Research Topics
| Sara K PasqualiSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Detail Information
Publications
Evaluation of failure to rescue as a quality metric in pediatric heart surgery: an analysis of the STS Congenital Heart Surgery DatabaseSara K Pasquali
Department of Pediatrics, Duke University School of Medicine, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27715, USA
Ann Thorac Surg 94:573-9; discussion 579-80. 2012..It is unknown whether this holds true in pediatric heart surgery. We characterized the relationship between complications, FTR, and mortality in this population...
Trends in endocarditis hospitalizations at US children's hospitals: impact of the 2007 American Heart Association Antibiotic Prophylaxis GuidelinesSara K Pasquali
Division of Cardiology, Department of Pediatrics, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
Am Heart J 163:894-9. 2012..The impact of these guidelines is unclear. We evaluated IE hospitalizations at US children's hospitals during this period...- The complex relationship between center volume and outcome in patients undergoing the Norwood operationSara K Pasquali
Department of Pediatrics, Duke University School of Medicine, Duke Clinical Research Institute, Durham, North Carolina 27715, USA
Ann Thorac Surg 93:1556-62. 2012..We evaluated the impact of patient risk status on the relationship between center volume and outcome, and the extent to which differences in center volume account for between-center variation in outcome... - Comparative analysis of antifibrinolytic medications in pediatric heart surgerySara K Pasquali
Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA
J Thorac Cardiovasc Surg 143:550-7. 2012..We performed a comparative analysis in a large multicenter cohort... - Perioperative methylprednisolone and outcome in neonates undergoing heart surgerySara K Pasquali
Department of Pediatrics, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC, USA
Pediatrics 129:e385-91. 2012..We evaluated outcomes across methylprednisolone regimens versus no steroids in a large cohort of neonates... - Association of center volume with mortality and complications in pediatric heart surgerySara K Pasquali
Division of Cardiology, Department of Pediatrics, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27715, USA
Pediatrics 129:e370-6. 2012..We examined this association in a large multicenter cohort... - Care models and associated outcomes in congenital heart surgeryDanielle S Burstein
Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
Pediatrics 127:e1482-9. 2011..The impact of this trend on patient outcomes is unclear. We evaluated postoperative outcomes associated with a CICU versus other ICU models... - Linking clinical registry data with administrative data using indirect identifiers: implementation and validation in the congenital heart surgery populationSara K Pasquali
Department of Pediatrics, Duke University School of Medicine, Durham, NC Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
Am Heart J 160:1099-104. 2010.... - Platelet activity associated with concomitant use of clopidogrel and proton pump inhibitors in children with cardiovascular diseaseSara K Pasquali
Department of Pediatrics, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27715, USA
Congenit Heart Dis 5:552-5. 2010..In adults with acute coronary syndrome, decreased platelet inhibition associated with concomitant use of clopidogrel and proton pump inhibitors (PPI) has been reported... - Corticosteroids and outcome in children undergoing congenital heart surgery: analysis of the Pediatric Health Information Systems databaseSara K Pasquali
Department of Pediatrics, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27715, USA
Circulation 122:2123-30. 2010..Children undergoing congenital heart surgery often receive corticosteroids with the aim of reducing the inflammatory response after cardiopulmonary bypass; however, the value of this approach is unclear... - Center variation in hospital costs for patients undergoing congenital heart surgerySara K Pasquali
Divisions of Pediatric Cardiology and Cardiothoracic Surgery and the Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
Circ Cardiovasc Qual Outcomes 4:306-12. 2011..The purpose of this study was to evaluate variation between centers in total hospital costs for 4 congenital heart operations of varying complexity and associated factors... - Globalization of pediatric research: analysis of clinical trials completed for pediatric exclusivitySara K Pasquali
Duke University Medical Center, Department of Pediatrics, Division of Cardiology, PO Box 17969, Durham, NC 27715, USA
Pediatrics 126:e687-92. 2010..We evaluated the setting of published studies conducted under the US Pediatric Exclusivity Provision, which provides economic incentives to pharmaceutical companies to conduct drug studies with children... - Safety of aprotinin in congenital heart operations: results from a large multicenter databaseSara K Pasquali
Division of Pediatric Cardiology, Duke University Medical Center, Durham, North Carolina 27715, USA
Ann Thorac Surg 90:14-21. 2010..We evaluated the safety of aprotinin in a large multicenter cohort of children undergoing congenital heart operations... - Off-label use of cardiovascular medications in children hospitalized with congenital and acquired heart diseaseSara K Pasquali
Division of Cardiology, Department of Pediatrics, Duke University Medical Center and Duke Clinical Research Institute, Durham, NC 27715, USA
Circ Cardiovasc Qual Outcomes 1:74-83. 2008..Recent legislation has aimed to stimulate pediatric research and improve drug labeling. This study describes off-label use of CV medications in children hospitalized with congenital and acquired CV disease... - Center variation in patient age and weight at Fontan operation and impact on postoperative outcomesMichelle C Wallace
Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina 27715, USA
Ann Thorac Surg 91:1445-52. 2011..We evaluated variation in age, weight, and weight-for-age z-score at Fontan across institutions, and the impact of these variables on postoperative morbidity and mortality... - Center variation and outcomes associated with delayed sternal closure after stage 1 palliation for hypoplastic left heart syndromeJason N Johnson
Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27715, USA
J Thorac Cardiovasc Surg 139:1205-10. 2010..We describe center variation in delayed sternal closure after stage 1 palliation and associated outcomes... - Following the arterial switch operation, obese children have risk factors for early cardiovascular diseaseSara K Pasquali
Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
Congenit Heart Dis 5:16-24. 2010..Obesity may also pose cardiovascular risk. The purpose of this study was to evaluate comorbidities and markers of early cardiovascular disease in obese ASO patients... - Relative impact of surgeon and center volume on early mortality after the Norwood operationChristoph P Hornik
Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina 27715, USA
Ann Thorac Surg 93:1992-7. 2012..We evaluated the relative impact of surgeon and center volume on mortality in a large Norwood cohort... - Congenital heart surgery outcomes in Down syndrome: analysis of a national clinical databaseJames C Fudge
Division of Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27715, USA
Pediatrics 126:315-22. 2010..We describe patient characteristics and postoperative morbidity and mortality rates for patients with Down syndrome undergoing congenital heart disease surgery... - Differential case ascertainment in clinical registry versus administrative data and impact on outcomes assessment for pediatric cardiac operationsSara K Pasquali
Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA
Ann Thorac Surg 95:197-203. 2013.... - Variation in perioperative care across centers for infants undergoing the Norwood procedureSara K Pasquali
Department of Pediatrics and Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
J Thorac Cardiovasc Surg 144:915-21. 2012..Apart from shunt type, subjects received the local standard of care. We evaluated variation in perioperative care during the Norwood hospitalization across 14 trial sites... - Complications after the Norwood operation: an analysis of The Society of Thoracic Surgeons Congenital Heart Surgery DatabaseChristoph P Hornik
Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA
Ann Thorac Surg 92:1734-40. 2011..Limited multicenter data exist regarding the prevalence of postoperative complications after the Norwood operation and their associated mortality risk... 
