Nicole L Schramm-Sapyta
Affiliation: Duke University Medical Center
- Are adolescents more vulnerable to drug addiction than adults? Evidence from animal modelsNicole L Schramm-Sapyta
Duke University, Durham, NC, USA
Psychopharmacology (Berl) 206:1-21. 2009..Animal models, in which age of onset can be tightly controlled, offer a platform for testing causality. Many animal models address drug effects that might promote or discourage drug intake and drug-induced neuroplasticity...
- Aversive effects of ethanol in adolescent versus adult rats: potential causes and implication for future drinkingNicole L Schramm-Sapyta
Duke University Medical Center, Durham, North Carolina 27710, USA
Alcohol Clin Exp Res 34:2061-9. 2010..First, do reduced aversive effects of ethanol in younger rats correlate with increased ethanol consumption? Second, are the reduced aversive effects in adolescents attributable to reduced sensitivity to ethanol's physiologic effects?..
- Role of individual and developmental differences in voluntary cocaine intake in ratsNicole L Schramm-Sapyta
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
Psychopharmacology (Berl) 215:493-504. 2011..Here, a rodent model is used to explore the causality of early onset in development of self-administration and addiction-like behavior and to examine factors that promote self-administration...
- Differential anxiogenic, aversive, and locomotor effects of THC in adolescent and adult ratsNicole L Schramm-Sapyta
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Room 100B Research Park Bldg 2, P O Box 3813, Durham, NC 27710, USA
Psychopharmacology (Berl) 191:867-77. 2007..Unpleasant side effects of drugs of abuse often limit their repeated use; however, such effects may be attenuated in adolescents compared to adults...
- Individual differences in cocaine conditioned taste aversion are developmentally stable and independent of locomotor effects of cocaineCaitlin Drescher
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, United States
Dev Cogn Neurosci 1:600-5. 2011..Taken together, these findings indicate that sensitivity to cocaine’s motivational effects is stable across development and part of a unique neurological process...
- Novelty-induced locomotion is positively associated with cocaine ingestion in adolescent rats; anxiety is correlated in adultsQ David Walker
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, United States
Pharmacol Biochem Behav 91:398-408. 2009..Thus, behavioral phenotypes correlated with individual differences in cocaine/saccharin consumption in an age-related manner...
- Adolescent rats are protected from the conditioned aversive properties of cocaine and lithium chlorideNicole L Schramm-Sapyta
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
Pharmacol Biochem Behav 84:344-52. 2006..This contributes to our understanding of why adolescence is a particularly vulnerable period for development of drug abuse...
- Early ethanol consumption predicts relapse-like behavior in adolescent male ratsNicole L Schramm-Sapyta
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Alcohol Clin Exp Res 32:754-62. 2008..We assessed an array of behavioral and hormonal characteristics in adolescent (28-day-old) male rats before exposure to ethanol, and then determined which rats were most prone to high levels of alcohol drinking...
- Characterization of a semi-rapid method for assessing delay discounting in rodentsEthan P Foscue
Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, PO Box 103604, Durham, NC 27710, United States
Pharmacol Biochem Behav 101:187-92. 2012..This faster version of the delay discounting task will facilitate future studies involving pharmacological, electrophysiological, and other mechanistic studies of the underlying basis of this important disease process...
- Role of HPA Axis in Adolescent Vulnerability to Drug AddictionNICOLE SCHRAMM SAPYTA; Fiscal Year: 2007..These studies will assess whether adolescence is truly a vulnerable period for development of addiction. ..
- Roles of PKA in AddictionNICOLE SCHRAMM SAPYTA; Fiscal Year: 2003..Finally, I will examine the effects of PKA transgene induction on Nac-dependent, addiction-related behavioral models, namely conditioned place preference and response reinforcement learning. ..