Uptal D Patel

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Association between high-dose erythropoiesis-stimulating agents, inflammatory biomarkers, and soluble erythropoietin receptors
    Jula K Inrig
    Department of Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 8523, USA
    BMC Nephrol 12:67. 2011
  2. doi request reprint Impact of anemia on physical function and survival among patients with coronary artery disease
    Uptal D Patel
    Division of Nephrology, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27710, USA
    Clin Cardiol 31:546-50. 2008
  3. doi request reprint Fetal origins of renal disparities
    Uptal D Patel
    Duke Clinical Research Institute, Duke University, Durham, NC 27705, USA
    Semin Nephrol 30:42-50. 2010
  4. pmc A secondary analysis of the CHOIR trial shows that comorbid conditions differentially affect outcomes during anemia treatment
    Lynda A Szczech
    Renal Division, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Kidney Int 77:239-46. 2010
  5. doi request reprint Increasing healthcare resource utilization after coronary artery bypass graft surgery in the United States
    Madhav Swaminathan
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Circ Cardiovasc Qual Outcomes 2:305-12. 2009
  6. pmc Perioperative outcomes among patients with end-stage renal disease following coronary artery bypass surgery in the USA
    Dipen S Parikh
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Nephrol Dial Transplant 25:2275-83. 2010
  7. doi request reprint Impact of early renal recovery on survival after cardiac surgery-associated acute kidney injury
    Madhav Swaminathan
    Division of Cardiothoracic Anesthesiology, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 89:1098-104. 2010
  8. pmc Relationship of the time interval between cardiac catheterization and elective coronary artery bypass surgery with postprocedural acute kidney injury
    Rajendra H Mehta
    Duke Clinical Research Institute, Box 17969, Durham, NC 27715, USA
    Circulation 124:S149-55. 2011
  9. pmc Comparison of outcomes for veterans receiving dialysis care from VA and non-VA providers
    Virginia Wang
    Health Services Research and Development, Durham VA Medical Center, Durham, NC, 27705, USA
    BMC Health Serv Res 13:26. 2013
  10. pmc Impact of higher hemoglobin targets on blood pressure and clinical outcomes: a secondary analysis of CHOIR
    Jula K Inrig
    Department of Medicine, Renal Division, Duke University Medical Center, Durham, NC, USA
    Nephrol Dial Transplant 27:3606-14. 2012

Detail Information

Publications39

  1. pmc Association between high-dose erythropoiesis-stimulating agents, inflammatory biomarkers, and soluble erythropoietin receptors
    Jula K Inrig
    Department of Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 8523, USA
    BMC Nephrol 12:67. 2011
    ..We hypothesized that high-dose ESA requirement would be associated with elevated inflammatory biomarkers, decreased adipokines, and increased circulating, endogenous soluble erythropoietin receptors (sEpoR)...
  2. doi request reprint Impact of anemia on physical function and survival among patients with coronary artery disease
    Uptal D Patel
    Division of Nephrology, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27710, USA
    Clin Cardiol 31:546-50. 2008
    ..Although anemia at the time of discharge has been associated with poor functional status and survival, its impact over time is not clear...
  3. doi request reprint Fetal origins of renal disparities
    Uptal D Patel
    Duke Clinical Research Institute, Duke University, Durham, NC 27705, USA
    Semin Nephrol 30:42-50. 2010
    ..Although current empiric evidence supports a link between fetal programming and childhood/adult kidney disease, affected pathways may vary by race...
  4. pmc A secondary analysis of the CHOIR trial shows that comorbid conditions differentially affect outcomes during anemia treatment
    Lynda A Szczech
    Renal Division, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Kidney Int 77:239-46. 2010
    ..These differential outcomes underscore the need for dedicated trials in these subpopulations...
  5. doi request reprint Increasing healthcare resource utilization after coronary artery bypass graft surgery in the United States
    Madhav Swaminathan
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Circ Cardiovasc Qual Outcomes 2:305-12. 2009
    ..Our objective was to determine patterns of discharge disposition after CABG surgery in the United States...
  6. pmc Perioperative outcomes among patients with end-stage renal disease following coronary artery bypass surgery in the USA
    Dipen S Parikh
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Nephrol Dial Transplant 25:2275-83. 2010
    ..However, the impact of changes in ESRD patient volume and characteristics over time on operative outcomes is unclear...
