A D Roses

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint The Alzheimer diseases
    A D Roses
    Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, North Carolina 27710 2900, USA
    Curr Opin Neurobiol 6:644-50. 1996
  2. ncbi request reprint A model for susceptibility polymorphisms for complex diseases: apolipoprotein E and Alzheimer disease
    A D Roses
    Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710 2900, USA
    Neurogenetics 1:3-11. 1997
  3. ncbi request reprint ApoE, Alzheimer's disease, and recovery from brain stress
    A D Roses
    Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann N Y Acad Sci 826:200-12. 1997
  4. pmc SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease
    E R Martin
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC, 27710, USA duke edu
    Am J Hum Genet 67:383-94. 2000
  5. ncbi request reprint Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12
    M A Pericak-Vance
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    JAMA 278:1237-41. 1997
  6. ncbi request reprint Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease
    E R Martin
    Center for Human Genetics, Box 2903, Duke University Medical Center, Durham, NC 27710, USA
    JAMA 286:2245-50. 2001
  7. pmc Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity
    W K Scott
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Am J Hum Genet 66:922-32. 2000
  8. ncbi request reprint Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism
    A D Roses
    Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann N Y Acad Sci 777:146-57. 1996
  9. ncbi request reprint Further exclusion of FSHD1B from the telomeric region of 10q
    M C Speer
    Duke University Medical Center, Department of Medicine, Durham, NC 27710, USA
    Neurogenetics 1:151-2. 1997
  10. pmc Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease
    W J Strittmatter
    Department of Medicine Neurology, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710
    Proc Natl Acad Sci U S A 91:11183-6. 1994

Detail Information

Publications55

  1. ncbi request reprint The Alzheimer diseases
    A D Roses
    Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, North Carolina 27710 2900, USA
    Curr Opin Neurobiol 6:644-50. 1996
    ..New hypotheses are being generated and old hypotheses are being modified to account for the wealth of new information...
  2. ncbi request reprint A model for susceptibility polymorphisms for complex diseases: apolipoprotein E and Alzheimer disease
    A D Roses
    Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710 2900, USA
    Neurogenetics 1:3-11. 1997
    ....
  3. ncbi request reprint ApoE, Alzheimer's disease, and recovery from brain stress
    A D Roses
    Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann N Y Acad Sci 826:200-12. 1997
    ..ApoE isoforms may also have different effects as antioxidants. The risk of stroke and vascular dementia has not been confirmed in neuropathological series to be related to specific APOE genotypes...
  4. pmc SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease
    E R Martin
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC, 27710, USA duke edu
    Am J Hum Genet 67:383-94. 2000
    ....
  5. ncbi request reprint Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12
    M A Pericak-Vance
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    JAMA 278:1237-41. 1997
    ....
  6. ncbi request reprint Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease
    E R Martin
    Center for Human Genetics, Box 2903, Duke University Medical Center, Durham, NC 27710, USA
    JAMA 286:2245-50. 2001
    ..001) was detected between 4 of the 5 SNPs (SNPs 3, 9i, 9ii, and 11). CONCLUSIONS: This integrated approach of genetic linkage and positional association analyses implicates tau as a susceptibility gene for idiopathic PD...
  7. pmc Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity
    W K Scott
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Am J Hum Genet 66:922-32. 2000
    ..Taken together, these results indicate that the chromosome 12 locus acts independently of APOE to increase the risk of late-onset familial AD and that it may be associated with the DLB variant of AD...
  8. ncbi request reprint Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism
    A D Roses
    Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann N Y Acad Sci 777:146-57. 1996
    ..These data are supported by recent data from APOE knock-out mice demonstrating dendritic alterations leading to synaptic simplification similar to that observed in AD...
  9. ncbi request reprint Further exclusion of FSHD1B from the telomeric region of 10q
    M C Speer
    Duke University Medical Center, Department of Medicine, Durham, NC 27710, USA
    Neurogenetics 1:151-2. 1997
    ..We have tested the most telomeric marker on 10q (sAVA4) and excluded approximately 17 cM on either side of this marker as harboring the FSHD1B gene...
