Justin Pollara

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses
    Justin Pollara
    Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    Cytometry A 79:603-12. 2011
  2. pmc Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG
    Georgia D Tomaras
    Duke Human Vaccine Institute, and Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 110:9019-24. 2013
  3. pmc Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2
    Hua Xin Liao
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
    Immunity 38:176-86. 2013
  4. pmc Epitope specificity of human immunodeficiency virus-1 antibody dependent cellular cytotoxicity [ADCC] responses
    Justin Pollara
    Department of Surgery, Duke University Medical Center, P O Box 2926, Durham, NC 27710, USA
    Curr HIV Res 11:378-87. 2013
  5. ncbi request reprint HIV-1 Vaccine-Induced C1 and V2 Env-Specific Antibodies Synergize for Increased Antiviral Activities
    Justin Pollara
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    J Virol 88:7715-26. 2014
  6. pmc Mucosal immunization of lactating female rhesus monkeys with a transmitted/founder HIV-1 envelope induces strong Env-specific IgA antibody responses in breast milk
    Genevieve G A Fouda
    Duke Human Vaccine Institute, Durham, North Carolina, USA
    J Virol 87:6986-99. 2013
  7. pmc Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrum
    James Friedman
    Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States
    PLoS ONE 7:e37648. 2012
  8. pmc Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family
    Mattia Bonsignori
    Duke University Medical Center, Durham, North Carolina, USA
    J Virol 86:11521-32. 2012
  9. pmc HIV-1 gp120 vaccine induces affinity maturation in both new and persistent antibody clonal lineages
    M Anthony Moody
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, USA
    J Virol 86:7496-507. 2012
  10. pmc HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodies
    Genevieve G Fouda
    Duke Human Vaccine Institute, Duke University Medical Center, Box 103020, Durham, NC 27710, USA
    J Virol 85:9555-67. 2011

Collaborators

Detail Information

Publications11

  1. pmc High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses
    Justin Pollara
    Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    Cytometry A 79:603-12. 2011
    ....
  2. pmc Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG
    Georgia D Tomaras
    Duke Human Vaccine Institute, and Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 110:9019-24. 2013
    ..We show that monomeric Env-specific IgA, as part of postvaccination polyclonal antibody response, may modulate vaccine-induced immunity by diminishing ADCC effector function...
  3. pmc Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2
    Hua Xin Liao
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
    Immunity 38:176-86. 2013
    ..Variation may signal sites of HIV-1 envelope vulnerability, providing vaccine designers with new options...
  4. pmc Epitope specificity of human immunodeficiency virus-1 antibody dependent cellular cytotoxicity [ADCC] responses
    Justin Pollara
    Department of Surgery, Duke University Medical Center, P O Box 2926, Durham, NC 27710, USA
    Curr HIV Res 11:378-87. 2013
    ..Here we discuss the HIV-1 envelope epitopes targeted by ADCC antibodies in the context of the potential protective capacities of ADCC. ..
  5. ncbi request reprint HIV-1 Vaccine-Induced C1 and V2 Env-Specific Antibodies Synergize for Increased Antiviral Activities
    Justin Pollara
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    J Virol 88:7715-26. 2014
    ....
  6. pmc Mucosal immunization of lactating female rhesus monkeys with a transmitted/founder HIV-1 envelope induces strong Env-specific IgA antibody responses in breast milk
    Genevieve G A Fouda
    Duke Human Vaccine Institute, Durham, North Carolina, USA
    J Virol 87:6986-99. 2013
    ..This study shows that systemic MVA prime followed by either intranasal or systemic protein boosts can elicit strong humoral responses in breast milk and may be a useful strategy to interrupt postnatal HIV-1 transmission...
  7. pmc Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrum
    James Friedman
    Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States
    PLoS ONE 7:e37648. 2012
    ..Therefore, characterization of HIV-specific antibodies produced by B cells in milk could guide the development of vaccines that elicit protective mucosal antibody responses...
  8. pmc Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family
    Mattia Bonsignori
    Duke University Medical Center, Durham, North Carolina, USA
    J Virol 86:11521-32. 2012
    ..The polyclonality and low mutation frequency of these VH1 antibodies reveal fundamental differences in the regulation and maturation of these ADCC-mediating responses compared to VH1 bNAbs...
  9. pmc HIV-1 gp120 vaccine induces affinity maturation in both new and persistent antibody clonal lineages
    M Anthony Moody
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, USA
    J Virol 86:7496-507. 2012
    ..Improved vaccination strategies will be needed to drive persistent stimulation of antibody clonal lineages to induce affinity maturation that results in highly mutated HIV-1 Env-reactive antibodies...
  10. pmc HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodies
    Genevieve G Fouda
    Duke Human Vaccine Institute, Duke University Medical Center, Box 103020, Durham, NC 27710, USA
    J Virol 85:9555-67. 2011
    ..These results suggest that plasma-derived IgG antibodies mediate the majority of the low-level HIV neutralization and ADCC activity in breast milk...
  11. pmc An HIV-1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serum
    Guido Ferrari
    Duke University Medical Center, Department of Surgery, P O Box 2926, Durham, NC 27710, USA
    J Virol 85:7029-36. 2011
    ..These data demonstrate that the epitope defined by MAb A32 is a major target on gp120 for plasma ADCC activity...