CLAUDE PIANTADOSI

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis
    Timothy E Sweeney
    Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 6:e25249. 2011
  2. pmc Redox regulation of mitochondrial biogenesis
    Claude A Piantadosi
    Department of Medicine, Duke University Medical Center and the Durham VA Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 53:2043-53. 2012
  3. pmc Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes
    Claude A Piantadosi
    Department of Medicine, Duke University Medical Center, and Durham VA Medical Center, Durham, NC 27710, USA
    Biochim Biophys Acta 1820:532-41. 2012
  4. pmc Regulation of mitochondrial processes by protein S-nitrosylation
    Claude A Piantadosi
    Departments of Medicine and Pathology, Box 3315, Duke University Medical Center, Durham, NC 27710, USA
    Biochim Biophys Acta 1820:712-21. 2012
  5. pmc Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis
    Nancy Chou Macgarvey
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 185:851-61. 2012
  6. pmc Iron homeostasis and oxidative stress in idiopathic pulmonary alveolar proteinosis: a case-control study
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Respir Res 9:10. 2008
  7. pmc Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression
    Claude A Piantadosi
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 286:16374-85. 2011
  8. ncbi request reprint Mitochondrial transcription factor A induction by redox activation of nuclear respiratory factor 1
    Claude A Piantadosi
    Department of Medicine, Duke University, Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 281:324-33. 2006
  9. doi request reprint Early development of near-infrared spectroscopy at Duke University
    Claude A Piantadosi
    Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biomed Opt 12:062102. 2007
  10. pmc Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1
    Claude A Piantadosi
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Circ Res 103:1232-40. 2008

Research Grants

  1. CORE--PRIMATE STUDIES
    CLAUDE PIANTADOSI; Fiscal Year: 2004
  2. Nitric oxide and mitochondrial biogenesis in sepsis
    Claude A Piantadosi; Fiscal Year: 2010
  3. Regulation of mitochondrial biogenesis by heme oxygenase-1
    CLAUDE PIANTADOSI; Fiscal Year: 2009
  4. Nitric oxide and mitochondrial biogenesis in sepsis
    CLAUDE PIANTADOSI; Fiscal Year: 2009
  5. Lung Injury Protection by Coagulation Blockade
    CLAUDE PIANTADOSI; Fiscal Year: 2007
  6. Nitric oxide and mitochondrial biogenesis in sepsis
    CLAUDE PIANTADOSI; Fiscal Year: 2007
  7. Lung Injury Protection by Coagulation Blockade
    CLAUDE PIANTADOSI; Fiscal Year: 2006
  8. Nitric oxide and mitochondrial biogenesis in sepsis
    CLAUDE PIANTADOSI; Fiscal Year: 2006
  9. Lung Injury Protection by Coagulation Blockade
    CLAUDE PIANTADOSI; Fiscal Year: 2005
  10. Regulation of mitochondrial biogenesis by heme oxygenase-1
    Claude A Piantadosi; Fiscal Year: 2010

Collaborators

Detail Information

Publications86

  1. pmc A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis
    Timothy E Sweeney
    Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 6:e25249. 2011
    ..aureus sepsis that links TLR2 and TLR4 signaling in innate immunity to Ppargc1a/b gene regulation in a critical metabolic organ, the liver, by means of TRAM, TRIF, and IRF-7...
  2. pmc Redox regulation of mitochondrial biogenesis
    Claude A Piantadosi
    Department of Medicine, Duke University Medical Center and the Durham VA Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 53:2043-53. 2012
    ....
  3. pmc Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes
    Claude A Piantadosi
    Department of Medicine, Duke University Medical Center, and Durham VA Medical Center, Durham, NC 27710, USA
    Biochim Biophys Acta 1820:532-41. 2012
    ..Recent evidence indicates that these cell defenses also include mitochondrial biogenesis and the clearance of damaged mitochondria through autophagy...
  4. pmc Regulation of mitochondrial processes by protein S-nitrosylation
    Claude A Piantadosi
    Departments of Medicine and Pathology, Box 3315, Duke University Medical Center, Durham, NC 27710, USA
    Biochim Biophys Acta 1820:712-21. 2012
    ..A small number of SNO proteins, generated by various mechanisms, are characteristically found in mammalian mitochondria and influence the regulation of oxidative phosphorylation and other aspects of mitochondrial function...
