John W Pyhtila

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Improved interferometric detection of scattered light with a 4f imaging system
    John W Pyhtila
    Department of Biomedical Engineering and the Fitzpatrick Center for Photonics, Duke University, Durham, North Carolina 27708, USA
    Appl Opt 44:1785-91. 2005
  2. ncbi request reprint Fourier-domain angle-resolved low coherence interferometry through an endoscopic fiber bundle for light-scattering spectroscopy
    John W Pyhtila
    Department of Biomedical Engineering and the Fitzpatrick Center for Photonics and Communication Systems, Duke University, Durham, North Carolina 27708, USA
    Opt Lett 31:772-4. 2006
  3. ncbi request reprint Analysis of long range correlations due to coherent light scattering from in-vitro cell arrays using angle-resolved low coherence interferometry
    John W Pyhtila
    Duke University, Department of Biomedical Engineering, Fitzpatrick Center for Photonics, Durham, North Carolina 27708
    J Biomed Opt 11:34022. 2006
  4. ncbi request reprint Polarization effects on scatterer sizing accuracy analyzed with frequency-domain angle-resolved low-coherence interferometry
    John W Pyhtila
    Department of Biomedical Engineering, Duke University, North Carolina 27708, USA
    Appl Opt 46:1735-41. 2007
  5. ncbi request reprint In situ detection of nuclear atypia in Barrett's esophagus by using angle-resolved low-coherence interferometry
    John W Pyhtila
    Department of Biomedical Engineering and the Fitzpatrick Institute for Photonics, Duke University Medical Center, Durham, NC, USA
    Gastrointest Endosc 65:487-91. 2007
  6. ncbi request reprint In situ assessment of intraepithelial neoplasia in hamster trachea epithelium using angle-resolved low-coherence interferometry
    Kevin J Chalut
    Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
    Cancer Epidemiol Biomarkers Prev 16:223-7. 2007
  7. pmc In situ nuclear morphology measurements using light scattering as biomarkers of neoplastic change in animal models of carcinogenesis
    Adam Wax
    Department of Biomedical Engineering, Fitzpatrick Institute for Photonics, Duke University, Durham, NC, USA
    Dis Markers 25:291-301. 2008
  8. ncbi request reprint Prospective grading of neoplastic change in rat esophagus epithelium using angle-resolved low-coherence interferometry
    Adam Wax
    Duke University, Department of Biomedical Engineering, Durham, North Carolina 27708, USA
    J Biomed Opt 10:051604. 2005
  9. ncbi request reprint Application of Mie theory to determine the structure of spheroidal scatterers in biological materials
    Justin D Keener
    Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
    Opt Lett 32:1326-8. 2007
  10. pmc Rapid, depth-resolved light scattering measurements using Fourier domain, angle-resolved low coherence interferometry
    John W Pyhtila
    Department of Biomedical Engineering and the Fitzpatrick Center for Photonics and Communication Systems, Duke University, Durham, NC 27708
    Opt Express 12:6178-83. 2004

Detail Information

Publications10

  1. ncbi request reprint Improved interferometric detection of scattered light with a 4f imaging system
    John W Pyhtila
    Department of Biomedical Engineering and the Fitzpatrick Center for Photonics, Duke University, Durham, North Carolina 27708, USA
    Appl Opt 44:1785-91. 2005
    ..Of the three systems analyzed, the 4f imaging system is determined to be most effective, because it accurately reproduces both the phase and the amplitude of the scattered field at the detector...
  2. ncbi request reprint Fourier-domain angle-resolved low coherence interferometry through an endoscopic fiber bundle for light-scattering spectroscopy
    John W Pyhtila
    Department of Biomedical Engineering and the Fitzpatrick Center for Photonics and Communication Systems, Duke University, Durham, North Carolina 27708, USA
    Opt Lett 31:772-4. 2006
    ..The data collected are processed in real time, producing a depth-resolved angular scattering distribution in 0.37 s. The data are used to determine the sizes of polystyrene microspheres with subwavelength precision and accuracy...
  3. ncbi request reprint Analysis of long range correlations due to coherent light scattering from in-vitro cell arrays using angle-resolved low coherence interferometry
    John W Pyhtila
    Duke University, Department of Biomedical Engineering, Fitzpatrick Center for Photonics, Durham, North Carolina 27708
    J Biomed Opt 11:34022. 2006
    ..The a/LCI results show that the impact of coherent scattering on nuclear morphology measurements can be eliminated through data filtering...
  4. ncbi request reprint Polarization effects on scatterer sizing accuracy analyzed with frequency-domain angle-resolved low-coherence interferometry
    John W Pyhtila
    Department of Biomedical Engineering, Duke University, North Carolina 27708, USA
    Appl Opt 46:1735-41. 2007
    ....
  5. ncbi request reprint In situ detection of nuclear atypia in Barrett's esophagus by using angle-resolved low-coherence interferometry
    John W Pyhtila
    Department of Biomedical Engineering and the Fitzpatrick Institute for Photonics, Duke University Medical Center, Durham, NC, USA
    Gastrointest Endosc 65:487-91. 2007
    ..Monitoring of patients with Barrett's esophagus (BE) for dysplasia, currently done by systematic biopsy, can be improved through increasing the proportion of at-risk tissue examined...
  6. ncbi request reprint In situ assessment of intraepithelial neoplasia in hamster trachea epithelium using angle-resolved low-coherence interferometry
    Kevin J Chalut
    Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
    Cancer Epidemiol Biomarkers Prev 16:223-7. 2007
    ....
  7. pmc In situ nuclear morphology measurements using light scattering as biomarkers of neoplastic change in animal models of carcinogenesis
    Adam Wax
    Department of Biomedical Engineering, Fitzpatrick Institute for Photonics, Duke University, Durham, NC, USA
    Dis Markers 25:291-301. 2008
    ..These models provide the opportunity to develop biomarkers and test chemopreventive and therapy strategies before application in humans...
  8. ncbi request reprint Prospective grading of neoplastic change in rat esophagus epithelium using angle-resolved low-coherence interferometry
    Adam Wax
    Duke University, Department of Biomedical Engineering, Durham, North Carolina 27708, USA
    J Biomed Opt 10:051604. 2005
    ..We demonstrate that a/LCI is highly effective for monitoring neoplastic change and can be applied to assessing the efficacy of chemopreventive agents in the rat esophagus...
  9. ncbi request reprint Application of Mie theory to determine the structure of spheroidal scatterers in biological materials
    Justin D Keener
    Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
    Opt Lett 32:1326-8. 2007
    ....
  10. pmc Rapid, depth-resolved light scattering measurements using Fourier domain, angle-resolved low coherence interferometry
    John W Pyhtila
    Department of Biomedical Engineering and the Fitzpatrick Center for Photonics and Communication Systems, Duke University, Durham, NC 27708
    Opt Express 12:6178-83. 2004
    ..The data are used to determine the microsphere size with good accuracy. Future clinical application to measuring the size of cell nuclei in living epithelial tissues using backscattered light is discussed...