  7. doi request reprint Impact of early renal recovery on survival after cardiac surgery-associated acute kidney injury
    Madhav Swaminathan
    Division of Cardiothoracic Anesthesiology, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 89:1098-104. 2010
    ..Although some early recovery is common, its effect on long-term outcomes is unclear. We tested the hypothesis that early renal recovery after CSA-AKI is independently associated with improved long-term survival...
  8. pmc Relationship of the time interval between cardiac catheterization and elective coronary artery bypass surgery with postprocedural acute kidney injury
    Rajendra H Mehta
    Duke Clinical Research Institute, Box 17969, Durham, NC 27715, USA
    Circulation 124:S149-55. 2011
    ..However, these studies, because of the small number of patients, were unable to adequately account for patient case-mix and included both those undergoing elective surgery and those undergoing urgent surgery...
  9. pmc Comparison of outcomes for veterans receiving dialysis care from VA and non-VA providers
    Virginia Wang
    Health Services Research and Development, Durham VA Medical Center, Durham, NC, 27705, USA
    BMC Health Serv Res 13:26. 2013
    ..We assessed the extent of chronic dialysis treatment utilization and differences in all-cause hospitalizations and mortality between veterans receiving dialysis from VA versus VA-outsourced providers...
  10. pmc Impact of higher hemoglobin targets on blood pressure and clinical outcomes: a secondary analysis of CHOIR
    Jula K Inrig
    Department of Medicine, Renal Division, Duke University Medical Center, Durham, NC, USA
    Nephrol Dial Transplant 27:3606-14. 2012
    ..Herein, we sought to determine whether changes in erythropoiesis-stimulating agent (ESA) dose and in hemoglobin were predictive of changes in blood pressure (BP) and whether these changes were associated with cardiovascular outcomes...
  11. pmc Secondary analysis of the CHOIR trial epoetin-alpha dose and achieved hemoglobin outcomes
    Lynda A Szczech
    Department of Medicine, The Renal Division, Duke University Medical Center, Durham, North Carolina, USA
    Kidney Int 74:791-8. 2008
    ..Prospective studies are needed to confirm this relationship and determine safe dosing algorithms for patients unable to achieve target hemoglobin...
  12. doi request reprint Longitudinal analysis of market factors associated with provision of peritoneal dialysis services
    Virginia Wang
    Duke University, Durham, NC, USA
    Med Care Res Rev 68:537-58. 2011
    ..These findings warrant further investigation on dialysis facilities' provision of a preferred, potentially beneficial, and cost-effective therapy...
  13. doi request reprint Mortality trends associated with acute renal failure requiring dialysis after CABG surgery in the United States
    Alina Nicoara
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, N C 27710, USA
    Blood Purif 28:359-63. 2009
    ..We examined a large nationwide database from 1988 to 2003 and hypothesized that mortality in CABG-associated acute renal failure needing dialysis (ARF-D) had declined during this period...
  14. pmc Decreased pulse pressure during hemodialysis is associated with improved 6-month outcomes
    Jula K Inrig
    Division of Nephrology, Department of Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8523, USA
    Kidney Int 76:1098-107. 2009
    ..Our study found that in prevalent dialysis subjects, a decrease in pulse pressure during dialysis was associated with improved outcomes. Further study is needed to identify how to control pulse pressure to improve outcomes...
  15. pmc Hospital performance and differences by kidney function in the use of recommended therapies after non-ST-elevation acute coronary syndromes
    Uptal D Patel
    Division of Nephrology, Duke University Medical Center, Durham, NC, USA
    Am J Kidney Dis 53:426-37. 2009
    ..The extent to which hospital performance affects the care of patients with CKD and non-ST-segment elevation acute coronary syndromes (NSTE ACSs) is unknown...
  16. doi request reprint Impact of recovery of renal function on long-term mortality after coronary artery bypass grafting
    Rajendra H Mehta
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 106:1728-34. 2010
    ..Thus, major emphasis should be on prevention of ARF in patients undergoing CABG...
