SILKE A SCHMIDT

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi Two-stage study designs for analyzing disease-associated covariates: linkage thresholds and case-selection strategies
    Mike Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    BMC Proc 1:S138. 2007
  2. ncbi Searching for epistatic interactions in nuclear families using conditional linkage analysis
    Svati H Shah
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    BMC Genet 6:S148. 2005
  3. ncbi Adjusting for covariates on a slippery slope: linkage analysis of change over time
    Evadnie Rampersaud
    Section of Medical Genetics, Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, USA
    BMC Genet 4:S50. 2003
  4. ncbi Association of ALS with head injury, cigarette smoking and APOE genotypes
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, 595 LaSalle Street, Durham, North Carolina, 27710, USA
    J Neurol Sci 291:22-9. 2010
  5. ncbi Genes and Environmental Exposures in Veterans with Amyotrophic Lateral Sclerosis: the GENEVA study. Rationale, study design and demographic characteristics
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Neuroepidemiology 30:191-204. 2008
  6. ncbi Increased efficiency of case-control association analysis by using allele-sharing and covariate information
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Hered 65:154-65. 2008
  7. ncbi Interpreting analyses of continuous covariates in affected sibling pair linkage studies
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genet Epidemiol 31:541-52. 2007
  8. ncbi Allelic association of sequence variants in the herpes virus entry mediator-B gene (PVRL2) with the severity of multiple sclerosis
    S Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Genes Immun 7:384-92. 2006
  9. ncbi Linkage analysis with gene-environment interaction: model illustration and performance of ordered subset analysis
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genet Epidemiol 30:409-22. 2006
  10. ncbi Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 78:852-64. 2006

Research Grants

  1. Statistical models for genetic studies of AMD
    Silke Schmidt; Fiscal Year: 2005
  2. Genetic Epidemiology of ALS in Veterans
    Silke Schmidt; Fiscal Year: 2007

Detail Information

Publications14

  1. ncbi Two-stage study designs for analyzing disease-associated covariates: linkage thresholds and case-selection strategies
    Mike Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    BMC Proc 1:S138. 2007
    ..The quantitative trait loci analysis performed well in identifying these loci, and the power to identify disease-associated alleles was increased by using ordered-subset analysis as a case selection tool...
  2. ncbi Searching for epistatic interactions in nuclear families using conditional linkage analysis
    Svati H Shah
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    BMC Genet 6:S148. 2005
    ..Ordered subsets analysis (OSA) is a method for conditional linkage analysis using continuous covariates...
  3. ncbi Adjusting for covariates on a slippery slope: linkage analysis of change over time
    Evadnie Rampersaud
    Section of Medical Genetics, Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, USA
    BMC Genet 4:S50. 2003
    ....
  4. ncbi Association of ALS with head injury, cigarette smoking and APOE genotypes
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, 595 LaSalle Street, Durham, North Carolina, 27710, USA
    J Neurol Sci 291:22-9. 2010
    ..Since head injury and cigarette smoking are two previously implicated environmental risk factors that are more common in military than civilian study populations, we tested their association with ALS in a US veteran study population...
  5. ncbi Genes and Environmental Exposures in Veterans with Amyotrophic Lateral Sclerosis: the GENEVA study. Rationale, study design and demographic characteristics
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Neuroepidemiology 30:191-204. 2008
    ....
  6. ncbi Increased efficiency of case-control association analysis by using allele-sharing and covariate information
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Hered 65:154-65. 2008
    ....
  7. ncbi Interpreting analyses of continuous covariates in affected sibling pair linkage studies
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genet Epidemiol 31:541-52. 2007
    ..They suggest that the side-by-side evaluation of OSA and QTL results may provide important information about the relationship of measured covariates with either disease risk or linkage heterogeneity...
  8. ncbi Allelic association of sequence variants in the herpes virus entry mediator-B gene (PVRL2) with the severity of multiple sclerosis
    S Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Genes Immun 7:384-92. 2006
    ....
  9. ncbi Linkage analysis with gene-environment interaction: model illustration and performance of ordered subset analysis
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genet Epidemiol 30:409-22. 2006
    ....
  10. ncbi Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 78:852-64. 2006
    ..We demonstrate, for the first time, that a genetic susceptibility coupled with a modifiable lifestyle factor such as cigarette smoking confers a significantly higher risk of AMD than either factor alone...
  11. ncbi Joint effects of smoking history and APOE genotypes in age-related macular degeneration
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Mol Vis 11:941-9. 2005
    ..Several studies have implicated the apolipoprotein E (APOE) gene as modulating AMD risk. The purpose of this study was to investigate whether APOE genotypes modify the smoking-associated risk of AMD...
  12. ncbi Ordered subset linkage analysis supports a susceptibility locus for age-related macular degeneration on chromosome 16p12
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    BMC Genet 5:18. 2004
    ..Chromosome-wide significance of increases in nonparametric multipoint lod scores in covariate-defined subsets relative to the overall sample was assessed by permutation...
  13. ncbi Association of the apolipoprotein E gene with age-related macular degeneration: possible effect modification by family history, age, and gender
    S Schmidt
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Mol Vis 6:287-93. 2000
    ..The purpose of our study was to examine whether an independent data set would support the proposed role of APOE in AMD etiology...
  14. ncbi Life after the screen: making sense of many P-values
    S Schmidt
    Center for Human Genetics, Duke University Medical Center, Box 3468, Durham, North Carolina 27710, USA
    Genet Epidemiol 21:S546-51. 2001
    ..Genet Epidemiol, in press]. It appears that this approach is helpful for visualizing priority regions for follow-up analysis and reducing the number of false-positive linkage signals...

Research Grants6

  1. Statistical models for genetic studies of AMD
    Silke Schmidt; Fiscal Year: 2005
    ..Significance: Our long-term goal is to advance our knowledge about the genetic and environmental risk factors for AMD to ultimately aid in the development of better prevention and treatment strategies. ..
  2. Genetic Epidemiology of ALS in Veterans
    Silke Schmidt; Fiscal Year: 2007
    ..Genetic and environmental effects on disease progression will also be examined. Our study will not only be of great relevance for the veteran population, but is also likely to improve our understanding of ALS in the general population. ..