Matthew Roe

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi Prasugrel versus clopidogrel for acute coronary syndromes without revascularization
    Matthew T Roe
    Duke Clinical Research Institute and Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA
    N Engl J Med 367:1297-309. 2012
  2. ncbi Regional patterns of use of a medical management strategy for patients with non-ST-segment elevation acute coronary syndromes: insights from the EARLY ACS Trial
    Matthew T Roe
    Duke Clinical Research Institute, Durham, NC, USA
    Circ Cardiovasc Qual Outcomes 5:205-13. 2012
  3. ncbi Influence of inpatient service specialty on care processes and outcomes for patients with non ST-segment elevation acute coronary syndromes
    Matthew T Roe
    Duke University Medical Center and Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27705, USA
    Circulation 116:1153-61. 2007
  4. ncbi Documented traditional cardiovascular risk factors and mortality in non-ST-segment elevation myocardial infarction
    Matthew T Roe
    Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 153:507-14. 2007
  5. ncbi Patterns and prognostic implications of low high-density lipoprotein levels in patients with non-ST-segment elevation acute coronary syndromes
    Matthew T Roe
    Department of Medicine, Division of Cardiovascular Medicine, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Eur Heart J 29:2480-8. 2008
  6. ncbi Temporal changes in the use of drug-eluting stents for patients with non-ST-Segment-elevation myocardial infarction undergoing percutaneous coronary intervention from 2006 to 2008: results from the can rapid risk stratification of unstable angina patients
    Matthew T Roe
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Circ Cardiovasc Qual Outcomes 2:414-20. 2009
  7. ncbi Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction
    Eric Bates
    Duke Clinical Research Institute, 2400 Pratt St, Room 7035, Durham, NC 27705
    Circulation 117:886-96. 2008
  8. ncbi Predicting long-term mortality in older patients after non-ST-segment elevation myocardial infarction: the CRUSADE long-term mortality model and risk score
    Matthew T Roe
    Duke Clinical Research Institute, Durham, NC, USA
    Am Heart J 162:875-883.e1. 2011
  9. ncbi Lipid management in patients with unstable angina pectoris and non-ST-segment elevation acute myocardial infarction (from CRUSADE)
    JoAnne M Foody
    Section of Cardiovascular Medicine, Department of Medicine, Yale School of Medicine, New Haven, Connecticut, USA
    Am J Cardiol 95:483-5. 2005
  10. ncbi Current perspectives on reperfusion therapy for acute ST-segment elevation myocardial infarction: integrating pharmacologic and mechanical reperfusion strategies
    Richard E Waters
    Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 146:958-68. 2003

Detail Information

Publications95

  1. ncbi Prasugrel versus clopidogrel for acute coronary syndromes without revascularization
    Matthew T Roe
    Duke Clinical Research Institute and Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA
    N Engl J Med 367:1297-309. 2012
    ..The effect of intensified platelet inhibition for patients with unstable angina or myocardial infarction without ST-segment elevation who do not undergo revascularization has not been delineated...
  2. ncbi Regional patterns of use of a medical management strategy for patients with non-ST-segment elevation acute coronary syndromes: insights from the EARLY ACS Trial
    Matthew T Roe
    Duke Clinical Research Institute, Durham, NC, USA
    Circ Cardiovasc Qual Outcomes 5:205-13. 2012
    ..Regional differences in the profile and prognosis of non-ST-segment elevation acute coronary syndrome (NSTE ACS) patients treated with medical management after angiography remain uncertain...
  3. ncbi Influence of inpatient service specialty on care processes and outcomes for patients with non ST-segment elevation acute coronary syndromes
    Matthew T Roe
    Duke University Medical Center and Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27705, USA
    Circulation 116:1153-61. 2007
    ..Since the broad dissemination of practice guidelines, the association of specialty care with the treatment of patients with acute coronary syndromes has not been studied...
  4. ncbi Documented traditional cardiovascular risk factors and mortality in non-ST-segment elevation myocardial infarction
    Matthew T Roe
    Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 153:507-14. 2007
    ....
  5. ncbi Patterns and prognostic implications of low high-density lipoprotein levels in patients with non-ST-segment elevation acute coronary syndromes
    Matthew T Roe
    Department of Medicine, Division of Cardiovascular Medicine, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Eur Heart J 29:2480-8. 2008
    ..We sought to determine the prevalence and prognostic significance of low HDL cholesterol levels in patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS)...
  6. ncbi Temporal changes in the use of drug-eluting stents for patients with non-ST-Segment-elevation myocardial infarction undergoing percutaneous coronary intervention from 2006 to 2008: results from the can rapid risk stratification of unstable angina patients
    Matthew T Roe
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Circ Cardiovasc Qual Outcomes 2:414-20. 2009
    ..We evaluated trends in the use of DES for patients with non-ST-elevation myocardial infarction undergoing percutaneous coronary intervention (PCI) from 2006 to 2008...