  5. pmc Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis
    Nancy Chou Macgarvey
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 185:851-61. 2012
    ....
  6. pmc Iron homeostasis and oxidative stress in idiopathic pulmonary alveolar proteinosis: a case-control study
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Respir Res 9:10. 2008
    ..Because inhaled particles, such as silica, and certain infections can cause secondary pulmonary alveolar proteinosis (PAP), we tested the hypothesis that idiopathic PAP is associated with an altered iron homeostasis in the human lung...
  7. pmc Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression
    Claude A Piantadosi
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 286:16374-85. 2011
    ..These findings disclose a highly structured transcriptional network that couples mitochondrial biogenesis to counter-inflammation with major implications for immune suppression in sepsis...
  8. ncbi request reprint Mitochondrial transcription factor A induction by redox activation of nuclear respiratory factor 1
    Claude A Piantadosi
    Department of Medicine, Duke University, Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 281:324-33. 2006
    ..This study discloses novel redox regulation of NRF-1 phosphorylation and nuclear translocation by phosphatidylinositol 3,4,5-triphosphate kinase/Akt signaling in controlling Tfam induction by an anti-oxidant pro-survival network...
  9. doi request reprint Early development of near-infrared spectroscopy at Duke University
    Claude A Piantadosi
    Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biomed Opt 12:062102. 2007
    ..The ability to noninvasively monitor the O(2) delivery-uptake relationship has made NIR spectroscopy a unique tool for the assessment of tissue oxygen sufficiency in health and disease...
  10. pmc Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1
    Claude A Piantadosi
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Circ Res 103:1232-40. 2008
    ....
  11. pmc Transcriptional Regulation of SDHa flavoprotein by nuclear respiratory factor-1 prevents pseudo-hypoxia in aerobic cardiac cells
    Claude A Piantadosi
    Department of Medicine, Duke University School of Medicine and the Durham Veteran s Administration Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 283:10967-77. 2008
    ..These findings disclose a novel role for NRF-1 in the transcriptional control of Complex II and prevention of pseudo-hypoxic gene expression in aerobic cardiac cells...
  12. pmc Carbon monoxide, reactive oxygen signaling, and oxidative stress
    Claude A Piantadosi
    Department of Medicine, Duke University Medical Center, Box 3315 CR II Building White Zone, Trent Drive, Durham, NC 27710, USA
    Free Radic Biol Med 45:562-9. 2008
    ..This brief overview provides a conceptual framework for understanding CO biology in terms of this physiological-pathological hierarchy...
  13. ncbi request reprint The acute respiratory distress syndrome
    Claude A Piantadosi
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Intern Med 141:460-70. 2004
  14. ncbi request reprint Pathology: whales, sonar and decompression sickness
    Claude A Piantadosi
    Center for Hyperbaric Medicine and Environmental Physiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 428:1 p following 716; discussion 2 p following 716. 2004
    ..Although gas-bubble formation may be aggravated by acoustic energy, more rigorous investigation is needed before sonar can be firmly linked to bubble formation in whales...
  15. ncbi request reprint Nitric oxide and differential effects of ATP on mitochondrial permeability transition
    Claude A Piantadosi
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nitric Oxide 6:45-60. 2002
    ..These data indicate NO can influence pore transition by oxidation of thiols that produce conformational changes governing the ATP interaction at the adenine nucleotide transporter...
  16. ncbi request reprint Lunar exploration and the advancement of biomedical research: a physiologist's view
    Claude A Piantadosi
    Department of Medicine, and Center for Hyperbaric Medicine and Environmental Physiology, Duke University Medical Center, Durham, NC 27710, USA
    Aviat Space Environ Med 77:1084-6. 2006
    ..This commentary presents a rationale for focusing American efforts in space on such a Moon base in order to promote understanding of the long-term physiological effects of living on a planetary body outside the Van Allen belts...
  17. ncbi request reprint Biological chemistry of carbon monoxide
    Claude A Piantadosi
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Antioxid Redox Signal 4:259-70. 2002
    ..This article provides a brief update on the biochemistry of CO as it relates to Hp binding, chemical oxidative processes, and cellular function...
