J M Schildkraut

..In this study, we investigate the relationship between the progestin and estrogen potency in combination OCs and the risk of developing ovarian cancer...

..Previous epidemiologic research suggests that analgesic use may reduce the risk of ovarian cancer, although results are not consistent...

..A larger study to determine risk factors for invasive serous PPC is warranted...

..The primary objective is to estimate the proportion of women taking folic acid (FA) doses exceeding the TUL before and during pregnancy, and to identify correlates of high FA use...

..Familial colorectal cancer has been linked to chromosome 7q31 by multiple affected relative pair studies. The MET proto-oncogene which resides in this chromosomal region is considered a candidate for genetic susceptibility...

..Inhibitors of kappaB (IkappaB) prevent NF-kappaB activation by sequestering NF-kappaB proteins in the cytoplasm until IkappaB proteins are phosphorylated and degraded...

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..Two trinucleotide repeat polymorphisms have been described in exon 1 of the androgen receptor (AR) gene that may affect its function. Previous studies of ovarian cancer and AR repeat polymorphisms have been inconsistent...

..The objective of this study was to determine whether cyclin E overexpression defines an etiologically distinct subgroup of ovarian cancer...

..Further research is needed to confirm these findings...

..This large study provides statistical evidence for a small increase in risk of ovarian cancer associated with common variants in the TP53 region...

..In addition, BMI may affect circulating levels of contaminants and should also be considered a potentially important modifying factor for exposure to lipophilic substances...

..To investigate the clinical prognostic factors that influence ovarian cancer survival in women with early-onset epithelial ovarian cancer using population-based data...

..To investigate the relationship between age at natural menopause and risk of developing epithelial ovarian cancer...

..We have examined whether BRCA2 N372H or common amino acid-changing polymorphisms in BRCA1 predispose to ovarian cancer...

..This analysis shows the importance of consortia, like the OCAC, in either confirming or refuting the validity of putative findings in studies with smaller sample sizes. (Cancer Epidemiol Biomarkers Prev 2008;17(12):3567-72)...

..0; 95% CI = 0.7-1.4). These findings support the hypothesis that obesity is an important risk factor of ovarian cancer among African-Americans and Whites and also suggest that height may be a risk factor specific to African-Americans...

..The objective was to describe and compare types and duration of symptoms among women with invasive versus borderline ovarian tumors...

..It has been suggested that the 6A allele of the type I TGFbeta receptor (TGFbetaR1) polyalanine repeat tract polymorphism may increase susceptibility to various types of cancer including ovarian cancer...

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..These controls seem to present a reasonable choice for clinic-centered case-control studies...

..The purpose of this analysis was to assess weight gain in premenopausal women in the first year after hysterectomy compared with a control group of women with intact uteri and ovaries...

..There is a clear need for further research on etiologic factors for ovarian cancer in African-American women...

..Factors associated with variation in circulating levels of these peptide hormones remain unclear...

..5002G > A genotype and EGA was not evident. These findings suggest that nonsynonymous polymorphisms in M6P/IGF2R may contribute to the risks of EGA and noncardia adenocarcinomas. Larger studies are required to confirm these findings...

..91% NPM; p < 0.05). TPMs showed an advantage in increasing knowledge and enhancing accuracy of perceived risk. Both are critical components of informed decision making...

..However, our results should be interpreted cautiously given the overall inconsistency in the epidemiologic literature on modifiers of BRCA1 and BRCA2...

..The objective of this study was to determine if use of menopausal hormones was associated with ovarian cancer and if risk varied by type of hormone used...

..Findings suggest that associations between ovarian cancer and reproductive characteristics vary by menopausal status. Additional research is needed to further elucidate risk factors for postmenopausal disease...

..Most studies have little information about nonparticipants, making it difficult to identify characteristics associated with enrolment and how they might vary by race...

..In this study, we sought to determine whether this polymorphism affects ovarian cancer risk...

..The objective of this paper was to evaluate whether women with ovarian cancer were more likely to report past use of antidepressants than control women...

..If confirmed in larger studies, these findings support the hypothesis that the association between IGFBP3 C allele and prostate cancer is grade specific in both ethnic groups...

..Most (79%) reported CRIS had "caused" their discussion. CRIS is an easily used, disseminable program that showed promising results in primary care settings...

..To compare two methods for calculating lifetime ovulatory cycles (LOC) to determine if more detailed menstrual cycle information results in stronger associations with ovarian cancer...

..We examined associations between self-reported physical activity and ovarian cancer risk and survival in a population-based, case-control study in North Carolina...

..Education was also bivariately associated with enrollment, but mediation analysis indicated that the operational mechanism of education's influence on enrollment was through trust...

..CONCLUSION: Earlier diagnosis of ovarian cancer may be possible if women and physicians recognize the importance of combinations of seemingly unrelated symptoms, especially those identified as occurring longer before diagnosis...

..015). Although preliminary, this study provides some support for the hypothesis that low-penetrance susceptibility alleles may influence risk of epithelial ovarian cancer...

..Existing studies have focused on Ashkenazi Jews (AJ) or on families from outside the United States. In this article, we consider the US population using the largest US-based cohort to date of both AJ and non-AJ families...

..At least 7 models for estimating the probabilities of having a mutation are used widely in clinical and scientific activities; however, the merits and limitations of these models are not fully understood...

..10 frequency; odds ratio, 0.07; P = 0.01) compared with the most common haplotype (0.39 frequency). These results suggest that genetic polymorphisms in the glycoslyation process may be novel risk factors for ovarian cancer...

..We investigated whether the odds ratios for ovarian cancer that were associated with oral contraceptive use, childbearing, hysterectomy, and tubal ligation differ among women with and without endometriosis...

..These null results for SNPs identified from relatively large initial studies shows the importance of replicating associations by a consortium approach...

..Interventions with modifiable factors such as multivitamin intake may reduce risk...

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..This review highlights current knowledge of meningioma epidemiology and new directions for research efforts in this field...

..Elucidation of the role of reproductive and environmental risk factors and genetic susceptibility could facilitate identification of high-risk women who would be ideal candidates for preventive interventions. ..

..Ness), Los Angeles (Drs. Pearce and Wu) and Seattle (Dr. Rossing). Further confirmation will be pursued in collaboration with the Ovarian Cancer Association Consortium (OCAC) in the future. ..

..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma. ..

..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma. ..

..This study will provide new insight into both the etiology and prognosis of ovarian cancer in African-American women. ..

..Published preliminary studies have already shown an association with abnormal expression of p53 in ovarian tumors and epidemiologic markers of ovulation. ..

..Within this application, we propose to take advantage of our expertise and resources to ascertain registrants by augmenting referral services and by piloting the selective use of our unique registries. ..

..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma. ..