  7. ncbi Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction
    Eric Bates
    Duke Clinical Research Institute, 2400 Pratt St, Room 7035, Durham, NC 27705
    Circulation 117:886-96. 2008
    ..KAI-9803, a delta-protein kinase C inhibitor, has been shown to ameliorate injury associated with ischemia and reperfusion in animal models of acute myocardial infarction (MI)...
  8. ncbi Predicting long-term mortality in older patients after non-ST-segment elevation myocardial infarction: the CRUSADE long-term mortality model and risk score
    Matthew T Roe
    Duke Clinical Research Institute, Durham, NC, USA
    Am Heart J 162:875-883.e1. 2011
    ..We sought to develop a long-term mortality risk prediction model and a simplified risk score for use in older patients with non-ST-segment elevation myocardial infarction (NSTEMI)...
  9. ncbi Lipid management in patients with unstable angina pectoris and non-ST-segment elevation acute myocardial infarction (from CRUSADE)
    JoAnne M Foody
    Section of Cardiovascular Medicine, Department of Medicine, Yale School of Medicine, New Haven, Connecticut, USA
    Am J Cardiol 95:483-5. 2005
    ....
  10. ncbi Current perspectives on reperfusion therapy for acute ST-segment elevation myocardial infarction: integrating pharmacologic and mechanical reperfusion strategies
    Richard E Waters
    Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 146:958-68. 2003
    ..Thus, as the reperfusion era continues to evolve, the ideal treatment strategy for patients with STEMI is being redefined to integrate pharmacologic and mechanical approaches to reperfusion...
  11. ncbi Acute coronary syndromes and diabetes mellitus
    Benjamin H Trichon
    Duke University Medical Center, Duke Clinical Research Institute, 2400 Pratt St--Room 7037, Durham, NC 27705, USA
    Diab Vasc Dis Res 1:23-32. 2004
    ....
  12. ncbi Heart failure with preserved left ventricular systolic function among patients with non-ST-segment elevation acute coronary syndromes
    Kyla M Bennett
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina
    Am J Cardiol 99:1351-6. 2007
    ..Guideline-recommended therapies and interventions are under-utilized in patients with NSTE ACS and HF, with and without preserved systolic function, compared with those without HF...
  13. ncbi Comparison of ST-segment resolution with combined fibrinolytic and glycoprotein IIb/IIIa inhibitor therapy versus fibrinolytic alone (data from four clinical trials)
    Abdallah G Rebeiz
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Am J Cardiol 95:611-4. 2005
    ..7% vs 48.0% with >/=50% ST-segment resolution, p = 0.03) and sustained over 180 minutes after drug administration; this transient benefit may suggest a time frame when more optimal percutaneous coronary intervention can be performed...
  14. ncbi Medical records and quality of care in acute coronary syndromes: results from CRUSADE
    Shannon M Dunlay
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Arch Intern Med 168:1692-8. 2008
    ..Patient medical records are important means of communication among health care providers. Limited evaluation has been performed of the quality of the medical records or its association with health care processes or outcomes...
  15. ncbi Prevalence, predictors, and impact of conservative medical management for patients with non-ST-segment elevation acute coronary syndromes who have angiographically documented significant coronary disease
    Mark Y Chan
    Duke Clinical Research Institute, Durham, North Carolina, USA
    JACC Cardiovasc Interv 1:369-78. 2008
    ..We sought to characterize the utilization and impact of a conservative medical management strategy for patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS) and significant coronary artery disease on early angiography...
  16. ncbi Pharmacological treatment of elderly patients with acute coronary syndromes without persistent ST segment elevation
    Manesh R Patel
    Duke University Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Drugs Aging 19:633-46. 2002
    ..An evidence-based approach to the treatment of elderly patients with ACS without persistent ST segment elevation will help to improve the use of beneficial therapies and interventions that are recommended by current practice guidelines...
  17. ncbi Use of and inhospital outcomes after early clopidogrel therapy in patients not undergoing an early invasive strategy for treatment of non-ST-segment elevation myocardial infarction: results from Can Rapid risk stratification of Unstable angina patients Su
    Deepu Alexander
    Division of Cardiovascular Medicine, State University of New York, Stony Brook School of Medicine, Stony Brook, NY 11794, USA
    Am Heart J 156:606-12. 2008
    ..We sought to determine patterns of early (<24 hours of arrival) clopidogrel use and its association with clinical outcomes in patients with NSTEMI not undergoing early percutaneous intervention (PCI)...
  18. ncbi Impact of acute beta-blocker therapy for patients with non-ST-segment elevation myocardial infarction
    Chadwick D Miller
    Wake Forest University Health Sciences, Winston Salem, NC, USA
    Am J Med 120:685-92. 2007
    ..We sought to determine the impact of acute beta-blocker therapy on outcomes in patients with NSTEMI...