  18. pmc "Oxygenated" water and athletic performance
    C A Piantadosi
    Duke University Medical Center, Durham, NC 27710, USA
    Br J Sports Med 40:740-1; discussion 740-1. 2006
  19. ncbi request reprint How do red blood cells cause hypoxic vasodilation? The SNO-hemoglobin paradigm
    Barry W Allen
    DUMC 3315, Durham, NC 27710, USA
    Am J Physiol Heart Circ Physiol 291:H1507-12. 2006
    ..SNO-hemoglobin is the archetype for the role of S-nitrosylation in a newly identified class of biological signals, and disturbances in SNO-hemoglobin activity are associated with the pathogenesis of several important vascular diseases...
  20. ncbi request reprint Carbon monoxide, oxidative stress, and mitochondrial permeability pore transition
    Claude A Piantadosi
    Departments of Medicine and Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 40:1332-9. 2006
    ..The implications are that cellular CO can activate or deactivate mitochondria for initiation of apoptosis in vivo...
  21. ncbi request reprint Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1
    Hagir B Suliman
    Departments of Medicine, Anesthesiology, and Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 278:41510-8. 2003
    ..NRF-1 expression and growth were restored by exogenous oxidant exposure indicating that oxidative stress stimulates biogenesis in part via NRF-1 activation and corresponding to recovery events after LPS-induced liver damage...
  22. ncbi request reprint Regulation of the brain's vascular responses to oxygen
    Ivan T Demchenko
    Duke University Medical Center, Durham NC 27710, USA
    Circ Res 91:1031-7. 2002
    ..Thus, EC-SOD promotes NO* vasodilation by scavenging *O2- while hyperoxia opposes NO* and promotes constriction by enhancing endogenous *O2- generation and decreasing basal vasodilator effects of NO*...
  23. pmc A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension
    Timothy J McMahon
    Department of Medicine and Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 102:14801-6. 2005
    ..Chemical restoration of SNO-Hb levels in both animals and patients restores the vasodilator activity of RBCs, and this activity is associated with improved oxygenation and lower PAPs...
  24. ncbi request reprint Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia
    Hagir B Suliman
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Blood 104:43-50. 2004
    ....
  25. ncbi request reprint Nitric oxide in the human respiratory cycle
    Timothy J McMahon
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Nat Med 8:711-7. 2002
    ..Our results also help elucidate the link between RBC dyscrasias and cardiovascular morbidity...
  26. pmc Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart
    Martha S Carraway
    Duke University Medical Center, 0570 CR II Building White Zone, 200 Trent Dr, Durham NC 27710, USA
    Circ Res 106:1722-30. 2010
    ....
  27. ncbi request reprint A new activating role for CO in cardiac mitochondrial biogenesis
    Hagit B Suliman
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Sci 120:299-308. 2007
    ..The findings disclose mitochondrial CO and H(2)O(2) as new activating factors in cardiac mitochondrial biogenesis...
  28. ncbi request reprint Similar but not the same: normobaric and hyperbaric pulmonary oxygen toxicity, the role of nitric oxide
    Ivan T Demchenko
    Center for Hyperbaric Medicine and Environmental Physiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 293:L229-38. 2007
    ..We propose that extrapulmonary, neurogenic events predominate in the pathogenesis of acute pulmonary oxygen toxicity in hyperbaric oxygenation, as nNOS activity drives lung injury by modulating the output of central autonomic pathways...
  29. pmc Mitochondrial biogenesis restores oxidative metabolism during Staphylococcus aureus sepsis
    Douglas W Haden
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 176:768-77. 2007
    ..The extent, timing, and significance of mitochondrial injury and recovery in bacterial sepsis are poorly characterized, although oxidative and nitrosative mitochondrial damage have been implicated in the development of organ failure...
  30. pmc Nitric oxide synthase-2 regulates mitochondrial Hsp60 chaperone function during bacterial peritonitis in mice
    Hagir B Suliman
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 48:736-46. 2010
    ....
  31. ncbi request reprint Superoxide-dependent iron uptake: a new role for anion exchange protein 2
    Andrew J Ghio
    P O Box 3315, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Cell Mol Biol 29:653-60. 2003
    ..We thus disclose a novel ferri-reductase mechanism of NTBI uptake by human lung cells that employs superoxide exchange for HCO3- by AE2 protein in the plasma membrane...
