Edward Patz

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. doi request reprint Biomarkers to help guide management of patients with pulmonary nodules
    Edward F Patz
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 188:461-5. 2013
  2. ncbi request reprint Panel of serum biomarkers for the diagnosis of lung cancer
    Edward F Patz
    Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710, USA
    J Clin Oncol 25:5578-83. 2007
  3. ncbi request reprint Lung cancer staging and management: comparison of contrast-enhanced and nonenhanced helical CT of the thorax
    E F Patz
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Radiology 212:56-60. 1999
  4. ncbi request reprint Integration of biomarkers and imaging
    Edward F Patz
    Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Thorac Oncol 1:78-80. 2006
  5. ncbi request reprint CT screening for lung cancer: not ready for routine practice
    E F Patz
    Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710, USA
    Radiology 221:587-91; discussion 598-9. 2001
  6. ncbi request reprint Correlation of tumor size and survival in patients with stage IA non-small cell lung cancer
    E F Patz
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Chest 117:1568-71. 2000
  7. ncbi request reprint Estimate of lung cancer mortality from low-dose spiral computed tomography screening trials: implications for current mass screening recommendations
    Edward F Patz
    Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710, USA
    J Clin Oncol 22:2202-6. 2004
  8. ncbi request reprint Lung cancer and positron emission tomography with fluorodeoxyglucose
    E M Marom
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Lung Cancer 28:187-202. 2000
  9. ncbi request reprint Frequency and prognostic significance of preoperatively detected enlarged regional lymph nodes in patients with pathological stage I non-small cell lung cancer following resection
    Jenny K Hoang
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Oncol 2:1103-6. 2007
  10. ncbi request reprint Molecular characterization of the human delta opioid receptor in lung cancer
    G Schreiber
    Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anticancer Res 18:1787-92. 1998