  19. ncbi Cockcroft-Gault versus modification of diet in renal disease: importance of glomerular filtration rate formula for classification of chronic kidney disease in patients with non-ST-segment elevation acute coronary syndromes
    Chiara Melloni
    Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27705, USA
    J Am Coll Cardiol 51:991-6. 2008
    ..Our purpose was to compare formulae for estimating glomerular filtration rate (GFR) in non-ST-segment elevation acute coronary syndromes (NSTE ACS) patients...
  20. ncbi Study design and rationale of a comparison of prasugrel and clopidogrel in medically managed patients with unstable angina/non-ST-segment elevation myocardial infarction: the TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage
    Chee Tang Chin
    Duke Clinical Research Institute, Durham, NC, USA
    Am Heart J 160:16-22.e1. 2010
    ....
  21. ncbi Pay for performance, quality of care, and outcomes in acute myocardial infarction
    Seth W Glickman
    Center for Clinical and Genetic Economics, Duke University Medical Center, Durham, NC, USA
    JAMA 297:2373-80. 2007
    ..In 2003, the Centers for Medicare & Medicaid Services (CMS) launched the largest pay-for-performance pilot project to date in the United States, including indicators for acute myocardial infarction...
  22. ncbi Platelet glycoprotein IIb/IIIa receptor antagonists in non-ST segment elevation acute coronary syndromes: a review and guide to patient selection
    Brett D Atwater
    Duke Clinical Research Institute, Durham, North Carolina 27705, USA
    Drugs 65:313-24. 2005
    ....
  23. ncbi Rationale and strategies for implementing community-based transfer protocols for primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction
    Richard E Waters
    Duke University Medical Center and Duke Clinical Research Institute, Durham, North Carolina, USA
    J Am Coll Cardiol 43:2153-9. 2004
    ..Consequently, this current evolution of reperfusion strategies has the potential to further reduce morbidity and mortality for patients presenting with STEMI...
  24. ncbi Patient satisfaction and its relationship with clinical quality and inpatient mortality in acute myocardial infarction
    Seth W Glickman
    Center for Clinical and Genetic Economics, Duke University, Durham, NC, USA
    Circ Cardiovasc Qual Outcomes 3:188-95. 2010
    ..The objective of this study was to determine whether patient satisfaction is associated with adherence to practice guidelines and outcomes for acute myocardial infarction and to identify the key drivers of patient satisfaction...
  25. ncbi Elevated creatine kinase-MB with normal creatine kinase predicts worse outcomes in patients with acute coronary syndromes: results from 4 large clinical trials
    John M Galla
    Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 151:16-24. 2006
    ..All patients with ACS should have CK-MB measurement to search for cardiac ischemia. Patients with elevated CK-MB should receive aggressive management commensurate with their increased risks...
  26. ncbi Low-molecular-weight heparin compared with unfractionated heparin for patients with non-ST-segment elevation acute coronary syndromes treated with glycoprotein IIb/IIIa inhibitors: results from the CRUSADE initiative
    Kanwar P Singh
    Division of Cardiology and Duke Clinical Research Institute, Durham, NC 27705, USA
    J Thromb Thrombolysis 21:211-20. 2006
    ....
  27. ncbi Quality of care by classification of myocardial infarction: treatment patterns for ST-segment elevation vs non-ST-segment elevation myocardial infarction
    Matthew T Roe
    Division of Cardiology, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27705, USA
    Arch Intern Med 165:1630-6. 2005
    ....
  28. ncbi Use of guidelines-recommended management and outcomes among women and men with low-level troponin elevation: insights from CRUSADE
    Sharif A Halim
    Department of Medicine and the Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715 7969, USA
    Circ Cardiovasc Qual Outcomes 2:199-206. 2009
    ..5x ULN) remains uncertain. Using the CRUSADE database, we explored relationships between sex and treatment and outcomes among patients with troponin 1 to 1.5x ULN...
  29. ncbi A comparison of acute coronary syndrome care at academic and nonacademic hospitals
    Manesh R Patel
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Am J Med 120:40-6. 2007
    ..We sought to identify hospital characteristics associated with high levels of adherence in order to gain insight into successful processes of care...
  30. ncbi A framework for quality improvement: an analysis of factors responsible for improvement at hospitals participating in the Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of the ACC/AHA Guidelin
    Seth W Glickman
    Center for Clinical and Genetic Economics, Duke University Medical Center, Durham, NC, USA
    Am Heart J 154:1206-20. 2007
    ....
  31. ncbi The implications of blood transfusions for patients with non-ST-segment elevation acute coronary syndromes: results from the CRUSADE National Quality Improvement Initiative
    Xin Yang
    Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27715, USA
    J Am Coll Cardiol 46:1490-5. 2005
    ..Given the wide variation in transfusion practice, further efforts to understand patient and process factors that result in bleeding and need for transfusion in NSTE ACS are needed...