  32. pmc Nitric oxide synthase-2 induction optimizes cardiac mitochondrial biogenesis after endotoxemia
    Crystal M Reynolds
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 46:564-72. 2009
    ..These findings demonstrate the decisive participation of NOS2 induction by TLR4 in optimization of mitochondrial biogenesis and MHC expression after gram-negative challenge...
  33. pmc Contributions of nitric oxide synthase isoforms to pulmonary oxygen toxicity, local vs. mediated effects
    Ivan T Demchenko
    Center for Hyperbaric Medicine and Environmental Physiology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Physiol Lung Cell Mol Physiol 294:L984-90. 2008
    ..In addition, we demonstrated that nitric oxide derived from nNOS is involved in a neurogenic mechanism of HBO2-induced lung injury that is linked to central nervous system oxygen toxicity through adrenergic/cholinergic pathways...
  34. ncbi request reprint Postlipopolysaccharide oxidative damage of mitochondrial DNA
    Hagir B Suliman
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Respir Crit Care Med 167:570-9. 2003
    ..These data provide the first link between LPS-mediated hepatic injury and a specific oxidative mtDNA deletion, which inhibits mitochondrial transcription and is restored by activation of mechanisms that lead to biogenesis...
  35. pmc Carbon monoxide, skeletal muscle oxidative stress, and mitochondrial biogenesis in humans
    Michael A Rhodes
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Physiol Heart Circ Physiol 297:H392-9. 2009
    ....
  36. ncbi request reprint Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli
    Hagir B Suliman
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    FASEB J 19:1531-3. 2005
    ..These data disclose the dual role of TLR4 in mtDNA damage and compensatory mitochondrial biogenic responses after innate immune activation...
  37. doi request reprint Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism
    Diana R Gutsaeva
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 28:2015-24. 2008
    ..These findings demonstrate that hypoxic preconditioning elicits subcortical mitochondrial biogenesis by a novel mechanism that requires nNOS regulation of PGC-1alpha and CREB...
  38. ncbi request reprint Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis
    Hagir B Suliman
    Department of Medicine, Duke University Medical Center, 0590 CR II Building, Duke South Hospital Trent Drive, Durham, NC 27710, USA
    Cardiovasc Res 64:279-88. 2004
    ..We postulated that LPS damages heart mitochondrial DNA and protein by oxidation, and that this is recovered by oxidative mechanisms of mitochondrial biogenesis...
  39. ncbi request reprint Discordant extracellular superoxide dismutase expression and activity in neonatal hyperoxic lung
    Lisa B Mamo
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA
    Am J Respir Crit Care Med 170:313-8. 2004
    ..These data provide the first direct evidence that EC-SOD is itself a target of nitration in hyperoxia, and offer a plausible explanation for low EC-SOD activity despite its increased secretion by O(2)-exposed neonatal lung...
  40. pmc Clinical review: oxygen as a signaling molecule
    Raquel R Bartz
    Department of Anesthesiology, Duke University School of Medicine, Box 3094, Durham, NC 27710, USA
    Crit Care 14:234. 2010
    ..The present review summarizes oxygen's capacity, acting through its reactive intermediates, to recruit the enzymatic antioxidant defenses, to stimulate cell repair processes, and to mitigate cellular damage...
  41. pmc Autonomic activation links CNS oxygen toxicity to acute cardiogenic pulmonary injury
    Ivan T Demchenko
    Center for Hyperbaric Medicine and Environmental Physiology, Duke Univ Medical Center, Durham, NC 27710, USA
    Am J Physiol Lung Cell Mol Physiol 300:L102-11. 2011
    ....
  42. pmc Staphylococcus aureus sepsis and mitochondrial accrual of the 8-oxoguanine DNA glycosylase DNA repair enzyme in mice
    Raquel R Bartz
    Department of Anesthesiology, DUMC Box 3094, Durham, NC 27710, USA
    Am J Respir Crit Care Med 183:226-33. 2011
    ..Damage to mitochondrial DNA (mtDNA) by the production of reactive oxygen species during inflammatory states, such as sepsis, is repaired by poorly understood mechanisms...