Research Grants

Collaborators

Detail Information

Publications44

  1. doi request reprint Biomarkers to help guide management of patients with pulmonary nodules
    Edward F Patz
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 188:461-5. 2013
    ..Indeterminate pulmonary nodules are a common radiographic finding and require further evaluation because of the concern for lung cancer...
  2. ncbi request reprint Panel of serum biomarkers for the diagnosis of lung cancer
    Edward F Patz
    Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710, USA
    J Clin Oncol 25:5578-83. 2007
    ..Serum biomarkers that could aid clinicians in making case management decisions would be enormously valuable. We used two proteomic platforms and a literature search to select candidate serum markers for the diagnosis of lung cancer...
  3. ncbi request reprint Lung cancer staging and management: comparison of contrast-enhanced and nonenhanced helical CT of the thorax
    E F Patz
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Radiology 212:56-60. 1999
    ..To determine whether contrast material-enhanced helical computed tomography (CT) of the thorax and upper abdomen changes the tumor stage and management compared with nonenhanced helical CT in patients with newly diagnosed lung cancer...
  4. ncbi request reprint Integration of biomarkers and imaging
    Edward F Patz
    Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Thorac Oncol 1:78-80. 2006
    ..This discussion focuses on integration of biomarkers with imaging in the effort to guide patient management...
  5. ncbi request reprint CT screening for lung cancer: not ready for routine practice
    E F Patz
    Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710, USA
    Radiology 221:587-91; discussion 598-9. 2001
    ..The appropriate hypothesis-driven studies still must be performed and the results carefully analyzed before CT screening for lung cancer can be accepted as the standard of care...
  6. ncbi request reprint Correlation of tumor size and survival in patients with stage IA non-small cell lung cancer
    E F Patz
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Chest 117:1568-71. 2000
    ..The purpose of this study was to determine the relationship between tumor size and survival in patients with stage IA non-small cell lung cancer (non-small cell lung cancer; ie, lesions < 3 cm)...
  7. ncbi request reprint Estimate of lung cancer mortality from low-dose spiral computed tomography screening trials: implications for current mass screening recommendations
    Edward F Patz
    Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710, USA
    J Clin Oncol 22:2202-6. 2004
    ..There are no mortality statistics, however, and the current study used published data from these trials to estimate the disease-specific mortality in this high-risk population...
  8. ncbi request reprint Lung cancer and positron emission tomography with fluorodeoxyglucose
    E M Marom
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Lung Cancer 28:187-202. 2000
    ..This review will discuss the current applications of FDG-PET as compared with conventional imaging in diagnosing, staging, and following patients with lung cancer...
  9. ncbi request reprint Frequency and prognostic significance of preoperatively detected enlarged regional lymph nodes in patients with pathological stage I non-small cell lung cancer following resection
    Jenny K Hoang
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Oncol 2:1103-6. 2007
    ..To explore the clinical significance of enlarged regional lymph nodes in patients with pathological stage I non-small cell lung cancer (NSCLC)...
  10. ncbi request reprint Molecular characterization of the human delta opioid receptor in lung cancer
    G Schreiber
    Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anticancer Res 18:1787-92. 1998
    ..This unique feature of lung cancer may be exploitable for diagnostic, prognostic, and therapeutic strategies...
  11. ncbi request reprint Correlation of FDG-PET imaging with Glut-1 and Glut-3 expression in early-stage non-small cell lung cancer
    E M Marom
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Lung Cancer 33:99-107. 2001
    ..To correlate FDG activity on PET with the expression of glucose transporter proteins Glut-1 and Glut-3 in patients with early stage non-small cell lung cancer (NSCLC)...
  12. ncbi request reprint Multimodality nuclear medicine imaging in three-dimensional radiation treatment planning for lung cancer: challenges and prospects
    M T Munley
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Lung Cancer 23:105-14. 1999
    ..The utilization of accurate nuclear medicine image reconstruction techniques and TCT may improve the treatment planning process...
  13. ncbi request reprint Management of malignant pleural effusions and pneumothorax
    J J Erasmus
    Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Radiol Clin North Am 38:375-83. 2000
    ..Percutaneous catheter placement enables safe and effective drainage of pneumothoraces with rapid relief of symptoms and restoration of vital capacity and oxygenation...
  14. ncbi request reprint Non-small cell lung cancer: FDG-PET imaging
    J J Erasmus
    Duke University Medical Center, Department of Radiology, Durham, NC 27710, USA
    J Thorac Imaging 14:247-56. 1999
    ..Positron emission tomography is a clinically useful imaging modality that complements conventional radiologic studies in the evaluation of focal pulmonary opacities, lung cancer staging, tumor recurrence, treatment response, and prognosis...
  15. ncbi request reprint Design of a novel small peptide targeted against a tumor-specific receptor
    M J Campa
    Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Biochem Biophys Res Commun 275:631-6. 2000
    ..These results demonstrate the utility of hydropathic complementarity as a basis for the design of highly specific ligands that may prove useful as tumor-targeting agents...
  16. ncbi request reprint FDG-PET imaging in patients with paraneoplastic syndromes and suspected small cell lung cancer
