Ashwin A Patkar

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Atypical antipsychotic augmentation strategies in the context of guideline-based care for the treatment of major depressive disorder
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA
    CNS Drugs 27:S29-37. 2013
  2. ncbi request reprint Relationship of disinhibition and aggression to blunted prolactin response to meta-chlorophenylpiperazine in cocaine-dependent patients
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC 27704, USA
    Psychopharmacology (Berl) 185:123-32. 2006
  3. ncbi request reprint Medical symptoms associated with tobacco smoking with and without marijuana abuse among crack cocaine-dependent patients
    Ashwin A Patkar
    Department of Psychiatry and Human Behavior, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Am J Addict 14:43-53. 2005
  4. ncbi request reprint Changes in tobacco smoking following treatment for cocaine dependence
    Ashwin A Patkar
    Department of Psychiatry Behavioral Sciences, Duke University, Durham, North Carolina 27704, USA
    Am J Drug Alcohol Abuse 32:135-48. 2006
  5. ncbi request reprint Transdermal selegiline: the new generation of monoamine oxidase inhibitors
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27704, USA
    CNS Spectr 11:363-75. 2006
  6. ncbi request reprint Relationship of prolactin response to meta-chlorophenylpiperazine with severity of drug use in cocaine dependence
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
    Hum Psychopharmacol 21:367-75. 2006
  7. ncbi request reprint Transdermal selegiline
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC 27705, USA
    Drugs Today (Barc) 43:361-77. 2007
  8. ncbi request reprint A randomized, double-blind, placebo-controlled trial of augmentation with an extended release formulation of methylphenidate in outpatients with treatment-resistant depression
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27704, USA
    J Clin Psychopharmacol 26:653-6. 2006
  9. doi request reprint Alterations in tryptophan and purine metabolism in cocaine addiction: a metabolomic study
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Psychopharmacology (Berl) 206:479-89. 2009
  10. ncbi request reprint Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, United States
    J Psychiatr Res 42:1213-9. 2008

Research Grants

Detail Information

Publications92

  1. ncbi request reprint Atypical antipsychotic augmentation strategies in the context of guideline-based care for the treatment of major depressive disorder
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA
    CNS Drugs 27:S29-37. 2013
    ..Therefore, they are intended to provide a useful framework for the management of depression and should be used in conjunction with other recognized sources of patient information and the application of clinical wisdom...
  2. ncbi request reprint Relationship of disinhibition and aggression to blunted prolactin response to meta-chlorophenylpiperazine in cocaine-dependent patients
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC 27704, USA
    Psychopharmacology (Berl) 185:123-32. 2006
    ..Considerable evidence indicates that serotonergic (5-HT) mechanisms may mediate central effects of cocaine, and disinhibition and aggression...
  3. ncbi request reprint Medical symptoms associated with tobacco smoking with and without marijuana abuse among crack cocaine-dependent patients
    Ashwin A Patkar
    Department of Psychiatry and Human Behavior, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Am J Addict 14:43-53. 2005
    ..Tobacco smoking was not related to changes in cocaine use. Also, marijuana smoking does not appear to be associated with a reduction in tobacco or cocaine use...
  4. ncbi request reprint Changes in tobacco smoking following treatment for cocaine dependence
    Ashwin A Patkar
    Department of Psychiatry Behavioral Sciences, Duke University, Durham, North Carolina 27704, USA
    Am J Drug Alcohol Abuse 32:135-48. 2006
    ..There is no evidence that reduction in crack cocaine smoking following treatment is accompanied by an increase in tobacco smoking. It appears that concerns over tobacco being substituted for cocaine may be unfounded in this population...
  5. ncbi request reprint Transdermal selegiline: the new generation of monoamine oxidase inhibitors
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27704, USA
    CNS Spectr 11:363-75. 2006
    ..However, more research is needed. Clinicians should familiarize themselves with the properties and indications for the new generation of MAOIs...
  6. ncbi request reprint Relationship of prolactin response to meta-chlorophenylpiperazine with severity of drug use in cocaine dependence
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
    Hum Psychopharmacol 21:367-75. 2006
    ..Serotonergic (5-HT) mechanisms appear to mediate central effects of cocaine. Therefore 5-HT disturbances could be associated with drug severity...
  7. ncbi request reprint Transdermal selegiline
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC 27705, USA
    Drugs Today (Barc) 43:361-77. 2007
    ..It is important for health-care professionals to be informed about the properties of STS...
