J M Provenzale

..We hypothesized that the rate of change in diffusion-tensor imaging parameters in the first year of life would be greater in the splenium, especially during months 3-9...

..Based on the high degree of intra-observer variability, tumor measurements producing an increase in BP of >25% can routinely be obtained solely by chance...

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..In this article, we show the usefulness of our scheme by applying it to a specific, and particularly problematic, diagnosis in emergency radiology, namely that of dural sinus thrombosis...

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..Evaluation of the child with epilepsy is a relatively common indication for imaging in the emergency room setting. This room outlines some of the more important imaging features of causes of epilepsy in children...

..Those entities are presented here. In addition, a number of disease processes other than SAH can produce worst headache of life. Some of the most important entities, and their CT and MR findings, are reviewed here...

..Test performance characteristics for predicting infarct age of <24 and <48 h were relatively poor. In particular, PPV was very low for predicting infarcts <24 h old...

..This entity should be suspected in patients who present with insomnia, seizures, or hallucinations when imaging abnormalities are evident in the hippocampus, amygdala, and limbic structures beyond the medial temporal lobe...

..In addition to innovative forms of imaging, this review describes therapeutic uses of nanoparticles, such as drug delivery systems, neuroprotection devices, and methods for tissue regeneration...

..To test the hypothesis that patterns of signal intensity abnormality in human herpesvirus 6 (HHV6)-positive patients would allow distinction from patients who did not test positive for HHV6 encephalitis...

..This review describes the advantages of these two techniques for diagnosis and describes diagnostic pitfalls...

..This self-assessment module is intended to test the knowledge base of radiologists working in the emergency room setting...

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..This review discusses the role of MR imaging relative to plain radiographs and computed tomography in the evaluation of the patient with spinal trauma and presents a method for systematic review of MR images for assessing spinal injury...

..The work described here in Krabbe disease may serve as a model for application of DTI to other therapies in various WM disorders such as multiple sclerosis and dysmyelinating disorders of childhood...

..In addition, given the increasing number of means of obtaining diagnostic information, cost effectiveness studies are needed to better formulate an appropriate algorithm for each diagnosis...

..The purpose of this study was to perform a meta-analysis of the medical literature on perfusion imaging to determine its role in clinical decision making for patients with acute cerebral ischemia...

..To determine the maximum-tolerated dose (MTD) of iodine 131 (131I)-labeled 81C6 monoclonal antibody (mAb) in brain tumor patients with surgically created resection cavities (SCRCs) and to identify any objective responses to this treatment...

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..We conducted a phase I trial of carmustine (BCNU) plus O(6)-BG to define the toxicity and maximum-tolerated dose (MTD) of BCNU in conjunction with the preadministration of O(6)-BG with recurrent or progressive malignant glioma...

..Further research is needed to further characterize this disorder, particularly in regards to cognitive function and treatment implications...

..This feature would be expected to be helpful when the distinction between acute and nonacute infarction cannot be determined on clinical grounds...

..To determine the activity, toxicity, and pharmacokinetics of irinotecan (CPT-11, Camptosar; Pharmacia & Upjohn, Kalamazoo, MI) in the treatment of adults with progressive, persistent, or recurrent malignant glioma...

..Our purpose was to test the hypothesis that hyperintense signal changes on T2-weighted images produced by such infusions can be used to track drug distribution...

..Further clinical studies are warranted to determine the effectiveness of (131)I-mu81C6 mAb based on a target dose of 44 Gy rather than a fixed administered activity...

..47, P =.02). CONCLUSION: Good correlation was seen between CT and MR for CBF and MTT abnormalities. It remains uncertain whether CT perfusion CBV abnormalities correspond well to whole-brain abnormalities...

..CONCLUSION: The signal intensity of infarcts on DW images normalizes at 57 days, which is substantially later than previously suggested. T2 (shine-through) effect contributes largely to the total infarct signal intensity...

..These findings may indicate a role for diffusion MR imaging in the detection of tumoral infiltration that is not visible on conventional MR images...

..The data suggest that the attentional demands of this task are relatively greater for older adults and consequently lead to the recruitment of additional neural systems during task performance...

..CONCLUSION: In this small preliminary study, dynamic susceptibility perfusion MRI allowed distinction of cerebral abscesses from rim-enhancing high-grade gliomas. Validation of these results using a prospective large study is warranted...

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..The slower injection rates permitted by deconvolution analysis substantially enhance the practicality of CT perfusion imaging for studying stroke...

..The neuroradiologic findings in two patients are reported, and include abnormalities within the globus pallidus (both patients) and periventricular white matter (one patient)...

..To compare diffusion tensor magnetic resonance imaging with conventional T2-weighted imaging for evaluation of white matter changes in patients with Krabbe disease...

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..Further research is needed to better understand the interaction of microstructural changes and bipolar symptoms and whether these changes are specific to bipolar disorder...

..We hypothesized that both presence of vascular brain lesions seen on baseline magnetic resonance imaging (MRI) scans and lower baseline social support measures would be related to worse depression outcome...

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..In addition, plasma concentrations of O6-BG and O6-benzyl-8-oxoguanine were evaluated after O6-BG...

..Our findings, which suggest that relative permeability and rCBV values may be correlated in high-grade glial neoplasms, deserve further study in a larger patient population...

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..To assess the efficacy and toxicity of intraresection cavity iodine-131-labeled murine antitenascin monoclonal antibody 81C6 (131I-m81C6) among recurrent malignant brain tumor patients...

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..We hypothesized that smaller OFC volume would be associated with depression, greater hyperintense lesion volume and severity, and APOE epsilon4 or 5HTTLPR short allele carriers...