  43. doi request reprint Two faces of nitric oxide: implications for cellular mechanisms of oxygen toxicity
    Barry W Allen
    Duke University Medical Center Center for Hyperbaric Medicine and Environmental Physiology, Durham, NC 27710, USA
    J Appl Physiol (1985) 106:662-7. 2009
    ..Likewise, improved knowledge of NO-based mechanisms of pulmonary oxygen toxicity may enhance our understanding of other types of lung injury associated with oxidative or nitrosative stress...
  44. pmc Iron accumulation in bronchial epithelial cells is dependent on concurrent sodium transport
    Jennifer L Turi
    Department of Pediatrics, Duke University Medical Center, P O Box 3046, Durham, NC 27710, USA
    Biometals 21:571-80. 2008
    ..Together, these data demonstrate that intracellular iron accumulation by airway epithelium requires concurrent Na(+)/K(+)exchange...
  45. pmc Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation
    Barry W Allen
    Center for Hyperbaric Medicine and Environmental Physiology, Duke University Medical Center, Durham, NC, USA
    Trends Mol Med 15:452-60. 2009
    ..In addition, the formation of S-nitrosothiols in other proteins may regulate an array of physiological functions...
  46. pmc Mitochondrial biogenesis in the pulmonary vasculature during inhalational lung injury and fibrosis
    Martha S Carraway
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Antioxid Redox Signal 10:269-75. 2008
    ..This finding indicates a unique and unexpected mechanism of metabolic adaptation to pulmonary fibrotic injuries...
  47. doi request reprint Multimodality surgical and hyperbaric management of mandibular osteoradionecrosis
    John J Freiberger
    Department of Anesthesiology, Center for Hyperbaric Medicine and Environmental Physiology, Duke University Medical Center, Durham, NC, USA
    Int J Radiat Oncol Biol Phys 75:717-24. 2009
    ..To elucidate long-term outcomes in 65 consecutive patients meeting a uniform definition of mandibular osteoradionecrosis (ORN) treated with multimodality therapy including hyperbaric oxygen (HBO)...
  48. pmc Pharmacologically augmented S-nitrosylated hemoglobin improves recovery from murine subarachnoid hemorrhage
    Huaxin Sheng
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 42:471-6. 2011
    ..This study tested the hypothesis that enhancement of S-nitrosylated hemoglobin by ethyl nitrite inhalation improves outcome after experimental subarachnoid hemorrhage (SAH)...
  49. ncbi request reprint Oxidative stress activates anion exchange protein 2 and AP-1 in airway epithelial cells
    Jennifer L Turi
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 283:L791-8. 2002
    ..This study demonstrates that AE2 expression is regulated by oxidative stress in airway epithelial cells and that this regulation correlates with activation of AP-1...
  50. ncbi request reprint Oxalate deposition on asbestos bodies
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, NC, USA
    Hum Pathol 34:737-42. 2003
    ..We conclude that iron-catalyzed production of oxalate from ascorbate can account for the deposition of this crystal on ferruginous bodies...
  51. ncbi request reprint Blockade of tissue factor: treatment for organ injury in established sepsis
    Martha Sue Carraway
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 167:1200-9. 2003
    ..These results show that blockade of coagulation attenuates acute lung and renal injury in established Gram-negative sepsis accompanied by antiinflammatory effects of therapy...
  52. ncbi request reprint Coagulation and inflammation in acute lung injury
    Karen E Welty-Wolf
    Division of Infectious Diseases, Department of Medicine, Duke University, Durham, NC, USA
    Thromb Haemost 88:17-25. 2002
    ....
  53. ncbi request reprint Electrochemical activation of electrodes for amperometric detection of nitric oxide
    Barry W Allen
    Department of Anesthesiology, Duke University Medical Center, Box 3823, Durham, NC 27710, USA
    Nitric Oxide 8:243-52. 2003
    ..Cycled ruthenium also exhibited a much greater increase in capacitance after cycling, consistent with the formation of a conductive surface layer...
  54. ncbi request reprint Extrinsic coagulation blockade attenuates lung injury and proinflammatory cytokine release after intratracheal lipopolysaccharide
    Debra L Miller
    Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Respir Cell Mol Biol 26:650-8. 2002
    ..Therefore, blockade of TF-FVIIa complex protects the lung from injury by LPS in part by reducing local expression of proinflammatory cytokines and may offer promise for therapy of acute lung injury...
