William K Scott

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi Deletion of CFHR3 and CFHR1 genes in age-related macular degeneration
    Kylee L Spencer
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Hum Mol Genet 17:971-7. 2008
  2. ncbi Family-based case-control study of cigarette smoking and Parkinson disease
    W K Scott
    Department of Medicine and Duke Center for Human Genetics, Duke University Medical Center, Box 3445, Durham, NC 27710, USA
    Neurology 64:442-7. 2005
  3. ncbi Independent effects of complement factor H Y402H polymorphism and cigarette smoking on risk of age-related macular degeneration
    William K Scott
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ophthalmology 114:1151-6. 2007
  4. pmc Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22
    William K Scott
    Department of Medicine, Duke University Medical Center, and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
    Am J Hum Genet 73:1041-51. 2003
  5. ncbi NOS2A and the modulating effect of cigarette smoking in Parkinson's disease
    Dana B Hancock
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Ann Neurol 60:366-73. 2006
  6. ncbi Linkage disequilibrium and haplotype tagging polymorphisms in the Tau H1 haplotype
    Sofia A Oliveira
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Neurogenetics 5:147-55. 2004
  7. ncbi Association study of Parkin gene polymorphisms with idiopathic Parkinson disease
    Sofia A Oliveira
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC
    Arch Neurol 60:975-80. 2003
  8. ncbi Analysis of European mitochondrial haplogroups with Alzheimer disease risk
    Joelle M van der Walt
    Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 365:28-32. 2004
  9. ncbi Neovascular age-related macular degeneration and its association with LOC387715 and complement factor H polymorphism
    R Keith Shuler
    Eye Center and Center for Human Genetics, Duke University, Durham, NC, USA
    Arch Ophthalmol 125:63-7. 2007
  10. pmc Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 78:852-64. 2006

Detail Information

Publications48

  1. ncbi Deletion of CFHR3 and CFHR1 genes in age-related macular degeneration
    Kylee L Spencer
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Hum Mol Genet 17:971-7. 2008
    ..The presence of protective haplotypes in CFH that do not carry the deletion, suggests that other protective variants in this region have yet to be discovered...
  2. ncbi Family-based case-control study of cigarette smoking and Parkinson disease
    W K Scott
    Department of Medicine and Duke Center for Human Genetics, Duke University Medical Center, Box 3445, Durham, NC 27710, USA
    Neurology 64:442-7. 2005
    ..To determine whether people with Parkinson disease (PD) are less likely to report a history of cigarette smoking than their unaffected siblings...
  3. ncbi Independent effects of complement factor H Y402H polymorphism and cigarette smoking on risk of age-related macular degeneration
    William K Scott
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ophthalmology 114:1151-6. 2007
    ..To examine the potential gene-environment interaction between cigarette smoking and the complement factor H (CFH) T1277C polymorphism, 2 strong risk factors for age-related macular degeneration (AMD)...
  4. pmc Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22
    William K Scott
    Department of Medicine, Duke University Medical Center, and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
    Am J Hum Genet 73:1041-51. 2003
    ..These results indicate that linkage to chromosome 9p is strongest in late-onset AD and that regions on chromosome 2q34 and 15q22 are linked to early-onset AD and very-late-onset AD, respectively...
  5. ncbi NOS2A and the modulating effect of cigarette smoking in Parkinson's disease
    Dana B Hancock
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Ann Neurol 60:366-73. 2006
    ..NOS2A is a candidate gene for Parkinson's disease (PD) that potentially interacts with cigarette smoking. We examined NOS2A for association with PD risk and age at onset (AAO) and for interaction with smoking...
  6. ncbi Linkage disequilibrium and haplotype tagging polymorphisms in the Tau H1 haplotype
    Sofia A Oliveira
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Neurogenetics 5:147-55. 2004
    ..02). These results define the genes and regulatory regions included in this region of LD, containing an important susceptibility allele contributing to increased risk of neurodegeneration...
  7. ncbi Association study of Parkin gene polymorphisms with idiopathic Parkinson disease
    Sofia A Oliveira
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC
    Arch Neurol 60:975-80. 2003
    ..However, previous case-control studies have reported conflicting results regarding the role of more common Parkin polymorphisms as susceptibility alleles for idiopathic PD...