  8. ncbi request reprint A randomized, double-blind, placebo-controlled trial of augmentation with an extended release formulation of methylphenidate in outpatients with treatment-resistant depression
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27704, USA
    J Clin Psychopharmacol 26:653-6. 2006
    ..Combination of methylphenidate with antidepressants was well tolerated. Adequately powered, randomized, controlled trials are necessary to fully evaluate the efficacy of extended-release methylphenidate in TRD...
  9. doi request reprint Alterations in tryptophan and purine metabolism in cocaine addiction: a metabolomic study
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Psychopharmacology (Berl) 206:479-89. 2009
    ..Mapping metabolic "signatures" can provide new insights into addictive mechanisms and potentially identify biomarkers and therapeutic targets...
  10. ncbi request reprint Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, United States
    J Psychiatr Res 42:1213-9. 2008
    ..However, little is known about the relationship between the 5-HTT and 5-HT receptors following cocaine exposure in humans...
  11. ncbi request reprint A randomized, controlled, trial of controlled release paroxetine in fibromyalgia
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27704, USA
    Am J Med 120:448-54. 2007
    ..We investigated the efficacy and tolerability of paroxetine controlled release, a selective serotonin reuptake inhibitor in fibromyalgia...
  12. ncbi request reprint Relationship between platelet serotonin uptake sites and measures of impulsivity, aggression, and craving among African-American cocaine abusers
    Ashwin A Patkar
    Division of Substance Abuse Programs, Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Addict 12:432-47. 2003
    ..Our findings indicate that densities of serotonin uptake sites may be reduced among cocaine abusers and related to impulsive-aggressive behavioral dimensions...
  13. ncbi request reprint Polymorphism in the serotonin transporter gene and moderators of prolactin response to meta-chlorophenylpiperazine in African-American cocaine abusers and controls
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
    Psychiatry Res 144:99-108. 2006
    ....
  14. ncbi request reprint Differences in platelet serotonin transporter sites between African-American tobacco smokers and non-smokers
    Ashwin A Patkar
    Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Psychopharmacology (Berl) 166:221-7. 2003
    ..Although nicotine and other constituents of tobacco smoke may influence serotonin turnover among animals, few studies have examined whether smoking is associated with alteration in 5HTT in humans...
  15. ncbi request reprint Seasonal variations in the binding of [3H]paroxetine to the platelet serotonin transporter sites in African-American cocaine-dependent patients and healthy volunteers
    Ashwin A Patkar
    Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Hum Psychopharmacol 18:103-11. 2003
    ..Biological studies that employ platelet serotonin transporter sites as a marker of serotonin function should consider seasonal variations in these markers as a potential source of variance...
  16. ncbi request reprint No association between polymorphisms in the serotonin transporter gene and susceptibility to cocaine dependence among African-American individuals
    Ashwin A Patkar
    Division of Substance Abuse Programs, Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Psychiatr Genet 12:161-4. 2002
    ..8%, 10 = 36.6%, 9 = 0.6%). Our findings do not seem to support a relationship between VNTR polymorphisms and cocaine dependence among African-American patients. Further studies involving larger samples are required to confirm our results...
  17. ncbi request reprint Relationship between serotonin transporter gene polymorphisms and platelet serotonin transporter sites among African-American cocaine-dependent individuals and healthy volunteers
    Ashwin A Patkar
    Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Psychiatr Genet 14:25-32. 2004
    ....
  18. doi request reprint Methylphenidate extended release (OROS MPH) for the treatment of antidepressant-related sexual dysfunction in patients with treatment-resistant depression: results from a 4-week, double-blind, placebo-controlled trial
    Chi Un Pae
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27705, USA
    Clin Neuropharmacol 32:85-8. 2009
    ..Adequately powered controlled trials are needed to fully evaluate the efficacy of OROS MPH in this area...
  19. ncbi request reprint Polymorphism in the serotonin transporter gene and response to treatment in African American cocaine and alcohol-abusing individuals
    Paolo Mannelli
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27704, USA
    Addict Biol 10:261-8. 2005
    ..Further investigations are required to determine the role of the 5-HTTLPR polymorphism in influencing treatment - outcome among substance abusers...
  20. ncbi request reprint Predicting treatment-outcome in cocaine dependence from admission urine drug screen and peripheral serotonergic measures
    Ashwin A Patkar
    Division of Substance Abuse Programs, Department of Psychiatry and Human Behavior, Thomas Jefferson University, 833 Chestnut Street East, Suite 210E, Philadelphia, PA 19107, USA
    J Subst Abuse Treat 23:33-40. 2002
    ..Although both admission UDS and paroxetine binding seem to contribute individually in predicting outcome of cocaine patients, a combination of the two variables seems to have a stronger effect in terms of predicting treatment-outcome...