  32. ncbi Relation of impaired Thrombolysis In Myocardial Infarction myocardial perfusion grades to residual thrombus following the restoration of epicardial patency in ST-elevation myocardial infarction
    Ajay J Kirtane
    Department of Medicine, Beth Israel Deaconess Medical Center, and TIMI Study Group, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA
    Am J Cardiol 95:224-7. 2005
    ..043). In multivariate analyses, angiographically evident thrombus was associated with higher corrected TIMI frame counts and worsened myocardial perfusion independent of clinical and angiographic covariates, including TIMI grade 3 flow...
  33. ncbi An evaluation of patient self-testing competency of prothrombin time for managing anticoagulation: pre-randomization results of VA Cooperative Study #481--The Home INR Study (THINRS)
    Rowena J Dolor
    Center for Health Services Research in Primary Care, VA Medical Center, Durham, NC, USA
    J Thromb Thrombolysis 30:263-75. 2010
    ..Successful home monitoring of PT with a PST device required adequate levels of cognition and manual dexterity. Training a caregiver modestly increased the proportion of patients who can perform PST...
  34. ncbi The NCDR ACTION Registry-GWTG: transforming contemporary acute myocardial infarction clinical care
    Eric D Peterson
    Duke Clinical Research Institute, 2400 Pratt Street, Durham, NC 27705, USA
    Heart 96:1798-802. 2010
    ..Data are available for research by application to: http://www.ncdr.com...
  35. ncbi Success stories: how hospitals are improving care
    Matthew T Roe
    Duke University Medical Center and Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 148:S52-5. 2004
    ..Techniques that work at the local level and practical tips that can be adopted to develop quality improvement (QI) initiatives are highlighted...
  36. ncbi Lessons learned from the CRUSADE National Quality Improvement Initiative
    Eric D Peterson
    Duke Clinical Research Institute, 2400 Pratt Street, Room 7009, Durham, NC 27705, USA
    Curr Cardiol Rep 10:285-90. 2008
    ..Ongoing quality improvement efforts will be needed to further improve evidence-based and personalized care of patients with ACS...
  37. ncbi Patterns of transfer for patients with non-ST-segment elevation acute coronary syndrome from community to tertiary care hospitals
    Matthew T Roe
    Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 156:185-92. 2008
    ....
  38. ncbi Prognostic value of troponins in patients with non-ST-segment elevation acute coronary syndromes and chronic kidney disease
    Chiara Melloni
    Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Clin Cardiol 31:125-9. 2008
    ..The prognostic value of cardiac troponins (cTn) in patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS) and chronic kidney disease (CKD) is debated...
  39. ncbi Impact of home warfarin use on treatment patterns and bleeding complications for patients with non-ST-segment elevation acute coronary syndromes: observations from the CRUSADE quality improvement initiative
    Tracy Y Wang
    Duke Clinical Research Institute, Duke University Medical Center, 2400 Pratt Street, Room 0311, Terrace Level, Durham, NC 27705, USA
    Eur Heart J 29:1103-9. 2008
    ..To examine treatment patterns and outcomes of patients with non-ST-segment elevation acute coronary syndrome (NSTE ACS) receiving long-term warfarin anticoagulation...
  40. ncbi Contemporary mortality risk prediction for percutaneous coronary intervention: results from 588,398 procedures in the National Cardiovascular Data Registry
    Eric D Peterson
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    J Am Coll Cardiol 55:1923-32. 2010
    ..We sought to create contemporary models for predicting mortality risk following percutaneous coronary intervention (PCI)...
  41. ncbi Excess dosing of antiplatelet and antithrombin agents in the treatment of non-ST-segment elevation acute coronary syndromes
    Karen P Alexander
    Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27715, USA
    JAMA 294:3108-16. 2005
    ..Effective medical care assumes delivery of evidence-based medicines to appropriate patients with doses comparable to those studied...
  42. ncbi Comparison of baseline characteristics, treatment patterns, and in-hospital outcomes of Asian versus non-Asian white Americans with non-ST-segment elevation acute coronary syndromes from the CRUSADE quality improvement initiative
    Tracy Y Wang
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 100:391-6. 2007
    ..Further investigation is needed to explore the potential for ethnic variability in antithrombotic susceptibility...
  43. ncbi An analysis of the Association of Society of Chest Pain Centers Accreditation to American College of Cardiology/American Heart Association non-ST-segment elevation myocardial infarction guideline adherence
    Abhinav Chandra
    Duke University Medical Center, Durham, NC, USA
    Ann Emerg Med 54:17-25. 2009
    ..The secondary objective is to describe the clinical outcomes and the association with accreditation...
