis and improved mood and cognitive function...
  3. pmc Issues to ponder when correlating hippocampal neurogenesis to a hippocampal-dependent memory function
    Ashok K Shetty
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA
    Neurobiol Aging 31:2181-4. 2010
    ....
  4. ncbi Aging in the rat hippocampus is associated with widespread reductions in the number of glutamate decarboxylase-67 positive interneurons but not interneuron degeneration
    Dirk P Stanley
    Medical Research Service, Veterans Affairs Medical Center, Durham, North Carolina 27710, USA
    J Neurochem 89:204-16. 2004
    ..Additionally, this study provides novel evidence that age-related reductions in hippocampal GAD-67 immunopositive interneuron numbers are due to loss of GAD-67 expression in interneurons rather than interneuron degeneration...
  5. ncbi Hippocampal neurotrophin levels after injury: Relationship to the age of the hippocampus at the time of injury
    Ashok K Shetty
    Medical Research Service, Veterans Affairs Medical Center, Durham, North Carolina 27710, USA
    J Neurosci Res 78:520-32. 2004
    ..Lower BDNF levels in the injured aging hippocampus might underlie the diminished spontaneous healing response observed in the aging hippocampus after injury, particularly in terms of synaptic reorganization and dentate neurogenesis...
  6. ncbi Stem/progenitor cell proliferation factors FGF-2, IGF-1, and VEGF exhibit early decline during the course of aging in the hippocampus: role of astrocytes
    Ashok K Shetty
    Department of Surgery, Division of Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Glia 51:173-86. 2005
    ..Additionally, the results demonstrate that decreased FGF-2 concentration during aging is a consequence of age-related impairment in FGF-2 synthesis by astrocytes...
  7. pmc Concise review: prospects of stem cell therapy for temporal lobe epilepsy
    Ashok K Shetty
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Stem Cells 25:2396-407. 2007
    ..The final part analyzes problems that remain to be resolved before initiating clinical application of stem cell-based therapies for TLE. Disclosure of potential conflicts of interest is found at the end of this article...
  8. ncbi Repair of the injured adult hippocampus through graft-mediated modulation of the plasticity of the dentate gyrus in a rat model of temporal lobe epilepsy
    Ashok K Shetty
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 25:8391-401. 2005
    ..The results also underscore that grafting of cells capable of differentiating into CA3 pyramidal neurons is highly efficacious for a lasting inhibition of the abnormal mossy fiber circuitry development in the injured hippocampus...
  9. pmc Restoration of calbindin after fetal hippocampal CA3 cell grafting into the injured hippocampus in a rat model of temporal lobe epilepsy
    Ashok K Shetty
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Hippocampus 17:943-56. 2007
    ..However, electrophysiological studies of KA-lesioned hippocampus receiving CA3 cell grafts are required in future to validate this possibility...
  10. pmc Promise of resveratrol for easing status epilepticus and epilepsy
    Ashok K Shetty
    Medical Research and Surgery Services, Veterans Affairs Medical Center, Durham, NC 27705, USA
    Pharmacol Ther 131:269-86. 2011
    ....
  11. pmc Behavior of hippocampal stem/progenitor cells following grafting into the injured aged hippocampus
    Ashok K Shetty
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA
    J Neurosci Res 86:3062-74. 2008
    ....
  12. pmc Vulnerability of hippocampal GABA-ergic interneurons to kainate-induced excitotoxic injury during old age
    Ashok K Shetty
    Medical Research and Surgery Services, Veterans Affairs Medical Center, Durham, NC, USA
    J Cell Mol Med 13:2408-23. 2009
    ..These results have implications towards understanding mechanisms underlying the evolution of initial precipitating injury into temporal lobe epilepsy in the elderly population...
  13. pmc Deafferentation enhances neurogenesis in the young and middle aged hippocampus but not in the aged hippocampus
    Ashok K Shetty
    Medical Research and Surgery Services, Veterans Affairs Medical Center, Durham, North Carolina, USA
    Hippocampus 21:631-46. 2011
    ..Thus, the plasticity of hippocampal NSCs to increase DG neurogenesis in response to a milder injury such as partial hippocampal deafferentation is preserved until middle age but lost at old age...
  14. ncbi Hippocampal neurotrophin levels in a kainate model of temporal lobe epilepsy: a lack of correlation between brain-derived neurotrophic factor content and progression of aberrant dentate mossy fiber sprouting
    Ashok K Shetty
    Medical Research Service, Veterans Affairs Medical Center, Durham, North Carolina, USA
    J Neurochem 87:147-59. 2003
    ..Rather, it shows a relationship with the time of upregulation of neurotrophins NGF and NT-3...