The relationship between neo-aortic root dilation, insufficiency, and reintervention following the Ross procedure in infants, children, and young adultsSara K Pasquali
Division of Cardiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Am Coll Cardiol 49:1806-12. 2007..The purpose of this study was to describe the relationship between neo-aortic root size, neo-aortic insufficiency (AI), and reintervention at mid-term follow-up...- Contemporary patterns of surgery and outcomes for aortic coarctation: an analysis of the Society of Thoracic Surgeons Congenital Heart Surgery DatabaseRoss M Ungerleider
Department of Cardiothoracic Surgery, Brenner Children s Hospital, Wake Forest Baptist Health, Winston Salem, NC, USA
J Thorac Cardiovasc Surg 145:150-7; discussion 157-8. 2013..The objective of this study was to describe characteristics and early outcomes across a large multicenter cohort undergoing coarctation or hypoplastic aortic arch repair... - Rhythm and conduction disturbances at midterm follow-up after the ross procedure in infants, children, and young adultsSara K Pasquali
Division of Cardiology, Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Ann Thorac Surg 85:2072-8. 2008..To our knowledge, late electrophysiologic outcomes after the Ross procedure have not been described. The purpose of this study was to assess rhythm and conduction disturbances at midterm follow-up after the Ross procedure... - Risk factors and comorbidities associated with obesity in children and adolescents after the arterial switch operation and Ross procedureSara K Pasquali
The Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Am Heart J 158:473-9. 2009..Unique factors such as activity restriction and early feeding practices may play a role. We evaluated a high-risk cohort predisposed to early coronary artery disease due to past surgery involving coronary artery reimplantation... - Cardiovascular abnormalities in late-onset Pompe disease and response to enzyme replacement therapyDaniel Forsha
Department of Pediatrics, Duke University Medical Center, Durham, NC 27715, USA
Genet Med 13:625-31. 2011..We evaluated the prevalence of cardiovascular abnormalities and the efficacy and safety of enzyme replacement therapy in patients with late-onset Pompe disease... - Pediatric cardiovascular drug trials, lessons learnedJennifer S Li
Department of Pediatrics and Duke Clinical Research Institute, Durham, NC, USA
J Cardiovasc Pharmacol 58:4-8. 2011..These lessons learned may help to inform future pediatric clinical trial development... - Celiac artery flow pattern in infants with single right ventricle following the Norwood procedure with a modified Blalock-Taussig or right ventricle to pulmonary artery shuntJason N Johnson
Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
Pediatr Cardiol 32:479-86. 2011..The celiac artery resistive index was higher in patients with the modified Blalock-Taussig shunt versus the right ventricle to pulmonary artery shunt but was not associated with measured gastrointestinal outcomes... - Exercise performance in children and adolescents after the Ross procedureBradley S Marino
Division of Cardiology, at the Cardiac Center of The Children's Hospital of Philadelphia, and the Department of Pediatrics at the University of Pennsylvania School of Medicine 19104, USA
Cardiol Young 16:40-7. 2006..CONCLUSIONS: In the majority of patients following the Ross procedure, exercise performance is stable and within the normal range of a healthy age and sex matched population, despite sedentary lifestyles and increased adiposity... - Coronary artery pattern and outcome of arterial switch operation for transposition of the great arteries: a meta-analysisSara K Pasquali
Pediatric Cardiovascular Program, Duke University Medical Center, Durham, NC 27710, USA
Circulation 106:2575-80. 2002..Those with intramural or single coronary arteries have significant added mortality that has persisted over time... - Use of cardiac magnetic resonance imaging to evaluate cardiac structure, function and fibrosis in children with infantile Pompe disease on enzyme replacement therapyPiers C A Barker
Division of Pediatric Cardiology, Duke University Medical Center, Durham, NC 27710, USA
Mol Genet Metab 101:332-7. 2010..We report the first use of CMR in a feasible protocol to quantify left ventricular (LV) mass, function, and the presence of myocardial fibrosis in the Pompe population... - Effect of cardiac rehabilitation on functional outcomes after coronary revascularizationSara K Pasquali
Outcomes Research and Assessment Group, Duke Clinical Research Institute, Durham, NC, USA
Am Heart J 145:445-51. 2003..Innovative strategies to facilitate CR enrollment and tailoring programs to better address the needs of all patient subgroups would extend these benefits to more eligible patients...