  44. ncbi Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: a randomised, double-blind, placebo-controlled phase II study
    Richard C Becker
    Duke Clinical Research Institute, Durham, NC, USA
    Lancet 373:919-28. 2009
    ..We therefore assessed the tolerability and safety of SCH 530348-an oral platelet protease-activated receptor-1 antagonist...
  45. ncbi Improved speed and stability of ST-segment recovery with reduced-dose tenecteplase and eptifibatide compared with full-dose tenecteplase for acute ST-segment elevation myocardial infarction
    Matthew T Roe
    Duke Clinical Research Institute and Division of Cardiology, Duke Medical Center, Durham, North Carolina 27715, USA
    J Am Coll Cardiol 43:549-56. 2004
    ....
  46. ncbi Rationale and design of the randomized, double-blind trial testing INtraveNous and Oral administration of elinogrel, a selective and reversible P2Y(12)-receptor inhibitor, versus clopidogrel to eVAluate Tolerability and Efficacy in nonurgent Percutaneous
    Sergio Leonardi
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Am Heart J 160:65-72. 2010
    ..The INNOVATE-PCI study is a phase 2 randomized, double-blind, clopidogrel-controlled trial to evaluate the safety, tolerability, and preliminary efficacy of this novel antiplatelet agent in patients undergoing nonurgent PCI...
  47. ncbi Changing the model of care for patients with acute coronary syndromes
    Matthew T Roe
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Am Heart J 146:605-12. 2003
    ..The shifting model of care for ACS therefore suggests that quality improvement and monitoring of adherence to practice guidelines should be considered components of optimal clinical practice...
  48. ncbi Influence of clinical trial participation on subsequent antithrombin use
    Bimal R Shah
    Duke Clinical Research Institute, Duke University Medical Center, 2400 Pratt Street, Durham, NC 27705, USA
    Clin Cardiol 33:E49-55. 2010
    ....
  49. ncbi Integrating GP IIb/IIIa inhibition into treatment strategies for acute ST-elevation myocardial infarction
    David E Kandzari
    Duke University Medical Center, Durham, NC 27710, USA
    J Invasive Cardiol 14:565-74. 2002
  50. ncbi A randomized, placebo-controlled trial of early eptifibatide for non-ST-segment elevation acute coronary syndromes
    Matthew T Roe
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Am Heart J 146:993-8. 2003
    ..The acute benefits of platelet glycoprotein IIb/IIIa inhibitors for non-ST-segment elevation acute coronary syndromes (NSTE ACS) remain unclear...
  51. ncbi Usefulness of the Duke Sudden Cardiac Death risk score for predicting sudden cardiac death in patients with angiographic (>75% narrowing) coronary artery disease
    Brett D Atwater
    Duke Clinical Research Institute, Durham, NC, USA
    Am J Cardiol 104:1624-30. 2009
    ....
  52. ncbi Safety and feasibility of adjunctive antiplatelet therapy with intravenous elinogrel, a direct-acting and reversible P2Y12 ADP-receptor antagonist, before primary percutaneous intervention in patients with ST-elevation myocardial infarction: the Early Rap
    Jeffrey S Berger
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Am Heart J 158:998-1004.e1. 2009
    ..We examined the safety and tolerability of a novel, direct-acting, reversible, intravenous P2Y12 ADP-receptor antagonist, elinogrel, versus placebo when administered to STEMI patients before primary PCI...
  53. ncbi Hypercholesterolemia paradox in relation to mortality in acute coronary syndrome
    Tracy Y Wang
    Division of Cardiology, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27705, USA
    Clin Cardiol 32:E22-8. 2009
    ..Hypercholesterolemia is a risk factor for coronary artery disease, yet is associated with lower risk of adverse outcomes in patients with acute coronary syndromes (ACS)...
  54. ncbi Predictors of early discontinuation of evidence-based medicine after acute coronary syndrome
    Chiara Melloni
    Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 104:175-81. 2009
    ..Patient education, better prescription drug coverage, and reminder strategies may improve use of EBMs at 3 months after discharge from ACS admission...
  55. ncbi Enoxaparin dosing and associated risk of in-hospital bleeding and death in patients with non ST-segment elevation acute coronary syndromes
    Nancy M Allen LaPointe
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Arch Intern Med 167:1539-44. 2007
    ..The extent to which bleeding risk is attributable to excess dosing of enoxaparin is unclear...
  56. ncbi Challenges in predicting the need for coronary artery bypass grafting at presentation in patients with non-ST-segment elevation acute coronary syndromes
    Rajendra H Mehta
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 98:624-7. 2006
    ....
  57. ncbi Prevalence, predictors, and outcomes of patients with non-ST-segment elevation myocardial infarction and insignificant coronary artery disease: results from the Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early
    Manesh R Patel
    Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Am Heart J 152:641-7. 2006
    ..We sought to determine the prevalence, predictors, and outcomes of patients with NSTEMI and insignificant CAD...