  21. ncbi request reprint Pre-treatment measures of impulsivity, aggression and sensation seeking are associated with treatment outcome for African-American cocaine-dependent patients
    Ashwin A Patkar
    Division of Substance Abuse Programs, Department of Psychiatry and Human Behavior, Thomas Jefferson University, 833 Chestnut Street East, Suite 210E, Philadelphia, PA 19107, USA
    J Addict Dis 23:109-22. 2004
    ..Combining these behavioral measures with other clinical predictors may help in early identification of 'poor responders' who may benefit from additional or alternative treatment approaches...
  22. pmc An item response theory modeling of alcohol and marijuana dependences: a National Drug Abuse Treatment Clinical Trials Network study
    Li Tzy Wu
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke Clinical Research Institute, Duke University, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Stud Alcohol Drugs 70:414-25. 2009
    ....
  23. ncbi request reprint Relationship of serum prolactin with severity of drug use and treatment outcome in cocaine dependence
    Ashwin A Patkar
    Department of Psychiatry and Human Behavior, Jefferson Medical College and Thomas Jefferson University Hospital, 33 South 9th Street, Suite 210E, Philadelphia, PA 19107, USA
    Psychopharmacology (Berl) 176:74-81. 2004
    ..Therefore, serum PRL may have a potential role as a biological marker of drug severity and treatment outcome in cocaine dependence...
  24. doi request reprint History of depressive and/or anxiety disorders as a predictor of treatment response: a post hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled release in patients with fibromyalgia
    Chi Un Pae
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27704, USA
    Prog Neuropsychopharmacol Biol Psychiatry 33:996-1002. 2009
    ..We investigated whether a history of depressive and/or anxiety disorders was associated with response to paroxetine controlled release (CR) in the treatment of fibromyalgia...
  25. pmc Early outcomes following low dose naltrexone enhancement of opioid detoxification
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27705, USA
    Am J Addict 18:109-16. 2009
    ..Further studies are needed to test the utility of this approach in easing the transition from detoxification to various follow-up treatment modalities designed to address opioid dependence...
  26. pmc Heterogeneity of stimulant dependence: a national drug abuse treatment clinical trials network study
    Li Tzy Wu
    Department of Psychiatry and Behavioral Sciences, Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA
    Am J Addict 18:206-18. 2009
    ..Regardless of stimulants used, most female users were in the most severe or the physiological dependence group. These results lend support for subtyping dependence in the emerging DSM-V...
  27. doi request reprint A double-blind, randomized, placebo-controlled trial of paroxetine controlled-release in irritable bowel syndrome
    Prakash S Masand
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 1001 Winstead Dr, Suite 200, Cary, NC 27513, USA
    Psychosomatics 50:78-86. 2009
    ..Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disease that causes significant impairment in quality of life and accounts for $8 billion per year to the healthcare system and loss of productivity in the workplace...
  28. ncbi request reprint Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence
    Rachel J Smith
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 133:105-9. 2005
    ..The results indicate that polymorphisms in the novel splice variant are not associated with opioid dependence, but are in LD with other polymorphisms in OPRM1...
  29. ncbi request reprint Relationship between platelet serotonin uptake sites and treatment outcome among African-American cocaine dependent individuals
    Ashwin A Patkar
    Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Addict Dis 22:79-92. 2003
    ..The findings indicate that serotonergic mechanisms may be involved in cocaine dependence and may influence treatment-outcome among cocaine patients...
  30. doi request reprint History of early abuse as a predictor of treatment response in patients with fibromyalgia: a post-hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled release
    Chi Un Pae
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    World J Biol Psychiatry 10:435-41. 2009
    ....
  31. pmc Very low dose naltrexone addition in opioid detoxification: a randomized, controlled trial
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, USA
    Addict Biol 14:204-13. 2009
    ..Further studies should explore the use of VLNTX, combined with full and partial opioid agonist medications, in detoxification and long-term treatment of opioid dependence...
  32. ncbi request reprint The genetic determinants of smoking
    Vikas Batra
    Department of Medicine, Division of Critical Care, Pulmonary, Allergic and Immunologic Diseases, Thomas Jefferson University, Philadelphia, USA
    Chest 123:1730-9. 2003
    ..Insights into the genetic contributions to smoking can potentially lead to more effective strategies to reduce smoking...