  8. ncbi Analysis of European mitochondrial haplogroups with Alzheimer disease risk
    Joelle M van der Walt
    Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 365:28-32. 2004
    ..We suggest that variations within haplogroup U may be involved in AD expression in combination with environmental exposures or nuclear proteins other than APOE...
  9. ncbi Neovascular age-related macular degeneration and its association with LOC387715 and complement factor H polymorphism
    R Keith Shuler
    Eye Center and Center for Human Genetics, Duke University, Durham, NC, USA
    Arch Ophthalmol 125:63-7. 2007
    ..To compare phenotypes of 2 age-related macular degeneration (AMD) susceptibility genes: LOC387715 and complement factor H (CFH)...
  10. pmc Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 78:852-64. 2006
    ..We demonstrate, for the first time, that a genetic susceptibility coupled with a modifiable lifestyle factor such as cigarette smoking confers a significantly higher risk of AMD than either factor alone...
  11. ncbi Peripheral reticular pigmentary change is associated with complement factor H polymorphism (Y402H) in age-related macular degeneration
    R Keith Shuler
    Duke University Eye Center, Durham, North Carolina 27710, USA
    Ophthalmology 115:520-4. 2008
    ..To examine phenotypes of age-related macular degeneration (AMD) patients with the complement factor H (CFH) variant (Y402H, C allele at rs1061170)...
  12. ncbi Family-based case-control study of MAOA and MAOB polymorphisms in Parkinson disease
    Sun J Kang
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mov Disord 21:2175-80. 2006
    ..02). No significant association was found in the male subset. Our results add to the evidence of involvement of MAOB in PD and suggest that the effect may be stronger in women...
  13. ncbi Phenotype analysis of patients with the risk variant LOC387715 (A69S) in age-related macular degeneration
    R Keith Shuler
    Duke University Eye Center, Durham, NC 27710, USA
    Am J Ophthalmol 145:303-307. 2008
    ..To examine phenotypes of age-related macular degeneration (AMD) patients with the LOC387715 variant (T allele at rs10490924, A69S)...
  14. ncbi Complement factor H increases risk for atrophic age-related macular degeneration
    Eric A Postel
    Duke University Eye Center, Durham, North Carolina, USA
    Ophthalmology 113:1504-7. 2006
    ..To determine if the complement factor H gene (CFH) determines risk for development of geographic atrophy (GA)...
  15. ncbi Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease
    Yi Ju Li
    Department of Medicine, Center for Human Genetics, Institute for Genome Science and Policy, Duke University Medical Center, Box 3445, Durham, NC 27710, USA
    Hum Mol Genet 12:3259-67. 2003
    ..This is provocative given reports of the possible role of inflammation in these two neurodegenerative disorders...
  16. ncbi The Q7R Saitohin gene polymorphism is not associated with Alzheimer disease
    Sofia A Oliveira
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Box 3445, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 347:143-6. 2003
    ..We found no evidence of significant association of this polymorphism with risk of AD using family-based and case-control tests of association...
  17. pmc Revealing the role of glutathione S-transferase omega in age-at-onset of Alzheimer and Parkinson diseases
    Yi Ju Li
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Box 3445, Durham, NC 27710, USA
    Neurobiol Aging 27:1087-93. 2006
    ..These findings suggest the presence of genetic heterogeneity for GSTO1h's effect on AAO, and support GSTO1h's role in modifying AAO in these two disorders...
  18. ncbi Parkin mutations and susceptibility alleles in late-onset Parkinson's disease
    Sofia A Oliveira
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Ann Neurol 53:624-9. 2003
    ..These findings suggest that mutations in Parkin contribute to the common form of PD and that heterozygous mutations, especially those lying in exon 7, act as susceptibility alleles for late-onset form of Parkinson disease...
  19. pmc Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein
    Gaofeng Wang
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 82:283-9. 2008
    ..We propose this is likely to be a common mechanism of genetic modulation of individual susceptibility to complex disease...
  20. ncbi Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson disease
    Dana B Hancock
    Center for Human Genetics and Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Arch Neurol 64:576-80. 2007
    ..To assess associations between Parkinson disease (PD) and putatively protective factors-smoking, caffeine (coffee, tea, and soft drinks), and nonsteroidal anti-inflammatory drugs (aspirin, ibuprofen, and naproxen)...
  21. ncbi Detailed analysis of allelic variation in the ABCA4 gene in age-related maculopathy
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Invest Ophthalmol Vis Sci 44:2868-75. 2003
    ....