  15. ncbi Fetal hippocampal grafts containing CA3 cells restore host hippocampal glutamate decarboxylase-positive interneuron numbers in a rat model of temporal lobe epilepsy
    A K Shetty
    Departments of Surgery Neurosurgery and Neurobiology, Duke University Medical Center Durham, North Carolina 27710, USA
    J Neurosci 20:8788-801. 2000
    ..This specific graft-mediated effect is beneficial because reactivation of interneurons could ameliorate both loss of functional inhibition and hyperexcitability in CA3-lesioned hippocampus...
  16. ncbi Entorhinal axons exhibit sprouting in CA1 subfield of the adult hippocampus in a rat model of temporal lobe epilepsy
    Ashok K Shetty
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Hippocampus 12:534-42. 2002
    ..This aberrant sprouting may lead to altered afferent excitatory connectivity in the CA1 subfield and contribute to the persistent CA1 hyperexcitability that occurs after the CA3 lesion...
  17. ncbi Pattern of long-distance projections from fetal hippocampal field CA3 and CA1 cell grafts in lesioned CA3 of adult hippocampus follows intrinsic character of respective donor cells
    A K Shetty
    Departments of Surgery Neurosurgery and Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neuroscience 99:243-55. 2000
    ....
  18. ncbi Glutamic acid decarboxylase-67-positive hippocampal interneurons undergo a permanent reduction in number following kainic acid-induced degeneration of ca3 pyramidal neurons
    A K Shetty
    Departments of Surgery Neurosurgery and Neurobiology, Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA
    Exp Neurol 169:276-97. 2001
    ..Nevertheless, a persistent decrease in interneuron activity, as evidenced by permanent down-regulation of GAD-67 in a major fraction of interneurons, would likely enhance the degree of hyperexcitability in the CA3-lesioned hippocampus...
  19. ncbi Aging impairs axonal sprouting response of dentate granule cells following target loss and partial deafferentation
    A K Shetty
    Departments of Surgery Neurosurgery and Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Comp Neurol 414:238-54. 1999
    ....
  20. ncbi Vulnerability of the dentate gyrus to aging and intracerebroventricular administration of kainic acid
    A K Shetty
    Medical Research and Surgery Neurosurgery Services, Duke University Medical Center, Durham, North Carolina, 27710, USA
    Exp Neurol 158:491-503. 1999
    ..Thus, aging in the dentate gyrus is characterized by a significantly decreased number of dentate hilar neurons and also a significantly increased susceptibility of dentate hilar neurons to excitotoxic damage...
  21. ncbi Neurite outgrowth from progeny of epidermal growth factor-responsive hippocampal stem cells is significantly less robust than from fetal hippocampal cells following grafting onto organotypic hippocampal slice cultures: effect of brain-derived neurotrophic
    A K Shetty
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurobiol 38:391-413. 1999
    ..However, neurite outgrowth from EGF-responsive stem cell-derived neurons can be enhanced by treating with specific neurotrophic factors such as BDNF...
  22. ncbi In vitro survival and differentiation of neurons derived from epidermal growth factor-responsive postnatal hippocampal stem cells: inducing effects of brain-derived neurotrophic factor
    A K Shetty
    Department of Surgery Neurosurgery and Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurobiol 35:395-425. 1998
    ....
  23. ncbi Hippocampal interneurons expressing glutamic acid decarboxylase and calcium-binding proteins decrease with aging in Fischer 344 rats
    A K Shetty
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Comp Neurol 394:252-69. 1998
    ..In addition, such a profound alteration in interneuron number will likely alter inhibitory control of excitability and neuronal synchrony with behavioral states...
  24. pmc Strategies for promoting anti-seizure effects of hippocampal fetal cells grafted into the hippocampus of rats exhibiting chronic temporal lobe epilepsy
    Muddanna S Rao
    Department of Surgery Neurosurgery Duke University Medical Center, Durham, NC 27710, USA
    Neurobiol Dis 27:117-32. 2007
    ..In contrast, HFCs treated and grafted with BNC or FC survive robustly in the chronically epileptic hippocampus, considerably reduce the frequency of SRMS and blunt the progression of chronic TLE...
  25. ncbi Fetal hippocampal CA3 cell grafts enriched with fibroblast growth factor-2 exhibit enhanced neuronal integration into the lesioned aging rat hippocampus in a kainate model of temporal lobe epilepsy
    Vandana Zaman
    Medical Research Service, Veterans Affairs Medical Center, Durham, North Carolina, USA
    Hippocampus 13:618-32. 2003
    ....
