A K Shetty

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi Development of fetal hippocampal grafts in intact and lesioned hippocampus
    A K Shetty
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, NC, USA
    Prog Neurobiol 50:597-653. 1996
  2. ncbi Fetal hippocampal CA3 cell grafts transplanted to lesioned CA3 region of the adult hippocampus exhibit long-term survival in a rat model of temporal lobe epilepsy
    V Zaman
    Medical Research Service, Veterans Affairs Medical Center, Durham, North Carolina 27705, USA
    Neurobiol Dis 8:942-52. 2001
  3. ncbi Prolonged postlesion transplantation delay adversely influences survival of both homotopic and heterotopic fetal hippocampal cell grafts in Kainate-lesioned CA3 region of adult hippocampus
    V Zaman
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Cell Transplant 10:41-52. 2001
  4. ncbi Pattern of long-distance projections from fetal hippocampal field CA3 and CA1 cell grafts in lesioned CA3 of adult hippocampus follows intrinsic character of respective donor cells
    A K Shetty
    Departments of Surgery Neurosurgery and Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neuroscience 99:243-55. 2000
  5. ncbi Incorporation of embryonic CA3 cell grafts into the adult hippocampus at 4-months after injury: effects of combined neurotrophic supplementation and caspase inhibition
    B Hattiangady
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA
    Neuroscience 139:1369-83. 2006
  6. ncbi In vitro survival and differentiation of neurons derived from epidermal growth factor-responsive postnatal hippocampal stem cells: inducing effects of brain-derived neurotrophic factor
    A K Shetty
    Department of Surgery Neurosurgery and Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurobiol 35:395-425. 1998
  7. ncbi Aging impairs axonal sprouting response of dentate granule cells following target loss and partial deafferentation
    A K Shetty
    Departments of Surgery Neurosurgery and Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Comp Neurol 414:238-54. 1999
  8. ncbi Glutamic acid decarboxylase-67-positive hippocampal interneurons undergo a permanent reduction in number following kainic acid-induced degeneration of ca3 pyramidal neurons
    A K Shetty
    Departments of Surgery Neurosurgery and Neurobiology, Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA
    Exp Neurol 169:276-97. 2001
  9. ncbi Vulnerability of the dentate gyrus to aging and intracerebroventricular administration of kainic acid
    A K Shetty
    Medical Research and Surgery Neurosurgery Services, Duke University Medical Center, Durham, North Carolina, 27710, USA
    Exp Neurol 158:491-503. 1999
  10. ncbi Neurite outgrowth from progeny of epidermal growth factor-responsive hippocampal stem cells is significantly less robust than from fetal hippocampal cells following grafting onto organotypic hippocampal slice cultures: effect of brain-derived neurotrophic
    A K Shetty
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurobiol 38:391-413. 1999

Collaborators

  • D A Turner
  • H E Rice
  • M S Rao
  • V Zaman
  • B Hattiangady
  • V K Parihar
  • B Waldau
  • K M Safford
  • A Abdel-Rahman
  • B Shuai
  • R Kuruba
  • S D Safford
  • J M Gimble
  • M B Abou-Donia