    E Crotty
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Imaging 16:89-93. 2001
    ..FDG-PET appears to be very useful in localizing suspected small cell lung cancer in patients presenting with paraneoplastic syndromes...
  17. ncbi request reprint Stage distribution in patients with a small (< or = 3 cm) primary nonsmall cell lung carcinoma. Implication for lung carcinoma screening
    L E Heyneman
    Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer 92:3051-5. 2001
    ..A reduction in mortality needs to be demonstrated by appropriate clinical trials prior to the initiation of mass CT screening programs...
  18. ncbi request reprint Integration of peripheral blood biomarkers with computed tomography to differentiate benign from malignant pulmonary opacities
    T Aloia
    Duke University Medical Center, Department of Surgery, Durham, NC 27710, USA
    Cancer Detect Prev 25:336-43. 2001
    ..Integration of imaging studies with the appropriate biomarkers may prove useful in evaluating indeterminate pulmonary nodules or masses...
  19. ncbi request reprint Identification of small lung nodules at autopsy: implications for lung cancer screening and overdiagnosis bias
    S Dammas
    Department of Pulmonary Medicine, Department of Medicine, Duke University Medical Center, PO Box 3177, Durham, NC 27710, USA
    Lung Cancer 33:11-6. 2001
    ..The true incidence of clinically insignificant lung cancer is thus uncertain, and overdiagnosis bias in lung cancer screening may be more important than previously recognized...
  20. ncbi request reprint PET imaging in patients with bronchioloalveolar cell carcinoma
    Laura E Heyneman
    Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710, USA
    Lung Cancer 38:261-6. 2002
    ..The purpose of this study was to examine the sensitivity of PET in detecting both forms of BAC...
  21. ncbi request reprint Tumor infiltrating Foxp3+ regulatory T-cells are associated with recurrence in pathologic stage I NSCLC patients
    Rebecca P Petersen
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer 107:2866-72. 2006
    ..This study examined the relation between tumor-regulatory T (Treg) cells and total tumor-infiltrating T-cell lymphocytes (TIL) to determine whether they correlated with recurrence...
  22. ncbi request reprint Practical approach to diagnostic CT combined with PET
    Terence Z Wong
    Department of Radiology, Duke University Medical Center, Box 3949 Duke University Medical Center, Durham, NC 27710, USA
    AJR Am J Roentgenol 188:622-9. 2007
    ..In this case, the PET and CT images are interpreted by the corresponding specialists, and equivocal or discordant findings are adjudicated through joint review of the PET/CT images...
  23. ncbi request reprint Does computed tomography or positron emission tomography response after neoadjuvant chemotherapy for resectable non-small-cell lung cancer predict survival?
    Edward F Patz
    J Clin Oncol 26:4542-3. 2008
  24. doi request reprint Prognostic value of fluorine-18 fluorodeoxyglucose positron emission tomography imaging in patients with advanced-stage non-small-cell lung carcinoma
    Jenny K Hoang
    Department of Radiology, Duke University Medical Center, Erwin Rd, Durham, NC 27710, USA
    J Clin Oncol 26:1459-64. 2008
    ....
  25. ncbi request reprint Clinical stage I non-small cell lung cancer including FDG-PET Imaging: sites and time to recurrence
    Joerg Gauger
    Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Thorac Oncol 2:499-505. 2007
    ..The purpose of this study was to determine the sites and time to recurrence in patients with clinical stage I NSCLC whose initial staging evaluation included conventional imaging and fluorodeoxyglucose-PET...
  26. ncbi request reprint Haptoglobin and posttranslational glycan-modified derivatives as serum biomarkers for the diagnosis of nonsmall cell lung cancer
    Luke F M Hoagland
    Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer 110:2260-8. 2007
    ..The purpose was to evaluate the clinical utility of serum haptoglobin (Hp) and posttranslational glycan modifications of Hp for the diagnosis of nonsmall cell lung cancer (NSCLC)...
  27. doi request reprint Primary tumor standardized uptake value (SUVmax) measured on fluorodeoxyglucose positron emission tomography (FDG-PET) is of prognostic value for survival in non-small cell lung cancer (NSCLC): a systematic review and meta-analysis (MA) by the European Lu
    Thierry Berghmans
    Department of Intensive Care Unit and Thoracic Oncology, Institut Jules Bordet, Universite Libre de Bruxelles ULB, Bruxelles, Belgium
    J Thorac Oncol 3:6-12. 2008
    ..Primary tumor standardized uptake value (SUV) has been studied as a potential prognostic factor for survival. However, the sample sizes are limited leading to conduct a meta-analysis to improve the precision in estimating its effect...
  28. ncbi request reprint Lung cancer screening, overdiagnosis bias, and reevaluation of the Mayo Lung Project
    Edward F Patz
    J Natl Cancer Inst 98:724-5. 2006
  29. ncbi request reprint Guidelines for management of small pulmonary nodules detected on CT scans: a statement from the Fleischner Society
    Heber Macmahon
    Radiology 237:395-400. 2005
    ....
  30. ncbi request reprint Stable RNA interference-mediated suppression of cyclophilin A diminishes non-small-cell lung tumor growth in vivo
    Brandon A Howard
    Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Res 65:8853-60. 2005
    ..These results establish the relevance of CypA to tumor growth in vivo, specifically to proliferation and apoptosis. Elucidation of the precise role of CypA in these pathways may lead to new targeted therapies for lung cancer...
  31. ncbi request reprint The role of imaging in malignant pleural mesothelioma
    Edith M Marom
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Semin Oncol 29:26-35. 2002
    ..Following patients after therapy usually relies on chest radiographs, although CT can more accurately describe response to therapy. This review will focus on radiologic evaluation in diagnosing, staging, and follow-up patients with MPM...
