Thomas D Petes
Affiliation: Duke University Medical Center
Quevedo O, Ramos PÃ©rez C, Petes T, MachÃn F. The Transient Inactivation of the Master Cell Cycle Phosphatase Cdc14 Causes Genomic Instability in Diploid Cells of Saccharomyces cerevisiae. Genetics. 2015;200:755-69 pubmed publisher
O Connell K, Jinks Robertson S, Petes T. Elevated Genome-Wide Instability in Yeast Mutants Lacking RNase H Activity. Genetics. 2015;201:963-75 pubmed publisher
..This result suggests that the elevated recombination observed in the absence of only RNase H2 is primarily a consequence of R-loops rather than misincorporated rNMPs. ..
Zheng D, Petes T. Genome Instability Induced by Low Levels of Replicative DNA Polymerases in Yeast. Genes (Basel). 2018;9: pubmed publisher
..In this review, we will summarize the methods used to monitor genome instability in yeast, and how this analysis contributes to understanding the linkage between genome instability and DNA replication stress. ..
Zhao Y, Strope P, Kozmin S, McCusker J, Dietrich F, Kokoska R, et al
. Structures of naturally evolved CUP1 tandem arrays in yeast indicate that these arrays are generated by unequal nonhomologous recombination. G3 (Bethesda). 2014;4:2259-69 pubmed publisher
..A comparison of the DNA sequences of these strains indicates that the CUP1 tandem arrays were generated by unequal nonhomologous recombination events from strains that had one CUP1 gene. ..
Kiktev D, Sheng Z, Lobachev K, Petes T. GC content elevates mutation and recombination rates in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2018;115:E7109-E7118 pubmed publisher
..Thus, base composition has a substantial effect on the basic parameters of genome stability and evolution. ..
Moore A, Dominska M, Greenwell P, Aksenova A, MIRKIN S, PETES T. Genetic Control of Genomic Alterations Induced in Yeast by Interstitial Telomeric Sequences. Genetics. 2018;209:425-438 pubmed publisher
..Unlike the terminal inversions, these events are not initiated by a double-stranded DNA break, but likely result from the error-prone repair of a single-stranded DNA gap or recruitment of DNA polymerase ? in the absence of DNA damage. ..
Zheng D, Zhang K, Wu X, Mieczkowski P, Petes T. Global analysis of genomic instability caused by DNA replication stress in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2016;113:E8114-E8121 pubmed
..These deletions conferred a selective growth advantage to cells, demonstrating that DRS can be one factor driving phenotypic evolution. ..
Zhao Y, Dominska M, Petrova A, Bagshaw H, Kokoska R, Petes T. Properties of Mitotic and Meiotic Recombination in the Tandemly-Repeated CUP1 Gene Cluster in the Yeast Saccharomyces cerevisiae. Genetics. 2017;206:785-800 pubmed publisher
..In summary, our study shows that some of the basic properties of recombination differ considerably between single-copy and tandemly-repeated genes. ..