  17. pmc Recognition of CKD After the Introduction of Automated Reporting of Estimated GFR in the Veterans Health Administration
    Virginia Wang
    Durham Veterans Affairs Medical Center, Durham, North Carolina, Duke University, Durham, North Carolina, Western University, London, Ontario, Canada
    Clin J Am Soc Nephrol 9:29-36. 2014
    ..Automated laboratory reporting of estimated GFR (eGFR) has been introduced in many health systems to improve CKD recognition, but its effect in large, United States-based health systems remains unclear...
  18. doi request reprint Veterans more likely to start hemodialysis with an arteriovenous fistula
    Dipen S Parikh
    Vascular Access Center of Durham, Durham, North Carolina 27707, USA
    Semin Dial 24:570-5. 2011
    ..Nonetheless, AVF rates remain suboptimal, indicating a need for ongoing vascular access evaluation and improvement...
  19. pmc Associations between worsening renal function and 30-day outcomes among Medicare beneficiaries hospitalized with heart failure
    Uptal D Patel
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
    Am Heart J 160:132-138.e1. 2010
    ..We examined associations between WRF and 30-day readmission, mortality, and costs among Medicare beneficiaries hospitalized with heart failure...
  20. pmc Negative trials in nephrology: what can we learn?
    James E Novak
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Kidney Int 74:1121-7. 2008
    ..In this article, general principles of trial design will be discussed and the potential lessons learned from recent trials in nephrology will be critically reviewed...
  21. ncbi request reprint Trends in acute renal failure associated with coronary artery bypass graft surgery in the United States
    Madhav Swaminathan
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA
    Crit Care Med 35:2286-91. 2007
    ..Based on similar observations in other clinical settings, we tested the hypothesis that the diagnosis of acute renal failure associated with coronary artery bypass graft surgery is increasing in the United States...
  22. ncbi request reprint Systematic review: comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for treating essential hypertension
    David B Matchar
    Duke Center for Clinical Health Policy Research, Duke Clinical Research Institute, Duke University, and Durham U S Department of Veterans Affairs Medical Center, Durham, North Carolina 27705, USA
    Ann Intern Med 148:16-29. 2008
    ..The relative effectiveness of angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) for lowering blood pressure is unknown...
  23. ncbi request reprint Falling into the doughnut hole: drug spending among beneficiaries with end-stage renal disease under Medicare Part D plans
    Uptal D Patel
    Duke University Medical Center, Box 3646, Division of Nephrology, Durham, NC 27710, USA
    J Am Soc Nephrol 17:2546-53. 2006
    ....
  24. doi request reprint Acute kidney injury and chronic kidney disease after cardiac surgery
    Mark Stafford-Smith
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Adv Chronic Kidney Dis 15:257-77. 2008
    ....
  25. ncbi request reprint Risk for cardiovascular outcomes among subjects with atherosclerotic cardiovascular disease and greater-than-normal estimated glomerular filtration rate
    Jula K Inrig
    Duke Clinical Research Institute, Duke University Medical Center, Box 3646, Durham, NC 27710, USA
    Clin J Am Soc Nephrol 2:1215-22. 2007
    ..This study sought to define the association of an elevated eGFR on the risk for death and cardiovascular outcomes among subjects with atherosclerotic cardiovascular disease...
  26. pmc Recommendations for a clinical decision support for the management of individuals with chronic kidney disease
    Meenal B Patwardhan
    Duke Center for Clinical Health Policy Research, 2200 W Main Street, Suite 220 Durham NC 27705, USA
    Clin J Am Soc Nephrol 4:273-83. 2009
    ..The Institute of Medicine has endorsed the use of clinical decision support (CDS) for implementing guidelines. The authors' objective was to identify the requirements of an optimal CDS system for CKD management...
  27. pmc Relationship between interdialytic weight gain and blood pressure among prevalent hemodialysis patients
    Jula K Inrig
    Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA
    Am J Kidney Dis 50:108-18, 118.e1-4. 2007
    ..This study seeks to define the relationship between IDWG and BP in prevalent hemodialysis subjects...
  28. pmc Discussions of the kidney disease trajectory by elderly patients and nephrologists: a qualitative study
    Jane O Schell
    Department of Medicine, Duke University, Durham, NC Center for Health Services Research in Primary Care, Durham VA Medical Center, Durham, NC 27705, USA
    Am J Kidney Dis 59:495-503. 2012
    ..We sought to describe how nephrologists and older patients discuss and understand the prognosis and course of kidney disease leading to renal replacement therapy...
