Affiliation: Duke University Medical Center
- High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responsesJustin Pollara
Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
Cytometry A 79:603-12. 2011....
- Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgGGeorgia D Tomaras
Duke Human Vaccine Institute, and Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 110:9019-24. 2013..We show that monomeric Env-specific IgA, as part of postvaccination polyclonal antibody response, may modulate vaccine-induced immunity by diminishing ADCC effector function...
- Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2Hua Xin Liao
Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
Immunity 38:176-86. 2013..Variation may signal sites of HIV-1 envelope vulnerability, providing vaccine designers with new options...
- Mucosal immunization of lactating female rhesus monkeys with a transmitted/founder HIV-1 envelope induces strong Env-specific IgA antibody responses in breast milkGenevieve G A Fouda
Duke Human Vaccine Institute, Durham, North Carolina, USA
J Virol 87:6986-99. 2013..This study shows that systemic MVA prime followed by either intranasal or systemic protein boosts can elicit strong humoral responses in breast milk and may be a useful strategy to interrupt postnatal HIV-1 transmission...
- Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrumJames Friedman
Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States
PLoS ONE 7:e37648. 2012..Therefore, characterization of HIV-specific antibodies produced by B cells in milk could guide the development of vaccines that elicit protective mucosal antibody responses...
- Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene familyMattia Bonsignori
Duke University Medical Center, Durham, North Carolina, USA
J Virol 86:11521-32. 2012..The polyclonality and low mutation frequency of these VH1 antibodies reveal fundamental differences in the regulation and maturation of these ADCC-mediating responses compared to VH1 bNAbs...
- HIV-1 gp120 vaccine induces affinity maturation in both new and persistent antibody clonal lineagesM Anthony Moody
Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, USA
J Virol 86:7496-507. 2012..Improved vaccination strategies will be needed to drive persistent stimulation of antibody clonal lineages to induce affinity maturation that results in highly mutated HIV-1 Env-reactive antibodies...
- HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodiesGenevieve G Fouda
Duke Human Vaccine Institute, Duke University Medical Center, Box 103020, Durham, NC 27710, USA
J Virol 85:9555-67. 2011..These results suggest that plasma-derived IgG antibodies mediate the majority of the low-level HIV neutralization and ADCC activity in breast milk...
- An HIV-1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serumGuido Ferrari
Duke University Medical Center, Department of Surgery, P O Box 2926, Durham, NC 27710, USA
J Virol 85:7029-36. 2011..These data demonstrate that the epitope defined by MAb A32 is a major target on gp120 for plasma ADCC activity...