Research Topics
| M V RockmanSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Detail Information
Publications
Phylogenetics of Planipapillus, lawn-headed onychophorans of the Australian Alps, based on nuclear and mitochondrial gene sequencesM V Rockman
Department of Botany and Zoology, Australian National University, Canberra, ACT 0200, Australia
Mol Phylogenet Evol 21:103-16. 2001..These analyses result in strong, congruent support for many clades. We infer multiple independent origins of spikes in Planipapillus male head structures...
Episodic chromosomal evolution in Planipapillus (Onychophora: Peripatopsidae): a phylogenetic approach to evolutionary dynamics and speciationMatthew V Rockman
Department of Botany and Zoology, Australian National University, Canberra, Australian Capital Territory
Evolution 56:58-69. 2002..Chromosomal evolution may play a role in speciation in Planipapillus, both by interactions between centric fusions with monobrachial homology and by the accumulation of multiple weakly underdominant fusions...
Abundant raw material for cis-regulatory evolution in humansMatthew V Rockman
Department of Biology, Duke University, Durham, NC 27708, USA
Mol Biol Evol 19:1991-2004. 2002..Ordinary small-scale mutations contribute to pervasive variation in transcription rates and consequently to patterns of human phenotypic variation...
Idiomatic (gene) expressionsMatthew V Rockman
Department of Biology, Duke University, Durham, NC 27708, USA
Bioessays 25:421-4. 2003..While we will continue to require a diverse arsenal of experimental methods, this versatile method will speed the identification of functional genetic variation...
Ancient and recent positive selection transformed opioid cis-regulation in humansMatthew V Rockman
Department of Biology, Duke University, Durham, North Carolina, USA
PLoS Biol 3:e387. 2005....
Ancient polymorphism and functional variation in the primate MHC-DQA1 5' cis-regulatory regionDagan A Loisel
Department of Biology, Duke University, Durham, NC 27705, USA
Proc Natl Acad Sci U S A 103:16331-6. 2006....
Positive selection on MMP3 regulation has shaped heart disease riskMatthew V Rockman
Department of Biology, Duke University, Box 90338, Durham, NC 27708, USA
Curr Biol 14:1531-9. 2004..The polymorphism contributes to variation in arterial traits and to the risk of coronary heart disease and its progression...
Multiple Functional Variants in cis Modulate PDYN ExpressionCourtney C Babbitt
Institute for Genome Sciences and Policy, Duke University, USA
Mol Biol Evol 27:465-79. 2010....
Positive selection on a human-specific transcription factor binding site regulating IL4 expressionMatthew V Rockman
Department of Biology, Duke University, Box 90338, Durham, NC 27708, USA
Curr Biol 13:2118-23. 2003..The allele frequencies of this binding site represent local adaptation to diverse pathogenic challenges; disease states associated with the common derived allele are side-effects of positive selection on other IL4 functions...
The evolution of transcriptional regulation in eukaryotesGregory A Wray
Department of Biology, Duke University, USA
Mol Biol Evol 20:1377-419. 2003..Despite these challenges, important insights have already been gained into the evolution of transcriptional regulation, and the pace of discovery is accelerating...
Molecular basis of the copulatory plug polymorphism in Caenorhabditis elegansMichael F Palopoli
Department of Biology, Bowdoin College, 6500 College Station, Brunswick, Maine 04011, USA
Nature 454:1019-22. 2008..The reduced selection on male?male competition associated with the origin of hermaphroditism may have permitted the global spread of a loss-of-function mutation with restricted pleiotropy...
Population genetic and phylogenetic evidence for positive selection on regulatory mutations at the factor VII locus in humansMatthew W Hahn
Department of Biology, Duke University, Durham, North Carolina 27708, USA
Genetics 167:867-77. 2004..Our results thus further support the hypothesis that regulatory mutations have been important in human evolution...
Reverse engineering the genotype-phenotype map with natural genetic variationMatthew V Rockman
Center for Genomics and Systems Biology, Department of Biology, New York University, 100 Washington Square East, New York, New York 10003, USA
Nature 456:738-44. 2008..It is then possible to use this information about causes and effects to build models of probabilistic 'causal networks'. These networks are beginning to define the outlines of the 'genotype-phenotype map'...
Breeding designs for recombinant inbred advanced intercross linesMatthew V Rockman
Lewis Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
Genetics 179:1069-78. 2008..We find that the easiest crosses to perform are well suited to the task of generating populations of highly recombinant inbred lines...
Analysis of common IL-6 promoter SNP variants and the AnTn tract in humans and primates and effects on plasma IL-6 levels following coronary artery bypass graft surgeryDaniel Kelberman
Centre for Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Royal Free and University College London Medical School, Rayne Building, 5 University Street, London WC1E 6JF, UK
Biochim Biophys Acta 1688:160-7. 2004..The conserved length of the AnTn tract and the association in vivo with IL-6 levels strongly suggest the functionality of the tract on IL-6 expression, independent of contributions from other polymorphic sites within the promoter...
Widespread genetic incompatibility in C. elegans maintained by balancing selectionHannah S Seidel
Lewis Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
Science 319:589-94. 2008..Our data suggest that long-term maintenance of a balanced polymorphism has permitted the incompatibility to persist despite gene flow across the rest of the genome...
Genetics of global gene expressionMatthew V Rockman
Lewis-Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
Nat Rev Genet 7:862-72. 2006....