  33. ncbi request reprint High- and low-structure treatments for substance dependence: role of learned helplessness
    Charles C Thornton
    Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, Pennsylvannia 19107, USA
    Am J Drug Alcohol Abuse 29:567-84. 2003
    ..A matching approach that assigns patients to high- and low-structure treatments based on pretreatment levels of LH might improve treatment outcomes for substance-dependent patients...
  34. ncbi request reprint A functional prodynorphin promoter polymorphism and opioid dependence
    Riju Ray
    Department of Pharmacology, University of Pennsylvania, Philadelphia, 19104, USA
    Psychiatr Genet 15:295-8. 2005
    ..We examined this polymorphism for association in our sample of 168 opioid-dependent patients and 122 ethnically and geographically matched controls...
  35. ncbi request reprint Effectiveness of low-dose naltrexone in the post-detoxification treatment of opioid dependence
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    J Clin Psychopharmacol 27:468-74. 2007
    ..The present study evaluated whether the augmentation with low-dose NTX during the post-detoxification treatment of opioid dependence would improve outcomes...
  36. ncbi request reprint Comparison of pretreatment characteristics and treatment outcomes for alcohol-, cocaine-, and multisubstance-dependent patients
    Ashwin A Patkar
    Division of Substance Abuse Programs, Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Addict Dis 23:93-109. 2004
    ..Clinicians should be cautious about forecasting treatment-outcomes for addicted patients based on their primary substances of abuse...
  37. ncbi request reprint Differences in peripheral noradrenergic function among actively drinking and abstinent alcohol-dependent individuals
    Ashwin A Patkar
    Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA, USA
    Am J Addict 13:225-35. 2004
    ..However, the changes in NA activity appears to normalize after a longer period of abstinence. Alterations in NA activity do not seem to be specific for Type I or Type II subtypes of alcoholism...
  38. pmc Problem drinking and low-dose naltrexone-assisted opioid detoxification
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 2218 Elder Street, Suite 123, Durham, North Carolina 27705, USA
    J Stud Alcohol Drugs 72:507-13. 2011
    ..In a secondary analysis of these data, we sought to determine whether problem drinking affects detoxification outcomes and whether symptoms are influenced by VLNTX use...
  39. ncbi request reprint Nicotine dependence and treatment outcome among African American cocaine-dependent patients
    Ashwin A Patkar
    Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA, USA
    Nicotine Tob Res 5:411-8. 2003
    ..It seems that severity of tobacco use predicts poor outcome for cocaine-dependent patients who are cocaine free at the time of admission into outpatient treatment...
  40. pmc Prescription pain reliever abuse and dependence among adolescents: a nationally representative study
    Li Tzy Wu
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University, Durham, NC 27710, USA
    J Am Acad Child Adolesc Psychiatry 47:1020-9. 2008
    ....
  41. ncbi request reprint Tobacco smoking: current concepts in etiology and treatment
    Ashwin A Patkar
    Department of Psychiatry, Thomas Jefferson University, 33 South 9th Street, Suite 210E, Philadelphia, PA 19107, USA
    Psychiatry 66:183-99. 2003
    ..It also makes recommendations for the rational use of these interventions to treat nicotine dependence in individuals with psychiatric disorders...
  42. pmc The combination very low-dose naltrexone-clonidine in the management of opioid withdrawal
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Am J Drug Alcohol Abuse 38:200-5. 2012
    ..Very low-dose naltrexone (VLNTX) has been shown to attenuate withdrawal intensity and noradrenaline release following opioid agonist taper, suggesting a combination with clonidine may result in improved safety and efficacy...
  43. ncbi request reprint Paroxetine: safety and tolerability issues
    David M Marks
    Duke University Medical Center, Department of Psychiatry and Behavioural Sciences, 2218 Elder Street, Durham 27705, USA
    Expert Opin Drug Saf 7:783-94. 2008
    ....
  44. ncbi request reprint Relationship between tobacco smoking and positive and negative symptoms in schizophrenia
    Ashwin A Patkar
    Department of Psychiatry and Human Behavior, Thomas Jefferson University, 833 Chestnut Street East, Suite 210E, Philadelphia, Pennsylvania, 19107, USA
    J Nerv Ment Dis 190:604-10. 2002
    ..A combination of negative symptoms, duration of illness, and alcohol use optimally predicted smoking in the sample. Neurobiological mechanisms could possibly underlie some of our findings and require further investigation...
  45. pmc HIV risk behavior in treatment-seeking opioid-dependent youth: results from a NIDA clinical trials network multisite study
    Christina S Meade
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    J Acquir Immune Defic Syndr 55:65-72. 2010
    ..To assess baseline rates of and changes in HIV drug and sexual risk behavior as a function of gender and treatment in opioid-dependent youth...