  58. ncbi Characterization of myocardial infarction as an end point in two large trials of acute coronary syndromes
    Kenneth W Mahaffey
    Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27715, USA
    Am J Cardiol 95:1404-8. 2005
    ..All MI types were associated with worse short- and long-term outcomes. Characterization of the type of MI provides an opportunity for more informed interpretation of clinical trial results and improved planning for future trials...
  59. ncbi Clopidogrel to treat patients with non-ST-segment elevation acute coronary syndromes after hospital discharge
    Pierluigi Tricoci
    Division of Cardiology, Duke University School of Medicine, and Duke Clinical Research Institute, Durham, NC, USA
    Arch Intern Med 166:806-11. 2006
    ....
  60. ncbi Recent trends in the care of patients with non-ST-segment elevation acute coronary syndromes: insights from the CRUSADE initiative
    Rajendra H Mehta
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Arch Intern Med 166:2027-34. 2006
    ..We sought to determine recent trends in adherence to guideline-based therapies for NSTE ACS...
  61. ncbi Influence of clinical trial enrollment on the quality of care and outcomes for patients with non-ST-segment elevation acute coronary syndromes
    David E Kandzari
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Am Heart J 149:474-81. 2005
    ....
  62. ncbi Association of intravenous morphine use and outcomes in acute coronary syndromes: results from the CRUSADE Quality Improvement Initiative
    Trip J Meine
    Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Am Heart J 149:1043-9. 2005
    ..This analysis raises concerns regarding the safety of using morphine in patients with NSTE ACS and emphasizes the need for a randomized trial...
  63. ncbi Creatine kinase-MB elevation after coronary artery bypass grafting surgery in patients with non-ST-segment elevation acute coronary syndromes predict worse outcomes: results from four large clinical trials
    Kenneth W Mahaffey
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA, and Catholic University Hospital, Leuven, Belgium
    Eur Heart J 28:425-32. 2007
    ..To assess the significance of creatine kinase (CK)-MB elevations in outcomes of patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS) who have undergone coronary artery bypass grafting (CABG) surgery...
  64. ncbi Relationship between risk stratification by cardiac troponin level and adherence to guidelines for non-ST-segment elevation acute coronary syndromes
    Matthew T Roe
    Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Arch Intern Med 165:1870-6. 2005
    ..The threshold of troponin elevation that stimulates changes in clinical decision making for patients with non-ST-segment elevation acute coronary syndromes (NSTE ACSs) has not been previously evaluated...
  65. ncbi Acute clopidogrel use and outcomes in patients with non-ST-segment elevation acute coronary syndromes undergoing coronary artery bypass surgery
    Rajendra H Mehta
    Division of Cardiology and the Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    J Am Coll Cardiol 48:281-6. 2006
    ....
  66. ncbi Evolution in cardiovascular care for elderly patients with non-ST-segment elevation acute coronary syndromes: results from the CRUSADE National Quality Improvement Initiative
    Karen P Alexander
    Duke Clinical Research Institute and Division of Cardiology, Duke University Medical Center, Durham, North Carolina 27715, USA
    J Am Coll Cardiol 46:1479-87. 2005
    ..This study evaluated the impact of age on care and outcomes for non-ST-segment elevation acute coronary syndromes (NSTE ACS)...
  67. ncbi Frequency, predictors, and outcomes of drug-eluting stent utilization in patients with high-risk non-ST-segment elevation acute coronary syndromes
    David E Kandzari
    Duke Clinical Research Institute and Division of Cardiology, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 96:750-5. 2005
    ....
  68. ncbi Sex differences in mortality following acute coronary syndromes
    Jeffrey S Berger
    Department of Medicine, New York University School of Medicine, 530 First Ave, Skirball 9R, New York, NY 10016, USA
    JAMA 302:874-82. 2009
    ..Conflicting information exists about whether sex differences modulate short-term mortality following acute coronary syndromes (ACS)...
  69. ncbi Effect of home testing of international normalized ratio on clinical events
    David B Matchar
    Health Services Research Field Program, Veterans Affairs Medical Center, Durham, NC, USA
    N Engl J Med 363:1608-20. 2010
    ..As compared with venous plasma testing, point-of-care INR measuring devices allow greater testing frequency and patient involvement and may improve clinical outcomes...
  70. ncbi Combination reperfusion therapy with eptifibatide and reduced-dose tenecteplase for ST-elevation myocardial infarction: results of the integrilin and tenecteplase in acute myocardial infarction (INTEGRITI) Phase II Angiographic Trial
    Robert P Giugliano
    TIMI Study Group, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 41:1251-60. 2003
    ..The goal of this study was to evaluate combinations of eptifibatide with reduced-dose tenecteplase (TNK) in ST-elevation myocardial infarction (STEMI)...
