Genomes and Genes
Dhavalkumar D Patel
Affiliation: Duke University Medical Center
- Thymic function after hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiencyD D Patel
Department of Medicine, Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
N Engl J Med 342:1325-32. 2000..The role of the thymus in this process is unknown...
- Escape from tolerance in the human X-linked autoimmunity-allergic disregulation syndrome and the Scurfy mouseD D Patel
Departments of Medicine and Immunology, Duke University Medical Center, Box 2632, 223 MSRB, Durham, North Carolina 27710, USA
J Clin Invest 107:155-7. 2001
- Chemokines have diverse abilities to form solid phase gradientsD D Patel
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Clin Immunol 99:43-52. 2001....
- Decreased Th17 and antigen-specific humoral responses in CX₃ CR1-deficient mice in the collagen-induced arthritis modelTeresa K Tarrant
Department of Medicine, University of North Carolina at Chapel Hill, CB 7280, 3300 Manning Drive, Chapel Hill, NC 27599, USA
Arthritis Rheum 64:1379-87. 2012..Because CX(3) CR1 is expressed on T cells and antigen-presenting cells, we also examined adaptive immune functions in this model...
- Abnormal development of thymic dendritic and epithelial cells in human X-linked severe combined immunodeficiencyLaura P Hale
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
Clin Immunol 110:63-70. 2004..These histopathologic findings indicate that in addition to T cells, thymic DC development and differentiation of TE cells are also abnormal in X-SCID...
- Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN)Teresa K Tarrant
Thurston Arthritis Research Center, Department of Medicine, Division of Rheumatology, Allergy and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Clin Immunol 129:115-22. 2008..We hypothesized that GRK subtypes differentially regulate granulocyte chemotaxis and clinical disease expression in the K/BxN model...
- T cell repertoire development in humans with SCID after nonablative allogeneic marrow transplantationMarcella Sarzotti
Department of Immunology, Medicine, and Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 170:2711-8. 2003..The TCR diversity positively correlates in these patients with TREC levels...
- The immune system in aging: roles of cytokines, T cells and NK cellsHai Huang
Center for Demographic Studies, Duke University, 2117 Campus Drive Box 90408, Durham, NC 27708, USA
Front Biosci 10:192-215. 2005..In this review, age-related changes in inflammatory cytokines, T and NK cells, and the biology of IL-6 and TNF-alpha and their relevance to senescence are considered...
- Hematopoietic stem cell transplantation for severe combined immunodeficiency in the neonatal period leads to superior thymic output and improved survivalLaurie A Myers
Duke University Medical Center, Durham, NC 27710, USA
Blood 99:872-8. 2002..An improved outcome for this otherwise fatal syndrome could be achieved with newborn screening for lymphopenia so that transplantation could be performed under favorable thymopoietic conditions...
- Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxisDacia L Hunton
Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Box 3821, Duke University Medical Center, Durham, NC 27710, USA
Mol Pharmacol 67:1229-36. 2005..These data suggest that beta-arrestin 2 can mediate chemotaxis through mechanisms which may be G-protein-independent (Ang II receptors) or -dependent (LPA receptors)...
- B cell loss leading to remission in severe systemic lupus erythematosusTeresa K Tarrant
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Rheumatol 30:412-4. 2003..Of those whose SLE and B cell status was reported, 5/5 with B cell loss and 1/10 without B cell loss experienced a durable response of SLE (p = 0.002). These cases illustrate that B cell ablative therapies may have efficacy for SLE...
- Beta-arrestin-2 regulates the development of allergic asthmaJulia K L Walker
Department of Medicine, Duke University Medical Center, Box 3821, Durham, North Carolina 27710, USA
J Clin Invest 112:566-74. 2003..Because beta-arrestin-2 regulates the development of allergic inflammation at a proximal step in the inflammatory cascade, novel therapies focused on this protein may prove useful in the treatment of asthma...
- CX3CR1 deficiency confers protection from intimal hyperplasia after arterial injuryPeng Liu
Department of Medicine, University of North Carolina at Chapel Hill, USA
Arterioscler Thromb Vasc Biol 26:2056-62. 2006..We investigated the mechanisms by which CX3CR1 may be involved by evaluating the inflammatory response to arterial injury in CX3CR1-deficient animals...
- Dual targeting of CCR2 and CX3CR1 in an arterial injury model of vascular inflammationMaya R Jerath
Department of Medicine, University of North Carolina, Chapel Hill, NC, USA
Thromb J 8:14. 2010..The chemokine receptors CCR2 and CX3CR1 are important in the development of coronary artery disease. The purpose of this study is to analyze the effect of a novel CCR2 inhibitor in conjunction with CX3CR1 deletion on vascular inflammation...
- Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: a soluble, secreted CD30 homologueJoanne Fanelli Panus
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 99:8348-53. 2002..Viral inhibition of CD30 also lends support to the potential therapeutic value of targeting CD30 in human inflammatory and autoimmune diseases...
- Randomized controlled trials of autologous hematopoietic stem cell transplantation for autoimmune diseases: the evolution from myeloablative to lymphoablative transplant regimensRichard K Burt
Northwestern University Feinberg School of Medicine, Chicago, Illinois 60011, USA
Arthritis Rheum 54:3750-60. 2006
- Human ribonuclease A superfamily members, eosinophil-derived neurotoxin and pancreatic ribonuclease, induce dendritic cell maturation and activationDe Yang
Basic Research Program, Science Applications International Corporation SAIC Frederick, MD 21702, USA
J Immunol 173:6134-42. 2004..We therefore propose these mediators be considered as endogenous multifunctional immune alarmins...
