Research Topics
| John W PyhtilaSummaryAffiliation: Duke University Medical Center Country: USA Publications
| Collaborators |
Detail Information
Publications
Improved interferometric detection of scattered light with a 4f imaging systemJohn W Pyhtila
Department of Biomedical Engineering and the Fitzpatrick Center for Photonics, Duke University, Durham, North Carolina 27708, USA
Appl Opt 44:1785-91. 2005..Of the three systems analyzed, the 4f imaging system is determined to be most effective, because it accurately reproduces both the phase and the amplitude of the scattered field at the detector...- Fourier-domain angle-resolved low coherence interferometry through an endoscopic fiber bundle for light-scattering spectroscopyJohn W Pyhtila
Department of Biomedical Engineering and the Fitzpatrick Center for Photonics and Communication Systems, Duke University, Durham, North Carolina 27708, USA
Opt Lett 31:772-4. 2006..The data collected are processed in real time, producing a depth-resolved angular scattering distribution in 0.37 s. The data are used to determine the sizes of polystyrene microspheres with subwavelength precision and accuracy... - Analysis of long range correlations due to coherent light scattering from in-vitro cell arrays using angle-resolved low coherence interferometryJohn W Pyhtila
Duke University, Department of Biomedical Engineering, Fitzpatrick Center for Photonics, Durham, North Carolina 27708
J Biomed Opt 11:34022. 2006..The a/LCI results show that the impact of coherent scattering on nuclear morphology measurements can be eliminated through data filtering... - Polarization effects on scatterer sizing accuracy analyzed with frequency-domain angle-resolved low-coherence interferometryJohn W Pyhtila
Department of Biomedical Engineering, Duke University, North Carolina 27708, USA
Appl Opt 46:1735-41. 2007.... - In situ detection of nuclear atypia in Barrett's esophagus by using angle-resolved low-coherence interferometryJohn W Pyhtila
Department of Biomedical Engineering and the Fitzpatrick Institute for Photonics, Duke University Medical Center, Durham, NC, USA
Gastrointest Endosc 65:487-91. 2007..Monitoring of patients with Barrett's esophagus (BE) for dysplasia, currently done by systematic biopsy, can be improved through increasing the proportion of at-risk tissue examined... - In situ assessment of intraepithelial neoplasia in hamster trachea epithelium using angle-resolved low-coherence interferometryKevin J Chalut
Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
Cancer Epidemiol Biomarkers Prev 16:223-7. 2007.... - In situ nuclear morphology measurements using light scattering as biomarkers of neoplastic change in animal models of carcinogenesisAdam Wax
Department of Biomedical Engineering, Fitzpatrick Institute for Photonics, Duke University, Durham, NC, USA
Dis Markers 25:291-301. 2008..These models provide the opportunity to develop biomarkers and test chemopreventive and therapy strategies before application in humans... - Prospective grading of neoplastic change in rat esophagus epithelium using angle-resolved low-coherence interferometryAdam Wax
Duke University, Department of Biomedical Engineering, Durham, North Carolina 27708, USA
J Biomed Opt 10:051604. 2005..We demonstrate that a/LCI is highly effective for monitoring neoplastic change and can be applied to assessing the efficacy of chemopreventive agents in the rat esophagus... - Application of Mie theory to determine the structure of spheroidal scatterers in biological materialsJustin D Keener
Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
Opt Lett 32:1326-8. 2007.... - Rapid, depth-resolved light scattering measurements using Fourier domain, angle-resolved low coherence interferometryJohn W Pyhtila
Department of Biomedical Engineering and the Fitzpatrick Center for Photonics and Communication Systems, Duke University, Durham, NC 27708
Opt Express 12:6178-83. 2004..The data are used to determine the microsphere size with good accuracy. Future clinical application to measuring the size of cell nuclei in living epithelial tissues using backscattered light is discussed...