  26. pmc Grafting of striatal precursor cells into hippocampus shortly after status epilepticus restrains chronic temporal lobe epilepsy
    Bharathi Hattiangady
    Department of Surgery Neurosurgery Duke University Medical Center, Durham, NC 27710, USA
    Exp Neurol 212:468-81. 2008
    ..Presence of a large number of GABA-ergic neurons in grafts further suggests that strengthening of the inhibitory control in host hippocampi likely underlies the beneficial effects mediated by grafts...
  27. ncbi Increased dentate neurogenesis after grafting of glial restricted progenitors or neural stem cells in the aging hippocampus
    Bharathi Hattiangady
    Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA
    Stem Cells 25:2104-17. 2007
    ..Grafting of GRPs or NSCs therefore provides an attractive approach for improving neurogenesis in the aging hippocampus. Disclosure of potential conflicts of interest is found at the end of this article...
  28. ncbi Fetal hippocampal CA3 cell grafts enriched with FGF-2 and BDNF exhibit robust long-term survival and integration and suppress aberrant mossy fiber sprouting in the injured middle-aged hippocampus
    Muddanna S Rao
    Medical Research and Surgery Services, Veterans Affairs Medical Center, Durham NC 27705, USA
    Neurobiol Dis 21:276-90. 2006
    ....
  29. pmc Plasticity of hippocampal stem/progenitor cells to enhance neurogenesis in response to kainate-induced injury is lost by middle age
    Bharathi Hattiangady
    Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Aging Cell 7:207-24. 2008
    ..These results underscore that the ability of the DG to increase neurogenesis after injury is lost as early as middle age...
  30. pmc Decreased neuronal differentiation of newly generated cells underlies reduced hippocampal neurogenesis in chronic temporal lobe epilepsy
    Bharathi Hattiangady
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Hippocampus 20:97-112. 2010
    ..Overall, the differentiation of newly born cells turns mainly into glia with chronic TLE from predominantly neuronal differentiation seen in control conditions...
  31. ncbi Pretreatment of donor cells with FGF-2 enhances survival of fetal hippocampal CA3 cell transplants in the chronically lesioned young adult hippocampus
    Vandana Zaman
    Medical Research Service, Veterans Affairs Medical Center, Durham, NC 27705, USA
    Exp Neurol 183:11-24. 2003
    ....
  32. ncbi Survival of fetal hippocampal CA3 cell grafts in the middle-aged and aged hippocampus: effect of host age and deafferentation
    Vandana Zaman
    Medical Research Service, Veterans Affairs Medical Center and Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci Res 70:190-9. 2002
    ..However, the overall extent of graft cell survival after deafferentation depends on the age of the mature brain at the time of deafferentation...
  33. ncbi Newly born cells in the ageing dentate gyrus display normal migration, survival and neuronal fate choice but endure retarded early maturation
    Muddanna S Rao
    Division of Neurosurgery, DUMC Box 3807, Duke University Medical Center, Durham, NC 27710, USA
    Eur J Neurosci 21:464-76. 2005
    ....
  34. pmc Aging does not alter the number or phenotype of putative stem/progenitor cells in the neurogenic region of the hippocampus
    Bharathi Hattiangady
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, NC 27710, United States
    Neurobiol Aging 29:129-47. 2008
    ..Thus, decreased dentate neurogenesis during aging is not attributable to altered number or phenotype of NSCs. Instead, it appears to be an outcome of increased quiescence of NSCs due to changes in NSC milieu...
  35. pmc Medial ganglionic eminence-derived neural stem cell grafts ease spontaneous seizures and restore GDNF expression in a rat model of chronic temporal lobe epilepsy
    Ben Waldau
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Stem Cells 28:1153-64. 2010
    ..Thus, MGE-NSC therapy is efficacious for diminishing SRMS in chronic TLE. Addition of new GABA-ergic neurons and GDNF+ cells, and restoration of GDNF in the hippocampal astrocytes may underlie the therapeutic effect of MGE-NSC grafts...
  36. ncbi Nestin expression in hippocampal astrocytes after injury depends on the age of the hippocampus
    Ali Abdel-Rahman
    Medical Research Service, Veterans Affairs Medical Center, Durham, North Carolina, USA
    Glia 47:299-313. 2004
    ..In contrast, nestin-immunoreactive radial glia framework after lesion is not impaired with aging in the ependymal lining of the CA3 region...
