B L Scott

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Pesticide exposure and risk of Parkinson's disease: a family-based case-control study
    Dana B Hancock
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    BMC Neurol 8:6. 2008
  2. ncbi request reprint A case of combined orthostatic tremor and primary gait ignition failure
    Bennett H Myers
    Department of Neurology, Strong Memorial Hospital, Box 673, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Clin Neurol Neurosurg 105:277-80. 2003
  3. ncbi request reprint Human apolipoprotein E accelerates microtubule polymerization in vitro
    B L Scott
    Department of Medicine Neurology, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 245:105-8. 1998
  4. ncbi request reprint Family-based case-control study of cigarette smoking and Parkinson disease
    W K Scott
    Department of Medicine and Duke Center for Human Genetics, Duke University Medical Center, Box 3445, Durham, NC 27710, USA
    Neurology 64:442-7. 2005
  5. ncbi request reprint Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease
    E R Martin
    Center for Human Genetics, Box 2903, Duke University Medical Center, Durham, NC 27710, USA
    JAMA 286:2245-50. 2001
  6. ncbi request reprint Complete genomic screen in Parkinson disease: evidence for multiple genes
    W K Scott
    Center for Human Genetics, Box 3445, Duke University Medical Center, Durham, NC 27710, USA
    JAMA 286:2239-44. 2001
  7. ncbi request reprint Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease
    J M van der Walt
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Neurology 60:1189-91. 2003
  8. ncbi request reprint Parkin mutations and susceptibility alleles in late-onset Parkinson's disease
    Sofia A Oliveira
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Ann Neurol 53:624-9. 2003
  9. ncbi request reprint Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson disease
    Dana B Hancock
    Center for Human Genetics and Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Arch Neurol 64:576-80. 2007
  10. ncbi request reprint NOS2A and the modulating effect of cigarette smoking in Parkinson's disease
    Dana B Hancock
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Ann Neurol 60:366-73. 2006