  55. ncbi request reprint Pulmonary vasoconstriction by serotonin is inhibited by S-nitrosoglutathione
    Eva Nozik-Grayck
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 282:L1057-65. 2002
    ..This study demonstrates that GSNO can regulate vascular tone in the intact lung by a reversible mechanism involving inhibition of the response to 5-HT...
  56. ncbi request reprint Bicarbonate-dependent superoxide release and pulmonary artery tone
    Eva Nozik-Grayck
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Physiol Heart Circ Physiol 285:H2327-35. 2003
    ..These results indicate that O2-* produced by endothelial NOS in normoxia and unidentified sources in hypoxia regulate pulmonary vascular tone via AE2...
  57. ncbi request reprint Blockade of tissue factor-factor X binding attenuates sepsis-induced respiratory and renal failure
    Karen E Welty-Wolf
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 290:L21-31. 2006
    ..Blockade of factor X binding to the tissue factor-factor VIIa complex attenuates lung and organ injuries in established E. coli sepsis by attenuating the neutrophilic response and inflammatory pathways...
  58. ncbi request reprint Alveolar barrier function assessed by hydrophobic and hydrophilic fluorescent solutes in rabbit lung
    Yuh Chin T Huang
    Department of Medicine, Box 3315, Duke University and Durham VA Medical Center, Durham, NC 27710, USA
    Respir Physiol Neurobiol 133:153-66. 2002
    ..We conclude that epithelial permeability in the intact lung can be assessed using fluorescent solutes, and that increased permeation of hydrophilic solutes may enhance lung edema formation...
  59. ncbi request reprint Carbon monoxide promotes hypoxic pulmonary vascular remodeling
    Martha Sue Carraway
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Physiol Lung Cell Mol Physiol 282:L693-702. 2002
    ..CO also increased lung HO activity and HO-1 mRNA and protein expression in small pulmonary arteries during hypoxia. These data indicate an overall propensity of CO in HH to promote vascular remodeling and increase PVR in vivo...
  60. pmc Differential regulation of the PGC family of genes in a mouse model of Staphylococcus aureus sepsis
    Timothy E Sweeney
    Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 5:e11606. 2010
    ..Moreover, the identification of mir-202-3p as a potential factor for Ppargc1a and Ppargc1b repression in acute inflammation may open new avenues for mitochondrial research and, potentially, therapy...
  61. ncbi request reprint Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure
    Hagir B Suliman
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 32:246-56. 2002
    ..This mtDNA damage is associated with altered expression of mitochondrial cell death proteins, thereby suggesting a novel mechanism for systemic or environmental pro-oxidants to influence apoptosis...
  62. ncbi request reprint A comparison of hyperbaric oxygen versus hypoxic cerebral preconditioning in neonatal rats
    John J Freiberger
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 1075:213-22. 2006
    ..007) but not after high dose HBO-PC. Thus, when temperature variability is eliminated, HBO-PC and HPC elicit similar preconditioning efficacy in neonatal brain but invoke different defenses against oxidative stress...
  63. ncbi request reprint Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells
    Jennifer L Turi
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Physiol Lung Cell Mol Physiol 291:L272-80. 2006
    ..production decreased when Dcytb function was blocked. The presence of Dcytb in airway epithelial cells and its regulation by iron therefore may contribute to pulmonary cytoprotection...
  64. doi request reprint Phosphodiesterase-5 inhibitors oppose hyperoxic vasoconstriction and accelerate seizure development in rats exposed to hyperbaric oxygen
    Ivan T Demchenko
    Center for Hyperbaric Medicine and Environmental Physiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    J Appl Physiol (1985) 106:1234-42. 2009
    ..Thus PDE-5 blockers oppose the protective vasoconstriction that is the initial response to hyperbaric hyperoxia, decreasing the safety of HBO(2) by hastening onset of CNS O(2) toxicity...
  65. ncbi request reprint The iron cycle and oxidative stress in the lung
    Jennifer L Turi
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 36:850-7. 2004
    ..These pathways seem to be the primary mechanism for control of oxidative stress presented by iron in the respiratory tract...
  66. ncbi request reprint Cerebral blood flow and brain oxygenation in rats breathing oxygen under pressure
    Ivan T Demchenko
    Center for Hyperbaric Medicine and Environmental Physiology, Duke University, Durham, North Carolina 27710, USA
    J Cereb Blood Flow Metab 25:1288-300. 2005
    ..These findings support our hypothesis that HBO(2) increases PO(2) in brain in direct proportion to rCBF...