  37. ncbi The window and mechanisms of major age-related decline in the production of new neurons within the dentate gyrus of the hippocampus
    Muddanna S Rao
    Department of Surgery Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA
    Aging Cell 5:545-58. 2006
    ..Thus, major decreases in DG neurogenesis occur at 7.5-12 months of age in Fischer 344 rats. Decreased production of new cells due to proliferation of far fewer NSCs in the SGZ mainly underlies this decline...
  38. ncbi Enhanced production and dendritic growth of new dentate granule cells in the middle-aged hippocampus following intracerebroventricular FGF-2 infusions
    Kiranmai S Rai
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA
    Eur J Neurosci 26:1765-79. 2007
    ....
  39. pmc Status epilepticus during old age is not associated with enhanced hippocampal neurogenesis
    Muddanna S Rao
    Medical Research and Surgery Services, Veterans Affairs Medical Center, Durham, NC 27705, USA
    Hippocampus 18:931-44. 2008
    ..These results have clinical relevance because earlier studies have implied that both increased and abnormal neurogenesis occurring after SE in young animals contributes to chronic epilepsy development...
  40. ncbi Hippocampal neurodegeneration, spontaneous seizures, and mossy fiber sprouting in the F344 rat model of temporal lobe epilepsy
    Muddanna S Rao
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci Res 83:1088-105. 2006
    ..Because most of the features are consistent with mesial TLE in humans, the F344 model appears ideal for testing the efficacy of potential treatment strategies for mesial TLE...
  41. pmc Hippocampal neurogenesis and neural stem cells in temporal lobe epilepsy
    Ramkumar Kuruba
    Department of SurgeryDuke University Medical Center, Durham, NC 27710, USA
    Epilepsy Behav 14:65-73. 2009
    ..We also discuss the consequences of chronic spontaneous seizures on differentiation of neural stem cell progeny in the hippocampus and strategies that are potentially useful for normalizing neurogenesis in chronic temporal lobe epilepsy...
  42. ncbi Brain-derived neurotrophic factor, phosphorylated cyclic AMP response element binding protein and neuropeptide Y decline as early as middle age in the dentate gyrus and CA1 and CA3 subfields of the hippocampus
    Bharathi Hattiangady
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA
    Exp Neurol 195:353-71. 2005
    ..Dramatically diminished CREB phosphorylation (and persistently reduced levels of BDNF and NPY) at old age may underlie the learning and memory impairments observed during senescence...
  43. ncbi Clinical prospects for neural grafting therapy for hippocampal lesions and epilepsy
    Dennis A Turner
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neurosurgery 52:632-44; discussion 641-4. 2003
    ..The goal of this review was to assess the clinical reality of this hypothesis of neural grafting and to determine the problems that remain to be resolved before grafting can be applied clinically...
  44. ncbi Chronic temporal lobe epilepsy is associated with severely declined dentate neurogenesis in the adult hippocampus
    Bharathi Hattiangady
    Department of Surgery, Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA
    Neurobiol Dis 17:473-90. 2004
    ..Likewise, the hippocampal-dependent learning and memory deficits observed in chronic TLE could be linked at least partially to the declined neurogenesis...
  45. pmc Implications of decreased hippocampal neurogenesis in chronic temporal lobe epilepsy
    Bharathi Hattiangady
    Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Epilepsia 49:26-41. 2008
    ..The final section suggests possible ramifications of increasing the DG neurogenesis in chronic epilepsy...
  46. ncbi Disruption of the blood-brain barrier and neuronal cell death in cingulate cortex, dentate gyrus, thalamus, and hypothalamus in a rat model of Gulf-War syndrome
    Ali Abdel-Rahman
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Caroloina 277109, USA
    Neurobiol Dis 10:306-26. 2002
    ..The various neurological symptoms reported by Gulf-War veterans could be linked to this kind of brain injury incurred during the war...
  47. ncbi Could hippocampal neurogenesis be a future drug target for treating temporal lobe epilepsy?
    Ramkumar Kuruba
    Department of Surgery Neurosurgery Duke University Medical Center, Durham, NC 27710, USA
    CNS Neurol Disord Drug Targets 6:342-57. 2007
    ....
  48. ncbi Prenatal choline supplementation protects against postnatal neurotoxicity
    Shirley X Guo-Ross
    Neurobiology Research Laboratory, Veterans Affairs Medical Center, Durham, North Carolina 27705, USA
    J Neurosci 22:RC195. 2002
    ..These data show that availability of a single nutrient, choline, during a brief period of prenatal development diminishes vulnerability to neurotoxicity in adolescent offspring...