Research Grants

Collaborators

Detail Information

Publications17

  1. pmc Pesticide exposure and risk of Parkinson's disease: a family-based case-control study
    Dana B Hancock
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    BMC Neurol 8:6. 2008
    ..Pesticides and correlated lifestyle factors (e.g., exposure to well-water and farming) are repeatedly reported risk factors for Parkinson's disease (PD), but few family-based studies have examined these relationships...
  2. ncbi request reprint A case of combined orthostatic tremor and primary gait ignition failure
    Bennett H Myers
    Department of Neurology, Strong Memorial Hospital, Box 673, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Clin Neurol Neurosurg 105:277-80. 2003
    ..We report a case of a woman with both orthostatic tremor and primary gait ignition failure, a novel combination. We review the literature on both of these conditions, and discuss possible neuroanatomic substrates...
  3. ncbi request reprint Human apolipoprotein E accelerates microtubule polymerization in vitro
    B L Scott
    Department of Medicine Neurology, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 245:105-8. 1998
    ....
  4. ncbi request reprint Family-based case-control study of cigarette smoking and Parkinson disease
    W K Scott
    Department of Medicine and Duke Center for Human Genetics, Duke University Medical Center, Box 3445, Durham, NC 27710, USA
    Neurology 64:442-7. 2005
    ..To determine whether people with Parkinson disease (PD) are less likely to report a history of cigarette smoking than their unaffected siblings...
  5. ncbi request reprint Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease
    E R Martin
    Center for Human Genetics, Box 2903, Duke University Medical Center, Durham, NC 27710, USA
    JAMA 286:2245-50. 2001
    ..001) was detected between 4 of the 5 SNPs (SNPs 3, 9i, 9ii, and 11). CONCLUSIONS: This integrated approach of genetic linkage and positional association analyses implicates tau as a susceptibility gene for idiopathic PD...
  6. ncbi request reprint Complete genomic screen in Parkinson disease: evidence for multiple genes
    W K Scott
    Center for Human Genetics, Box 3445, Duke University Medical Center, Durham, NC 27710, USA
    JAMA 286:2239-44. 2001
    ..CONCLUSIONS: Our data suggest that the parkin gene is important in early-onset PD and that multiple genetic factors may be important in the development of idiopathic late-onset PD...
  7. ncbi request reprint Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease
    J M van der Walt
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Neurology 60:1189-91. 2003
    ..The authors did not find evidence for association with increased risk for PD between any individual NAT1 or NAT2 SNP or acetylation haplotype (N = 397 families, 1,580 individuals)...
  8. ncbi request reprint Parkin mutations and susceptibility alleles in late-onset Parkinson's disease
    Sofia A Oliveira
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Ann Neurol 53:624-9. 2003
    ..These findings suggest that mutations in Parkin contribute to the common form of PD and that heterozygous mutations, especially those lying in exon 7, act as susceptibility alleles for late-onset form of Parkinson disease...
  9. ncbi request reprint Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson disease
    Dana B Hancock
    Center for Human Genetics and Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Arch Neurol 64:576-80. 2007
    ..To assess associations between Parkinson disease (PD) and putatively protective factors-smoking, caffeine (coffee, tea, and soft drinks), and nonsteroidal anti-inflammatory drugs (aspirin, ibuprofen, and naproxen)...
  10. ncbi request reprint NOS2A and the modulating effect of cigarette smoking in Parkinson's disease
    Dana B Hancock
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Ann Neurol 60:366-73. 2006
    ..NOS2A is a candidate gene for Parkinson's disease (PD) that potentially interacts with cigarette smoking. We examined NOS2A for association with PD risk and age at onset (AAO) and for interaction with smoking...
  11. ncbi request reprint Genomic convergence to identify candidate genes for Parkinson disease: SAGE analysis of the substantia nigra
    Maher A Noureddine
    Center for Human Genetics, Duke University, Durham, North Carolina 27710 2903, USA
    Mov Disord 20:1299-309. 2005
    ..The next step in the genomic convergence process will be to screen these 50 high-quality candidate genes for association with PD risk susceptibility and genetic effects on AAO...
  12. ncbi request reprint Expression profiling of substantia nigra in Parkinson disease, progressive supranuclear palsy, and frontotemporal dementia with parkinsonism
    Michael A Hauser
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Arch Neurol 62:917-21. 2005
    ..Genes contributing to rare mendelian forms of PD have been identified, but the genes involved in the more common idiopathic PD are not well understood...
  13. pmc Age at onset in two common neurodegenerative diseases is genetically controlled
    Yi Ju Li
    Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 70:985-93. 2002
    ..62. These data suggest that a common gene affects AAO in these two common complex neurodegenerative diseases...
  14. ncbi request reprint Linkage disequilibrium and haplotype tagging polymorphisms in the Tau H1 haplotype
    Sofia A Oliveira
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Neurogenetics 5:147-55. 2004
    ..02). These results define the genes and regulatory regions included in this region of LD, containing an important susceptibility allele contributing to increased risk of neurodegeneration...
  15. pmc Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease
    Joelle M van der Walt
    Department of Medicine, and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 72:804-11. 2003
    ..45; 95% CI 0.22-0.93; P=.03). Our results suggest that ND3 is an important factor in PD susceptibility among white individuals and could help explain the role of complex I in PD expression...
  16. ncbi request reprint Association study of Parkin gene polymorphisms with idiopathic Parkinson disease
    Sofia A Oliveira
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC
    Arch Neurol 60:975-80. 2003
    ..However, previous case-control studies have reported conflicting results regarding the role of more common Parkin polymorphisms as susceptibility alleles for idiopathic PD...
  17. pmc Fibroblast growth factor 20 polymorphisms and haplotypes strongly influence risk of Parkinson disease
    Joelle M van der Walt
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 74:1121-7. 2004
    ..0003), whereas a second haplotype (A-G-G-G-C) was found to be negatively associated with risk of PD (P=.0009). Our results strongly support FGF20 as a risk factor for PD...

Research Grants3

  1. Parkinson's Disease Neuroprotection Clinical Trial: Clinical Center
    Burton Scott; Fiscal Year: 2007
    ..Approval of the Duke Medical Center Internal Review Board (IRB) will be obtained prior to starting any clinical trial at Duke. ..