  10. pmc Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease
    W J Strittmatter
    Department of Medicine Neurology, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710
    Proc Natl Acad Sci U S A 91:11183-6. 1994
    ..Isoform-specific interactions of apoE with tau may regulate intraneuronal tau metabolism in Alzheimer disease and alter the rate of formation of paired helical filaments and neurofibrillary tangles...
  11. ncbi request reprint Complete genomic screen in late-onset familial Alzheimer's disease
    M A Pericak-Vance
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Neurobiol Aging 19:S39-42. 1998
    ..Multipoint MLS analysis supported these findings. Saturation mapping of all available markers in the chromosome 12 region as well as further investigation of the regions on 4, 6, and 20 is ongoing with candidate gene analysis to follow...
  12. ncbi request reprint Sialylated human apolipoprotein E (apoEs) is preferentially associated with neuron-enriched cultures from APOE transgenic mice
    P T Xu
    Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neurobiol Dis 6:63-75. 1999
    ..In situ hybridization and immunocytochemistry demonstrate apoE mRNA and apoE immunoreactivity are predominantly located in cell soma of neurons, not in neuronal processes...
  13. ncbi request reprint The role of apolipoprotein E in Alzheimer's disease: pharmacogenomic target selection
    A M Saunders
    Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Biochim Biophys Acta 1502:85-94. 2000
    ..This review summarizes part of an experimental approach to identify biological pathways influenced by the different APOE polymorphisms that are relevant to the pathogenesis of AD...
  14. ncbi request reprint Identification of novel genes in late-onset Alzheimer's disease
    M A Pericak-Vance
    Duke University Medical Center, North Carolina, Durham 27710, USA
    Exp Gerontol 35:1343-52. 2000
    ..Such strategies are necessary if we are to understand the subtle and complex threads that, woven together, create the intricate tapestry of AD...
  15. ncbi request reprint Complete genomic screen in Parkinson disease: evidence for multiple genes
    W K Scott
    Center for Human Genetics, Box 3445, Duke University Medical Center, Durham, NC 27710, USA
    JAMA 286:2239-44. 2001
    ..CONCLUSIONS: Our data suggest that the parkin gene is important in early-onset PD and that multiple genetic factors may be important in the development of idiopathic late-onset PD...
  16. ncbi request reprint Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    E H Corder
    Department of Medicine, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710
    Science 261:921-3. 1993
    ..Thus APOE-epsilon 4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-epsilon 4 was virtually sufficient to cause AD by age 80...
  17. ncbi request reprint Mutation and polymorphism analysis in the tuberous sclerosis 2 (TSC2) gene
    J R Gilbert
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, USA
    Neurogenetics 1:267-72. 1998
    ..The majority of putative TSC2 mutations were found in sporadic rather than TSC2-linked families. We have also detected 15 polymorphisms which occur in the TSC2 gene...
  18. doi request reprint Using genetics to enable studies on the prevention of Alzheimer's disease
    D G Crenshaw
    Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Department of Neurology, Duke University Medical Center, Durham, North Carolina, USA
    Clin Pharmacol Ther 93:177-85. 2013
    ..In addition, we discuss the rationale for the use of pioglitazone to delay the onset of AD in individuals at high risk...
  19. pmc A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease
    A D Roses
    Department of Medicine, Duke University, Durham, NC 27708 0120, USA
    Pharmacogenomics J 10:375-84. 2010
    ..In addition, these results show the effective use of a phylogenetic approach for analysis of haplotypes of polymorphisms, including structural polymorphisms, which contribute to complex diseases...
  20. ncbi request reprint Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease
    J M van der Walt
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Neurology 60:1189-91. 2003
    ..The authors did not find evidence for association with increased risk for PD between any individual NAT1 or NAT2 SNP or acetylation haplotype (N = 397 families, 1,580 individuals)...
  21. pmc Linkage of frontotemporal dementia to chromosome 17: clinical and neuropathological characterization of phenotype
    L H Yamaoka
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 59:1306-12. 1996
    ..These studies emphasize that genetic linkage analysis remains a useful tool for differentiating disease loci in clinically complex traits...