  67. pmc The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy
    Hagir B Suliman
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 117:3730-41. 2007
    ..These findings imply that the therapeutic index of anthracycline cancer chemotherapeutics can be improved by the protection of cardiac mitochondrial biogenesis...
  68. ncbi request reprint Hemodynamic effects of metalloporphyrin catalytic antioxidants: structure-activity relationships and species specificity
    Aron D Ross
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80209, USA
    Free Radic Biol Med 33:1657-69. 2002
    ..Chlorpheniramine attenuated the effect, suggesting that the blood pressure response in rats is related to histamine release rather than the protection of nitric oxide...
  69. ncbi request reprint Electrochemical detection of nitric oxide in biological fluids
    Barry W Allen
    Department of Anesthesiology and Center for Hyperbaric Medicine and Environmental Physiology Duke University Medical Center, Durham, NC 27710, USA
    Methods Enzymol 396:68-77. 2005
    ..We elicit the NO release by decreasing the oxygen concentration in the gaseous atmosphere surrounding the drop...
  70. ncbi request reprint Electrochemical detection of physiological nitric oxide: materials and methods
    Barry W Allen
    Department of Anesthesiology, Duke Center for Hyperbaric Medicine and Environmental Physiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Methods Enzymol 359:125-34. 2002
    ....
  71. ncbi request reprint Glutathione regulates susceptibility to oxidant-induced mitochondrial DNA damage in human lymphocytes
    Dawn L Hollins
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 40:1220-6. 2006
    ....
  72. ncbi request reprint A mini-forum on air breaks and O2 toxicity in clinical HBO2 therapy
    Claude A Piantadosi
    Duke University Medical Center, USA
    Undersea Hyperb Med 31:185. 2004
  73. ncbi request reprint Iron increases expression of iron-export protein MTP1 in lung cells
    Funmei Yang
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas 78284, USA
    Am J Physiol Lung Cell Mol Physiol 283:L932-9. 2002
    ..These studies suggest the presence of iron mobilization and/or detoxification pathways in the lung that are crucial for iron homeostasis and lung defense...
  74. ncbi request reprint Iron uptake and Nramp2/DMT1/DCT1 in human bronchial epithelial cells
    Xinchao Wang
    Center for Environmental Medicine and Lung Biology, University of North Carolina, Chapel Hill 27599, USA
    Am J Physiol Lung Cell Mol Physiol 282:L987-95. 2002
    ..We conclude that airway epithelial cells increase mRNA and expression of the Nramp2/DMT1/DCT1 without an IRE after exposure to iron. The increase results in an elevated transport of iron and its probable detoxification by these cells...
  75. ncbi request reprint Prenatal hypoxia decreases lung extracellular superoxide dismutase expression and activity
    Brenda Louise Giles
    Department of Pediatrics, University of Manitoba, Winnipeg, Manitoba R3A 1S1
    Am J Physiol Lung Cell Mol Physiol 283:L549-54. 2002
    ..Furthermore, prenatal hypoxia delays secretion of active EC-SOD enzyme. These findings have important implications for the effects of prenatal asphyxia on postnatal response to oxidant stress...
  76. ncbi request reprint DMT1 expression is increased in the lungs of hypotransferrinemic mice
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Am J Physiol Lung Cell Mol Physiol 284:L938-44. 2003
    ..Increased expression of -IRE DMT1 in the lungs of the Hp mice could be responsible for elevated concentrations of the metal in these tissues...
  77. ncbi request reprint Oxidant generation promotes iron sequestration in BEAS-2B cells exposed to asbestos
    Xinchao Wang
    Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina, Chapel Hill, USA
    Am J Respir Cell Mol Biol 34:286-92. 2006
    ..We conclude that the response of respiratory epithelial cells to asbestos includes oxidant-mediated mechanisms to sequester catalytically active iron associated with the fiber...
  78. ncbi request reprint S-nitrosoglutathione inhibits alpha1-adrenergic receptor-mediated vasoconstriction and ligand binding in pulmonary artery
    Eva Nozik-Grayck
    Department of Pediatrics, University of Colorado Health Science Center, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 290:L136-43. 2006
    ..These data demonstrate a novel cGMP-independent mechanism of reversible alpha1-adrenergic receptor inhibition by S-nitrosothiols...