  46. pmc The high prevalence of substance use disorders among recent MDMA users compared with other drug users: Implications for intervention
    Li Tzy Wu
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke Clinical Research Institute, Duke University Medical Center, Box 3419, Durham, NC 27710, USA
    Addict Behav 34:654-61. 2009
    ....
  47. doi request reprint Influence of BDNF variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia
    Chi Un Pae
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Neuropsychobiology 65:1-11. 2012
    ....
  48. pmc The impact of the CONSORT statement on reporting of randomized clinical trials in psychiatry
    Changsu Han
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center and Duke Clinical Research Institute, Durham, NC, USA
    Contemp Clin Trials 30:116-22. 2009
    ..Although the overall quality of reporting on psychiatric RCTs generally improved after publication of the CONSORT statement, reporting the details of randomization, blinding, and obtaining informed consent remain insufficient...
  49. pmc The construct and measurement equivalence of cocaine and opioid dependences: a National Drug Abuse Treatment Clinical Trials Network (CTN) study
    Li Tzy Wu
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Duke Clinical Research Institute, Durham, NC 27710, USA
    Drug Alcohol Depend 103:114-23. 2009
    ....
  50. ncbi request reprint Asenapine, blonanserin, iloperidone, lurasidone, and sertindole: distinctive clinical characteristics of 5 novel atypical antipsychotics
    Sheng Min Wang
    Department of Psychiatry, The Catholic University of Korea, College of Medicine Department of Psychiatry, Korea University College of Medicine, Seoul, Republic of Korea Department of Psychiatry and Behavioural Sciences, Duke University Medical Center, Durham, NC and Global Medical Education, New York, NY
    Clin Neuropharmacol 36:223-38. 2013
    ....
  51. pmc Infrequent illicit methadone use among stimulant-using patients in methadone maintenance treatment programs: a national drug abuse treatment clinical trials network study
    Li Tzy Wu
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina 27710, USA
    Am J Addict 17:304-11. 2008
    ..Illicit methadone use among patients in maintenance programs is infrequent; however, a number of factors may increase risk of illicit use...
  52. ncbi request reprint Tobacco and alcohol use and medical symptoms among cocaine dependent patients
    Ashwin A Patkar
    Department of Psychiatry, Jefferson Medical College and Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA
    Subst Abus 23:105-14. 2002
    ....
  53. ncbi request reprint Relationship between tobacco smoking and medical symptoms among cocaine-, alcohol-, and opiate-dependent patients
    Ashwin A Patkar
    Division of Substance Abuse Programs, Department of Psychiatry, Jefferson Medical College and Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Am J Addict 11:209-18. 2002
    ..In particular, cocaine patients seem to be affected differently than alcohol and opiate patients...
  54. ncbi request reprint A comparison of smoking habits among medical and nursing students
    Ashwin A Patkar
    Department of Psychiatry and Human Behavior, Jefferson Medical College and Thomas Jefferson University, Philadelphia, PA 19107, USA
    Chest 124:1415-20. 2003
    ..We compared smoking habits among medical and nursing students, and examined whether these habits changed during the course of education for each cohort...
  55. ncbi request reprint Long-acting injectable naltrexone for the treatment of alcohol dependence
    Paolo Mannelli
    Duke University Medical Center, 2218 Elder Street, Suite 123, Durham, NC 27705, USA
    Expert Rev Neurother 7:1265-77. 2007
    ..The clinical availability of extended-release naltrexone has the potential to enhance treatment outcomes for alcohol and other drug dependence disorders...
  56. ncbi request reprint Trends in nonheroin opioid abuse admissions: 1992-2004
    Kathleen S Peindl
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA
    J Opioid Manag 3:215-23. 2007
    ..This study examines trends for treatment admissions for nonheroin opioid abuse from 1992 to 2004...
  57. doi request reprint Safety of selegiline transdermal system in clinical practice: analysis of adverse events from postmarketing exposures
    Chi Un Pae
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27705, USA
    J Clin Psychiatry 73:661-8. 2012
    ..The objective of this analysis is to present the safety profile of selegiline transdermal system (STS) in clinical practice after US Food and Drug Administration approval by analyzing reported postmarketing adverse events (AEs)...