  22. ncbi Joint effects of smoking history and APOE genotypes in age-related macular degeneration
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Mol Vis 11:941-9. 2005
    ..Several studies have implicated the apolipoprotein E (APOE) gene as modulating AMD risk. The purpose of this study was to investigate whether APOE genotypes modify the smoking-associated risk of AMD...
  23. pmc Ordered subset linkage analysis supports a susceptibility locus for age-related macular degeneration on chromosome 16p12
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    BMC Genet 5:18. 2004
    ..Chromosome-wide significance of increases in nonparametric multipoint lod scores in covariate-defined subsets relative to the overall sample was assessed by permutation...
  24. pmc Fibroblast growth factor 20 polymorphisms and haplotypes strongly influence risk of Parkinson disease
    Joelle M van der Walt
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 74:1121-7. 2004
    ..0003), whereas a second haplotype (A-G-G-G-C) was found to be negatively associated with risk of PD (P=.0009). Our results strongly support FGF20 as a risk factor for PD...
  25. pmc Nitric oxide synthase genes and their interactions with environmental factors in Parkinson's disease
    Dana B Hancock
    University Program in Genetics and Genomics, Duke University, Durham, NC 27710, USA
    Neurogenetics 9:249-62. 2008
    ..021) and rs1060826 (p = 0.013). These data implicate NOS1 and NOS2A as genetic risk factors for PD and demonstrate that their interactions with established environmental factors may modulate the environmental effects...
  26. pmc Linkage disequilibrium inflates type I error rates in multipoint linkage analysis when parental genotypes are missing
    Abee L Boyles
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Hered 59:220-7. 2005
    ..Describe the inflation in nonparametric multipoint LOD scores due to inter-marker linkage disequilibrium (LD) across many markers with varied allele frequencies...
  27. pmc Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease
    Joelle M van der Walt
    Department of Medicine, and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 72:804-11. 2003
    ..45; 95% CI 0.22-0.93; P=.03). Our results suggest that ND3 is an important factor in PD susceptibility among white individuals and could help explain the role of complex I in PD expression...
  28. pmc Pesticide exposure and risk of Parkinson's disease: a family-based case-control study
    Dana B Hancock
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    BMC Neurol 8:6. 2008
    ..Pesticides and correlated lifestyle factors (e.g., exposure to well-water and farming) are repeatedly reported risk factors for Parkinson's disease (PD), but few family-based studies have examined these relationships...
  29. ncbi Methods for interaction analyses using family-based case-control data: conditional logistic regression versus generalized estimating equations
    Dana B Hancock
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    Genet Epidemiol 31:883-93. 2007
    ..g., population stratification) and the interpretation of its OR estimates...
  30. ncbi Design of the Genetics of Early Onset Cardiovascular Disease (GENECARD) study
    Elizabeth R Hauser
    Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 145:602-13. 2003
    ..Early onset (premature) coronary artery disease (EOCAD) is known to have a particularly strong genetic component. However, the actual genes leading to this increased risk of CAD remain obscure...
  31. ncbi Comparing age-related macular degeneration phenotype in probands from singleton and multiplex families
    Eric A Postel
    Duke University Eye Center, Box 3802, Durham, NC 27710, USA
    Am J Ophthalmol 139:820-5. 2005
    ..To compare age-related macular degeneration (AMD) phenotype between probands in singleton and multiplex families to determine whether data from these two groups may be combined for consolidated genetic analyses...
  32. pmc Vitamin D receptor gene as a candidate gene for Parkinson disease
    Megan W Butler
    Department of Pediatrics, Duke University Medical Center, Duke University School of Medicine, Durham, NC, USA
    Ann Hum Genet 75:201-10. 2011
    ..003) but not risk. The 3' end SNP has been associated with both MS and AD in previous studies. Our findings suggest VDR as a potential susceptibility gene and support an essential role of vitamin D in PD...
  33. ncbi Maternal lineages and Alzheimer disease risk in the Old Order Amish
    Joelle M van der Walt
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Genet 118:115-22. 2005
    ..Therefore, we suggest that the genetic effect responsible for AD dementia in the affected Amish pedigrees is unlikely to be of mitochondrial origin and may be caused by nuclear genetic factors...
  34. pmc Age at onset in two common neurodegenerative diseases is genetically controlled
    Yi Ju Li
    Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 70:985-93. 2002
    ..62. These data suggest that a common gene affects AAO in these two common complex neurodegenerative diseases...
