Nicole L Schramm-Sapyta

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. doi request reprint Effect of sex on ethanol consumption and conditioned taste aversion in adolescent and adult rats
    Nicole L Schramm-Sapyta
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, 27710, USA
    Psychopharmacology (Berl) 231:1831-9. 2014
  2. pmc Role of individual and developmental differences in voluntary cocaine intake in rats
    Nicole L Schramm-Sapyta
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Psychopharmacology (Berl) 215:493-504. 2011
  3. pmc Are adolescents more vulnerable to drug addiction than adults? Evidence from animal models
    Nicole L Schramm-Sapyta
    Duke University, Durham, NC, USA
    Psychopharmacology (Berl) 206:1-21. 2009
  4. pmc Aversive effects of ethanol in adolescent versus adult rats: potential causes and implication for future drinking
    Nicole L Schramm-Sapyta
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Alcohol Clin Exp Res 34:2061-9. 2010
  5. ncbi request reprint Differential anxiogenic, aversive, and locomotor effects of THC in adolescent and adult rats
    Nicole L Schramm-Sapyta
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Room 100B Research Park Bldg 2, P O Box 3813, Durham, NC 27710, USA
    Psychopharmacology (Berl) 191:867-77. 2007
  6. pmc Individual differences in cocaine conditioned taste aversion are developmentally stable and independent of locomotor effects of cocaine
    Caitlin Drescher
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, United States
    Dev Cogn Neurosci 1:600-5. 2011
  7. pmc Novelty-induced locomotion is positively associated with cocaine ingestion in adolescent rats; anxiety is correlated in adults
    Q David Walker
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, United States
    Pharmacol Biochem Behav 91:398-408. 2009
  8. pmc Adolescent rats are protected from the conditioned aversive properties of cocaine and lithium chloride
    Nicole L Schramm-Sapyta
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Pharmacol Biochem Behav 84:344-52. 2006
  9. pmc Early ethanol consumption predicts relapse-like behavior in adolescent male rats
    Nicole L Schramm-Sapyta
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Alcohol Clin Exp Res 32:754-62. 2008
  10. pmc Depression inhibits the anti-inflammatory effects of leisure time physical activity and light to moderate alcohol consumption
    Edward C Suarez
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Brain Behav Immun 32:144-52. 2013

Research Grants

  1. Role of HPA Axis in Adolescent Vulnerability to Drug Addiction
    NICOLE SCHRAMM SAPYTA; Fiscal Year: 2007
  2. Roles of PKA in Addiction
    NICOLE SCHRAMM SAPYTA; Fiscal Year: 2003