  32. ncbi request reprint T1 lung cancers: sensitivity of diagnosis with fluorodeoxyglucose PET
    Edith M Marom
    Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710, USA
    Radiology 223:453-9. 2002
    ..To determine the sensitivity of fluorodeoxyglucose (FDG) positron emission tomography (PET) in patients with T1 (< or =3 cm) lung cancers...
  33. ncbi request reprint Development of novel tumor imaging agents with phage-display combinatorial peptide libraries
    Michael J Campa
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Acad Radiol 9:927-32. 2002
    ..The present investigation sought to address this deficiency by developing a system for designing novel small molecules targeted against tumor-specific molecules for use as radionuclide imaging agents...
  34. ncbi request reprint False-negative findings for primary lung tumors on FDG positron emission tomography: staging and prognostic implications
    Sendhil Kumar Cheran
    School of Medicine, Duke University, Durham, NC 27710, USA
    AJR Am J Roentgenol 182:1129-32. 2004
    ..The aim of this study was to determine the stage and outcome of patients with primary lung tumors who had a negative finding on a FDG positron emission tomography (PET) study at the time of diagnosis...
  35. ncbi request reprint Comparison of whole-body FDG-PET to bone scan for detection of bone metastases in patients with a new diagnosis of lung cancer
    Sendhil Kumar Cheran
    School of Medicine, Duke University, Durham, NC 27710, USA
    Lung Cancer 44:317-25. 2004
    ..A prospective trial with appropriate verification of bony metastases is suggested to confirm the results...
  36. ncbi request reprint Clinical utility of serum amyloid A and macrophage migration inhibitory factor as serum biomarkers for the detection of nonsmall cell lung carcinoma
    Nayela Khan
    Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer 101:379-84. 2004
    ..In the current pilot study, the authors evaluated two overexpressed proteins in lung carcinoma, serum amyloid A (SAA) and macrophage migration inhibitory factor (MIF), as potential diagnostic serum biomarkers for this malignancy...
  37. ncbi request reprint Translating biomarkers into clinical practice: prognostic implications of cyclophilin A and macrophage migratory inhibitory factor identified from protein expression profiles in non-small cell lung cancer
    Brandon A Howard
    Department of Radiology, Duke University, Durham, NC, USA
    Lung Cancer 46:313-23. 2004
    ..While both proteins considered in this study were overexpressed in the vast majority of NSCLCs, they were not found to be of prognostic significance...
  38. ncbi request reprint Radiographic imaging of bronchioloalveolar carcinoma: screening, patterns of presentation and response assessment
    David R Gandara
    University of California Davis Cancer Center, Sacramento, CA, USA
    J Thorac Oncol 1:S20-6. 2006
    ....
  39. ncbi request reprint The IASLC Lung Cancer Staging Project: proposals for revision of the M descriptors in the forthcoming (seventh) edition of the TNM classification of lung cancer
    Pieter E Postmus
    Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Thorac Oncol 2:686-93. 2007
    ..To analyze all nonlymphatic metastatic components (T4 and M1) of the current TNM system of lung cancer, with the objective of providing suggestions for the next edition of the TNM classification for lung cancer...
  40. ncbi request reprint Identification and validation of a potential lung cancer serum biomarker detected by matrix-assisted laser desorption/ionization-time of flight spectra analysis
    Brandon A Howard
    Duke University Medical Center, Department of Radiology, Durham, NC, USA
    Proteomics 3:1720-4. 2003
    ..34.1 ng/mL in the serum of individuals without cancer. These data suggest that the combination of MALDI-TOF MS and computer analysis can be a powerful tool in the search for serum biomarkers of lung cancer and other diseases...
  41. ncbi request reprint Protein expression profiling identifies macrophage migration inhibitory factor and cyclophilin a as potential molecular targets in non-small cell lung cancer
    Michael J Campa
    Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Res 63:1652-6. 2003
    ..These data demonstrate the feasibility of using a MALDI-TOF platform to generate protein expression profiles and identify potential molecular targets for cancer diagnostics and therapeutics...
  42. ncbi request reprint Thermodynamic analysis of cyclosporin a binding to cyclophilin a in a lung tumor tissue lysate
    Michael Z Wang
    Department of Chemistry, Duke University, Box 90346, Durham, North Carolina 27708, USA
    Anal Chem 76:4343-8. 2004
    ..the thermodynamic analysis of proteins and protein-ligand binding interactions in the unpurified, ex vivo conditions of human tissue lysates,and they represent the first K(d) measurement on a protein-ligand complex under such conditions..
  43. ncbi request reprint Accentuation of differentially expressed proteins using phage technology
    R Lee Suber
    Department of Radiology, Duke University Medical Center, Durham, NC, USA
    Anal Biochem 333:351-7. 2004
    ..While the current study used this method to demonstrate differentially expressed proteins in lung cancer tissue in comparison to normal lung tissue, this approach is applicable to a wide range of sample types...
  44. pmc Throughput and efficiency of a mass spectrometry-based screening assay for protein-ligand binding detection
    Erin D Hopper
    Department of Chemistry, Duke University, Durham, North Carolina 27708 0346, USA
    J Am Soc Mass Spectrom 19:1303-11. 2008
    ..We also describe a new strategy to eliminate some of the complications related to back exchange that can arise in screening applications of SUPREX...

Research Grants5

  1. Discovery of Biomarkers for Lung Cancer Metastasis
    Edward Patz; Fiscal Year: 2009
    ..This translational project will focus on an essential prognostic issue in lung cancer, but this model can be applied to any other diagnostic question in oncology. ..