  58. ncbi request reprint Serum prolactin and response to treatment among cocaine-dependent individuals
    Ashwin A Patkar
    Division of Substance Abuse Programs, Department of Psychiatry and Human Behavior, Jefferson Medical College and Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Addict Biol 7:45-53. 2002
    ..Moreover, higher prolactin seems to be related negatively with certain measures of response to treatment among cocaine patients...
  59. pmc An open-label, rater-blinded, flexible-dose, 8-week trial of escitalopram in patients with major depressive disorder with atypical features
    Chi Un Pae
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N C, and the Department of Psychiatry, College of Medicine, The Catholic University of Korea and Department of Psychiatry, Korea University, Seoul, South Korea
    Prim Care Companion J Clin Psychiatry 10:205-10. 2008
    ..Adequately powered, randomized, double-blind, placebo-controlled trials are necessary to determine the efficacy of escitalopram in this disorder.Trial Registration: clinicaltrials.gov Identifier: NCT00610506...
  60. pmc History of depressive and anxiety disorders and paroxetine response in patients with irritable bowel syndrome: post hoc analysis from a placebo-controlled study
    David M Marks
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N C and GlaxoSmithKline, King of Prussia, PA
    Prim Care Companion J Clin Psychiatry 10:368-75. 2008
    ..We investigated whether a history of depressive and/or anxiety disorders was associated with response to treatment in a double-blind, randomized, placebo-controlled trial of paroxetine controlled release (CR) in IBS...
  61. pmc Non-prescribed use of pain relievers among adolescents in the United States
    Li Tzy Wu
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University Medical Center, Box 17969, Durham, NC 27715, USA
    Drug Alcohol Depend 94:1-11. 2008
    ..We examined gender-specific prevalences, patterns, and correlates of non-prescribed use of pain relievers - mainly opioids - in a representative sample of American adolescents (N=18,678)...
  62. ncbi request reprint A genetic association study of the mu opioid receptor and severe opioid dependence
    James J Crowley
    Department of Pharmacology, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Psychiatr Genet 13:169-73. 2003
    ..A recent report (Hoehe et al., 2000) found a significant association between a specific combination of OPRM1 single nucleotide polymorphisms (SNPs) and substance dependence...
  63. pmc Hallucinogen use disorders among adult users of MDMA and other hallucinogens
    Li Tzy Wu
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University, Durham, North Carolina 27710, USA
    Am J Addict 17:354-63. 2008
    ..Subthreshold hallucinogen dependence is relatively prevalent and represents a clinically important subgroup that warrants future research and consideration in a major diagnostic classification system...
  64. ncbi request reprint Serotonin transporter polymorphisms and measures of impulsivity, aggression, and sensation seeking among African-American cocaine-dependent individuals
    Ashwin A Patkar
    Division of Substance Abuse Programs, Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Psychiatry Res 110:103-15. 2002
    ..The findings do not seem to support an association between these polymorphisms in the 5HTT gene and impulsive-aggressive traits among cocaine-dependent African-American individuals...
  65. doi request reprint Short-, intermediate-, and long-term outcomes of Pennsylvania's continuum of tobacco education pilot project
    Frank T Leone
    Center for Tobacco Research and Treatment, Jefferson Medical College, Thomas Jefferson University, 834 Walnut Street, Suite 650, Philadelphia, PA 19107, USA
    Nicotine Tob Res 11:387-93. 2009
    ....
  66. ncbi request reprint Selegiline transdermal system: current awareness and promise
    Chi Un Pae
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:1153-63. 2007
    ....
  67. ncbi request reprint Paroxetine: current status in psychiatry
    Chi Un Pae
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Expert Rev Neurother 7:107-20. 2007
    ..It also discusses emerging evidence in other clinical areas and recent data that have led to modifications in the safety profile of paroxetine...
  68. ncbi request reprint Changes in plasma noradrenaline and serotonin levels and craving during alcohol withdrawal
    Ashwin A Patkar
    Department of Psychiatry, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Alcohol Alcohol 38:224-31. 2003
    ..We also explored whether alterations in NA and 5-HT activity differ between type I and type II alcohol-dependent patients during withdrawal...
  69. ncbi request reprint Does minocycline have antidepressant effect?
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, South Korea
    Biomed Pharmacother 62:308-11. 2008
    ..Further studies of the potential therapeutic mechanism of minocycline and its therapeutic implications for major depression are warranted, and may substantially contribute to the development of newer and more effective antidepressants...
  70. ncbi request reprint Clinical variables associated with early administration of antipsychotics in bipolar mania
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, Republic of Korea
    Prog Neuropsychopharmacol Biol Psychiatry 30:151-4. 2006
    ..0 and 13.1, respectively). This study suggests that some clinical factors in bipolar mania might be linked to the earlier antipsychotic treatment. However, more studies will be needed to confirm this finding...
