Sara K Pasquali

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Evaluation of failure to rescue as a quality metric in pediatric heart surgery: an analysis of the STS Congenital Heart Surgery Database
    Sara K Pasquali
    Department of Pediatrics, Duke University School of Medicine, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27715, USA
    Ann Thorac Surg 94:573-9; discussion 579-80. 2012
  2. pmc Trends in endocarditis hospitalizations at US children's hospitals: impact of the 2007 American Heart Association Antibiotic Prophylaxis Guidelines
    Sara K Pasquali
    Division of Cardiology, Department of Pediatrics, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Am Heart J 163:894-9. 2012
  3. pmc The complex relationship between center volume and outcome in patients undergoing the Norwood operation
    Sara K Pasquali
    Department of Pediatrics, Duke University School of Medicine, Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Ann Thorac Surg 93:1556-62. 2012
  4. pmc Comparative analysis of antifibrinolytic medications in pediatric heart surgery
    Sara K Pasquali
    Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA
    J Thorac Cardiovasc Surg 143:550-7. 2012
  5. pmc Association of center volume with mortality and complications in pediatric heart surgery
    Sara K Pasquali
    Division of Cardiology, Department of Pediatrics, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27715, USA
    Pediatrics 129:e370-6. 2012
  6. pmc Perioperative methylprednisolone and outcome in neonates undergoing heart surgery
    Sara K Pasquali
    Department of Pediatrics, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC, USA
    Pediatrics 129:e385-91. 2012
  7. pmc Care models and associated outcomes in congenital heart surgery
    Danielle S Burstein
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Pediatrics 127:e1482-9. 2011
  8. pmc Center variation in hospital costs for patients undergoing congenital heart surgery
    Sara K Pasquali
    Divisions of Pediatric Cardiology and Cardiothoracic Surgery and the Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Circ Cardiovasc Qual Outcomes 4:306-12. 2011
  9. pmc Linking clinical registry data with administrative data using indirect identifiers: implementation and validation in the congenital heart surgery population
    Sara K Pasquali
    Department of Pediatrics, Duke University School of Medicine, Durham, NC Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Am Heart J 160:1099-104. 2010
  10. pmc Platelet activity associated with concomitant use of clopidogrel and proton pump inhibitors in children with cardiovascular disease
    Sara K Pasquali
    Department of Pediatrics, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27715, USA
    Congenit Heart Dis 5:552-5. 2010

Detail Information

Publications39

  1. pmc Evaluation of failure to rescue as a quality metric in pediatric heart surgery: an analysis of the STS Congenital Heart Surgery Database
    Sara K Pasquali
    Department of Pediatrics, Duke University School of Medicine, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27715, USA
    Ann Thorac Surg 94:573-9; discussion 579-80. 2012
    ..It is unknown whether this holds true in pediatric heart surgery. We characterized the relationship between complications, FTR, and mortality in this population...
  2. pmc Trends in endocarditis hospitalizations at US children's hospitals: impact of the 2007 American Heart Association Antibiotic Prophylaxis Guidelines
    Sara K Pasquali
    Division of Cardiology, Department of Pediatrics, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Am Heart J 163:894-9. 2012
    ..The impact of these guidelines is unclear. We evaluated IE hospitalizations at US children's hospitals during this period...
  3. pmc The complex relationship between center volume and outcome in patients undergoing the Norwood operation
    Sara K Pasquali
    Department of Pediatrics, Duke University School of Medicine, Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Ann Thorac Surg 93:1556-62. 2012
    ..We evaluated the impact of patient risk status on the relationship between center volume and outcome, and the extent to which differences in center volume account for between-center variation in outcome...
  4. pmc Comparative analysis of antifibrinolytic medications in pediatric heart surgery
    Sara K Pasquali
    Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA
    J Thorac Cardiovasc Surg 143:550-7. 2012
    ..We performed a comparative analysis in a large multicenter cohort...
  5. pmc Association of center volume with mortality and complications in pediatric heart surgery
    Sara K Pasquali
    Division of Cardiology, Department of Pediatrics, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27715, USA
    Pediatrics 129:e370-6. 2012
    ..We examined this association in a large multicenter cohort...