  49. pmc Progress in neuroprotective strategies for preventing epilepsy
    Munjal M Acharya
    Medical Research and Surgery Services, Veterans Affairs Medical Center, Durham, NC 27705, USA
    Prog Neurobiol 84:363-404. 2008
    ..Nevertheless, ideal strategies that are capable of facilitating repair and functional recovery of the brain after an IPI and preventing the evolution of IPI into chronic epilepsy are still hard to pin down...
  50. pmc Is exposure to enriched environment beneficial for functional post-lesional recovery in temporal lobe epilepsy?
    Anandh Dhanushkodi
    Medical Research and Surgery Services, Veterans Affairs Medical Center, Durham, NC 27705, USA
    Neurosci Biobehav Rev 32:657-74. 2008
    ..The final segment discusses studies that are essential for further understanding the efficacy of this approach for preventing or treating TLE...
  51. ncbi Prenatal dietary choline availability alters postnatal neurotoxic vulnerability in the adult rat
    Shirley X Guo-Ross
    Neurobiology Research Laboratory, VA Medical Center, 27705, Durham, NC, USA
    Neurosci Lett 341:161-3. 2003
    ..These data show that availability of choline during a brief prenatal period diminishes vulnerability to neurotoxicity in adult offspring...

Research Grants15

  1. Neural Grafts and Injury-Induced Hippocampal Dysfunction
    Ashok K Shetty; Fiscal Year: 2010
    ..Collectively, the proposed experiments have immense value for the development of apt treatment strategy that prevents both chronic epilepsy and learning and memory impairments after hippocampal injury in adults. ..
  2. Behavior of Stem Cells in the Lesioned Aging Hippocampus
    Ashok Shetty; Fiscal Year: 2002
    ..abstract_text> ..
  3. Neural Grafts and Injury-Induced Hippocampal Dysfunction
    Ashok Shetty; Fiscal Year: 2009
    ..Collectively, the proposed experiments have immense value for the development of apt treatment strategy that prevents both chronic epilepsy and learning and memory impairments after hippocampal injury in adults. ..
  4. Neural Grafts and Injury-Induced Hippocampal Dysfunction
    Ashok Shetty; Fiscal Year: 2009
    ..Collectively, the proposed experiments have immense value for the development of apt treatment strategy that prevents both chronic epilepsy and learning and memory impairments after hippocampal injury in adults. ..
  5. Neural Grafts and Injury-Induced Hippocampal Dysfunction
    Ashok Shetty; Fiscal Year: 2007
    ..Collectively, the proposed experiments have immense value for the development of apt treatment strategy that prevents both chronic epilepsy and learning and memory impairments after hippocampal injury in adults. ..
  6. Repair of Chronially Injured Hippocampus by Grafts
    Ashok Shetty; Fiscal Year: 2006
    ..These studies also have implications for the treatment of other neurodegenerative conditions such as stroke and head injury. ..
  7. Neural Grafts and Injury-Induced Hippocampal Dysfunction
    Ashok Shetty; Fiscal Year: 2006
    ..Collectively, the proposed experiments have immense value for the development of apt treatment strategy that prevents both chronic epilepsy and learning and memory impairments after hippocampal injury in adults. ..
  8. Behavior of Stem Cells in the Lesioned Aging Hippocampus
    Ashok Shetty; Fiscal Year: 2006
    ..abstract_text> ..
  9. Repair of Chronially Injured Hippocampus by Grafts
    Ashok Shetty; Fiscal Year: 2005
    ..These studies also have implications for the treatment of other neurodegenerative conditions such as stroke and head injury. ..
  10. Behavior of Stem Cells in the Lesioned Aging Hippocampus
    Ashok Shetty; Fiscal Year: 2005
    ..abstract_text> ..
  11. Repair of Chronially Injured Hippocampus by Grafts
    Ashok Shetty; Fiscal Year: 2004
    ..These studies also have implications for the treatment of other neurodegenerative conditions such as stroke and head injury. ..
  12. Behavior of Stem Cells in the Lesioned Aging Hippocampus
    Ashok Shetty; Fiscal Year: 2004
    ..abstract_text> ..
  13. Repair of Chronially Injured Hippocampus by Grafts
    Ashok Shetty; Fiscal Year: 2003
    ..These studies also have implications for the treatment of other neurodegenerative conditions such as stroke and head injury. ..
  14. Behavior of Stem Cells in the Lesioned Aging Hippocampus
    Ashok Shetty; Fiscal Year: 2003
    ..abstract_text> ..