Collaborators

Detail Information

Publications13

  1. doi request reprint Effect of sex on ethanol consumption and conditioned taste aversion in adolescent and adult rats
    Nicole L Schramm-Sapyta
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, 27710, USA
    Psychopharmacology (Berl) 231:1831-9. 2014
    ..Female sex and adolescent age are associated with lower sensitivity to intake-reducing effects and more rapid development of alcohol abuse...
  2. pmc Role of individual and developmental differences in voluntary cocaine intake in rats
    Nicole L Schramm-Sapyta
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Psychopharmacology (Berl) 215:493-504. 2011
    ..Here, a rodent model is used to explore the causality of early onset in development of self-administration and addiction-like behavior and to examine factors that promote self-administration...
  3. pmc Are adolescents more vulnerable to drug addiction than adults? Evidence from animal models
    Nicole L Schramm-Sapyta
    Duke University, Durham, NC, USA
    Psychopharmacology (Berl) 206:1-21. 2009
    ..Animal models, in which age of onset can be tightly controlled, offer a platform for testing causality. Many animal models address drug effects that might promote or discourage drug intake and drug-induced neuroplasticity...
  4. pmc Aversive effects of ethanol in adolescent versus adult rats: potential causes and implication for future drinking
    Nicole L Schramm-Sapyta
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Alcohol Clin Exp Res 34:2061-9. 2010
    ..First, do reduced aversive effects of ethanol in younger rats correlate with increased ethanol consumption? Second, are the reduced aversive effects in adolescents attributable to reduced sensitivity to ethanol's physiologic effects?..
  5. ncbi request reprint Differential anxiogenic, aversive, and locomotor effects of THC in adolescent and adult rats
    Nicole L Schramm-Sapyta
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Room 100B Research Park Bldg 2, P O Box 3813, Durham, NC 27710, USA
    Psychopharmacology (Berl) 191:867-77. 2007
    ..Unpleasant side effects of drugs of abuse often limit their repeated use; however, such effects may be attenuated in adolescents compared to adults...
  6. pmc Individual differences in cocaine conditioned taste aversion are developmentally stable and independent of locomotor effects of cocaine
    Caitlin Drescher
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, United States
    Dev Cogn Neurosci 1:600-5. 2011
    ..Taken together, these findings indicate that sensitivity to cocaine’s motivational effects is stable across development and part of a unique neurological process...
  7. pmc Novelty-induced locomotion is positively associated with cocaine ingestion in adolescent rats; anxiety is correlated in adults
    Q David Walker
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, United States
    Pharmacol Biochem Behav 91:398-408. 2009
    ..Thus, behavioral phenotypes correlated with individual differences in cocaine/saccharin consumption in an age-related manner...
  8. pmc Adolescent rats are protected from the conditioned aversive properties of cocaine and lithium chloride
    Nicole L Schramm-Sapyta
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Pharmacol Biochem Behav 84:344-52. 2006
    ..This contributes to our understanding of why adolescence is a particularly vulnerable period for development of drug abuse...
  9. pmc Early ethanol consumption predicts relapse-like behavior in adolescent male rats
    Nicole L Schramm-Sapyta
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Alcohol Clin Exp Res 32:754-62. 2008
    ..We assessed an array of behavioral and hormonal characteristics in adolescent (28-day-old) male rats before exposure to ethanol, and then determined which rats were most prone to high levels of alcohol drinking...
  10. pmc Depression inhibits the anti-inflammatory effects of leisure time physical activity and light to moderate alcohol consumption
    Edward C Suarez
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Brain Behav Immun 32:144-52. 2013
    ....
  11. pmc Characterization of a semi-rapid method for assessing delay discounting in rodents
    Ethan P Foscue
    Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, PO Box 103604, Durham, NC 27710, United States
    Pharmacol Biochem Behav 101:187-92. 2012
    ..This faster version of the delay discounting task will facilitate future studies involving pharmacological, electrophysiological, and other mechanistic studies of the underlying basis of this important disease process...
  12. doi request reprint Race differences in the relation of vitamins A, C, E, and β-carotene to metabolic and inflammatory biomarkers
    Edward C Suarez
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC Electronic address
    Nutr Res 34:1-10. 2014
    ..Whether or not lower levels of micronutrients contribute uniquely to racial health disparities is a worthwhile aim for future research. ..
  13. doi request reprint Use of the light/dark test for anxiety in adult and adolescent male rats
    Andrew E Arrant
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Behav Brain Res 256:119-27. 2013
    ..These data support the results of the factor analysis and indicate that GABAergic and noradrenergic modulation of LD anxiety-like behavior may be immature during adolescence...

Research Grants3

  1. Role of HPA Axis in Adolescent Vulnerability to Drug Addiction
    NICOLE SCHRAMM SAPYTA; Fiscal Year: 2007
    ..These studies will assess whether adolescence is truly a vulnerable period for development of addiction. ..
  2. Roles of PKA in Addiction
    NICOLE SCHRAMM SAPYTA; Fiscal Year: 2003
    ..Finally, I will examine the effects of PKA transgene induction on Nac-dependent, addiction-related behavioral models, namely conditioned place preference and response reinforcement learning. ..