  6. pmc Perioperative methylprednisolone and outcome in neonates undergoing heart surgery
    Sara K Pasquali
    Department of Pediatrics, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC, USA
    Pediatrics 129:e385-91. 2012
    ..We evaluated outcomes across methylprednisolone regimens versus no steroids in a large cohort of neonates...
  7. pmc Care models and associated outcomes in congenital heart surgery
    Danielle S Burstein
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Pediatrics 127:e1482-9. 2011
    ..The impact of this trend on patient outcomes is unclear. We evaluated postoperative outcomes associated with a CICU versus other ICU models...
  8. pmc Center variation in hospital costs for patients undergoing congenital heart surgery
    Sara K Pasquali
    Divisions of Pediatric Cardiology and Cardiothoracic Surgery and the Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Circ Cardiovasc Qual Outcomes 4:306-12. 2011
    ..The purpose of this study was to evaluate variation between centers in total hospital costs for 4 congenital heart operations of varying complexity and associated factors...
  9. pmc Linking clinical registry data with administrative data using indirect identifiers: implementation and validation in the congenital heart surgery population
    Sara K Pasquali
    Department of Pediatrics, Duke University School of Medicine, Durham, NC Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Am Heart J 160:1099-104. 2010
    ....
  10. pmc Platelet activity associated with concomitant use of clopidogrel and proton pump inhibitors in children with cardiovascular disease
    Sara K Pasquali
    Department of Pediatrics, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27715, USA
    Congenit Heart Dis 5:552-5. 2010
    ..In adults with acute coronary syndrome, decreased platelet inhibition associated with concomitant use of clopidogrel and proton pump inhibitors (PPI) has been reported...
  11. pmc Corticosteroids and outcome in children undergoing congenital heart surgery: analysis of the Pediatric Health Information Systems database
    Sara K Pasquali
    Department of Pediatrics, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27715, USA
    Circulation 122:2123-30. 2010
    ..Children undergoing congenital heart surgery often receive corticosteroids with the aim of reducing the inflammatory response after cardiopulmonary bypass; however, the value of this approach is unclear...
  12. pmc Globalization of pediatric research: analysis of clinical trials completed for pediatric exclusivity
    Sara K Pasquali
    Duke University Medical Center, Department of Pediatrics, Division of Cardiology, PO Box 17969, Durham, NC 27715, USA
    Pediatrics 126:e687-92. 2010
    ..We evaluated the setting of published studies conducted under the US Pediatric Exclusivity Provision, which provides economic incentives to pharmaceutical companies to conduct drug studies with children...
  13. doi request reprint Off-label use of cardiovascular medications in children hospitalized with congenital and acquired heart disease
    Sara K Pasquali
    Division of Cardiology, Department of Pediatrics, Duke University Medical Center and Duke Clinical Research Institute, Durham, NC 27715, USA
    Circ Cardiovasc Qual Outcomes 1:74-83. 2008
    ..Recent legislation has aimed to stimulate pediatric research and improve drug labeling. This study describes off-label use of CV medications in children hospitalized with congenital and acquired CV disease...
  14. pmc Safety of aprotinin in congenital heart operations: results from a large multicenter database
    Sara K Pasquali
    Division of Pediatric Cardiology, Duke University Medical Center, Durham, North Carolina 27715, USA
    Ann Thorac Surg 90:14-21. 2010
    ..We evaluated the safety of aprotinin in a large multicenter cohort of children undergoing congenital heart operations...
  15. pmc Center variation in patient age and weight at Fontan operation and impact on postoperative outcomes
    Michelle C Wallace
    Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina 27715, USA
    Ann Thorac Surg 91:1445-52. 2011
    ..We evaluated variation in age, weight, and weight-for-age z-score at Fontan across institutions, and the impact of these variables on postoperative morbidity and mortality...
  16. pmc Center variation and outcomes associated with delayed sternal closure after stage 1 palliation for hypoplastic left heart syndrome
    Jason N Johnson
    Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27715, USA
    J Thorac Cardiovasc Surg 139:1205-10. 2010
    ..We describe center variation in delayed sternal closure after stage 1 palliation and associated outcomes...
  17. doi request reprint Following the arterial switch operation, obese children have risk factors for early cardiovascular disease
    Sara K Pasquali
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Congenit Heart Dis 5:16-24. 2010
    ..Obesity may also pose cardiovascular risk. The purpose of this study was to evaluate comorbidities and markers of early cardiovascular disease in obese ASO patients...