  71. ncbi Clinical characteristics, process of care, and outcomes of Hispanic patients presenting with non-ST-segment elevation acute coronary syndromes: results from Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early imp
    Mauricio G Cohen
    Division of Cardiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7075, USA
    Am Heart J 152:110-7. 2006
    ..Data regarding the management of non-ST-segment elevation acute coronary syndromes (NSTE ACS) in Hispanic patients, the largest and fastest-growing minority in the United States, are scarce...
  72. ncbi Promise of combined low-molecular-weight heparin and platelet glycoprotein IIb/IIIa inhibition: results from Platelet IIb/IIIa Antagonist for the Reduction of Acute coronary syndrome events in a Global Organization Network B (PARAGON B)
    Debabrata Mukherjee
    University of Michigan Health System, Ann Arbor, Mich, USA
    Am Heart J 144:995-1002. 2002
    ..These findings support the rationale and promise for combining GP IIb/IIIa blockers and LMWH for future management of acute coronary syndrome...
  73. ncbi 2002 update to the ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction: implications for emergency department practice
    Charles V Pollack
    University of Pennsylvania Health System, Pennsylvania Hospital, 800 Spruce Street, Philadelphia, PA 19107, USA
    Ann Emerg Med 41:355-69. 2003
    ..Several of the modified and new recommendations again potentially affect ED management. These are presented and discussed here...
  74. ncbi Treatment disparities in the care of patients with and without diabetes presenting with non-ST-segment elevation acute coronary syndromes
    Gerard X Brogan
    Department of Emergency Medicine, New York University School of Medicine North Shore Long Island Jewish Health System, Plainview, New York 11803, USA
    Diabetes Care 29:9-14. 2006
    ..The objective of this study was to characterize treatment patterns among patients with diabetes presenting with non-ST-segment elevation (NSTE) acute coronary syndromes (ACSs)...
  75. ncbi Chronic kidney disease in patients with non-ST-segment elevation acute coronary syndromes
    Jin H Han
    Department of Emergency Medicine, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA
    Am J Med 119:248-54. 2006
    ..We examined the treatment and outcomes of patients with both non-ST-segment elevation acute coronary syndromes and moderate to severe chronic kidney disease...
  76. ncbi Optimal timing of intervention in non-ST-segment elevation acute coronary syndromes: insights from the CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) Regist
    Jason W Ryan
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Circulation 112:3049-57. 2005
    ..Using weekend status as an instrumental variable, we found no significant benefit to early catheterization, although we could not exclude an important risk reduction, particularly for catheterization within 12 hours of presentation...
  77. ncbi Overcoming the challenges facing quality-improvement strategies for non-ST-segment elevation acute coronary syndromes
    Matthew T Roe
    Am Fam Physician 70:1868, 1874, 1876. 2004
  78. ncbi The obesity paradox in non-ST-segment elevation acute coronary syndromes: results from the Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the American College of Cardiology/American Heart A
    Deborah B Diercks
    Department of Emergency Medicine, University of California, Davis, School of Medicine, Sacramento, CA, USA
    Am Heart J 152:140-8. 2006
    ..Although obesity is a known risk factor for coronary artery disease, its impact on the presentation, treatment, and outcome of patients with acute coronary syndromes (ACS) has not been well studied...
  79. ncbi Prolonged emergency department stays of non-ST-segment-elevation myocardial infarction patients are associated with worse adherence to the American College of Cardiology/American Heart Association guidelines for management and increased adverse events
    Deborah B Diercks
    University of California, Davis, School of Medicine, Sacramento, CA, USA
    Ann Emerg Med 50:489-96. 2007
    ..We hypothesized that patients with non-ST-segment-elevation myocardial infarction who have ED stays of greater than 8 hours may have lower quality of care and worse outcomes...
  80. ncbi Gender disparities in the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes: large-scale observations from the CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementatio
    Andra L Blomkalns
    Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0769, USA
    J Am Coll Cardiol 45:832-7. 2005
    ..We hypothesized that significant disparities in gender exist in the management of patients with non-ST-segment elevation (NSTE) acute coronary syndromes (ACS)...
  81. ncbi Patterns of aspirin dosing in non-ST-elevation acute coronary syndromes in the CRUSADE Quality Improvement Initiative
    Sumit Tickoo
    Bridgeport Hospital, Bridgeport, Connecticut, USA
    Am J Cardiol 99:1496-9. 2007
    ....
  82. ncbi Racial variations in treatment and outcomes of black and white patients with high-risk non-ST-elevation acute coronary syndromes: insights from CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Impleme
    Ali F Sonel
    Center for Health Equity Research and Promotion, Pittsburgh, PA, USA
    Circulation 111:1225-32. 2005
    ..It is unknown whether racial disparities exist for other treatments for non-ST-segment elevation acute coronary syndromes (NSTE ACS) and how different treatments affect outcomes...