  29. pmc Geographic and temporal trends in peritoneal dialysis services in the United States between 1995 and 2003
    Virginia Wang
    Health Services Research and Development, Durham VA Medical Center, Durham, NC 27705, USA
    Am J Kidney Dis 55:1079-87. 2010
    ..This study describes trends in the regional supply of PD services in dialysis facilities between 1995 and 2003...
  30. pmc Implementation of automated reporting of estimated glomerular filtration rate among Veterans Affairs laboratories: a retrospective study
    Rasheeda K Hall
    Center for Health Services Research in Primary Care, Veterans Affairs Health Services Research and Development, Durham, NC, USA
    BMC Med Inform Decis Mak 12:69. 2012
    ..This study examines the timing of software implementation by individual VHA laboratories and factors associated with implementation...
  31. pmc The chronic kidney disease model: a general purpose model of disease progression and treatment
    Lori A Orlando
    Duke University, 3475 Erwin Rd, Wallace Clinic Ste 204, Durham, NC 27705, USA
    BMC Med Inform Decis Mak 11:41. 2011
    ..The objective of the Chronic Kidney Disease model is to provide guidance to decision makers. We describe this model and give an example of how it can inform clinical and policy decisions...
  32. ncbi request reprint Mortality, kidney disease and cardiac procedures following acute coronary syndrome
    Jula K Inrig
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    Nephrol Dial Transplant 23:934-40. 2008
    ..Cardiac interventions are underutilized in patients with chronic kidney disease (CKD) following acute coronary syndrome (ACS) partly due to nephrotoxicity concerns...
  33. pmc Quality of care and outcomes among patients with heart failure and chronic kidney disease: A Get With the Guidelines -- Heart Failure Program study
    Uptal D Patel
    Division of Nephrology, Duke University Medical Center, Durham, NC, USA
    Am Heart J 156:674-81. 2008
    ..Both heart failure (HF) and chronic kidney disease (CKD) are highly prevalent conditions that often coexist; however, the quality of care received by hospitalized patients with both is not known...
  34. doi request reprint Renal transplant imaging using magnetic resonance angiography with a nonnephrotoxic contrast agent
    Mustafa R Bashir
    Department of Radiology, Duke University Medical Center, Durham, NC, USA
    Transplantation 96:91-6. 2013
    ....
  35. pmc Impact of 5-year weight change on blood pressure: results from the weight loss maintenance trial
    Crystal C Tyson
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA
    J Clin Hypertens (Greenwich) 15:458-64. 2013
    ..Although aging may have contributed to rise in BP at 60 months, it does not appear to fully account for observed BP changes. These results suggest that continued modest weight loss may be sufficient for long-term BP lowering. ..
  36. doi request reprint Management of coronary artery disease in end-stage renal disease
    John K Roberts
    Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA
    Semin Dial 24:525-32. 2011
    ..Several considerations that arise while making such decisions are discussed...
  37. doi request reprint Device therapy in heart failure patients with chronic kidney disease
    Leon A Cannizzaro
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    J Am Coll Cardiol 58:889-96. 2011
    ..Given this lack of clear evidence, pragmatic clinical trials and comparative effectiveness studies are needed to help identify the appropriate use of ICD and CRT devices in this high-risk population of patients with HF and CKD...
  38. doi request reprint Trends in cardiac surgery-associated acute renal failure in the United States: a disproportionate increase after heart transplantation
    Susan M Martinelli
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ren Fail 31:633-40. 2009
    ..The disproportionate increase in ARF burden after heart transplantation is a concern due to its strong association with chronic kidney disease and mortality...
  39. pmc Emerging concepts in acute kidney injury following cardiac surgery
    Christopher Hudson
    Department of Anesthesiology Duke University Medical Center, Durham, North Carolina 27710, USA
    Semin Cardiothorac Vasc Anesth 12:320-30. 2008
    ..In this review, the focus will be on advances in risk stratification, evolving definitions and improving early diagnosis of AKI, identification of effective individualized therapies, and future directions...