  79. ncbi request reprint Divalent metal transporter-1 decreases metal-related injury in the lung
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Am J Physiol Lung Cell Mol Physiol 289:L460-7. 2005
    ..These results thus demonstrate for the first time a primary role for DMT1 in lung metal transport and detoxification...
  80. doi request reprint Carbon monoxide reversibly alters iron homeostasis and respiratory epithelial cell function
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Am J Respir Cell Mol Biol 38:715-23. 2008
    ..This loss of cellular iron after CO is in line with certain biological effects of the gas that have been implicated in the protection of cell viability...
  81. ncbi request reprint TNF, IFN-gamma, and endotoxin increase expression of DMT1 in bronchial epithelial cells
    Xinchao Wang
    Center for Environmental Medicine and Lung Biology, University of North Carolina, Chapel Hill, USA
    Am J Physiol Lung Cell Mol Physiol 289:L24-33. 2005
    ..Increased expression of this protein appears to be included in a coordinated response of the cell and tissue where the function might be to diminish availability of metal...
  82. ncbi request reprint How do red blood cells dilate blood vessels?
    Barry W Allen
    Circ Res 94:e105. 2004
  83. ncbi request reprint Oxygenated water and athletic performance
    Neil B Hampson
    JAMA 290:2408-9. 2003
  84. ncbi request reprint S-nitrosohemoglobin is distinguished from other nitrosovasodilators by unique oxygen-dependent responses that support an allosteric mechanism of action
    Timothy J McMahon
    Blood 102:410-1; author reply 412-3. 2003
  85. ncbi request reprint Oxygen seizure latency and peroxynitrite formation in mice lacking neuronal or endothelial nitric oxide synthases
    Ivan T Demchenko
    Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St Petersburg, 194223, Russia
    Neurosci Lett 344:53-6. 2003
    ....
  86. doi request reprint SNO-hemoglobin and hypoxic vasodilation
    Jonathan S Stamler
    Nat Med 14:1008-9; author reply 1009-10. 2008

Research Grants13

  1. CORE--PRIMATE STUDIES
    CLAUDE PIANTADOSI; Fiscal Year: 2004
    ..subproject abstract not available ..
  2. Nitric oxide and mitochondrial biogenesis in sepsis
    Claude A Piantadosi; Fiscal Year: 2010
    ..abstract_text> ..
  3. Regulation of mitochondrial biogenesis by heme oxygenase-1
    CLAUDE PIANTADOSI; Fiscal Year: 2009
    ..A successful test of our hypothesis would establish a unifying mechanism for the diverse protective roles of HO-1 in health and disease. ..
  4. Nitric oxide and mitochondrial biogenesis in sepsis
    CLAUDE PIANTADOSI; Fiscal Year: 2009
    ..abstract_text> ..
  5. Lung Injury Protection by Coagulation Blockade
    CLAUDE PIANTADOSI; Fiscal Year: 2007
    ..A successfully optimized strategy could greatly attenuate persistence of pulmonary inflammation and facilitate the resolution of human ARDS. ..
  6. Nitric oxide and mitochondrial biogenesis in sepsis
    CLAUDE PIANTADOSI; Fiscal Year: 2007
    ....
  7. Lung Injury Protection by Coagulation Blockade
    CLAUDE PIANTADOSI; Fiscal Year: 2006
    ..A successfully optimized strategy could greatly attenuate persistence of pulmonary inflammation and facilitate the resolution of human ARDS. ..
  8. Nitric oxide and mitochondrial biogenesis in sepsis
    CLAUDE PIANTADOSI; Fiscal Year: 2006
    ....
  9. Lung Injury Protection by Coagulation Blockade
    CLAUDE PIANTADOSI; Fiscal Year: 2005
    ..A successfully optimized strategy could greatly attenuate persistence of pulmonary inflammation and facilitate the resolution of human ARDS. ..
  10. Regulation of mitochondrial biogenesis by heme oxygenase-1
    Claude A Piantadosi; Fiscal Year: 2010
    ..A successful test of our hypothesis would establish a unifying mechanism for the diverse protective roles of HO-1 in health and disease. ..