  22. ncbi request reprint Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice
    P T Xu
    Department of Medicine Neurology, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neurobiol Dis 3:229-45. 1996
    ..This pattern of immunoreactivity is similar to that observed in nonhuman primates and man, and contrasts with the strictly glial staining pattern of normal rodents...
  23. ncbi request reprint Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study
    S H Han
    Department of Medicine Neurology, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710
    J Neuropathol Exp Neurol 53:535-44. 1994
    ..Isoform-specific interactions with microtubule-associated proteins, such as tau or MAP2C, could influence the rate of pathology in neurodegenerative diseases such as Alzheimer's disease...
  24. pmc Apolipoprotein E and Alzheimer disease
    W J Strittmatter
    Department of Medicine Neurology, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 92:4725-7. 1995
    ....
  25. ncbi request reprint Human apolipoprotein E accelerates microtubule polymerization in vitro
    B L Scott
    Department of Medicine Neurology, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 245:105-8. 1998
    ....
  26. ncbi request reprint Transcriptional regulation of the mouse presenilin-1 gene
    N Mitsuda
    Division of Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 272:23489-97. 1997
    ..Although human PS-1 mRNA expression is clearly different from the mouse PS-1 mRNA pattern, the human and mouse core promoters do share limited homology...
  27. ncbi request reprint Analysis of association at single nucleotide polymorphisms in the APOE region
    E R Martin
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genomics 63:7-12. 2000
    ..Our goal was to examine patterns of allelic association to begin to investigate the question of whether APOE could have been identified using SNPs. Our strongest evidence of association was at the 2 SNPs immediately flanking APOE...
  28. ncbi request reprint Linkage of a locus (CMT4A) for autosomal recessive Charcot-Marie-Tooth disease to chromosome 8q
    K Ben Othmane
    Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710
    Hum Mol Genet 2:1625-8. 1993
    ..00-0.08) was obtained for D8S164. No evidence of genetic heterogeneity was found. The chromosomal localization of one form of CMT4 will have important implications in clarifying the nosology of this complex group of disorders...
  29. ncbi request reprint Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH
    J R Burke
    Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Med 2:347-50. 1996
    ..We sought to identify proteins in the brain that selectively interact with polyglutamine-domain proteins, hypothesizing that the polyglutamine domain may determine protein-protein interactions...
  30. ncbi request reprint Thymocytes and cultured thymic epithelial cells express transcripts encoding alpha-3, alpha-5 and beta-4 subunits of neuronal nicotinic acetylcholine receptors: preferential transcription of the alpha-3 and beta-4 genes by immature CD4 + 8 + thymocytes
    M Mihovilovic
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Neuroimmunol 79:176-84. 1997
    ....
  31. ncbi request reprint ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation
    D Y Huang
    Department of Medicine Neurology, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 192:209-12. 1995
    ..Understanding the molecular mechanisms of the high avidity, isoform-specific interactions of ApoE with tau may help in developing approaches for disease intervention...
  32. ncbi request reprint Mutation analysis of the TSC2 gene in an African-American family
    A Kumar
    Division of Neurology, Duke Unversity Medical Center, Durham, NC 27710, USA
    Hum Mol Genet 4:2295-8. 1995
    ..The polymorphism has been detected in six of 72 African-American control chromosomes examined, and has not been detected in 80 Caucasian control chromosomes examined...
  33. ncbi request reprint Polymorphisms in the endothelin-1 (EDN1) are associated with asthma in two populations
    G Zhu
    Medical Genetics, GlaxoSmithKline, Research Triangle Park, NC 27709, USA
    Genes Immun 9:23-9. 2008
    ..The results of haplotype-based association analyses strongly supported the ones of single SNP associations. This study demonstrates the significant evidence of association between polymorphisms in EDN1 and asthma...
  34. ncbi request reprint Impaired neuronal plasticity in transgenic mice expressing human apolipoprotein E4 compared to E3 in a model of entorhinal cortex lesion
    F White
    Wellcome Surgical Institute and Department of Neuropathology, University of Glasgow, Bearsden Road, Garscube Estate, G61 1QH, United Kingdom
    Neurobiol Dis 8:611-25. 2001
    ..These isoform-specific differences in plasticity may relate to the severity of AD and poor, long-term recovery after head injury in APOE epsilon 4 individuals...
