Tannishtha Reya

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint A role for Wnt signalling in self-renewal of haematopoietic stem cells
    Tannishtha Reya
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 423:409-14. 2003
  2. ncbi request reprint The elements of stem cell self-renewal: a genetic perspective
    Gregory Pazianos
    Duke University Medical Center, Durham, NC, USA
    Biotechniques 35:1240-7. 2003
  3. pmc Imaging hematopoietic precursor division in real time
    Mingfu Wu
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cell Stem Cell 1:541-54. 2007
  4. ncbi request reprint Identification of adiponectin as a novel hemopoietic stem cell growth factor
    Leah DiMascio
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 178:3511-20. 2007
  5. pmc Regulation of myeloid leukaemia by the cell-fate determinant Musashi
    Takahiro Ito
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 466:765-8. 2010
  6. ncbi request reprint Wnt signalling in stem cells and cancer
    Tannishtha Reya
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 434:843-50. 2005
  7. ncbi request reprint Regulation of hematopoietic stem cell self-renewal
    Tannishtha Reya
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Recent Prog Horm Res 58:283-95. 2003
  8. doi request reprint Activation of Wnt signaling in hematopoietic regeneration
    Kendra L Congdon
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, USA
    Stem Cells 26:1202-10. 2008
  9. pmc Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo
    Chen Zhao
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 12:528-41. 2007
  10. pmc Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche
    Heather A Himburg
    Division of Cellular Therapy, Department of Medicine, Duke University Medical Center, Duke University, Durham, NC 27710, USA
    Cell Rep 2:964-75. 2012