  18. pmc Relative impact of surgeon and center volume on early mortality after the Norwood operation
    Christoph P Hornik
    Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina 27715, USA
    Ann Thorac Surg 93:1992-7. 2012
    ..We evaluated the relative impact of surgeon and center volume on mortality in a large Norwood cohort...
  19. doi request reprint Congenital heart surgery outcomes in Down syndrome: analysis of a national clinical database
    James C Fudge
    Division of Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27715, USA
    Pediatrics 126:315-22. 2010
    ..We describe patient characteristics and postoperative morbidity and mortality rates for patients with Down syndrome undergoing congenital heart disease surgery...
  20. pmc Hospital variation in postoperative infection and outcome after congenital heart surgery
    Sara K Pasquali
    Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA
    Ann Thorac Surg 96:657-63. 2013
    ..However, the association of infection rates with hospital-level outcomes and resource utilization has not been well described. We evaluated this association across a multicenter cohort undergoing congenital heart surgery...
  21. pmc Differential case ascertainment in clinical registry versus administrative data and impact on outcomes assessment for pediatric cardiac operations
    Sara K Pasquali
    Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA
    Ann Thorac Surg 95:197-203. 2013
    ....
  22. pmc Variation in perioperative care across centers for infants undergoing the Norwood procedure
    Sara K Pasquali
    Department of Pediatrics and Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    J Thorac Cardiovasc Surg 144:915-21. 2012
    ..Apart from shunt type, subjects received the local standard of care. We evaluated variation in perioperative care during the Norwood hospitalization across 14 trial sites...
  23. pmc Complications after the Norwood operation: an analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database
    Christoph P Hornik
    Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA
    Ann Thorac Surg 92:1734-40. 2011
    ..Limited multicenter data exist regarding the prevalence of postoperative complications after the Norwood operation and their associated mortality risk...
  24. ncbi request reprint The relationship between neo-aortic root dilation, insufficiency, and reintervention following the Ross procedure in infants, children, and young adults
    Sara K Pasquali
    Division of Cardiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 49:1806-12. 2007
    ..The purpose of this study was to describe the relationship between neo-aortic root size, neo-aortic insufficiency (AI), and reintervention at mid-term follow-up...
  25. pmc Contemporary patterns of surgery and outcomes for aortic coarctation: an analysis of the Society of Thoracic Surgeons Congenital Heart Surgery Database
    Ross M Ungerleider
    Department of Cardiothoracic Surgery, Brenner Children s Hospital, Wake Forest Baptist Health, Winston Salem, NC, USA
    J Thorac Cardiovasc Surg 145:150-7; discussion 157-8. 2013
    ..The objective of this study was to describe characteristics and early outcomes across a large multicenter cohort undergoing coarctation or hypoplastic aortic arch repair...
  26. pmc Intervention for recoarctation in the single ventricle reconstruction trial: incidence, risk, and outcomes
    Kevin D Hill
    Clinical Research Institute, Duke University Medical Center, 2400 Pratt St, Durham, NC 27705, USA
    Circulation 128:954-61. 2013
    ..We sought to determine the incidence of recoarctation, risk factors, and outcomes in the SVR trial...
  27. pmc Variation in models of care delivery for children undergoing congenital heart surgery in the United States
    Danielle S Burstein
    Duke University Medical Center and Duke Clinical Research Institute, Durham, NC, USA
    World J Pediatr Congenit Heart Surg 1:8-14. 2010
    ..Further study is necessary to evaluate the implications of this variability on quality of care and patient outcomes. ..
  28. doi request reprint Rhythm and conduction disturbances at midterm follow-up after the ross procedure in infants, children, and young adults
    Sara K Pasquali
    Division of Cardiology, Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 85:2072-8. 2008
    ..To our knowledge, late electrophysiologic outcomes after the Ross procedure have not been described. The purpose of this study was to assess rhythm and conduction disturbances at midterm follow-up after the Ross procedure...
  29. pmc Cardiovascular abnormalities in late-onset Pompe disease and response to enzyme replacement therapy
    Daniel Forsha
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27715, USA
    Genet Med 13:625-31. 2011
    ..We evaluated the prevalence of cardiovascular abnormalities and the efficacy and safety of enzyme replacement therapy in patients with late-onset Pompe disease...
