Pisetsky D. Cell death in the pathogenesis of immune-mediated diseases: the role of HMGB1 and DAMP-PAMP complexes. Swiss Med Wkly. 2011;141:w13256 pubmed publisher
Pisetsky D, Jiang N. The generation of extracellular DNA in SLE: the role of death and sex. Scand J Immunol. 2006;64:200-4 pubmed
..Together, these studies clarify the origin of extracellular DNA circulating in the blood in SLE and suggest steps in this process that can be interdicted by novel therapy. ..
Pisetsky D, Ullal A. The blood nucleome in the pathogenesis of SLE. Autoimmun Rev. 2010;10:35-7 pubmed publisher
..Together, these findings suggest that cell death is an important event in lupus pathogenesis and can provide a supply of blood DNA essential for immune complex formation. ..
Pisetsky D. Antinuclear antibodies in rheumatic disease: a proposal for a function-based classification. Scand J Immunol. 2012;76:223-8 pubmed publisher
..This classification provides a framework to elucidate the serological features of rheumatic disease and the often uncertain relationship between ANA expression and disease manifestations. ..
Pisetsky D, Lipsky P. Microparticles as autoadjuvants in the pathogenesis of SLE. Nat Rev Rheumatol. 2010;6:368-72 pubmed publisher
..We would therefore advance the idea that a model for SLE based on MP autoadjuvants can provide a new paradigm to elucidate the mechanisms by which DNA and RNA affect the immune system and critically influence B-cell fate. ..