Affiliation: Duke University Medical Center
Wang L, Wansleeben C, Zhao S, Miao P, Paschen W, Yang W. SUMO2 is essential while SUMO3 is dispensable for mouse embryonic development. EMBO Rep. 2014;15:878-85 pubmed publisher
..Thus, our findings suggest that expression levels and not functional differences between SUMO2 and SUMO3 are critical for normal embryogenesis. ..
Jiang M, Yu S, Yu Z, Sheng H, Li Y, Liu S, et al
. XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G. Stroke. 2017;48:1646-1654 pubmed publisher
..Boosting prosurvival pathways to counterbalance the age-related decline in the brain's self-healing capacity could be a promising strategy to improve ischemic stroke outcome in aged brains. ..
Paschen W, Proud C, Mies G. Shut-down of translation, a global neuronal stress response: mechanisms and pathological relevance. Curr Pharm Des. 2007;13:1887-902 pubmed
Liu S, Sheng H, Yu Z, Paschen W, Yang W. O-linked Î²-N-acetylglucosamine modification of proteins is activated in post-ischemic brains of young but not aged mice: Implications for impaired functional recovery from ischemic stress. J Cereb Blood Flow Metab. 2016;36:393-8 pubmed publisher
Zhang L, Liu X, Sheng H, Liu S, Li Y, Zhao J, et al
. Neuron-specific SUMO knockdown suppresses global gene expression response and worsens functional outcome after transient forebrain ischemia in mice. Neuroscience. 2017;343:190-212 pubmed publisher
..Together, our data provide a basis for future studies to mechanistically link SUMOylation to neurologic function in health and disease. ..