  35. ncbi request reprint Further investigation of linkage disequilibrium SNPs and their ability to identify associated susceptibility loci
    B V North
    Academic Department of Psychiatry, Queen Mary s School of Medicine and Dentistry, London E1 1BB, UK
    Ann Hum Genet 68:240-8. 2004
    ..We conclude that one may need to use very dense SNP maps in order to avoid overlooking polymorphisms affecting susceptibility to a common phenotype...
  36. ncbi request reprint Single-nucleotide polymorphism alleles in the insulin receptor gene are associated with typical migraine
    L C McCarthy
    GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, UK
    Genomics 78:135-49. 2001
    ..We used experiments with insulin receptor RNA and protein to investigate functionality for the migraine-associated single-nucleotide polymorphisms. We suggest possible functions for the insulin receptor in migraine pathogenesis...
  37. ncbi request reprint Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease
    M E Risner
    World Wide Development, Research and Development, GlaxoSmithKline, Research Triangle Park, NC 27709 3398, USA
    Pharmacogenomics J 6:246-54. 2006
    ..These preliminary findings require confirmation in appropriate clinical studies...
  38. ncbi request reprint Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease)
    A D Roses
    Genetics Research, GlaxoSmithKline Research and Development, NC 27709, USA
    Pharmacogenomics J 7:10-28. 2007
    ..Pharmacogenetics is currently being used across the pipeline to prevent attrition and to create safer and more effective medicines...
  39. ncbi request reprint Neurodegeneration in the central nervous system of apoE-deficient mice
    E Masliah
    Department of Neurosciences, University of California at San Diego School of Medicine, La Jolla 92093 0624, USA
    Exp Neurol 136:107-22. 1995
    ....
  40. ncbi request reprint Use of pairwise marker combination and recursive partitioning in a pharmacogenetic genome-wide scan
    L L Warren
    GlaxoSmithKline, RTP, NC 27709, USA
    Pharmacogenomics J 7:180-9. 2007
    ..These methods can be readily applied in pharmacogenetic candidate gene studies as well as in genome-wide scans...
  41. ncbi request reprint Apolipoprotein E4 decreases whereas apolipoprotein E3 increases the level of secreted amyloid precursor protein after closed head injury
    Y Ezra
    Department of Neurobiochemistry, Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Neuroscience 121:315-25. 2003
    ..Similar isoform-specific interactions between apoE and APP may play a role in the acute, short-term effects of head trauma in humans...
  42. ncbi request reprint Pharmacogenetics and disease genetics of complex diseases
    V D Schmith
    Genetics Research, 5 Moore Drive, GlaxoSmithKline, North Carolina 27709, USA
    Cell Mol Life Sci 60:1636-46. 2003
    ..e. the right drug to the right patient) a reality...
  43. ncbi request reprint Increased neuronal damage in apolipoprotein E-deficient mice following global ischaemia
    K Horsburgh
    Department of Neuropathology and Wellcome Surgical Institute, University of Glasgow, UK
    Neuroreport 10:837-41. 1999
    ..05). The data substantiate a role for apoE in modifying the response of the CNS to acute injury...
  44. ncbi request reprint Defective neuronal sprouting by human apolipoprotein E4 is a gain-of-negative function
    B Teter
    Veterans Administration Greater Los Angeles Healthcare System and Department of Medicine, University of California, Los Angeles, Sepulveda, California 91343, USA
    J Neurosci Res 68:331-6. 2002
    ..These results may have important pharmacogenomic implications for AD therapies that modulate apoE expression levels...
