Research Topics
Genomes and Genes | S R PinnellSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Publications
Microfine zinc oxide is a superior sunscreen ingredient to microfine titanium dioxideS R Pinnell
Division of Dermatology, Duke University Medical Center, Durham, North Carolina, USA
Dermatol Surg 26:309-14. 2000..Microfine zinc oxide and microfine titanium dioxide are particulate sunscreen ingredients that absorb broad-spectrum ultraviolet (UV) irradiation...
Topical L-ascorbic acid: percutaneous absorption studiesS R Pinnell
Duke University Medical Center, Department of Medicine, Durham, North Carolina 27707, USA
Dermatol Surg 27:137-42. 2001..Reactive oxygen species generated by ultraviolet light result in photocarcinogenic and photoaging changes in the skin. Antioxidants protect skin from these insults...
Cutaneous photodamage, oxidative stress, and topical antioxidant protectionSheldon R Pinnell
Duke University Medical Center, Department of Medicine, Division of Dermatology, Durham, North Carolina 27707, USA
J Am Acad Dermatol 48:1-19; quiz 20-2. 2003....
Regulation of lysyl oxidase mRNA in dermal fibroblasts from normal donors and patients with inherited connective tissue disordersH N Yeowell
Division of Dermatology, Duke University Medical Center, Durham, North Carolina 27710
Arch Biochem Biophys 308:299-305. 1994....
Construction of a full-length murine pro alpha 2(I) collagen cDNA by the polymerase chain reactionC L Phillips
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
J Invest Dermatol 97:980-4. 1991..The homology between human and mouse is less in the amino terminal propeptide than in the triple helical domain; exon 5 of murine COL1A2 codes for an additional six amino acids not found in human COL1A2...
A patient with Ehlers-Danlos syndrome type VI is a compound heterozygote for mutations in the lysyl hydroxylase geneV T Ha
Division of Dermatology, Duke University Medical Center, Durham, North Carolina 27710
J Clin Invest 93:1716-21. 1994..This study represents the first example of compound heterozygosity for the LH gene in an EDS VI patient, and it appears that there is an additive effect of each mutant allele on clinical expression in this patient...
Characterization of a partial cDNA for lysyl hydroxylase from human skin fibroblasts; lysyl hydroxylase mRNAs are regulated differently by minoxidil derivatives and hydralazineH N Yeowell
Duke University Medical Center, Division of Dermatology, Durham, NC 27710
J Invest Dermatol 99:864-9. 1992....
A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiationJohn C Murray
Division of Dermatology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Am Acad Dermatol 59:418-25. 2008..Skin cancer and photoaging changes result from ultraviolet (UV)-induced oxidative stress. Topical antioxidants may protect skin from these effects...
Evidence supporting zinc as an important antioxidant for skinElizabeth F Rostan
Duke University, Durham, NC 27710, USA
Int J Dermatol 41:606-11. 2002..No matter how they work, topical zinc ions may provide an important and helpful antioxidant defense for skin...
UV photoprotection by combination topical antioxidants vitamin C and vitamin EJing-Yi Lin
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
J Am Acad Dermatol 48:866-74. 2003..CONCLUSION: Appreciable photoprotection can be obtained from the combination of topical vitamins C and E. We suggest that these natural products may protect against skin cancer and photoaging...
Alpha-lipoic acid is ineffective as a topical antioxidant for photoprotection of skinJing-Yi Lin
J Invest Dermatol 123:996-8. 2004
Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skinFu-Hsiung Lin
Duke University Medical Center, Durham, North Carolina 27710, USA
J Invest Dermatol 125:826-32. 2005..This combination of pure natural low molecular weight antioxidants provides meaningful synergistic protection against oxidative stress in skin and should be useful for protection against photoaging and skin cancer...
Ubiquinone, idebenone, and kinetin provide ineffective photoprotection to skin when compared to a topical antioxidant combination of vitamins C and E with ferulic acidJoshua A Tournas
J Invest Dermatol 126:1185-7. 2006
Ascorbyl-6-palmitate is not ascorbic acidSheldon R Pinnell
Department of Medicine, Duke University Medical Center, USA
J Invest Dermatol 119:991. 2002
