Justin Pollara

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses
    Justin Pollara
    Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    Cytometry A 79:603-12. 2011
  2. pmc Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG
    Georgia D Tomaras
    Duke Human Vaccine Institute, and Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 110:9019-24. 2013
  3. pmc Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2
    Hua Xin Liao
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
    Immunity 38:176-86. 2013
  4. pmc Mucosal immunization of lactating female rhesus monkeys with a transmitted/founder HIV-1 envelope induces strong Env-specific IgA antibody responses in breast milk
    Genevieve G A Fouda
    Duke Human Vaccine Institute, Durham, North Carolina, USA
    J Virol 87:6986-99. 2013
  5. pmc Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrum
    James Friedman
    Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States
    PLoS ONE 7:e37648. 2012
  6. pmc Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family
    Mattia Bonsignori
    Duke University Medical Center, Durham, North Carolina, USA
    J Virol 86:11521-32. 2012
  7. pmc HIV-1 gp120 vaccine induces affinity maturation in both new and persistent antibody clonal lineages
    M Anthony Moody
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, USA
    J Virol 86:7496-507. 2012
  8. pmc HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodies
    Genevieve G Fouda
    Duke Human Vaccine Institute, Duke University Medical Center, Box 103020, Durham, NC 27710, USA
    J Virol 85:9555-67. 2011
  9. pmc An HIV-1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serum
    Guido Ferrari
    Duke University Medical Center, Department of Surgery, P O Box 2926, Durham, NC 27710, USA
    J Virol 85:7029-36. 2011

Collaborators

Detail Information

Publications9

  1. pmc High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses
    Justin Pollara
    Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    Cytometry A 79:603-12. 2011
    ....
  2. pmc Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG
    Georgia D Tomaras
    Duke Human Vaccine Institute, and Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 110:9019-24. 2013
    ..We show that monomeric Env-specific IgA, as part of postvaccination polyclonal antibody response, may modulate vaccine-induced immunity by diminishing ADCC effector function...
  3. pmc Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2
    Hua Xin Liao
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
    Immunity 38:176-86. 2013
    ..Variation may signal sites of HIV-1 envelope vulnerability, providing vaccine designers with new options...
  4. pmc Mucosal immunization of lactating female rhesus monkeys with a transmitted/founder HIV-1 envelope induces strong Env-specific IgA antibody responses in breast milk
    Genevieve G A Fouda
    Duke Human Vaccine Institute, Durham, North Carolina, USA
    J Virol 87:6986-99. 2013
    ..This study shows that systemic MVA prime followed by either intranasal or systemic protein boosts can elicit strong humoral responses in breast milk and may be a useful strategy to interrupt postnatal HIV-1 transmission...
  5. pmc Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrum
    James Friedman
    Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States
    PLoS ONE 7:e37648. 2012
    ..Therefore, characterization of HIV-specific antibodies produced by B cells in milk could guide the development of vaccines that elicit protective mucosal antibody responses...
  6. pmc Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family
    Mattia Bonsignori
    Duke University Medical Center, Durham, North Carolina, USA
    J Virol 86:11521-32. 2012
    ..The polyclonality and low mutation frequency of these VH1 antibodies reveal fundamental differences in the regulation and maturation of these ADCC-mediating responses compared to VH1 bNAbs...
  7. pmc HIV-1 gp120 vaccine induces affinity maturation in both new and persistent antibody clonal lineages
    M Anthony Moody
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, USA
    J Virol 86:7496-507. 2012
    ..Improved vaccination strategies will be needed to drive persistent stimulation of antibody clonal lineages to induce affinity maturation that results in highly mutated HIV-1 Env-reactive antibodies...
  8. pmc HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodies
    Genevieve G Fouda
    Duke Human Vaccine Institute, Duke University Medical Center, Box 103020, Durham, NC 27710, USA
    J Virol 85:9555-67. 2011
    ..These results suggest that plasma-derived IgG antibodies mediate the majority of the low-level HIV neutralization and ADCC activity in breast milk...
  9. pmc An HIV-1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serum
    Guido Ferrari
    Duke University Medical Center, Department of Surgery, P O Box 2926, Durham, NC 27710, USA
    J Virol 85:7029-36. 2011
    ..These data demonstrate that the epitope defined by MAb A32 is a major target on gp120 for plasma ADCC activity...