  30. doi request reprint Risk factors and comorbidities associated with obesity in children and adolescents after the arterial switch operation and Ross procedure
    Sara K Pasquali
    The Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am Heart J 158:473-9. 2009
    ..Unique factors such as activity restriction and early feeding practices may play a role. We evaluated a high-risk cohort predisposed to early coronary artery disease due to past surgery involving coronary artery reimplantation...
  31. pmc Cardiac performance and quality of life in patients who have undergone the Fontan procedure with and without prior superior cavopulmonary connection
    Andrew M Atz
    Division of Cardiology, Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Cardiol Young 23:335-43. 2013
    ..Data are limited regarding associations between a prior superior cavopulmonary connection and functional and ventricular performance late after the Fontan procedure...
  32. doi request reprint Status of the pediatric clinical trials enterprise: an analysis of the US ClinicalTrials.gov registry
    Sara K Pasquali
    Department of Pediatrics, Duke University School of Medicine, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Pediatrics 130:e1269-77. 2012
    ..gov has enabled evaluation of the clinical trial enterprise as a whole, which was previously not possible. The purpose of this study was to create a snapshot of the pediatric clinical trial portfolio...
  33. pmc Pediatric cardiovascular drug trials, lessons learned
    Jennifer S Li
    Department of Pediatrics and Duke Clinical Research Institute, Durham, NC, USA
    J Cardiovasc Pharmacol 58:4-8. 2011
    ..These lessons learned may help to inform future pediatric clinical trial development...
  34. pmc Celiac artery flow pattern in infants with single right ventricle following the Norwood procedure with a modified Blalock-Taussig or right ventricle to pulmonary artery shunt
    Jason N Johnson
    Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Pediatr Cardiol 32:479-86. 2011
    ..The celiac artery resistive index was higher in patients with the modified Blalock-Taussig shunt versus the right ventricle to pulmonary artery shunt but was not associated with measured gastrointestinal outcomes...
  35. ncbi request reprint Coronary artery pattern and outcome of arterial switch operation for transposition of the great arteries: a meta-analysis
    Sara K Pasquali
    Pediatric Cardiovascular Program, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 106:2575-80. 2002
    ..This meta-analysis assesses the effect of coronary anatomy on post-ASO mortality, both overall and adjusted for time...
  36. ncbi request reprint Exercise performance in children and adolescents after the Ross procedure
    Bradley S Marino
    Division of Cardiology, at the Cardiac Center of The Children s Hospital of Philadelphia, and the Department of Pediatrics at the University of Pennsylvania School of Medicine 19104, USA
    Cardiol Young 16:40-7. 2006
    ..The Ross procedure is increasingly utilized in the treatment of aortic valvar disease in children and adolescents. Our purpose was to compare pre- and post-operative exercise state in this population...
  37. doi request reprint Survey of nongovernmental organizations providing pediatric cardiovascular care in low- and middle-income countries
    Nguyenvu Nguyen
    Department of Pediatrics, Ann and Robert H Lurie Children s Hospital of Chicago, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
    World J Pediatr Congenit Heart Surg 5:248-55. 2014
    ..Nongovernmental organizations (NGOs) have played crucial roles in providing clinical services and infrastructure supports to LMICs CV programs; however, these outreach efforts are dispersed, inadequate, and lack coordination...
  38. pmc Use of cardiac magnetic resonance imaging to evaluate cardiac structure, function and fibrosis in children with infantile Pompe disease on enzyme replacement therapy
    Piers C A Barker
    Division of Pediatric Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    Mol Genet Metab 101:332-7. 2010
    ..We report the first use of CMR in a feasible protocol to quantify left ventricular (LV) mass, function, and the presence of myocardial fibrosis in the Pompe population...
  39. ncbi request reprint Effect of cardiac rehabilitation on functional outcomes after coronary revascularization
    Sara K Pasquali
    Outcomes Research and Assessment Group, Duke Clinical Research Institute, Durham, NC, USA
    Am Heart J 145:445-51. 2003
    ..The main objective of this study was to evaluate the impact of CR in a diverse contemporary population on patient functional outcomes...