J A Pitcher

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi G protein-coupled receptor kinases
    J A Pitcher
    Howard Hughes Medical Institute, Department of Medicine Cardiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Biochem 67:653-92. 1998
  2. ncbi beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein
    R T Premont
    Departments of Medicine Cardiology and Biochemistry, Howard Hughes Medical Institute, Box 3821, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 95:14082-7. 1998
  3. ncbi G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction
    R A Hall
    Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 274:24328-34. 1999
  4. ncbi Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases
    J A Pitcher
    Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 274:34531-4. 1999
  5. ncbi Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79
    M Cong
    Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 276:15192-9. 2001
  6. ncbi Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation
    P H McDonald
    Howard Hughes Medical Institute and the Departments of Medicine Cardiology and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 274:10677-80. 1999
  7. ncbi Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor
    Y Tang
    Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 96:12559-64. 1999
  8. ncbi Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor
    Z L Fredericks
    Department of Biochemistry, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 271:13796-803. 1996
  9. ncbi The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange
    R A Hall
    Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 392:626-30. 1998
  10. ncbi Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1
    F T Lin
    Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 272:31051-7. 1997

Collaborators

Detail Information

Publications11

  1. ncbi G protein-coupled receptor kinases
    J A Pitcher
    Howard Hughes Medical Institute, Department of Medicine Cardiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Biochem 67:653-92. 1998
    ..Studies employing recombinant, purified proteins, cell culture, and transgenic animal models attest to the general importance of GRKs in regulating a vast array of GPCRs both in vitro and in vivo...
  2. ncbi beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein
    R T Premont
    Departments of Medicine Cardiology and Biochemistry, Howard Hughes Medical Institute, Box 3821, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 95:14082-7. 1998
    ..Moreover, they provide a mechanism for integration of receptor activation and endocytosis through regulation of ARF protein activation by GRK-mediated recruitment of the GIT1 ARF GAP to the plasma membrane...
  3. ncbi G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction
    R A Hall
    Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 274:24328-34. 1999
    ..These data suggest that GRK6A phosphorylates NHERF via a PDZ domain-mediated interaction and that GRK6A is the kinase in HEK-293 cells responsible for the constitutive phosphorylation of NHERF...
  4. ncbi Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases
    J A Pitcher
    Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 274:34531-4. 1999
    ....
  5. ncbi Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79
    M Cong
    Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 276:15192-9. 2001
    ..Agonist-stimulated PKA-mediated phosphorylation of GRK2 may represent a mechanism for enhancing receptor phosphorylation and desensitization...
  6. ncbi Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation
    P H McDonald
    Howard Hughes Medical Institute and the Departments of Medicine Cardiology and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 274:10677-80. 1999
    ....
  7. ncbi Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor
    Y Tang
    Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 96:12559-64. 1999
    ....
  8. ncbi Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor
    Z L Fredericks
    Department of Biochemistry, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 271:13796-803. 1996
    ..The location of multiple GRK2 and GRK5 phosphoacceptor sites at the extreme carboxyl terminus of the beta2AR is highly reminiscent of GRK1-mediated phosphorylation of rhodopsin...
  9. ncbi The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange
    R A Hall
    Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 392:626-30. 1998
    ..Our findings indicate that agonist-dependent beta2-adrenergic receptor binding of NHERF plays a role in beta2-adrenergic receptor-mediated regulation of Na+/H+ exchange...
  10. ncbi Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1
    F T Lin
    Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 272:31051-7. 1997
    ..Thus, as with the classical endocytic adaptor protein complex AP2, beta-arrestin1 functions as a clathrin adaptor in receptor endocytosis which is regulated by dephosphorylation at the plasma membrane...
  11. ncbi Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants
    R T Premont
    Department of Medicine Cardiology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 271:6403-10. 1996
    ....