  83. ncbi Changes in patterns of coronary revascularization strategies for patients with acute coronary syndromes (from the CRUSADE Quality Improvement Initiative)
    Prospero B Gogo
    University of Vermont College of Medicine, Burlington, Vermont, USA
    Am J Cardiol 99:1222-6. 2007
    ..Long-term implications of this shift remain uncertain, especially in patients with 3VD...
  84. ncbi Paradoxical use of invasive cardiac procedures for patients with non-ST segment elevation myocardial infarction: an international perspective from the CRUSADE Initiative and the Canadian ACS Registries I and II
    Mohammad I Zia
    Canadian Heart Research Centre, Toronto, Canada
    Can J Cardiol 23:1073-9. 2007
    ..Practice guidelines support an early invasive strategy in patients with non-ST segment elevation acute coronary syndromes, particularly in those at higher risk...
  85. ncbi Clinical trial--derived risk model may not generalize to real-world patients with acute coronary syndrome
    Andrew T Yan
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 148:1020-7. 2004
    ..Our findings underscore the potential importance of risk model validation in the general ACS population rather than a clinical trial population to establish its generalizability before integration into clinical practice...
  86. ncbi Culprit-only or multivessel revascularization in patients with acute coronary syndromes: an American College of Cardiology National Cardiovascular Database Registry report
    Sorin J Brener
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Am Heart J 155:140-6. 2008
    ..Although an early invasive strategy improves outcome in these patients, there are limited data on culprit-only, single-vessel (SV) percutaneous coronary intervention (PCI) or MV PCI in the NSTE ACS setting...
  87. ncbi Characteristics, management, and outcomes of 5,557 patients age > or =90 years with acute coronary syndromes: results from the CRUSADE Initiative
    Adam H Skolnick
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Am Coll Cardiol 49:1790-7. 2007
    ..The goal of this work was to explore the treatment and outcomes of patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS) age > or =90 years...
  88. ncbi Utilization of early invasive management strategies for high-risk patients with non-ST-segment elevation acute coronary syndromes: results from the CRUSADE Quality Improvement Initiative
    Deepak L Bhatt
    Cleveland Clinic Foundation, Department of Cardiovascular Medicine Desk F25, Cleveland, Ohio 44195, USA
    JAMA 292:2096-104. 2004
    ..This strategy appears to be reserved for patients without significant comorbidities and those cared for by cardiologists and is associated with a lower risk of in-hospital mortality...
  89. ncbi Early glycoprotein IIb/IIIa inhibitor use for non-ST-segment elevation acute coronary syndrome: patient selection and associated treatment patterns
    James W Hoekstra
    Department of Emergency Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Acad Emerg Med 12:431-8. 2005
    ....
  90. ncbi Impact of home warfarin use on the treatment and outcomes of patients undergoing percutaneous coronary intervention
    Atul Aggarwal
    Nebraska Heart Institute, Hastings, Nebraska, USA
    Am J Cardiol 101:1413-7. 2008
    ..76). In conclusion, while fewer than 5% of patients undergoing PCI are taking previous warfarin, these patients have a higher risk of in-hospital bleeding events but a similar risk of mortality despite lower use of antiplatelet agents...
  91. ncbi Insurance coverage and care of patients with non-ST-segment elevation acute coronary syndromes
    James E Calvin
    Section of Cardiology, Rush University Medical Center, Chicago, Illinois 60612, USA
    Ann Intern Med 145:739-48. 2006
    ..The impact of insurance coverage on the care of patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS) is unclear...
  92. ncbi Care of non-ST-segment elevation patients: insights from the CRUSADE national quality improvement initiative
    E Magnus Ohman
    Division of Cardiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am Heart J 148:S34-9. 2004
    ..These ACC/AHA guidelines are intended to help physicians make appropriate decisions when diagnosing and treating patients with NSTE ACS...
  93. ncbi Combined assessment of thrombolysis in myocardial infarction flow grade, myocardial perfusion grade, and ST-segment resolution to evaluate epicardial and myocardial reperfusion
    Robert P Giugliano
    TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, 350 Longwood Avenue, 1st Floor Offices, Boston, MA 02115, USA
    Am J Cardiol 93:1362-7, A5-6. 2004
    ..This new end point is proposed to evaluate the success of reperfusion therapy in patients who undergo early angiography...
  94. ncbi Anatomic distribution of the culprit lesion in patients with non-ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention: findings from the National Cardiovascular Data Registry
    William C Dixon
    J Am Coll Cardiol 52:1347-8. 2008
  95. ncbi Improving the care of patients with non-ST-elevation acute coronary syndromes in the emergency department: the CRUSADE initiative
    James W Hoekstra
    Ohio State University, Columbus, OH 43210, USA
    Acad Emerg Med 9:1146-55. 2002
    ..It is the intent of CRUSADE to improve patient care in the ED by tracking and encouraging compliance with evidence-based guidelines for the evaluation and management of NSTE ACS...