  45. ncbi request reprint The human NACP/alpha-synuclein gene: chromosome assignment to 4q21.3-q22 and TaqI RFLP analysis
    X Chen
    Department of Neurosciences 0624, School of Medicine, University of California at San Diego, La Jolla 92093 0624, USA
    Genomics 26:425-7. 1995
  46. ncbi request reprint Age-related congophilic inclusions in the brains of apolipoprotein E-deficient mice
    T A Robertson
    Department of Pathology, University of Western Australia, Nedlands, Australia
    Neuroscience 82:171-80. 1998
    ..The data indicate that an amyloid-like protein accumulates in the protoplasmic astrocytes of the hippocampus of apolipoprotein E-deficient mice, especially in the brains of old animals...
  47. ncbi request reprint Human endopeptidase (THOP1) is localized on chromosome 19 within the linkage region for the late-onset alzheimer disease AD2 locus
    B Meckelein
    Department of Medicine, Boston University School of Medicine, Massachusetts 02118, USA
    Genomics 31:246-9. 1996
    ..Hybridization to DNA from human-rodent somatic cell hybrids assigned the human gene to chromosome 19. Fluorescence in situ hybridization on human metaphase chromosomes localized the human endopeptidase 24.15 to 19q13.3...
  48. ncbi request reprint A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex. The Multiple Sclerosis Genetics Group
    J L Haines
    Molecular Neurogenetics Unit, Massachusetts General Hospital, Boston 02129, USA
    Nat Genet 13:469-71. 1996
    ..Our results suggest that a multifactorial aetiology, including both environmental and multiple genetic factors of moderate effect, is more likely than an aetiology consisting of simple mendelian disease gene(s)...
  49. ncbi request reprint Reversal of presynaptic deficits of apolipoprotein E-deficient mice in human apolipoprotein E transgenic mice
    S Chapman
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, 69978, Ramat Aviv, Israel
    Neuroscience 97:419-24. 2000
    ....
  50. ncbi request reprint The identification and characterization of KRAB-domain-containing zinc finger proteins
    C D Constantinou-Deltas
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Genomics 12:581-9. 1992
    ..Based on the data, it is tempting to speculate that the FAX- and KRAB-containing zinc finger genes define subfamilies of genes with overlapping functions that participate in the regulation of common or similar developmental programs...
  51. ncbi request reprint Characterization of amyloid fibril beta-peptide in familial Alzheimer's disease with APP717 mutations
    J J Liepnieks
    Department of Medicine, Indiana University School of Medicine, Indianapolis 46202 5120
    Biochem Biophys Res Commun 197:386-92. 1993
    ..These findings show that the amino acid substitution at position 717 is not incorporated into the amyloid deposits and suggests that the mutation may have metabolic affects which determine pathogenesis...
  52. ncbi request reprint Increased neuronal damage and apoE immunoreactivity in human apolipoprotein E, E4 isoform-specific, transgenic mice after global cerebral ischaemia
    K Horsburgh
    Department of Neuropathology, University of Glasgow, Glasgow, UK
    Eur J Neurosci 12:4309-17. 2000
    ..The data extend previous work and are consistent with an association of the APOE-epsilon4 allele with a poor outcome after acute brain injury in humans...
  53. ncbi request reprint Novel amyloid precursor protein gene mutation (codon 665Asp) in a patient with late-onset Alzheimer's disease
    M L Peacock
    Department of Neurology, University of Michigan, Ann Arbor, MI
    Ann Neurol 35:432-8. 1994
    ..The BglII restriction fragment length polymorphism enables investigators to determine the frequency of this polymorphism in normal subjects and Alzheimer's disease patients...
  54. pmc RFLP analysis for APP 717 mutations associated with Alzheimer's disease
    S R Zeldenrust
    Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202
    J Med Genet 30:476-8. 1993
    ..In addition, DNA from 145 FAD subjects were tested for the three known APP 717 mutations...
  55. ncbi request reprint Identification of a pharmacogenetic effect by linkage disequilibrium mapping
    C F Xu
    Discovery and Pipeline Genetics, GlaxoSmithKline Medicines Research Centre, Stevenage, Hertfordshire, UK
    Pharmacogenomics J 4:374-8. 2004
    ..Our data illustrated that a genome-wide LD scan of 100,000-200,000 SNPs is sufficient to identify a pharmacogenetic association with a drug-induced adverse event...