Detail Information

Publications16

  1. ncbi Development of fetal hippocampal grafts in intact and lesioned hippocampus
    A K Shetty
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, NC, USA
    Prog Neurobiol 50:597-653. 1996
    ....
  2. ncbi Fetal hippocampal CA3 cell grafts transplanted to lesioned CA3 region of the adult hippocampus exhibit long-term survival in a rat model of temporal lobe epilepsy
    V Zaman
    Medical Research Service, Veterans Affairs Medical Center, Durham, North Carolina 27705, USA
    Neurobiol Dis 8:942-52. 2001
    ....
  3. ncbi Prolonged postlesion transplantation delay adversely influences survival of both homotopic and heterotopic fetal hippocampal cell grafts in Kainate-lesioned CA3 region of adult hippocampus
    V Zaman
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Cell Transplant 10:41-52. 2001
    ..Strategies that considerably augment graft cell survival may therefore be critical for optimal integration of fetal grafts into the adult CNS at late postlesion time points...
  4. ncbi Pattern of long-distance projections from fetal hippocampal field CA3 and CA1 cell grafts in lesioned CA3 of adult hippocampus follows intrinsic character of respective donor cells
    A K Shetty
    Departments of Surgery Neurosurgery and Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neuroscience 99:243-55. 2000
    ....
  5. ncbi Incorporation of embryonic CA3 cell grafts into the adult hippocampus at 4-months after injury: effects of combined neurotrophic supplementation and caspase inhibition
    B Hattiangady
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA
    Neuroscience 139:1369-83. 2006
    ..Apt grafting is also efficacious for reversing some of the abnormal synaptic reorganization prevalent in the hippocampus at later time-points after injury...
  6. ncbi In vitro survival and differentiation of neurons derived from epidermal growth factor-responsive postnatal hippocampal stem cells: inducing effects of brain-derived neurotrophic factor
    A K Shetty
    Department of Surgery Neurosurgery and Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurobiol 35:395-425. 1998
    ....
  7. ncbi Aging impairs axonal sprouting response of dentate granule cells following target loss and partial deafferentation
    A K Shetty
    Departments of Surgery Neurosurgery and Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Comp Neurol 414:238-54. 1999
    ....
  8. ncbi Glutamic acid decarboxylase-67-positive hippocampal interneurons undergo a permanent reduction in number following kainic acid-induced degeneration of ca3 pyramidal neurons
    A K Shetty
    Departments of Surgery Neurosurgery and Neurobiology, Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA
    Exp Neurol 169:276-97. 2001
    ..Nevertheless, a persistent decrease in interneuron activity, as evidenced by permanent down-regulation of GAD-67 in a major fraction of interneurons, would likely enhance the degree of hyperexcitability in the CA3-lesioned hippocampus...
  9. ncbi Vulnerability of the dentate gyrus to aging and intracerebroventricular administration of kainic acid
    A K Shetty
    Medical Research and Surgery Neurosurgery Services, Duke University Medical Center, Durham, North Carolina, 27710, USA
    Exp Neurol 158:491-503. 1999
    ..Thus, aging in the dentate gyrus is characterized by a significantly decreased number of dentate hilar neurons and also a significantly increased susceptibility of dentate hilar neurons to excitotoxic damage...
  10. ncbi Neurite outgrowth from progeny of epidermal growth factor-responsive hippocampal stem cells is significantly less robust than from fetal hippocampal cells following grafting onto organotypic hippocampal slice cultures: effect of brain-derived neurotrophic
    A K Shetty
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurobiol 38:391-413. 1999
    ..However, neurite outgrowth from EGF-responsive stem cell-derived neurons can be enhanced by treating with specific neurotrophic factors such as BDNF...
  11. ncbi Hippocampal interneurons expressing glutamic acid decarboxylase and calcium-binding proteins decrease with aging in Fischer 344 rats
    A K Shetty
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Comp Neurol 394:252-69. 1998
    ..In addition, such a profound alteration in interneuron number will likely alter inhibitory control of excitability and neuronal synchrony with behavioral states...
  12. pmc Predictable chronic mild stress improves mood, hippocampal neurogenesis and memory
    V K Parihar
    Medical Research and Surgery Services, Veterans Affairs Medical Center, Durham, NC, USA
    Mol Psychiatry 16:171-83. 2011
    ..Collectively, these findings reveal that PCMS is beneficial to adult brain function, which is exemplified by increased hippocampal neurogenesis and improved mood and cognitive function...
  13. ncbi Subchronic dermal application of N,N-diethyl m-toluamide (DEET) and permethrin to adult rats, alone or in combination, causes diffuse neuronal cell death and cytoskeletal abnormalities in the cerebral cortex and the hippocampus, and Purkinje neuron loss i
    A Abdel-Rahman
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Exp Neurol 172:153-71. 2001
    ..Collectively, the above alterations can lead to many physiological, pharmacological, and behavioral abnormalities, particularly motor deficits and learning and memory dysfunction...
  14. ncbi Characterization of neuronal/glial differentiation of murine adipose-derived adult stromal cells
    K M Safford
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Exp Neurol 187:319-28. 2004
    ..These findings suggest that muADAS cells can be induced to exhibit several phenotypic, morphologic, and excitotoxic characteristics consistent with developing neuronal and glial tissue...
  15. pmc Behavior of neural stem cells in the Alzheimer brain
    B Waldau
    Department of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA
    Cell Mol Life Sci 65:2372-84. 2008
    ..Therefore, altering the brain microenvironment for fostering apt maturation of graft-derived neurons may be critical for improving the efficacy of NSC transplantation therapy for AD...
  16. ncbi Combined neurotrophic supplementation and caspase inhibition enhances survival of fetal hippocampal CA3 cell grafts in lesioned CA3 region of the aging hippocampus
    V Zaman
    Medical Research Service, Veterans Affairs Medical Center, Durham, NC 27705, USA
    Neuroscience 109:537-53. 2002
    ..Thus, pre-treatment and grafting of donor cells with a combination of factors that support growth of specific donor cells may considerably enhance survival and integration of fetal grafts into the lesioned aging CNS in clinical trials...