  71. ncbi request reprint Reduction in methamphetamine induced sensitization and reinstatement after combined pergolide plus ondansetron treatment during withdrawal
    Colin Davidson
    Psychiatry, Box 3870, Duke University Medical Center, NC 27710, United States
    Eur J Pharmacol 565:113-8. 2007
    ..These data suggest that pergolide plus ondansetron treatment may be useful as a therapy to reduce relapse in methamphetamine abusers...
  72. ncbi request reprint Telephone enhancement of long-term engagement (TELE) in continuing care for substance abuse treatment: a NIDA clinical trials network (CTN) study
    Robert L Hubbard
    Duke University Medical Center, Durham, North Carolina, USA
    Am J Addict 16:495-502. 2007
    ..While the phone calls were feasible, the lack of clear evidence of efficacy of the calls suggests the need for further investigation of the role of telephone intervention to encourage compliance and improve outcomes...
  73. ncbi request reprint Buprenorphine treatment: factors and first-hand experiences for providers to consider
    Bradley R Meier
    Department of Psychiatry, Thomas Jefferson University, Philadelphia, PA, USA
    J Addict Dis 26:3-14. 2007
    ....
  74. ncbi request reprint Psychotic symptoms in patients with medical disorders
    Ashwin A Patkar
    Section of Biological Psychiatry and Clinical Trials, Thomas Jefferson University, 33 South 9th Street, Suite 210E, Philadelphia, PA 19107, USA
    Curr Psychiatry Rep 6:216-24. 2004
    ..Understanding the neuropsychiatric effects of medications and drug-drug interactions may help in preventing psychotic symptoms...
  75. ncbi request reprint Changes in mu opioid receptors and rheological properties of erythrocytes among opioid abusers
    Allen R Zeiger
    Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, PA, USA
    Addict Biol 7:207-17. 2002
    ..This study may offer clues to the biological properties of peripheral blood cells that may be mediated by mu opioid receptors and lead to a better understanding of some of the clinical effects of opioid use...
  76. ncbi request reprint The implementation of buprenorphine/naloxone in college health practice
    Peter A Demaria
    Tuttleman Counseling Services, Temple University, 1810 Liacouris Walk, Philadelphia, PA 19122, USA
    J Am Coll Health 56:391-3. 2008
    ..The authors review the pharmacology of buprenorphine/naloxone and discuss how it can be implemented in college health practice. They also present a case report...
  77. ncbi request reprint Management of fibromyalgia
    Ashwin A Patkar
    Department of Psychiatry, Thomas Jefferson University, 833 Chestnut Street, Suite 210E, Philadelphia, PA 19107, USA
    Curr Psychiatry Rep 5:218-24. 2003
    ..Patience and positive attitude on part of the physician and active involvement of patients and their families in treatment are likely to enhance improvement...
  78. ncbi request reprint Rapid versus conventional initiation of quetiapine in the treatment of schizophrenia: a randomized, parallel-group trial
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, Seocho Gu, Seoul, South Korea
    J Clin Psychiatry 68:399-405. 2007
    ..S. Food and Drug Administration (FDA). The secondary objectives included assessment of the efficacy of a rapid initiation of quetiapine compared with a conventional initiation approved by the FDA...
  79. ncbi request reprint Fluoxetine versus sertraline in the treatment of patients with undifferentiated somatoform disorder: a randomized, open-label, 12-week, parallel-group trial
    Changsu Han
    Department of Psychiatry, Korea University, College of Medicine, Seoul, South Korea
    Prog Neuropsychopharmacol Biol Psychiatry 32:437-44. 2008
    ..This study suggests that both agents may have a potential role in the treatment of USD. A double-blind, placebo-controlled trial and/or head-to-head comparison study with larger samples are required to draw more definite conclusions...
  80. ncbi request reprint Is there protective haplotype of dysbindin gene (DTNBP1) 3 polymorphisms for major depressive disorder
    Jung Jin Kim
    Department of Psychiatry, The Catholic University of Korea College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, South Korea
    Prog Neuropsychopharmacol Biol Psychiatry 32:375-9. 2008
    ..Coupled with previous findings on schizophrenia, our finding suggests that dysbindin gene variants may have a role in the susceptibility to MDD. Adequately powered further studies in different ethnic groups are warranted...