  35. pmc Searching for epistatic interactions in nuclear families using conditional linkage analysis
    Svati H Shah
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    BMC Genet 6:S148. 2005
    ..Ordered subsets analysis (OSA) is a method for conditional linkage analysis using continuous covariates...
  36. ncbi Population-based case-control association studies
    Dana B Hancock
    Duke University Medical Center, Durham, North Carolina, USA
    Curr Protoc Hum Genet . 2007
    ..Readers are referred to basic texts on epidemiology for more details on general conduct of case-control studies...
  37. pmc Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses
    Sun Hee Ahn
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Pathog 6:e1001088. 2010
    ..These findings suggest that two genes, Tnfaip8 and Seh1l, may contribute to susceptibility to S. aureus in A/J mice, and represent promising candidates for human genetic susceptibility studies...
  38. pmc A new locus for familial FSGS on chromosome 2p
    Rasheed Gbadegesin
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    J Am Soc Nephrol 21:1390-7. 2010
    ..These data support a new gene locus for familial FSGS on chromosome 2p15. Identification of the mutated gene at this locus may provide further insight into the disease mechanisms of FSGS...
  39. pmc Cytokine gene polymorphisms and the outcome of invasive candidiasis: a prospective cohort study
    Melissa D Johnson
    Duke University Medical Center, Durham, North Carolina, USA
    Clin Infect Dis 54:502-10. 2012
    ..Although clinical and microbiological factors affecting prognosis have been identified, the impact of genetic variation in the innate immune responses mediated by cytokines on outcomes of infection remains to be studied...
  40. pmc C3 R102G polymorphism increases risk of age-related macular degeneration
    Kylee L Spencer
    Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232, USA
    Hum Mol Genet 17:1821-4. 2008
    ..17]. Therefore, while the strong LD between R102G and L314P makes it difficult to disentangle their individual effects on disease risk, the R102G polymorphism acting alone provides the best model for disease in our data...
  41. ncbi Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration
    Kylee L Spencer
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, USA
    Hum Mol Genet 16:1986-92. 2007
    ..21, 95% confidence interval 0.11-0.39; P < 10(-4)). Likelihood ratio testing and conditional analyses in the case-control data set suggest that a weaker, independent protective effect exists for CC2 E318D...
  42. ncbi Complement factor H variant increases the risk of age-related macular degeneration
    Jonathan L Haines
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Science 308:419-21. 2005
    ..45 and 5.57. This common variant likely explains approximately 43% of AMD in older adults...
  43. pmc Combinatorial Mismatch Scan (CMS) for loci associated with dementia in the Amish
    Jacob L McCauley
    Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA
    BMC Med Genet 7:19. 2006
    ..The Amish communities located in Indiana and Ohio are relatively isolated populations that may have increased power to detect disease susceptibility genes...
  44. pmc A genome-wide linkage analysis of dementia in the Amish
    Daniel W Hahs
    Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Am J Med Genet B Neuropsychiatr Genet 141:160-6. 2006
    ..Our results identify regions of the genome that may harbor genes involved in a subset of dementia patients, in particular the North American Amish community...
  45. ncbi Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6
    Jonathan L Haines
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Invest Ophthalmol Vis Sci 47:329-35. 2006
    ..Identification of the underlying genes has been difficult, with both genomic screen (locational) and candidate gene (functional) approaches being used. The present study tested candidate genes for association with AMD...
  46. ncbi Haplotypes spanning the complement factor H gene are protective against age-related macular degeneration
    Kylee L Spencer
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Invest Ophthalmol Vis Sci 48:4277-83. 2007
    ..Besides the well-known risk imparted by carrying the Y402H variant in the complement factor H (CFH) gene on chromosome 1, recent evidence of the existence of protective haplotypes spanning CFH has been reported...
  47. ncbi Linkage of a gene causing familial membranoproliferative glomerulonephritis type III to chromosome 1
    John J Neary
    Departments of Nephrology, Beaumont Hospital, Dublin, Ireland
    J Am Soc Nephrol 13:2052-7. 2002
    ..The data provide evidence for a gene for familial MPGN on chromosome 1q...
  48. ncbi Linkage of Parkinsonism and Alzheimer's disease with Lewy body pathology to chromosome 12
    William K Scott
    Ann Neurol 52:524; author reply 524. 2002