J A Pitcher

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint G protein-coupled receptor kinases
    J A Pitcher
    Howard Hughes Medical Institute, Department of Medicine Cardiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Biochem 67:653-92. 1998
  2. pmc beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein
    R T Premont
    Departments of Medicine Cardiology and Biochemistry, Howard Hughes Medical Institute, Box 3821, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 95:14082-7. 1998
  3. ncbi request reprint G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction
    R A Hall
    Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 274:24328-34. 1999
  4. ncbi request reprint Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies
    J A Pitcher
    Departments of Medicine and Biochemistry, Howard Hughes Medical Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 271:24907-13. 1996
  5. ncbi request reprint Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases
    J A Pitcher
    Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 274:34531-4. 1999
  6. ncbi request reprint Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79
    M Cong
    Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 276:15192-9. 2001
  7. ncbi request reprint Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation
    P H McDonald
    Howard Hughes Medical Institute and the Departments of Medicine Cardiology and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 274:10677-80. 1999
  8. pmc Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor
    Y Tang
    Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 96:12559-64. 1999
  9. ncbi request reprint Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor
    Z L Fredericks
    Department of Biochemistry, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 271:13796-803. 1996
  10. ncbi request reprint The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange
    R A Hall
    Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 392:626-30. 1998

Collaborators

Detail Information

Publications12

  1. ncbi request reprint G protein-coupled receptor kinases
    J A Pitcher
    Howard Hughes Medical Institute, Department of Medicine Cardiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Biochem 67:653-92. 1998
    ..Studies employing recombinant, purified proteins, cell culture, and transgenic animal models attest to the general importance of GRKs in regulating a vast array of GPCRs both in vitro and in vivo...
  2. pmc beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein
    R T Premont
    Departments of Medicine Cardiology and Biochemistry, Howard Hughes Medical Institute, Box 3821, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 95:14082-7. 1998
    ..Moreover, they provide a mechanism for integration of receptor activation and endocytosis through regulation of ARF protein activation by GRK-mediated recruitment of the GIT1 ARF GAP to the plasma membrane...
  3. ncbi request reprint G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction
    R A Hall
    Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 274:24328-34. 1999
    ..These data suggest that GRK6A phosphorylates NHERF via a PDZ domain-mediated interaction and that GRK6A is the kinase in HEK-293 cells responsible for the constitutive phosphorylation of NHERF...
  4. ncbi request reprint Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies
    J A Pitcher
    Departments of Medicine and Biochemistry, Howard Hughes Medical Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 271:24907-13. 1996
    ..However, the structure, location, and regulation of the PIP2 binding site distinguishes the betaARK (GRK2 and GRK3) and GRK4 (GRK4, GRK5, and GRK6) subfamilies...
  5. ncbi request reprint Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases
    J A Pitcher
    Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 274:34531-4. 1999
    ....
  6. ncbi request reprint Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79
    M Cong
    Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 276:15192-9. 2001
    ..Agonist-stimulated PKA-mediated phosphorylation of GRK2 may represent a mechanism for enhancing receptor phosphorylation and desensitization...
  7. ncbi request reprint Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation
    P H McDonald
    Howard Hughes Medical Institute and the Departments of Medicine Cardiology and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 274:10677-80. 1999
    ....
  8. pmc Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor
    Y Tang
    Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 96:12559-64. 1999
    ....
  9. ncbi request reprint Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor
    Z L Fredericks
    Department of Biochemistry, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 271:13796-803. 1996
    ..The location of multiple GRK2 and GRK5 phosphoacceptor sites at the extreme carboxyl terminus of the beta2AR is highly reminiscent of GRK1-mediated phosphorylation of rhodopsin...
  10. ncbi request reprint The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange
    R A Hall
    Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 392:626-30. 1998
    ..Our findings indicate that agonist-dependent beta2-adrenergic receptor binding of NHERF plays a role in beta2-adrenergic receptor-mediated regulation of Na+/H+ exchange...
  11. ncbi request reprint Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1
    F T Lin
    Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 272:31051-7. 1997
    ..Thus, as with the classical endocytic adaptor protein complex AP2, beta-arrestin1 functions as a clathrin adaptor in receptor endocytosis which is regulated by dephosphorylation at the plasma membrane...
  12. ncbi request reprint Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants
    R T Premont
    Department of Medicine Cardiology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 271:6403-10. 1996
    ....