- Defective antitumor responses in CX3CR1-deficient miceYen Rei A Yu
Thurston Arthritis Research Center and the Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Int J Cancer 121:316-22. 2007..Our studies indicate that CX3CR1 is an important contributor to innate immunity at multiple levels. Its role in tumor immunity is not limited by expression of CX3CL1 by tumor cells...
- Genomic-based therapy: targeting interleukin-1 for autoinflammatory diseasesHal M Hoffman
Arthritis Rheum 50:345-9. 2004
- B cell-ablative therapy for the treatment of autoimmune diseasesDhavalkumar D Patel
Arthritis Rheum 46:1984-5. 2002
- Multiplexed protein profiling on antibody-based microarrays by rolling circle amplificationStephen F Kingsmore
Molecular Staging Inc, 300 George Street, New Haven, CT 06511, USA
Curr Opin Biotechnol 14:74-81. 2003..When allied with multivariate statistical analysis, RCA protein chips have the potential to identify multiplexed biomarker classifiers for disease diagnosis and drug response...
- CX3CR1 deficiency impairs dendritic cell accumulation in arterial intima and reduces atherosclerotic burdenPeng Liu
Thurston Arthritis Research Center and Department of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599 7280, USA
Arterioscler Thromb Vasc Biol 28:243-50. 2008..The chemokine receptor CX3CR1 is associated with arterial injury and atherosclerosis. We sought to determine whether a link exists between arterial DC accumulation, CX3CR1, and atherosclerosis...
- Ozone enhancement of lower airway allergic inflammation is prevented by gamma-tocopherolJames G Wagner
Department of Pathobiology and Diagnostic Investigation, Michigan State University, 211 Food Safety and Toxicology Building, East Lansing, MI 48824, USA
Free Radic Biol Med 43:1176-88. 2007..These data demonstrate broad anti-inflammatory effects of a gammaT and suggest that it may be an effective therapy of allergic airway inflammation...
- Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6Annemieke Kavelaars
Laboratory for Psychoneuroimmunology, University Medical Center Utrecht, Utrecht, The Netherlands
J Immunol 171:6128-34. 2003..In conclusion, GRK6 deficiency leads to prolonged BLT1 signaling and increased neutrophil migration...
- Elevated serum levels of interferon-regulated chemokines are biomarkers for active human systemic lupus erythematosusJason W Bauer
Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America
PLoS Med 3:e491. 2006..Furthermore, the levels of serum chemokines may serve as convenient biomarkers for disease activity in lupus...
- The chemokine CX3CL1 regulates NK cell activity in vivoLisa A Robinson
The Hospital for Sick Children Research Institute, and the University of Toronto, Toronto, Canada
Cell Immunol 225:122-30. 2003..NK cell binding to activated endothelial monolayers was significantly inhibited by anti-CX(3)CR1 Ab or soluble CX(3)CL1 (p<0.001). These studies identify a critical role for CX(3)CL1 in modulating NK cell activity in vivo...
- Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signalingSang Hoon Sin
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, NC 27599 7290, USA
Blood 109:2165-73. 2007..This validates sirolimus as a new treatment option for PEL...
- Cerebral palsy is characterized by protein mediators in cord serumTuula Kaukola
Department of Pediatrics and Biocenter Oulu, University of Oulu, Oulu, Finland
Ann Neurol 55:186-94. 2004..The cytokine patterns at birth differ between premature and term infants who develop CP...
- Use of intravenous immunoglobulin in human disease: a review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and ImmunologyJordan S Orange
Department of Pediatrics, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, Philadelphia 19104, USA
J Allergy Clin Immunol 117:S525-53. 2006..Given the potential risks and inherent scarcity of IGIV, careful consideration of the indications for and administration of IGIV is warranted...
- AIRE recruits multiple transcriptional components to specific genomic regions through tethering to nuclear matrixYunxia Tao
Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, 4200 East Ninth Ave C 238, Denver, CO 80262, USA
Mol Immunol 43:335-45. 2006..Together, these data suggest that AIRE regulates gene expression by recruiting components of the transcription complex to specific regions of the genome via interactions with nuclear matrix...
- Acute LPS inhalation in healthy volunteers induces dendritic cell maturation in vivoNeil E Alexis
Center for Environmental Biology, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, NC 27599, USA
J Allergy Clin Immunol 115:345-50. 2005..We have been studying the innate immune response of airways cells of healthy human volunteers to inhaled LPS, a Toll-like receptor 4 (TLR4) ligand, and have shown that macrophage phagocytic capacity is blunted...
- Protein microarray analysis of disease activity in pediatric inflammatory bowel disease demonstrates elevated serum PLGF, IL-7, TGF-beta1, and IL-12p40 levels in Crohn's disease and ulcerative colitis patients in remission versus active diseaseHoward A Kader
Pediatric Gastroenterology Associates, The Children's Hospital at Sinai, 2411 W. Belvedere Avenue, Baltimore, MD 21215, USA
Am J Gastroenterol 100:414-23. 2005..Further studies will be needed to validate our results to define the molecular pathways involved in the intestinal immune response in man...
- Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient miceAlan M Fong
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 99:7478-83. 2002..Thus, these results indicate that beta-arrestin2 and GRK6 actually play positive regulatory roles in mediating the chemotactic responses of T and B lymphocytes to CXCL12...