..This result is the first demonstration that the integrity of specific white matter tracts is a mediator of age-related changes in cognitive performance...

..We performed the current phase 2 study to evaluate this regimen among patients with recurrent WHO grade III malignant glioma (MG)...

..6% of catheters. Routine use of this algorithm, and its further developments, should improve prospective selection of catheter trajectories, and thereby improve the efficacy of drugs delivered by this promising technique...

..We hypothesized that hyperintense lesions are associated with alterations in white matter structure beyond the visible lesion boundaries as assessed with diffusion tensor imaging (DTI)...

..However, the potential efficacy of drugs delivered by this technique may be severely constrained by ineffective infusion in many patients...

..To measure mean cerebral blood flow (CBF) in ischemic and nonischemic territories and in low-attenuation regions in patients with acute stroke by using deconvolution-derived hemodynamic imaging...

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..This article reviews the sensitivity of CT for detection of SAH, some major patterns of SAH related to a ruptured aneurysm, and the differential diagnosis of SAH not due to aneurysmal rupture...

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..Future research should combine similar volumetric techniques with methods of identifying the location of lesions specific to late-life depression...

..99). CONCLUSION: The highest-rated AJR reviewers tended to be young and from academic institutions. The quality of peer review did not correlate with the sex, academic rank, or subspecialty of the reviewer...

..Older adults may place relatively greater emphasis on the attentional control of response regulation, in compensation for the age-related decline in visual processing efficiency...

..Dynamic CT perfusion imaging represents a widely available and minimally invasive alternative to other available methods of cerebral perfusion imaging...

..To assess the efficacy and toxicity of intraresection cavity (131)I-labeled murine antitenascin monoclonal antibody 81C6 and determine its true response rate among patients with newly diagnosed malignant glioma...

..Mean change in lesion volume and mean percentage of change were determined between the two time points. Logistic regression models were used to examine the differential effects of age, sex, race, and self-reported medical morbidity...

..We conclude that aging affects the neural mechanisms supporting word identification performance although behavioral measures of this ability are generally constant as a function of age...

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..We have extended these results, and now we report results of a phase II trial of Temodar for patients with progressive, low-grade glioma...

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..3 ml for gray matter, and from 0.4 to 96.8 ml for white matter. Our method proved to be efficient and reliable for quantifying lesions in MRI scans of the elderly...

..In this article, we review the hypotheses and MRI evidence relating to hippocampal injury during prolonged febrile seizures and the later development of medial temporal sclerosis...

..The authors correlated magnetic resonance imaging (MRI) lesion severity and mortality among depressed elderly patients...

..Because they are associated with age, they should increase in number and size over time. To our knowledge, this is the first longitudinal, volumetric MRI study of WMHs in depression...

..We concluded that white matter lesions are independently associated with functional impairment. Further studies are needed to understand how these lesions affect function, e.g., through effects on cognition or motor skills...

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..Reviewers who were older and of higher academic rank tended to discount the importance of manuscripts...

..The purpose of this study was to determine whether microstructural abnormalities in the white matter of the dorsolateral prefrontal cortex are associated with late-life depression...

..Deep white matter hyperintense lesions are associated with advanced age and late-life depression. The authors examined where age-related cerebral lesions occurred in elderly depressed and healthy control subjects...

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..9 weeks for recurrent anaplastic astrocytoma/ anaplastic oligodendroglioma patients. We conclude that the activity of BCNU plus CPT-11 for patients with MG appears comparable to that of CPT-11 alone and may be more toxic...

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..Gray matter hyperintensities in the basal ganglia may be especially associated with risk for suicide attempts...

..30. CONCLUSION: Vasogenic edema was more severe in posterior WM. Isointense lesions result from a balance of T2 effects and increased water diffusibility. Hypointense lesions have higher ADC values, which are not balanced by T2 effects...

..We report dynamic CT perfusion imaging assessment of hemodynamics in a patient with a high-grade cerebral glioma and compare our results to those of previously published studies...

..94; SEM, 0.36), and that of high-grade astrocytomas was 0.24 (SD, 0.18; SEM, 0.05) (P <.01). CONCLUSION: Measurements of water diffusivity and cellularity suggest that higher cellularity contributes to more restricted diffusion...

..e., mesial temporal sclerosis)...

..In addition, the role of these techniques for evaluating response to tumor therapy is outlined...

..Supratentorial subependymomas are generally solid, intraventricular masses that are usually smaller than ependymomas and occur in an order patient population...

..Small increases in cyst size did occur but were not associated with specific clinical findings. These findings suggest that typical pineal cysts may be followed up on a clinical basis alone rather than on imaging...

..Because treatment and prognosis are vastly different, the proper diagnosis of CNS-EES versus c-PNET is critical...

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..Currently, the patient remains neurologically normal except for a mild bilateral hearing loss more than 4 years after treatment and has no radiographic evidence of neoplastic meningitis...

..CONCLUSIONS: Hyperintensities damage the structure of brain tissue, and do so comparably in depressed subjects and control subjects...

..Anisotropy measurements may be more sensitive than those of MTRs in detecting subtle abnormalities in PWM...

..Our study demonstrates that TEMO can be given safely after placement of Gliadel (3.85%) wafers. The recommended dosage for TEMO for a phase II study of this combination is 200 mg/m2 per day for 5 days...

..The goals of this study were to systematically measure image quality and determine the prevalence of various types of artifacts produced by a 64-section scanner...

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..CONCLUSION: All patients had decreases in FA ratios over time. The early group had higher initial FA ratios and lower subsequent decreases, which may indicate amelioration of the dysmyelinating process...