  81. ncbi request reprint Comments on "Addition of lamotrigine to valproic acid: a successful outcome in a case of rapid-cycling bipolar affective disorder"
    Chi Un Pae
    Prog Neuropsychopharmacol Biol Psychiatry 32:595-6. 2008
  82. ncbi request reprint Venlafaxine versus mirtazapine in the treatment of undifferentiated somatoform disorder: a 12-week prospective, open-label, randomized, parallel-group trial
    Changsu Han
    Department of Psychiatry, Korea University, College of Medicine, Seoul, Korea
    Clin Drug Investig 28:251-61. 2008
    ..We set out to compare the efficacy and tolerability of mirtazapine versus venlafaxine in patients with undifferentiated somatoform disorder (USD) using the Patient Health Questionnaire-15 (PHQ-15)...
  83. doi request reprint A case of transient hallucination with ropinirole augmentation antidepressant in a patient with treatment-resistant depression: Is there differential effect of ropinirole dose on developing psychotic symptom?
    Chi Un Pae
    Prog Neuropsychopharmacol Biol Psychiatry 32:1087-8. 2008
  84. ncbi request reprint DTNBP1 haplotype influences baseline assessment scores of schizophrenic in-patients
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, South Korea
    Neurosci Lett 440:150-4. 2008
    ..008; 0.005). Covariate analysis revealed a more stable significant association between A-A haplotype and baseline scores. These results suggest a protective effect of A-A haplotype on psychotic positive symptoms at baseline...
  85. ncbi request reprint Usefulness of long-acting injectable risperidone during 12-month maintenance therapy of bipolar disorder
    Changsu Han
    Department of Psychiatry, Korea University, College of Medicine, Seoul, South Korea
    Prog Neuropsychopharmacol Biol Psychiatry 31:1219-23. 2007
    ....
  86. ncbi request reprint Aripiprazole augmentation for treatment of patients with inadequate antidepressants response
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea, College of Medicine, Seoul, South Korea
    Depress Anxiety 24:522-6. 2007
    ..These results highlight the potential benefits of aripiprazole for these patients. However, adequately powered, randomized, controlled trials are needed to confirm these results...
  87. ncbi request reprint Heat-shock protein-70 genes and response to antidepressants in major depression
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, Seoul, South Korea
    Prog Neuropsychopharmacol Biol Psychiatry 31:1006-11. 2007
    ..In conclusion, genetic variants within the genes coding for HSP-70 family proteins may affect the action of antidepressants and thus their therapeutic efficacy...
  88. ncbi request reprint Dysbindin associated with selective serotonin reuptake inhibitor antidepressant efficacy
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, Seocho Gu, Seoul, Korea
    Pharmacogenet Genomics 17:69-75. 2007
    ..In the search for further genes influencing antidepressant response we focused on the dysbindin gene (dystrobrevin-binding-protein 1, DTNBP1)...
  89. ncbi request reprint Do estradiol levels influence on the cognitive function during antidepressant treatments in post-menopausal women with major depressive disorder? A comparison with pre-menopausal women
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, South Korea
    Neuro Endocrinol Lett 29:500-6. 2008
    ..Hence, this study aimed to investigate the role of menopausal status including the level of sex hormones on cognitive function during antidepressant treatment...
  90. ncbi request reprint Aripiprazole in the treatment of depressive and anxiety disorders: a review of current evidence
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, Seoul, South Korea
    CNS Drugs 22:367-88. 2008
    ..Clinical data also suggest that aripiprazole may have a lower adverse effect burden than the other atypical drugs. Future research may confirm the potential utility of aripiprazole in the treatment of depressive and anxiety disorders...
  91. ncbi request reprint Quinone oxidoreductase (NQO1) gene polymorphism may not confer a susceptibility to mood disorders
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, South Korea
    Psychiatry Res 153:83-6. 2007
    ..These preliminary results showed that the NQO1 gene polymorphism was not related to a susceptibility to mood disorders...
  92. ncbi request reprint The atypical antipsychotics olanzapine and risperidone in the treatment of posttraumatic stress disorder: a meta-analysis of randomized, double-blind, placebo-controlled clinical trials
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea, College of Medicine, Seoul, South Korea
    Int Clin Psychopharmacol 23:1-8. 2008
    ..Clinical significance of the results, however, should be carefully interpreted and translated into clinical practice, given that the quality and availability of currently existing RCTs included in the analysis...

Research Grants1

  1. Serotonin and cocaine dependence:Treatment implications
    Ashwin Patkar; Fiscal Year: 2004
    ..Moreover, the results may help to improve pharmacological strategies for the treatment of cocaine dependence. ..