Research Grants

Collaborators

Detail Information

Publications21

  1. ncbi request reprint A role for Wnt signalling in self-renewal of haematopoietic stem cells
    Tannishtha Reya
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 423:409-14. 2003
    ..We conclude that the Wnt signalling pathway is critical for normal HSC homeostasis in vitro and in vivo, and provide insight into a potential molecular hierarchy of regulation of HSC development...
  2. ncbi request reprint The elements of stem cell self-renewal: a genetic perspective
    Gregory Pazianos
    Duke University Medical Center, Durham, NC, USA
    Biotechniques 35:1240-7. 2003
    ..The emerging picture these data provide of the regulation of self-renewal in HSCs has provided a better understanding of the basic biology of stem cells and holds promise for designing strategies to improve bone marrow transplantation...
  3. pmc Imaging hematopoietic precursor division in real time
    Mingfu Wu
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cell Stem Cell 1:541-54. 2007
    ..These studies establish a system for tracking division of hematopoietic precursors and show that the balance of symmetric and asymmetric division can be influenced by the microenvironment and subverted by oncogenes...
  4. ncbi request reprint Identification of adiponectin as a novel hemopoietic stem cell growth factor
    Leah DiMascio
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 178:3511-20. 2007
    ..These studies collectively identify adiponectin as a novel regulator of HSC function and suggest that it acts through a p38 dependent pathway...
  5. pmc Regulation of myeloid leukaemia by the cell-fate determinant Musashi
    Takahiro Ito
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 466:765-8. 2010
    ..These data show that the Musashi-Numb pathway can control the differentiation of CML cells, and raise the possibility that targeting this pathway may provide a new strategy for the therapy of aggressive leukaemias...
  6. ncbi request reprint Wnt signalling in stem cells and cancer
    Tannishtha Reya
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 434:843-50. 2005
    ....
  7. ncbi request reprint Regulation of hematopoietic stem cell self-renewal
    Tannishtha Reya
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Recent Prog Horm Res 58:283-95. 2003
    ....
  8. doi request reprint Activation of Wnt signaling in hematopoietic regeneration
    Kendra L Congdon
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, USA
    Stem Cells 26:1202-10. 2008
    ..Cumulatively, our data reveal that growth signals in the hematopoietic system are re-activated during injury, and provide novel insight into the influence of the microenvironment during regeneration...
  9. pmc Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo
    Chen Zhao
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 12:528-41. 2007
    ..These studies demonstrate that Wnt signaling is required for the self-renewal of normal and neoplastic stem cells in the hematopoietic system...
  10. pmc Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche
    Heather A Himburg
    Division of Cellular Therapy, Department of Medicine, Duke University Medical Center, Duke University, Durham, NC 27710, USA
    Cell Rep 2:964-75. 2012
    ..PTN is a secreted component of the BM vascular niche that regulates HSC self-renewal and retention in vivo...
  11. ncbi request reprint Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance
    Andrew W Duncan
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Immunol 6:314-22. 2005
    ..These data suggest that Notch signaling has a dominant function in inhibiting differentiation and provide a model for how HSCs may integrate multiple signals to maintain the stem cell state...
  12. doi request reprint Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia
    Bryan Zimdahl
    1 Department of Pharmacology, University of California San Diego School of Medicine, La Jolla, California, USA 2 Sanford Consortium for Regenerative Medicine, La Jolla, California, USA 3 Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, USA 4
    Nat Genet 46:245-52. 2014
    ..These data identify a key role for Lis1 in hematopoietic stem cells and mark its directed control of asymmetric division as a critical regulator of normal and malignant hematopoietic development. ..
  13. pmc Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells
    Heather A Himburg
    Division of Cellular Therapy, Department of Medicine, Duke University, Durham, North Carolina, USA
    Nat Med 16:475-82. 2010
    ..We identify the secreted growth factor pleiotrophin as a new regulator of both HSC expansion and regeneration...
  14. pmc Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
    Chen Zhao
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 458:776-9. 2009
    ....
  15. ncbi request reprint Wnt signaling in the stem cell niche
    Frédérique Marie Rattis
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Curr Opin Hematol 11:88-94. 2004
    ..This review focuses on studies that identify the Wnt signaling pathway as a mediator of HSC self-renewal and maintenance and analyzes its potential influence in context of the HSC niche...
  16. pmc Inhibition of apoptosome formation by suppression of Hsp90beta phosphorylation in tyrosine kinase-induced leukemias
    Manabu Kurokawa
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813, Durham, NC 27710, USA
    Mol Cell Biol 28:5494-506. 2008
    ..These data provide an explanation for apoptosome inhibition by activated leukemogenic tyrosine kinases and suggest that alterations in Hsp90beta-apoptosome interactions may contribute to chemoresistance in leukemias...
  17. pmc Divide and conquer: how asymmetric division shapes cell fate in the hematopoietic system
    Kendra L Congdon
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Curr Opin Immunol 20:302-7. 2008
    ..These discoveries have opened new doors to understanding how regulation of division pattern contributes to the normal development and function of the immune system as well as how its dysregulation can lead to cancer...
  18. ncbi request reprint Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance
    Christine M Kitsos
    Department of Pharmacology and Cancer Biology, Duke University, Medical Center, Durham, North Carolina 27715, USA
    J Biol Chem 280:33101-8. 2005
    ..These studies show that CaMKIV is a regulator of HSC homeostasis and suggest that its effects may be in part mediated via regulation of CBP and Bcl-2...
  19. pmc Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1
    Yuxing Zhao
    Department of Pharmacology and Cancer Biology, DUMC Box 3813, Durham, NC 27710, USA
    Mol Cell Biol 27:4328-39. 2007
    ....
  20. ncbi request reprint Wnt proteins are lipid-modified and can act as stem cell growth factors
    Karl Willert
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 423:448-52. 2003
    ..The purified Wnt3a protein induces self-renewal of haematopoietic stem cells, signifying its potential use in tissue engineering...
  21. ncbi request reprint Frizzled 9 knock-out mice have abnormal B-cell development
    Erik A Ranheim
    Departments of Pathology and Genetics, Stanford University School of Medicine, Stanford, CA, USA
    Blood 105:2487-94. 2005
    ..Mature B cells are present in normal numbers in lymph node and spleen. These findings suggest a role for Fzd9 signaling in lymphoid development, particularly at points where B cells undergo self-renewal prior to further differentiation...

Research Grants17

  1. Imaging the stem cell niche in regeneration and cancer
    Tannishtha Reya; Fiscal Year: 2010
    ....
  2. Regulation of Hematopoietic Stem Cell Self-Renewal
    Tannishtha Reya; Fiscal Year: 2010
    ..abstract_text> ..
  3. Regulation of Hematopoietic Stem Cell Self-Renewal
    Tannishtha Reya; Fiscal Year: 2006
    ..abstract_text> ..
  4. Damage and regeneration in the hematopoietic system
    Tannishtha Reya; Fiscal Year: 2007
    ..Furthermore, understanding the basis of impaired regeneration in the aging hematopoietic system may allow us to design novel means to improve the health and quality of life of aging patients. ..
  5. Imaging self-renewal and transformation in hematopoietic stem cells
    Tannishtha Reya; Fiscal Year: 2009
    ..Public Health Relevance The research proposed here will allow for in vivo monitoring of the signals and niche components that contribute ..
  6. Regulation of Hematopoietic Stem Cell Self-Renewal
    Tannishtha Reya; Fiscal Year: 2003
    ..abstract_text> ..
  7. Damage and regeneration in the hematopoietic system
    Tannishtha Reya; Fiscal Year: 2009
    ..Furthermore, understanding the basis of impaired regeneration in the aging hematopoietic system may allow us to design novel means to improve the health and quality of life of aging patients. ..